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Published in Nature communications (09.08.2023)
Published in Nature communications (09.08.2023)
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A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase
Ruan, Jingjing, Liang, Dongdong, Yan, Wenjing, Zhong, Yongwang, Talley, Daniel C, Rai, Ganesha, Tao, Dingyin, LeClair, Christopher A, Simeonov, Anton, Zhang, Yinghua, Chen, Feihu, Quinney, Nancy L, Boyles, Susan E, Cholon, Deborah M, Gentzsch, Martina, Henderson, Mark J, Xue, Fengtian, Fang, Shengyun
Published in Molecular biology of the cell (01.11.2022)
Published in Molecular biology of the cell (01.11.2022)
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Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1
Hu, Zongyi, Rolt, Adam, Hu, Xin, Ma, Christopher D., Le, Derek J., Park, Seung Bum, Houghton, Michael, Southall, Noel, Anderson, D. Eric, Talley, Daniel C., Lloyd, John R., Marugan, Juan C., Liang, T. Jake
Published in Cell chemical biology (16.07.2020)
Published in Cell chemical biology (16.07.2020)
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Discovery and Optimization of a 4‑Aminopiperidine Scaffold for Inhibition of Hepatitis C Virus Assembly
Rolt, Adam, Talley, Daniel C, Park, Seung Bum, Hu, Zongyi, Dulcey, Andrés, Ma, Christopher, Irvin, Parker, Leek, Madeleine, Wang, Amy Q, Stachulski, Andrew V, Xu, Xin, Southall, Noel, Ferrer, Marc, Liang, T. Jake, Marugan, Juan J
Published in Journal of medicinal chemistry (08.07.2021)
Published in Journal of medicinal chemistry (08.07.2021)
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Hybrid In Silico Approach Reveals Novel Inhibitors of Multiple SARS-CoV‑2 Variants
Jain, Sankalp, Talley, Daniel C, Baljinnyam, Bolormaa, Choe, Jun, Hanson, Quinlin, Zhu, Wei, Xu, Miao, Chen, Catherine Z, Zheng, Wei, Hu, Xin, Shen, Min, Rai, Ganesha, Hall, Matthew D, Simeonov, Anton, Zakharov, Alexey V
Published in ACS pharmacology & translational science (08.10.2021)
Published in ACS pharmacology & translational science (08.10.2021)
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Allosteric Binders of ACE2 Are Promising Anti-SARS-CoV‑2 Agents
Hochuli, Joshua E., Jain, Sankalp, Melo-Filho, Cleber, Sessions, Zoe L., Bobrowski, Tesia, Choe, Jun, Zheng, Johnny, Eastman, Richard, Talley, Daniel C., Rai, Ganesha, Simeonov, Anton, Tropsha, Alexander, Muratov, Eugene N., Baljinnyam, Bolormaa, Zakharov, Alexey V.
Published in ACS pharmacology & translational science (08.07.2022)
Published in ACS pharmacology & translational science (08.07.2022)
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Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion
Ma, Christopher D, Imamura, Michio, Talley, Daniel C, Rolt, Adam, Xu, Xin, Wang, Amy Q, Le, Derek, Uchida, Takuro, Osawa, Mitsutaka, Teraoka, Yuji, Li, Kelin, Hu, Xin, Park, Seung Bum, Chalasani, Nishanth, Irvin, Parker H, Dulcey, Andres E, Southall, Noel, Marugan, Juan J, Hu, Zongyi, Chayama, Kazuaki, Frankowski, Kevin J, Liang, Tsanyang Jake
Published in Nature microbiology (01.12.2020)
Published in Nature microbiology (01.12.2020)
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Progress Towards Synthetic Chlorins with Graded Polarity, Conjugatable Substituents, and Wavelength Tunability
Ra, Doyoung, Gauger, Kelly A, Muthukumaran, Kannan, Balasubramanian, Thiagarajan, Chandrashaker, Vanampally, Taniguchi, Masahiko, Yu, Zhanqian, Talley, Daniel C, Ehudin, Melanie, Ptaszek, Marcin, Lindsey, Jonathan S
Published in Journal of porphyrins and phthalocyanines (01.04.2015)
Published in Journal of porphyrins and phthalocyanines (01.04.2015)
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Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites
