SV2A protein is a broad-spectrum anticonvulsant target: Functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy
Kaminski, Rafal M., Matagne, Alain, Leclercq, Karine, Gillard, Michel, Michel, Philippe, Kenda, Benoit, Talaga, Patrice, Klitgaard, Henrik
Published in Neuropharmacology (01.03.2008)
Published in Neuropharmacology (01.03.2008)
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Discovery of 4-Substituted Pyrrolidone Butanamides as New Agents with Significant Antiepileptic Activity
Kenda, Benoit M, Matagne, Alain C, Talaga, Patrice E, Pasau, Patrick M, Differding, Edmond, Lallemand, Bénédicte I, Frycia, Anne M, Moureau, Florence G, Klitgaard, Henrik V, Gillard, Michel R, Fuks, Bruno, Michel, Philippe
Published in Journal of medicinal chemistry (29.01.2004)
Published in Journal of medicinal chemistry (29.01.2004)
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4-Benzyl-1H-imidazoles with Oxazoline Termini as Histamine H3 Receptor Agonists
Wijtmans, Maikel, Celanire, Sylvain, Snip, Erwin, Gillard, Michel R, Gelens, Edith, Collart, Philippe P, Venhuis, Bastiaan J, Christophe, Bernard, Hulscher, Saskia, Goot, Henk van der, Lebon, Florence, Timmerman, Henk, Bakker, Remko A, Lallemand, Bénédicte I. L. F, Leurs, Rob, Talaga, Patrice E, Esch, Iwan J. P. de
Published in Journal of medicinal chemistry (22.05.2008)
Published in Journal of medicinal chemistry (22.05.2008)
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Keynote review: Histamine H3 receptor antagonists reach out for the clinic
Celanire, Sylvain, Wijtmans, Maikel, Talaga, Patrice, Leurs, Rob, de Esch, Iwan J.P.
Published in Drug discovery today (01.12.2005)
Published in Drug discovery today (01.12.2005)
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Pyrazolo[4,3-c]isoquinolines as potential inhibitors of NF-κB activation
Mortier, Jérémie, Frederick, Raphaël, Ganeff, Corinne, Remouchamps, Caroline, Talaga, Patrice, Pochet, Lionel, Wouters, Johan, Piette, Jacques, Dejardin, Emmanuel, Masereel, Bernard
Published in Biochemical pharmacology (15.05.2010)
Published in Biochemical pharmacology (15.05.2010)
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4-benzyl-1H-imidazoles with oxazoline termini as histamine H-3 receptor agonists
Wijtmans, Maikel, Celanire, Sylvain, Snip, Erwin, Gillard, Michel R., Gelens, Edith, Collart, Philippe P., Venhuis, Bastiaan J., Christophe, Bernard, Hulscher, Saskia, van der Goot, Henk, Lebon, Florence, Timmerman, Henk, Bakker, Remko A., Lallemand, Benedicte I. L. F., Leurs, Rob, Talaga, Patrice E., de Esch, Iwan J. P.
Published in Journal of medicinal chemistry (22.05.2008)
Published in Journal of medicinal chemistry (22.05.2008)
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Identification of 4-(1H-Imidazol-4(5)-ylmethyl)pyridine (Immethridine) as a Novel, Potent, and Highly Selective Histamine H3 Receptor Agonist
Kitbunnadaj, Ruengwit, Zuiderveld, Obbe P, Christophe, Bernard, Hulscher, Saskia, Menge, Wiro M. P. B, Gelens, Edith, Snip, Erwin, Bakker, Remko A, Celanire, Sylvain, Gillard, Michel, Talaga, Patrice, Timmerman, Henk, Leurs, Rob
Published in Journal of medicinal chemistry (06.05.2004)
Published in Journal of medicinal chemistry (06.05.2004)
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Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H-3 receptor agonist
Kitbunnadaj, R, Zuiderveld, OP, Christophe, B, Hulscher, S, Menge, WMPB, Gelens, E, Snip, E, Bakker, RA, Celanire, S, Gillard, M, Talaga, P, Timmerman, H, Leurs, R
Published in Journal of medicinal chemistry (06.05.2004)
Published in Journal of medicinal chemistry (06.05.2004)
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First dual NK1 antagonists-serotonin reuptake inhibitors: Synthesis and SAR of a new class of potential antidepressants
RYCKMANS, Thomas, BALANCON, Laurent, BERTON, Olivier, GENICOT, Christophe, LAMBERTY, Yves, LALLEMAND, Benedicte, PASAU, Patrick, PIRLOT, Nathalie, QUERE, Luc, TALAGA, Patrice
Published in Bioorganic & medicinal chemistry letters (21.01.2002)
Published in Bioorganic & medicinal chemistry letters (21.01.2002)
