ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia
Zhou, Jianbiao, Yiying Quah, Jessie, Ng, Yvonne, Chooi, Jing-Yuan, Hui-Min Toh, Sabrina, Lin, Baohong, Zea Tan, Tuan, Hosoi, Hiroki, Osato, Motomi, Seet, Qihui, Ooi, Lisa A G, Lindmark, Bertil, McHale, Mark, Chng, Wee-Joo
Published in Haematologica (Roma) (01.09.2020)
Published in Haematologica (Roma) (01.09.2020)
Get full text
Journal Article
Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma
Chen, Ye, Xu, Liang, Mayakonda, Anand, Huang, Mo-Li, Kanojia, Deepika, Tan, Tuan Zea, Dakle, Pushkar, Lin, Ruby Yu-Tong, Ke, Xin-Yu, Said, Jonathan W., Chen, Jianxiang, Gery, Sigal, Ding, Ling-Wen, Jiang, Yan-Yi, Pang, Angela, Puhaindran, Mark Edward, Goh, Boon Cher, Koeffler, H. Phillip
Published in Nature communications (22.03.2019)
Published in Nature communications (22.03.2019)
Get full text
Journal Article
BET Bromodomain inhibition promotes De-repression of TXNIP and activation of ASK1-MAPK pathway in acute myeloid leukemia
Zhou, Yafeng, Zhou, Jianbiao, Lu, Xiao, Tan, Tuan-Zea, Chng, Wee-Joo
Published in BMC cancer (11.07.2018)
Published in BMC cancer (11.07.2018)
Get full text
Journal Article
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation
Kong, Li Ren, Ong, Richard Weijie, Tan, Tuan Zea, Mohamed Salleh, Nur Afiqah Binte, Thangavelu, Matan, Chan, Jane Vin, Koh, Lie Yong Judice, Periyasamy, Giridharan, Lau, Jieying Amelia, Le, Thi Bich Uyen, Wang, Lingzhi, Lee, Miyoung, Kannan, Srinivasaraghavan, Verma, Chandra S., Lim, Chwee Ming, Chng, Wee Joo, Lane, David P., Venkitaraman, Ashok, Hung, Huynh The, Cheok, Chit Fang, Goh, Boon Cher
Published in Nature communications (29.04.2020)
Published in Nature communications (29.04.2020)
Get full text
Journal Article
The role of GRHL2 and epigenetic remodeling in epithelial–mesenchymal plasticity in ovarian cancer cells
Chung, Vin Yee, Tan, Tuan Zea, Ye, Jieru, Huang, Rui-Lan, Lai, Hung-Cheng, Kappei, Dennis, Wollmann, Heike, Guccione, Ernesto, Huang, Ruby Yun-Ju
Published in Communications biology (24.07.2019)
Published in Communications biology (24.07.2019)
Get full text
Journal Article
SNAI1-Driven Sequential EMT Changes Attributed by Selective Chromatin Enrichment of RAD21 and GRHL2
Sundararajan, Vignesh, Tan, Ming, Zea Tan, Tuan, Pang, Qing You, Ye, Jieru, Chung, Vin Yee, Huang, Ruby Yun-Ju
Published in Cancers (02.05.2020)
Published in Cancers (02.05.2020)
Get full text
Journal Article
Disruption of Runx1 and Runx3 Leads to Bone Marrow Failure and Leukemia Predisposition due to Transcriptional and DNA Repair Defects
Wang, Chelsia Qiuxia, Krishnan, Vaidehi, Tay, Lavina Sierra, Chin, Desmond Wai Loon, Koh, Cai Ping, Chooi, Jing Yuan, Nah, Giselle Sek Suan, Du, Linsen, Jacob, Bindya, Yamashita, Namiko, Lai, Soak Kuan, Tan, Tuan Zea, Mori, Seiichi, Tanuichi, Ichiro, Tergaonkar, Vinay, Ito, Yoshiaki, Osato, Motomi
Published in Cell reports (Cambridge) (07.08.2014)
Published in Cell reports (Cambridge) (07.08.2014)
Get full text
Journal Article
A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma
Kong, Li Ren, Mohamed Salleh, Nur Afiqah Binte, Ong, Richard Weijie, Tan, Tuan Zea, Syn, Nicholas L., Goh, Robby Miguel, Fhu, Chee Wai, Tan, Daniel S. W., Iyer, N. Gopalakrishna, Kannan, Srinivasaraghavan, Verma, Chandra S., Lim, Yaw Chyn, Soo, Ross, Ho, Jingshan, Huang, Yiqing, Lim, Joline S. J., Yan, Benedict Junrong, Nga, Min En, Lim, Seng Gee, Koeffler, H. Phillip, Lee, Soo Chin, Kappei, Dennis, Hung, Huynh The, Goh, Boon Cher
Published in Nature communications (25.03.2020)
Published in Nature communications (25.03.2020)
Get full text
Journal Article
Pharmacological Inhibition of TFF3 Enhances Sensitivity of CMS4 Colorectal Carcinoma to 5-Fluorouracil through Inhibition of p44/42 MAPK
Chen, Ru-Mei, Chiou, Yi-Shiou, Chong, Qing-Yun, Poh, Han-Ming, Tan, Tuan-Zea, Zhang, Meng-Yi, Ma, Lan, Zhu, Tao, Pandey, Vijay, Basappa, Kumar, Alan Prem, Lobie, Peter E
Published in International journal of molecular sciences (09.12.2019)
