Hit and lead criteria in drug discovery for infectious diseases of the developing world
Katsuno, Kei, Burrows, Jeremy N., Duncan, Ken, van Huijsduijnen, Rob Hooft, Kaneko, Takushi, Kita, Kiyoshi, Mowbray, Charles E., Schmatz, Dennis, Warner, Peter, Slingsby, B. T.
Published in Nature reviews. Drug discovery (01.11.2015)
Published in Nature reviews. Drug discovery (01.11.2015)
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Journal Article
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis
Wang, Feng, Sambandan, Dhinakaran, Halder, Rajkumar, Wang, Jianing, Batt, Sarah M, Weinrick, Brian, Ahmad, Insha, Yang, Pengyu, Zhang, Yong, Kim, John, Hassani, Morad, Huszar, Stanislav, Trefzer, Claudia, Ma, Zhenkun, Kaneko, Takushi, Mdluli, Khisi E, Franzblau, Scott, Chatterjee, Arnab K, Johnsson, Kai, Johnson, Kai, Mikusova, Katarina, Besra, Gurdyal S, Fütterer, Klaus, Robbins, Scott H, Barnes, S Whitney, Walker, John R, Jacobs, Jr, William R, Schultz, Peter G
Published in Proceedings of the National Academy of Sciences - PNAS (02.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (02.07.2013)
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Journal Article
Design, Synthesis, and Structure–Activity Relationship Studies of Tryptanthrins As Antitubercular Agents
Hwang, Jae-Min, Oh, Taegwon, Kaneko, Takushi, Upton, Anna M, Franzblau, Scott G, Ma, Zhenkun, Cho, Sang-Nae, Kim, Pilho
Published in Journal of natural products (Washington, D.C.) (22.03.2013)
Published in Journal of natural products (Washington, D.C.) (22.03.2013)
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Journal Article
New target for inhibition of bacterial RNA polymerase: ‘switch region’
Srivastava, Aashish, Talaue, Meliza, Liu, Shuang, Degen, David, Ebright, Richard Y, Sineva, Elena, Chakraborty, Anirban, Druzhinin, Sergey Y, Chatterjee, Sujoy, Mukhopadhyay, Jayanta, Ebright, Yon W, Zozula, Alex, Shen, Juan, Sengupta, Sonali, Niedfeldt, Rui Rong, Xin, Cai, Kaneko, Takushi, Irschik, Herbert, Jansen, Rolf, Donadio, Stefano, Connell, Nancy, Ebright, Richard H
Published in Current opinion in microbiology (01.10.2011)
Published in Current opinion in microbiology (01.10.2011)
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Journal Article
A novel antimycobacterial compound acts as an intracellular iron chelator
Dragset, Marte S, Poce, Giovanna, Alfonso, Salvatore, Padilla-Benavides, Teresita, Ioerger, Thomas R, Kaneko, Takushi, Sacchettini, James C, Biava, Mariangela, Parish, Tanya, Argüello, José M, Steigedal, Magnus, Rubin, Eric J
Published in Antimicrobial agents and chemotherapy (01.04.2015)
Published in Antimicrobial agents and chemotherapy (01.04.2015)
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Journal Article
Aqueous Phosphoric Acid as a Mild Reagent for Deprotection of tert-Butyl Carbamates, Esters, and Ethers
Li, Bryan, Berliner, Martin, Buzon, Richard, Chiu, Charles K.-F, Colgan, Stephen T, Kaneko, Takushi, Keene, Nandell, Kissel, William, Le, Tung, Leeman, Kyle R, Marquez, Brian, Morris, Ronald, Newell, Lisa, Wunderwald, Silke, Witt, Michael, Weaver, John, Zhang, Zhijun, Zhang, Zhongli
Published in Journal of organic chemistry (24.11.2006)
Published in Journal of organic chemistry (24.11.2006)
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Journal Article
Antituberculosis Activity of Brotowali (Tinospora crispa) Extract and Fractions against Mycobacterium tuberculosis using Microplate Alamar Blue Assay Method
Wahyuningrum, Retno, Ritmaleni, Ritmaleni, Irianti, Tatang, Wahyuono, Subagus, Kaneko, Takushi, Nuryastuti, Titik
Published in Majalah obat tradisional = Traditional medicine journal (31.08.2017)
Published in Majalah obat tradisional = Traditional medicine journal (31.08.2017)
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Journal Article
Synthesis and structure–activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents
Vara Prasad, J.V.N., Boyer, Frederick E., Chupak, Lou, Dermyer, Michael, Ding, Qizhu, Gavardinas, K., Hagen, Susan E., Huband, Michael D., Jiao, Wenhua, Kaneko, Takushi, Maiti, Samarendra N., Melnick, Michael, Romero, Karina, Patterson, M., Wu, Xiujuan
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
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Journal Article
Tuberculosis drug discovery and emerging targets
Mdluli, Khisimuzi, Kaneko, Takushi, Upton, Anna