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Alkyne–quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD
Starck, Jean-Philippe, Provins, Laurent, Christophe, Bernard, Gillard, Michel, Jadot, Sophie, Lo Brutto, Patrick, Quéré, Luc, Talaga, Patrice, Guyaux, Michel
Published in Bioorganic & medicinal chemistry (15.04.2008)
Published in Bioorganic & medicinal chemistry (15.04.2008)
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In vitro properties of 5-(benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone: A novel permeability transition pore inhibitor
Fuks, Bruno, Talaga, Patrice, Huart, Catherine, Hénichart, Jean-Pierre, Bertrand, Karine, Grimée, Renée, Lorent, Geneviève
Published in European journal of pharmacology (05.09.2005)
Published in European journal of pharmacology (05.09.2005)
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Discovery of a New Class of Non‐imidazole Oxazoline‐Based Histamine H 3 Receptor (H 3 R) Inverse Agonists
Célanire, Sylvain, Wijtmans, Maikel, Christophe, Bernard, Collart, Philippe, de Esch, Iwan, Dassesse, Donald, Delaunoy, Christel, Denonne, Frédéric, Durieu, Véronique, Gelens, Edith, Gillard, Michel, Lallemand, Bénédicte, Lamberty, Yves, Lebon, Florence, Nicolas, Jean‐Marie, Quéré, Luc, Snip, Erwin, Vanbellinghen, Alain, Van houtvin, Nathalie, Verbois, Valérie, Timmerman, Henk, Talaga, Patrice, Leurs, Rob, Provins, Laurent
Published in ChemMedChem (06.07.2009)
Published in ChemMedChem (06.07.2009)
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4-Benzyl-1 H -imidazoles with Oxazoline Termini as Histamine H 3 Receptor Agonists
Wijtmans, Maikel, Celanire, Sylvain, Snip, Erwin, Gillard, Michel R., Gelens, Edith, Collart, Philippe P., Venhuis, Bastiaan J., Christophe, Bernard, Hulscher, Saskia, Goot, Henk van der, Lebon, Florence, Timmerman, Henk, Bakker, Remko A., Lallemand, Bénédicte I. L. F., Leurs, Rob, Talaga, Patrice E., Esch, Iwan J. P. de
Published in Journal of medicinal chemistry (01.05.2008)
Published in Journal of medicinal chemistry (01.05.2008)
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Histamine H3 receptor antagonists reach out for the clinic
CELANIRE, Sylvain, WIJTMANS, Maikel, TALAGA, Patrice, LEURS, Rob, DE ESCH, Iwan J. P
Published in Drug discovery today (2005)
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Published in Drug discovery today (2005)
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4-Benzyl-lH-imidazoles with Oxazoline Termini as Histamine H3 Receptor Agonists
WIJTMANS, Maikel, CELANIRE, Sylvain, LEBON, Florence, TIMMERMAN, Henk, BAKKER, Remko A, LALLEMAND, Bénédicte I. L. F, LEURS, Rob, TALAGA, Patrice E, DE ESCH, Iwan J. P, SNIP, Erwin, GILLARD, Michel R, GELENS, Edith, COLLART, Philippe P, VENHUIS, Bastiaan J, CHRISTOPHE, Bernard, HULSCHER, Saskia, VAN DER GOOT, Henk
Published in Journal of medicinal chemistry (2008)
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Published in Journal of medicinal chemistry (2008)
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Dual NK1 antagonists: Serotonin reuptake inhibitors as potential antidepressants. Part 2: Sar and activity of benzyloxyphenethyl piperazine derivatives
RYCKMANS, Thomas, BERTON, Olivier, GRIMEE, Renée, KOGEJ, Thierry, LAMBERTY, Yves, PASAU, Patrick, TALAGA, Patrice, GENICOT, Christophe
Published in Bioorganic & medicinal chemistry letters (04.11.2002)
Published in Bioorganic & medicinal chemistry letters (04.11.2002)
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Histamine H3 receptor ligands with a 3-cyclobutoxy motif: a novel and versatile constraint of the classical 3-propoxy linker
Wijtmans, Maikel, Denonne, Frédéric, Célanire, Sylvain, Gillard, Michel, Hulscher, Saskia, Delaunoy, Christel, Van houtvin, Nathalie, Bakker, Remko A., Defays, Sabine, Gérard, Julien, Grooters, Luc, Hubert, Delphine, Timmerman, Henk, Leurs, Rob, Talaga, Patrice, de Esch, Iwan J. P., Provins, Laurent
Published in MedChemComm (01.07.2010)
Published in MedChemComm (01.07.2010)
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