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Published in Scientific reports (17.07.2017)
Published in Scientific reports (17.07.2017)
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Discovery and dimeric approach of novel Natriuretic Peptide Receptor A (NPR-A) agonists
Iwaki, Takehiko, Oyama, Yoshiaki, Tomoo, Toshiyuki, Tanaka, Taisaku, Okamura, Yoshihiko, Sugiyama, Masako, Yamaki, Akira, Furuya, Mayumi
Published in Bioorganic & medicinal chemistry (15.03.2017)
Published in Bioorganic & medicinal chemistry (15.03.2017)
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Discovery and SAR of a novel series of Natriuretic Peptide Receptor-A (NPR-A) agonists
Iwaki, Takehiko, Nakamura, Yuji, Tanaka, Taisaku, Ogawa, Yasuyuki, Iwamoto, Osamu, Okamura, Yoshihiko, Kawase, Yumi, Furuya, Mayumi, Oyama, Yoshiaki, Nagayama, Takahiro
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
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Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors
Futamura-Takahashi, Junko, Tanaka, Taisaku, Sugawara, Hajime, Iwashita, Shinzo, Imajo, Seiichi, Oyama, Yoshiaki, Muto, Tsuyoshi
Published in Bioorganic & medicinal chemistry letters (15.01.2018)
Published in Bioorganic & medicinal chemistry letters (15.01.2018)
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Oral chymase inhibitor SUN13834 ameliorates skin inflammation as well as pruritus in mouse model for atopic dermatitis
Terakawa, Maki, Fujieda, Yusuke, Tomimori, Yoshiaki, Muto, Tsuyoshi, Tanaka, Taisaku, Maruoka, Hiroshi, Nagahira, Kazuhiro, Ogata, Atsuto, Nakatsuka, Takashi, Fukuda, Yoshiaki
Published in European journal of pharmacology (28.12.2008)
Published in European journal of pharmacology (28.12.2008)
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Oral Administration of Chymase Inhibitor Improves Dermatitis in NC/Nga Mice
Watanabe, Naohiro, Tomimori, Yoshiaki, Terakawa, Maki, Ishiwata, Kenji, Wada, Adumi, Muto, Tsuyoshi, Tanaka, Taisaku, Maruoka, Hiroshi, Nagahira, Kazuhiro, Nakatsuka, Takashi, Fukuda, Yoshiaki
Published in Journal of investigative dermatology (01.04.2007)
Published in Journal of investigative dermatology (01.04.2007)
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ASB17061, a novel chymase inhibitor, prevented the development of angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice
Tomimori, Yoshiaki, Manno, Atsushi, Tanaka, Taisaku, Futamura-Takahashi, Junko, Muto, Tsuyoshi, Nagahira, Kazuhiro
Published in European journal of pharmacology (05.08.2019)
Published in European journal of pharmacology (05.08.2019)
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Discovery and in vivo effects of novel human natriuretic peptide receptor A (NPR-A) agonists with improved activity for rat NPR-A
Iwaki, Takehiko, Tanaka, Taisaku, Miyazaki, Kazuo, Suzuki, Yamato, Okamura, Yoshihiko, Yamaki, Akira, Iwanami, Makoto, Morozumi, Naomi, Furuya, Mayumi, Oyama, Yoshiaki
Published in Bioorganic & medicinal chemistry (15.12.2017)
Published in Bioorganic & medicinal chemistry (15.12.2017)
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Discovery of novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as human chymase inhibitors using structure-based drug design
Tanaka, Taisaku, Sugawara, Hajime, Maruoka, Hiroshi, Imajo, Seiichi, Muto, Tsuyoshi
Published in Bioorganic & medicinal chemistry (15.07.2013)
Published in Bioorganic & medicinal chemistry (15.07.2013)
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Journal Article
Pharmacokinetic/pharmacodynamic analyses of chymase inhibitor SUN13834 in NC/Nga mice and prediction of effective dosage for atopic dermatitis patients
Ogata, Atsuto, Fujieda, Yusuke, Terakawa, Maki, Muto, Tsuyoshi, Tanaka, Taisaku, Maruoka, Hiroshi, Nagahira, Kazuhiro, Fukuda, Yoshiaki, Tomimori, Yoshiaki, Watanabe, Naohiro
Published in International immunopharmacology (01.10.2011)
Published in International immunopharmacology (01.10.2011)
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Journal Article
Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors
Tanaka, Taisaku, Muto, Tsuyoshi, Maruoka, Hiroshi, Imajo, Seiichi, Fukami, Harukazu, Tomimori, Yoshiaki, Fukuda, Yoshiaki, Nakatsuka, Takashi
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
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Journal Article
Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors
Maruoka, Hiroshi, Muto, Tsuyoshi, Tanaka, Taisaku, Imajo, Seiichi, Tomimori, Yoshiaki, Fukuda, Yoshiaki, Nakatsuka, Takashi
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
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7-MEMBERED RING COMPOUND, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF
MUTO TSUYOSHI, TOMIMORI YOSHIAKI, MARUOKA HIROSHI, IMAJO SEIICHI, TANAKA TAISAKU
Year of Publication 16.01.2013
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Year of Publication 16.01.2013
Patent
SEVEN-MEMBERED RING COMPOUND AND PHARMACEUTICAL USE THEREFOR
SUGAWARA HAJIME, MUTO TSUYOSHI, FUTAMURA JUNKO, IMAJO SEIICHI, TANAKA TAISAKU
Year of Publication 04.10.2012
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Year of Publication 04.10.2012
Patent
Involvement of mast cell chymase in bleomycin-induced pulmonary fibrosis in mice
Tomimori, Yoshiaki, Muto, Tsuyoshi, Saito, Kayo, Tanaka, Taisaku, Maruoka, Hiroshi, Sumida, Motoo, Fukami, Harukazu, Fukuda, Yoshiaki
Published in European journal of pharmacology (08.10.2003)
Published in European journal of pharmacology (08.10.2003)
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Journal Article
SEVEN-MEMBERED RING COMPOUND AND PHARMACEUTICAL USE THEREFOR
MUTO, TSUYOSHI, TANAKA, TAISAKU, FUTAMURA, JUNKO, IMAJO, SEICHI, SUGAWARA, HAJIME
Year of Publication 30.06.2011
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Year of Publication 30.06.2011
Patent