Application of Human Induced Pluripotent Stem Cell-Derived Intestinal Organoids as a Model of Epithelial Damage and Fibrosis in Inflammatory Bowel Disease
Onozato, Daichi, Akagawa, Takumi, Kida, Yuriko, Ogawa, Isamu, Hashita, Tadahiro, Iwao, Takahiro, Matsunaga, Tamihide
Published in Biological & pharmaceutical bulletin (01.07.2020)
Published in Biological & pharmaceutical bulletin (01.07.2020)
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Journal Article
Accumulation of Toxic Advanced Glycation End-Products Induces Cytotoxicity and Inflammation in Hepatocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells
Kikuchi, Chigusa, Sakasai-Sakai, Akiko, Okimura, Risa, Tanaka, Hinako, Takata, Takanobu, Takeuchi, Masayoshi, Matsunaga, Tamihide
Published in Biological & pharmaceutical bulletin (01.10.2021)
Published in Biological & pharmaceutical bulletin (01.10.2021)
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Journal Article
Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells
Onozato, Daichi, Yamashita, Misaki, Nakanishi, Anna, Akagawa, Takumi, Kida, Yuriko, Ogawa, Isamu, Hashita, Tadahiro, Iwao, Takahiro, Matsunaga, Tamihide
Published in Drug metabolism and disposition (01.11.2018)
Published in Drug metabolism and disposition (01.11.2018)
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Journal Article
Pharmacokinetic functions of human induced pluripotent stem cell-derived small intestinal epithelial cells
Kabeya, Tomoki, Mima, Shinji, Imakura, Yuki, Miyashita, Toshihide, Ogura, Izumi, Yamada, Tadanori, Yasujima, Tomoya, Yuasa, Hiroaki, Iwao, Takahiro, Matsunaga, Tamihide
Published in Drug metabolism and pharmacokinetics (01.08.2020)
Published in Drug metabolism and pharmacokinetics (01.08.2020)
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Journal Article
Effect of Topiroxostat on Reducing Oxidative Stress in the Aorta of Streptozotocin-Induced Diabetic Rats
Noda, Masato, Kikuchi, Chigusa, Tarui, Ryota, Nakamura, Takashi, Murase, Takayo, Hori, Eisei, Matsunaga, Tamihide
Published in Biological & pharmaceutical bulletin (01.02.2023)
Published in Biological & pharmaceutical bulletin (01.02.2023)
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Journal Article
Application of a Human Intestinal Epithelial Cell Monolayer to the Prediction of Oral Drug Absorption in Humans as a Superior Alternative to the Caco-2 Cell Monolayer
Takenaka, Toru, Harada, Naomoto, Kuze, Jiro, Chiba, Masato, Iwao, Takahiro, Matsunaga, Tamihide
Published in Journal of pharmaceutical sciences (01.02.2016)
Published in Journal of pharmaceutical sciences (01.02.2016)
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Journal Article
New Maintenance Culture Method for Intestinal Stem Cells Derived from Human Induced Pluripotent Stem Cells
Mizuno, Shota, Jinnoh, Yumi, Arita, Ayaka, Qiu, Shimeng, Hashita, Tadahiro, Hori, Eisei, Iwao, Takahiro, Matsunaga, Tamihide
Published in Biological & pharmaceutical bulletin (01.01.2024)
Published in Biological & pharmaceutical bulletin (01.01.2024)
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Journal Article
Laminin 221 fragment is suitable for the differentiation of human induced pluripotent stem cells into brain microvascular endothelial-like cells with robust barrier integrity
Aoki, Hiromasa, Yamashita, Misaki, Hashita, Tadahiro, Iwao, Takahiro, Matsunaga, Tamihide
Published in Fluids and barriers of the CNS (30.03.2020)
Published in Fluids and barriers of the CNS (30.03.2020)
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Journal Article
Inhibition of transforming growth factor beta signaling pathway promotes differentiation of human induced pluripotent stem cell-derived brain microvascular endothelial-like cells
Yamashita, Misaki, Aoki, Hiromasa, Hashita, Tadahiro, Iwao, Takahiro, Matsunaga, Tamihide
Published in Fluids and barriers of the CNS (26.05.2020)
Published in Fluids and barriers of the CNS (26.05.2020)
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Journal Article
Human small intestinal epithelial cells differentiated from adult intestinal stem cells as a novel system for predicting oral drug absorption in humans
Takenaka, Toru, Harada, Naomoto, Kuze, Jiro, Chiba, Masato, Iwao, Takahiro, Matsunaga, Tamihide
Published in Drug metabolism and disposition (01.11.2014)
Published in Drug metabolism and disposition (01.11.2014)
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Journal Article
SARS-CoV-2 causes dysfunction in human iPSC-derived brain microvascular endothelial cells potentially by modulating the Wnt signaling pathway
Yamada, Shigeru, Hashita, Tadahiro, Yanagida, Shota, Sato, Hiroyuki, Yasuhiko, Yukuto, Okabe, Kaori, Noda, Takamasa, Nishida, Motohiro, Matsunaga, Tamihide, Kanda, Yasunari
Published in Fluids and barriers of the CNS (08.04.2024)
Published in Fluids and barriers of the CNS (08.04.2024)
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Journal Article
Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase-Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell-Derived Small Intestinal Epithelial Cells
Kitaguchi, Takashi, Mizota, Taisei, Ito, Mina, Ohno, Katsutoshi, Kobayashi, Kazuhiro, Ogawa, Isamu, Qiu, Shimeng, Iwao, Takahiro, Hanioka, Nobumitsu, Tanaka, Mitsuru, Matsunaga, Tamihide
Published in Drug metabolism and disposition (01.01.2022)
Published in Drug metabolism and disposition (01.01.2022)
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Journal Article
Development of an in vitro cholestatic drug-induced liver injury evaluation system using HepG2-hNTCP-C4 cells in sandwich configuration
Sakai, Yoko, Okumura, Hiroki, Iwao, Takahiro, Watashi, Koichi, Ito, Kousei, Matsunaga, Tamihide
Published in Toxicology in vitro (01.12.2019)
Published in Toxicology in vitro (01.12.2019)
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Journal Article
A novel perfusion culture system for screening mitochondrial toxicity in primary mouse hepatocytes
Yamamoto, Chika, Takemura, Akinori, Ishii, Sanae, Doi, Atsushi, Saito, Isao, Yamada, Hideki, Sakai, Yoko, Matsunaga, Tamihide, Ito, Kousei
Published in Journal of toxicological sciences (2022)
Published in Journal of toxicological sciences (2022)
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Journal Article
Protective Effect of Irsogladine against Aspirin-Induced Mucosal Injury in Human Induced Pluripotent Stem Cell-Derived Small Intestine
Kanno, Takuya, Katano, Takahito, Ogawa, Isamu, Iwao, Takahiro, Matsunaga, Tamihide, Kataoka, Hiromi
Published in Medicina (Kaunas, Lithuania) (31.12.2022)
Published in Medicina (Kaunas, Lithuania) (31.12.2022)
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Journal Article
Development of a Perfusing Small Intestine–Liver Microphysiological System Device
Sakai, Yoko, Matsumura, Masanari, Yamada, Hideki, Doi, Atsushi, Saito, Isao, Iwao, Takahiro, Matsunaga, Tamihide
Published in Applied sciences (01.09.2023)
Published in Applied sciences (01.09.2023)
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Journal Article