Dorjsuren, Dorjbal, Eastman, Richard T, Wicht, Kathryn J, Jansen, Daniel, Talley, Daniel C, Sigmon, Benjamin A, Zakharov, Alexey V, Roncal, Norma, Girvin, Andrew T, Antonova-Koch, Yevgeniya, Will, Paul M, Shah, Pranav, Sun, Hongmao, Klumpp-Thomas, Carleen, Mok, Sachel, Yeo, Tomas, Meister, Stephan, Marugan, Juan Jose, Ross, Leila S, Xu, Xin, Maloney, David J, Jadhav, Ajit, Mott, Bryan T, Sciotti, Richard J, Winzeler, Elizabeth A, Waters, Norman C, Campbell, Robert F, Huang, Wenwei, Simeonov, Anton, Fidock, David A
Published in Scientific reports (22.01.2021)
Published in Scientific reports (22.01.2021)
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Allosteric binders of ACE2 are promising anti-SARS-CoV-2 agents
Hochuli, Joshua E, Jain, Sankalp, Melo-Filho, Cleber, Sessions, Zoe L, Bobrowski, Tesia, Choe, Jun, Zheng, Johnny, Eastman, Richard, Talley, Daniel C, Rai, Ganesha, Simeonov, Anton, Tropsha, Alexander, Muratov, Eugene N, Baljinnyam, Bolormaa, Zakharov, Alexey V
Published in bioRxiv (16.03.2022)
Published in bioRxiv (16.03.2022)
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Venglustat Inhibits Protein N‑Terminal Methyltransferase 1 in a Substrate-Competitive Manner
Dong, Guangping, Deng, Youchao, Yasgar, Adam, Yadav, Ravi, Talley, Daniel, Zakharov, Alexey V., Jain, Sankalp, Rai, Ganesha, Noinaj, Nicholas, Simeonov, Anton, Huang, Rong
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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Venglustat inhibits protein N-terminal methyltransferases 1 in a substrate-competitive manner
Dong, Guangping, Deng, Youchao, Yasgar, Adam, Yadav, Ravi, Talley, Daniel, Zakharov, Alexey V., Jain, Sankalp, Rai, Ganesha, Noinaj, Nicholas, Simeonov, Anton, Huang, Rong
Published in Journal of medicinal chemistry (08.09.2022)
Published in Journal of medicinal chemistry (08.09.2022)
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Optimization of High-Throughput Methyltransferase Assays for the Discovery of Small Molecule Inhibitors
Dong, Guangping, Yasgar, Adam, Peterson, Darrell L, Zakharov, Alexey, Talley, Daniel, Cheng, Ken Chih-Chien, Jadhav, Ajit, Simeonov, Anton, Huang, Rong
Published in ACS combinatorial science (10.08.2020)
Published in ACS combinatorial science (10.08.2020)
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Real-Time Cellular Thermal Shift Assay to Monitor Target Engagement
Sanchez, Tino W., Ronzetti, Michael H., Owens, Ashley E., Antony, Maria, Voss, Ty, Wallgren, Eric, Talley, Daniel, Balakrishnan, Krishna, Leyes Porello, Sebastian E., Rai, Ganesha, Marugan, Juan J., Michael, Samuel G., Baljinnyam, Bolormaa, Southall, Noel, Simeonov, Anton, Henderson, Mark J.
Published in ACS chemical biology (16.09.2022)
Published in ACS chemical biology (16.09.2022)
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Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts
Le Manach, Claire, Dam, Jean, Woodland, John G, Kaur, Gurminder, Khonde, Lutete P, Brunschwig, Christel, Njoroge, Mathew, Wicht, Kathryn J, Horatscheck, André, Paquet, Tanya, Boyle, Grant A, Gibhard, Liezl, Taylor, Dale, Lawrence, Nina, Yeo, Tomas, Mok, Sachel, Eastman, Richard T, Dorjsuren, Dorjbal, Talley, Daniel C, Guo, Hui, Simeonov, Anton, Reader, Janette, van der Watt, Mariëtte, Erlank, Erica, Venter, Nelius, Zawada, Jacek W, Aswat, Ayesha, Nardini, Luisa, Coetzer, Theresa L, Lauterbach, Sonja B, Bezuidenhout, Belinda C, Theron, Anjo, Mancama, Dalu, Koekemoer, Lizette L, Birkholtz, Lyn-Marie, Wittlin, Sergio, Delves, Michael, Ottilie, Sabine, Winzeler, Elizabeth A, von Geldern, Thomas W, Smith, Dennis, Fidock, David A, Street, Leslie J, Basarab, Gregory S, Duffy, James, Chibale, Kelly
Published in Journal of medicinal chemistry (25.02.2021)
Published in Journal of medicinal chemistry (25.02.2021)
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