Nanomolar-potency 'co-potentiator' therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants
Phuan, Puay-Wah, Tan, Joseph-Anthony, Rivera, Amber A, Zlock, Lorna, Nielson, Dennis W, Finkbeiner, Walter E, Haggie, Peter M, Verkman, Alan S
Published in Scientific reports (27.11.2019)
Published in Scientific reports (27.11.2019)
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Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis
Haggie, Peter M, Phuan, Puay-Wah, Tan, Joseph-Anthony, Zlock, Lorna, Finkbeiner, Walter E, Verkman, A S
Published in The FASEB journal (01.06.2016)
Published in The FASEB journal (01.06.2016)
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Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders
Chu, Tifany, Karmakar, Joy, Haggie, Peter M, Tan, Joseph-Anthony, Master, Riya, Ramaswamy, Keerthana, Verkman, Alan S, Anderson, Marc O, Cil, Onur
Published in MedChemComm (15.11.2023)
Published in MedChemComm (15.11.2023)
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SUMO Conjugation to the Matrix Attachment Region-binding Protein, Special AT-rich Sequence-binding Protein-1 (SATB1), Targets SATB1 to Promyelocytic Nuclear Bodies Where It Undergoes Caspase Cleavage
Tan, Joseph-Anthony T., Sun, Yujie, Song, Jing, Chen, Yuan, Krontiris, Theodore G., Durrin, Linda K.
Published in The Journal of biological chemistry (27.06.2008)
Published in The Journal of biological chemistry (27.06.2008)
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Journal Article
Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product
Haggie, Peter M., Phuan, Puay-Wah, Tan, Joseph-Anthony, Xu, Haijin, Avramescu, Radu G., Perdomo, Doranda, Zlock, Lorna, Nielson, Dennis W., Finkbeiner, Walter E., Lukacs, Gergely L., Verkman, Alan S.
Published in The Journal of biological chemistry (20.01.2017)
Published in The Journal of biological chemistry (20.01.2017)
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Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action
Cil, Onur, Anderson, Marc O., de Souza Goncalves, Livia, Tan, Joseph-Anthony, Haggie, Peter M., Verkman, Alan S.
Published in European journal of medicinal chemistry (05.03.2023)
Published in European journal of medicinal chemistry (05.03.2023)
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Combination potentiator (‘co-potentiator’) therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators
Phuan, Puay-Wah, Son, Jung-Ho, Tan, Joseph-Anthony, Li, Clarabella, Musante, Ilaria, Zlock, Lorna, Nielson, Dennis W., Finkbeiner, Walter E., Kurth, Mark J., Galietta, Luis J., Haggie, Peter M., Verkman, Alan S.
Published in Journal of cystic fibrosis (01.09.2018)
Published in Journal of cystic fibrosis (01.09.2018)
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Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases
Lee, Sujin, Phuan, Puay-Wah, Felix, Christian M, Tan, Joseph-Anthony, Levin, Marc H, Verkman, Alan S
Published in Journal of medicinal chemistry (09.02.2017)
Published in Journal of medicinal chemistry (09.02.2017)
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Journal Article
Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin)
Zhu, Jie S., Lu, Julia Y., Tan, Joseph-Anthony, Rivera, Amber A., Phuan, Puay-Wah, Shatskikh, Marina E., Son, Jung-Ho, Haggie, Peter M., Verkman, Alan S., Kurth, Mark J.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Journal Article
Su1580 A Small-Molecule CFTR Activator Increases Intestinal Fluid Secretion and Normalizes Stool Output in a Mouse Model of Constipation
Cil, Onur, Phuan, Puay-Wah, Lee, Sujin, Tan, Joseph-Anthony T, Haggie, Peter, Levin, Marc H, Sun, Liang, Thiagarajah, Jay, Ma, Tonghui, Verkman, Alan S
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2016)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2016)
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Journal Article
ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter
Phuan, Puay-Wah, Veit, Guido, Tan, Joseph-Anthony, Roldan, Ariel, Finkbeiner, Walter E., Haggie, Peter M., Lukacs, Gergely L., Verkman, Alan S.
Published in SLAS discovery (01.09.2018)
Published in SLAS discovery (01.09.2018)
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