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Brown, Brian S, Keddy, Ryan, Perner, Richard J, DiDomenico, Stanley, Koenig, John R, Jinkerson, Tammie K, Hannick, Steven M, McDonald, Heath A, Bianchi, Bruce R, Honore, Prisca, Puttfarcken, Pamela S, Moreland, Robert B, Marsh, Kennan C, Faltynek, Connie R, Lee, Chih-Hung
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
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α-Methylation at benzylic fragment of N-aryl- N′-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model
Gomtsyan, Arthur, Bayburt, Erol K., Keddy, Ryan, Turner, Sean C., Jinkerson, Tammie K., Didomenico, Stanley, Perner, Richard J., Koenig, John R., Drizin, Irene, McDonald, Heath A., Surowy, Carol S., Honore, Prisca, Mikusa, Joe, Marsh, Kennan C., Wetter, Jill M., Faltynek, Connie R., Lee, Chih-Hung
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
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Structure–activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists
Drizin, Irene, Gomtsyan, Arthur, Bayburt, Erol K., Schmidt, Robert G., Zheng, Guo Zhu, Perner, Richard J., DiDomenico, Stanley, Koenig, John R., Turner, Sean C., Jinkerson, Tammie K., Brown, Brian S., Keddy, Ryan G., McDonald, Heath A., Honore, Prisca, Wismer, Carol T., Marsh, Kennan C., Wetter, Jill M., Polakowski, James S., Segreti, Jason A., Jarvis, Michael F., Faltynek, Connie R., Lee, Chih-Hung
Published in Bioorganic & medicinal chemistry (15.07.2006)
Published in Bioorganic & medicinal chemistry (15.07.2006)
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Novel Transient Receptor Potential Vanilloid 1 Receptor Antagonists for the Treatment of Pain: Structure−Activity Relationships for Ureas with Quinoline, Isoquinoline, Quinazoline, Phthalazine, Quinoxaline, and Cinnoline Moieties
Gomtsyan, Arthur, Bayburt, Erol K, Schmidt, Robert G, Zheng, Guo Zhu, Perner, Richard J, Didomenico, Stanley, Koenig, John R, Turner, Sean, Jinkerson, Tammie, Drizin, Irene, Hannick, Steven M, Macri, Bryan S, McDonald, Heath A, Honore, Prisca, Wismer, Carol T, Marsh, Kennan C, Wetter, Jill, Stewart, Kent D, Oie, Tetsuro, Jarvis, Michael F, Surowy, Carol S, Faltynek, Connie R, Lee, Chih-Hung
Published in Journal of medicinal chemistry (10.02.2005)
Published in Journal of medicinal chemistry (10.02.2005)
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In Vitro Structure−Activity Relationship and In Vivo Characterization of 1-(Aryl)-3-(4-(amino)benzyl)urea Transient Receptor Potential Vanilloid 1 Antagonists
Perner, Richard J, DiDomenico, Stanley, Koenig, John R, Gomtsyan, Arthur, Bayburt, Erol K, Schmidt, Robert G, Drizin, Irene, Zheng, Guo Zhu, Turner, Sean C, Jinkerson, Tammie, Brown, Brian S, Keddy, Ryan G, Lukin, Kurill, McDonald, Heath A, Honore, Prisca, Mikusa, Joe, Marsh, Kennan C, Wetter, Jill M, St. George, Karen, Jarvis, Michael F, Faltynek, Connie R, Lee, Chih-Hung
Published in Journal of medicinal chemistry (26.07.2007)
Published in Journal of medicinal chemistry (26.07.2007)
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α-Μethylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model
GOMTSYAN, Arthur, BAYBURT, Erol K, SUROWY, Carol S, HONORE, Prisca, MIKUSA, Joe, MARSH, Kennan C, WETTER, Jill M, FALTYNEK, Connie R, LEE, Chih-Hung, KEDDY, Ryan, TURNER, Sean C, JINKERSON, Tammie K, DIDOMENICO, Stanley, PERNER, Richard J, KOENIG, John R, DRIZIN, Irene, MCDONALD, Heath A
Published in Bioorganic & medicinal chemistry letters (2007)
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Published in Bioorganic & medicinal chemistry letters (2007)
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Anti-Viral Compounds
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Year of Publication 14.09.2023
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Year of Publication 14.09.2023
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(INDAZOL-4-YL)HEXAHYDROPYRROLOPYRROLONES AND METHOD OF USE
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Year of Publication 17.01.2018
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Year of Publication 17.01.2018
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(Indazol-4-yl) hexahydropyrrolopyrrolones and methods of use
Frost Jennifer M, Daanen Jerome, Shi Lei, Jinkerson Tammie, Latshaw Steve, DeGoey David
Year of Publication 20.06.2017
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Year of Publication 20.06.2017
