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A Phase 2b randomized trial of lorecivivint, a novel intra-articular CLK2/DYRK1A inhibitor and Wnt pathway modulator for knee osteoarthritis
Yazici, Y., McAlindon, T.E., Gibofsky, A., Lane, N.E., Lattermann, C., Skrepnik, N., Swearingen, C.J., Simsek, I., Ghandehari, H., DiFrancesco, A., Gibbs, J., Tambiah, J.R.S., Hochberg, M.C.
Published in Osteoarthritis and cartilage (01.05.2021)
Published in Osteoarthritis and cartilage (01.05.2021)
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A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee
Deshmukh, V., Hu, H., Barroga, C., Bossard, C., KC, S., Dellamary, L., Stewart, J., Chiu, K., Ibanez, M., Pedraza, M., Seo, T., Do, L., Cho, S., Cahiwat, J., Tam, B., Tambiah, J.R.S., Hood, J., Lane, N.E., Yazici, Y.
Published in Osteoarthritis and cartilage (01.01.2018)
Published in Osteoarthritis and cartilage (01.01.2018)
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A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study
Yazici, Y., McAlindon, T.E., Fleischmann, R., Gibofsky, A., Lane, N.E., Kivitz, A.J., Skrepnik, N., Armas, E., Swearingen, C.J., DiFrancesco, A., Tambiah, J.R.S., Hood, J., Hochberg, M.C.
Published in Osteoarthritis and cartilage (01.10.2017)
Published in Osteoarthritis and cartilage (01.10.2017)
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OP0326 RADIOGRAPHIC AND PAIN OUTCOMES FROM A PHASE 3 EXTENSION STUDY (OA-07) EVALUATING THE SAFETY AND EFFICACY OF REPEAT LORECIVIVINT INJECTIONS OVER 3 YEARS IN SUBJECTS WITH SEVERE KNEE OSTEOARTHRITIS
Yazici, Y., Swearingen, C., Tambiah, J. R. S., Mcalindon, T.
Published in Annals of the rheumatic diseases (01.06.2024)
Published in Annals of the rheumatic diseases (01.06.2024)
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POS1177 TREATMENT WITH LORECIVIVINT LEADS TO IMPROVED LONG-TERM PATIENT ACCEPTABLE SYMPTOM STATE (PASS) COMPARED TO PLACEBO: DATA FROM PHASE 3 EXTENSION TRIAL
Swearingen, C., Yazici, Y., Tambiah, J. R. S., Conaghan, P. G.
Published in Annals of the rheumatic diseases (01.06.2024)
Published in Annals of the rheumatic diseases (01.06.2024)
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POS0786 EFFECT OF LORECIVIVINT ON CARTILAGE REPAIR IN A MOUSE MODEL OF JOINT SURFACE INJURY
Roelofs, A. J., Clark, S. M., Mcclure, J. J., Symons, R. A., Cunningham, I., Robertson, M., Richmond, A., Collins, F. L., Kennedy, S., Tambiah, J. R. S., De Bari, C.
Published in Annals of the rheumatic diseases (01.06.2024)
Published in Annals of the rheumatic diseases (01.06.2024)
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