Published in International journal of molecular sciences (09.12.2019)
Get full text
Journal Article
The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions
Davidson, Ben, MD PhD, Holth, Arild, BSc, Hellesylt, Ellen, MSc, Tan, Tuan Zea, PhD, Huang, Ruby Yun-Ju, MD PhD, Tropé, Claes, MD PhD, Nesland, Jahn M., MD PhD, Thiery, Jean Paul, PhD
Published in Human pathology (01.01.2015)
Published in Human pathology (01.01.2015)
Get full text
Journal Article
E74 like ETS transcription factor 3 (ELF3) is a negative regulator of epithelial- mesenchymal transition in bladder carcinoma
Gondkar, Kirti, Patel, Krishna, Krishnappa, Shobha, Patil, Akkamahadevi, Nair, Bipin, Sundaram, Gopinath Meenakshi, Zea, Tan Tuan, Kumar, Prashant
Published in Cancer biomarkers : section A of Disease markers (01.01.2019)
Published in Cancer biomarkers : section A of Disease markers (01.01.2019)
Get full text
Journal Article
LIN28B Activation by PRL-3 Promotes Leukemogenesis and a Stem Cell-like Transcriptional Program in AML
Zhou, Jianbiao, Chan, Zit-Liang, Bi, Chonglei, Lu, Xiao, Chong, Phyllis S Y, Chooi, Jing-Yuan, Cheong, Lip-Lee, Liu, Shaw-Cheng, Ching, Ying Qing, Zhou, Yafeng, Osato, Motomi, Tan, Tuan Zea, Ng, Chin Hin, Ng, Siok-Bian, Wang, Shi, Zeng, Qi, Chng, Wee-Joo
Published in Molecular cancer research (01.03.2017)
Published in Molecular cancer research (01.03.2017)
Get full text
Journal Article
Epithelial-to-Mesenchymal Transition is a Cause of Both Intrinsic and Acquired Resistance to KRAS G12C Inhibitor in KRAS G12C-Mutant Non-Small Cell Lung Cancer
Adachi, Yuta, Ito, Kentaro, Hayashi, Yuko, Kimura, Ryo, Tan, Tuan Zea, Yamaguchi, Rui, Ebi, Hiromichi
Published in Clinical cancer research (15.11.2020)
Published in Clinical cancer research (15.11.2020)
Get full text
Journal Article
Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers
Loo, Ser Yue, Syn, Nicholas L., Koh, Angele Pei-Fern, Teng, Janet Cheng-Fei, Deivasigamani, Amudha, Tan, Tuan Zea, Thike, Aye Aye, Vali, Shireen, Kapoor, Shweta, Wang, Xiaoyuan, Wang, Jiong Wei, Tan, Puay Hoon, Yip, George W., Sethi, Gautam, Huang, Ruby Yun-Ju, Hui, Kam Man, Wang, Lingzhi, Goh, Boon Cher, Kumar, Alan Prem
Published in Cell death discovery (27.09.2021)
Published in Cell death discovery (27.09.2021)
Get full text
Journal Article
Dual role of autophagy in hallmarks of cancer
Singh, Shikha Satendra, Vats, Somya, Chia, Amelia Yi-Qian, Tan, Tuan Zea, Deng, Shuo, Ong, Mei Shan, Arfuso, Frank, Yap, Celestial T., Goh, Boon Cher, Sethi, Gautam, Huang, Ruby Yun-Ju, Shen, Han Ming, Manjithaya, Ravi, Kumar, Alan Prem
Published in Oncogene (01.03.2018)
Published in Oncogene (01.03.2018)
Get full text
Journal Article
Epithelial‐mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients
Tan, Tuan Zea, Miow, Qing Hao, Miki, Yoshio, Noda, Tetsuo, Mori, Seiichi, Huang, Ruby Yun‐Ju, Thiery, Jean Paul
Published in EMBO molecular medicine (01.10.2014)
Published in EMBO molecular medicine (01.10.2014)
Get full text
Journal Article
The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200
Noman, Muhammad Zaeem, Janji, Bassam, Abdou, Abderemane, Hasmim, Meriem, Terry, Stéphane, Tan, Tuan Zea, Mami-Chouaib, Fathia, Thiery, Jean Paul, Chouaib, Salem
Published in Oncoimmunology (02.01.2017)
Published in Oncoimmunology (02.01.2017)
Get full text
Journal Article
Cytoskeletal Dynamics in Epithelial-Mesenchymal Transition: Insights into Therapeutic Targets for Cancer Metastasis
Datta, Arpita, Deng, Shuo, Gopal, Vennila, Yap, Kenneth Chun-Hong, Halim, Clarissa Esmeralda, Lye, Mun Leng, Ong, Mei Shan, Tan, Tuan Zea, Sethi, Gautam, Hooi, Shing Chuan, Kumar, Alan Prem, Yap, Celestial T
Published in Cancers (14.04.2021)
Published in Cancers (14.04.2021)
Get full text
Journal Article
SNAI1 recruits HDAC1 to suppress SNAI2 transcription during epithelial to mesenchymal transition
Sundararajan, Vignesh, Tan, Ming, Tan, Tuan Zea, Ye, Jieru, Thiery, Jean Paul, Huang, Ruby Yun-Ju
Published in Scientific reports (05.06.2019)
Published in Scientific reports (05.06.2019)
Get full text
Journal Article