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(INDAZOL-4-YL)HEXAHYDROPYRROLOPYRROLONES AND METHOD OF USE
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Year of Publication 22.09.2016
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Year of Publication 22.09.2016
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(INDAZOL-4-YL)HEXAHYDROPYRROLOPYRROLONES AND METHOD OF USE
DAANEN, Jerome, SHI, Lei, DEGOEY, David A, JINKERSON, Tammie, FROST, Jennifer M, LATSHAW, Steve
Year of Publication 22.09.2016
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Year of Publication 22.09.2016
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(Indazol-4-YL) Hexahydropyrrolopyrrolones and Methods of Use
Frost Jennifer M, Daanen Jerome, Shi Lei, Jinkerson Tammie, Latshaw Steve, DeGoey David
Year of Publication 15.09.2016
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Year of Publication 15.09.2016
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HETEROCYCLIC COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS (HCV)
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Year of Publication 31.07.2021
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Year of Publication 31.07.2021
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ANTI-VIRAL COMPOUNDS
HUTCHINS CHARLES W, WOLLER KEVIN R, BETEBENNER DAVID A, HUTCHINSON DOUGLAS K, ROCKWAY TODD W, FLENTGE CHARLES A, PATEL SACHIN V, SARRIS KATHY, JINKERSON TAMMIE K, GAO YI, DEGOEY DAVID A, KEDDY RYAN G, KATI WARREN M, MATULENKO MARK A, CALIFANO JEAN C, CASPI DANIEL D, MARING CLARENCE J, PRATT JOHN K, DONNER PAMELA L, NELSON LISSA T, WAGNER ROLF, RANDOLPH JOHN T, CARROLL WILLIAM A, TUFANO MICHAEL D, KRUEGER ALLAN C, MOTTER CHRISTOPHER E, LIU DACHUN, LI WENKE, WAGAW SEBLE H, BELLIZZI MARY E
Year of Publication 26.05.2021
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Year of Publication 26.05.2021
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6-heteroaryloxy- and 6-aryloxy-quinoline-2-carboxamides and uses thereof
Bogdan, Andrew, Koenig, John R, Peltier, Hillary, Cowart, Marlon D, Jinkerson, Tammie K, Kort, Michael E, Wakefield, Brian D, Liu, Bo, Matulenko, Mark A, Scanio, Marc J, Degoey, David A, Nelson, Derek W, Patel, Meena V
Year of Publication 18.04.2019
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Year of Publication 18.04.2019
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Year of Publication 27.01.2021
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Year of Publication 27.01.2021
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Anti-viral compounds
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Year of Publication 03.12.2020
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Year of Publication 03.12.2020
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6-HETEROARYLOXY- OR 6-ARYLOXY-QUINOLINE-2-CARBOXAMIDES AND METHOD OF USE
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Year of Publication 22.11.2018
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Year of Publication 22.11.2018
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6-heteroaryloxy- or 6-aryloxy-quinoline-2-carboxamides and method of use
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Year of Publication 15.05.2018
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Year of Publication 15.05.2018
Patent
PROCESS FOR PREPARING METHYL{(2S,3R)-1-[(2S)-2-{5-[(2R,5R)-1-{3,5-DIFLUORO-4-[4-(4-FLUOROPHENYL)PIPERIDINE-1-YL]PHENYL}-5-(6-FLUORO-2-{(2S)-1-[N-(METHOXYCARBONYL)-O-METHYL-L-THREONYL]PYRROLIDINE-2-YL}-1H-BENZIMIDAZOLE-5-YL)pyrrolidinePYRROLIDINE-2-YL]-6-FLUORO-1H-BENZIMIDAZOLE-2-YL}PYRROLIDINE-1-YL]-3-METHOXY-1-OXOBUTANE-2-YL}CARBAMATE
WAGAW, Seble H, CALIFANO, Jean C, WOLLER, Kevin R, CASPI, Daniel D, JINKERSON, Tammie K, SARRIS, Kathy, KRUEGER, Allan C, MATULENKO, Mark A, NELSON, Lissa T, BETEBENNER, David A, MARING, Clarence J, LI, Wenke, MOTTER, Christopher E, GAO, Yi, HUTCHINS, Charles W, KEDDY, Ryan G, PRATT, John K, PATEL, Sachin V, DEGOEY, David A, LIU, Dachun, DONNER, Pamela L, RANDOLPH, John T, WAGNER, Rolf, ROCKWAY, Todd W, HUTCHINSON, Douglas K, BELLIZZI, Mary E, CARROLL, William A, KATI, Warren M, FLENTGE, Charles A, TUFANO, Michael D
Year of Publication 30.09.2019
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Year of Publication 30.09.2019
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