Published in Annals of the New York Academy of Sciences (01.09.2014)
Published in Annals of the New York Academy of Sciences (01.09.2014)
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Journal Article
Effect of InGaN/GaN Superlattice on Lattice Curvature of GaN Layers Grown on Sapphire Substrates
Kaneko, Takushi, Okada, Narihito, Tadatomo, Kazuyuki
Published in physica status solidi (b) (01.04.2020)
Published in physica status solidi (b) (01.04.2020)
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Journal Article
The tuberculosis drug discovery and development pipeline and emerging drug targets
Mdluli, Khisimuzi, Kaneko, Takushi, Upton, Anna
Published in Cold Spring Harbor perspectives in medicine (01.06.2015)
Published in Cold Spring Harbor perspectives in medicine (01.06.2015)
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Journal Article
(6-Maleimidocaproyl)hydrazone of doxorubicin. A new derivative for the preparation of immunoconjugates of doxorubicin
Willner, David, Trail, Pamela A, Hofstead, Sandra J, King, H. Dalton, Lasch, Shirley J, Braslawsky, Gary R, Greenfield, Robert S, Kaneko, Takushi, Firestone, Raymond A
Published in Bioconjugate chemistry (01.11.1993)
Published in Bioconjugate chemistry (01.11.1993)
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Journal Article
Challenges and opportunities in developing novel drugs for TB
Kaneko, Takushi, Cooper, Christopher, Mdluli, Khisimuzi
Published in Future medicinal chemistry (01.09.2011)
Published in Future medicinal chemistry (01.09.2011)
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Journal Article
Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline
Wang, Zhe, Soni, Vijay, Marriner, Gwendolyn, Kaneko, Takushi, Boshoff, Helena I. M., Barry, Clifton E., Rhee, Kyu Y.
Published in Proceedings of the National Academy of Sciences - PNAS (24.09.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (24.09.2019)
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Journal Article
CP-225, 917 and CP-263, 114, Novel Ras Farnesylation Inhibitors from an Unidentified Fungus: I. Taxonomy, Fermentation, Isolation, and Biochemical Properties
DABRAH, THOMAS T., HARWOOD, H. JAMES, HUANG, LIANG H., JANKOVICH, NANCY D., KANEKO, TAKUSHI, LI, JIAN-CHENG, LINDSEY, SARALYN, MOSHIER, PETER M., SUBASHI, TIMOTHY A., THERRIEN, MICHELLE, WATTS, PAUL C.
Published in Journal of antibiotics (1997)
Published in Journal of antibiotics (1997)
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Journal Article
Effects of Desalted Deep Seawater on Hematologic and Blood Chemical Values in Mice
Tsuchiya, Yasuo, Watanabe, Atsuo, Fujisawa, Nobuyoshi, Kaneko, Takushi, Ishizu, Teiji, Fujimoto, Takanori, Nakamura, Kazutoshi, Yamamoto, Masaharu
Published in The Tohoku Journal of Experimental Medicine (01.07.2004)
Published in The Tohoku Journal of Experimental Medicine (01.07.2004)
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Journal Article
Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents
Zhang, Jidong, Lair, Christine, Roubert, Christine, Amaning, Kwame, Barrio, María Belén, Benedetti, Yannick, Cui, Zhicheng, Xing, Zhongliang, Li, Xiaojun, Franzblau, Scott G., Baurin, Nicolas, Bordon-Pallier, Florence, Cantalloube, Cathy, Sans, Stephanie, Silve, Sandra, Blanc, Isabelle, Fraisse, Laurent, Rak, Alexey, Jenner, Lasse B., Yusupova, Gulnara, Yusupov, Marat, Zhang, Junjie, Kaneko, Takushi, Yang, T.J., Fotouhi, Nader, Nuermberger, Eric, Tyagi, Sandeep, Betoudji, Fabrice, Upton, Anna, Sacchettini, James C., Lagrange, Sophie
Published in Cell (02.03.2023)
Published in Cell (02.03.2023)
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Journal Article
Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents
Zhang, Jidong, Lair, Christine, Roubert, Christine, Amaning, Kwame, Barrio, María Belén, Benedetti, Yannick, Cui, Zhicheng, Xing, Zhongliang, Li, Xiaojun, Franzblau, Scott, Baurin, Nicolas, Bordon-Pallier, Florence, Cantalloube, Cathy, Sans, Stephanie, Silve, Sandra, Blanc, Isabelle, Fraisse, Laurent, Rak, Alexey, Jenner, Lasse, Yusupova, Gulnara, Yusupov, Marat, Zhang, Junjie, Kaneko, Takushi, Yang, T.J., Fotouhi, Nader, Nuermberger, Eric, Tyagi, Sandeep, Betoudji, Fabrice, Upton, Anna, Sacchettini, James, Lagrange, Sophie
Published in Cell (01.03.2023)
Published in Cell (01.03.2023)
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