Advancing novel therapies for neurodegeneration through an innovative model for industry–academia collaborations: A decade of the Eisai–UCL experience
Atkinson, Peter J., Swami, Meera, Ridgway, Nicola, Roberts, Malcolm, Kinghorn, Jane, Warner, Thomas T., Staddon, James M., Takle, Andrew K.
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Published in Drug discovery today (01.10.2023)
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Takeda, Kunitoshi, Watanabe, Toru, Smith, James R., Vesey, David, Tiberghien, Nathalie, Lewis, Sian, Powney, Ben, Schapira, Anthony H.V., Hoshikawa, Tamaki, Takle, Andrew K.
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Published in Bioorganic & medicinal chemistry letters (15.11.2023)
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The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7
Wright, Zoë V. F, McCarthy, Stephen, Dickman, Rachael, Reyes, Francis E, Sanchez-Martinez, Silvia, Cryar, Adam, Kilford, Ian, Hall, Adrian, Takle, Andrew K, Topf, Maya, Gonen, Tamir, Thalassinos, Konstantinos, Tabor, Alethea B
Published in Journal of the American Chemical Society (20.09.2017)
Published in Journal of the American Chemical Society (20.09.2017)
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Hoshikawa, Tamaki, Watanabe, Toru, Kotake, Makoto, Tiberghien, Nathalie, Woo, Chi-kit, Lewis, Sian, Briston, Thomas, Koglin, Mumta, Staddon, James M., Powney, Ben, Schapira, Anthony H.V., Takle, Andrew K.
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Published in Bioorganic & medicinal chemistry letters (01.02.2023)
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The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Na v 1.7
Wright, Zoë V F, McCarthy, Stephen, Dickman, Rachael, Reyes, Francis E, Sanchez-Martinez, Silvia, Cryar, Adam, Kilford, Ian, Hall, Adrian, Takle, Andrew K, Topf, Maya, Gonen, Tamir, Thalassinos, Konstantinos, Tabor, Alethea B
Published in Journal of the American Chemical Society (20.09.2017)
Published in Journal of the American Chemical Society (20.09.2017)
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The identification of potent and selective imidazole-based inhibitors of B-Raf kinase
Takle, Andrew K., Brown, Murray J.B., Davies, Susannah, Dean, David K., Francis, Gerraint, Gaiba, Alessandra, Hird, Alex W., King, Frank D., Lovell, Peter J., Naylor, Antoinette, Reith, Alastair D., Steadman, Jon G., Wilson, David M.
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
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Asymmetric synthesis of N-protected amino acids by the addition of organolithium carboxyl synthons to ROPHy/SOPHy-derived aldoximes and ketoximesChiral oxime ethers in asymmetric synthesis. Part 6.1
Cooper, Tracey S., Laurent, Pierre, Moody, Christopher J., Takle, Andrew K.
Published in Organic & biomolecular chemistry (2004)
Published in Organic & biomolecular chemistry (2004)
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Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists
Wilson, David M., Apps, James, Bailey, Nicholas, Bamford, Mark J., Beresford, Isabel J., Brackenborough, Kim, Briggs, Michael A., Brough, Stephen, Calver, Andrew R., Crook, Barry, Davis, Rebecca K., Davis, Robert P., Davis, Susannah, Dean, David K., Harris, Leanne, Heslop, Teresa, Holland, Vicky, Jeffrey, Phillip, Panchal, Terrance A., Parr, Christopher A., Quashie, Nigel, Schogger, Joanne, Sehmi, Sanjeet S., Stean, Tania O., Steadman, Jon G.A., Trail, Brenda, Wald, Jeffrey, Worby, Angela, Takle, Andrew K., Witherington, Jason, Medhurst, Andrew D.
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds
Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Suijkerbuijk, Bart M.J.M., Ménard, Delphine, Zambon, Alfonso, Nourry, Arnaud, Davies, Lawrence, Manne, Helen A., Friedlos, Frank, Ogilvie, Lesley, Hedley, Douglas, Takle, Andrew K., Wilson, David M., Pons, Jean-Francois, Coulter, Tom, Kirk, Ruth, Cantarino, Neus, Whittaker, Steven, Marais, Richard, Springer, Caroline J.
Published in Bioorganic & medicinal chemistry (15.09.2010)
Published in Bioorganic & medicinal chemistry (15.09.2010)
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6-Aryl-pyrazolo[3,4- b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)
Witherington, Jason, Bordas, Vincent, Gaiba, Alessandra, Garton, Neil S., Naylor, Antoinette, Rawlings, Anthony D., Slingsby, Brian P., Smith, David G., Takle, Andrew K., Ward, Robert W.
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
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The discovery of the benzazepine class of histamine H3 receptor antagonists
Wilson, David M., Apps, James, Bailey, Nicholas, Bamford, Mark J., Beresford, Isabel J., Briggs, Michael A., Calver, Andrew R., Crook, Barry, Davis, Robert P., Davis, Susannah, Dean, David K., Harris, Leanne, Heightman, Tom D., Panchal, Terry, Parr, Christopher A., Quashie, Nigel, Steadman, Jon G.A., Schogger, Joanne, Sehmi, Sanjeet S., Stean, Tania O., Takle, Andrew K., Trail, Brenda K., White, Trevor, Witherington, Jason, Worby, Angela, Medhurst, Andrew D.
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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6-Heteroaryl-pyrazolo[3,4- b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)
Witherington, Jason, Bordas, Vincent, Gaiba, Alessandra, Naylor, Antoinette, Rawlings, Anthony D., Slingsby, Brian P., Smith, David G., Takle, Andrew K., Ward, Robert W.
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
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Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2- a]pyridine acid pump antagonists (APAs)
Bailey, Nick, Bamford, Mark J., Brissy, Delphine, Brookfield, Joanna, Demont, Emmanuel, Elliott, Richard, Garton, Neil, Farre-Gutierrez, Irene, Hayhow, Thomas, Hutley, Gail, Naylor, Antoinette, Panchal, Terry A., Seow, Hui-Xian, Spalding, David, Takle, Andrew K.
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
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Potent oxadiazole CGRP receptor antagonists for the potential treatment of migraine
Nichols, Paula L., Brand, Jonathan, Briggs, Michael, D’Angeli, Mathilde, Farge, Jennifer, Garland, Stephen L., Goldsmith, Paul, Hutchings, Rio, Kilford, Ian, Li, Ho Y., MacPherson, David, Nimmo, Fiona, Sanderson, Francis Dominic, Sehmi, Sanjeet, Shuker, Nicola, Skidmore, John, Stott, Michael, Sweeting, Jennifer, Tajuddin, Hasmi, Takle, Andrew K., Trani, Giancarlo, Wall, Ian D., Ward, Robert, Wilson, David M., Witty, David
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
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The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase
Takle, Andrew K., Bamford, Mark J., Davies, Susannah, Davis, Robert P., Dean, David K., Gaiba, Alessandra, Irving, Elaine A., King, Frank D., Naylor, Antoinette, Parr, Christopher A., Ray, Alison M., Reith, Alastair D., Smith, Beverley B., Staton, Penelope C., Steadman, Jon G.A., Stean, Tania O., Wilson, David M.
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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Chiral oxime ethers in asymmetric synthesis. O-(1-Phenylbutyl)benzyloxyacetaldoxime, a versatile reagent for the asymmetric synthesis of protected 1,2-aminoalcohols, alpha-amino acid derivatives, and 2-hydroxymethyl nitrogen heterocycles including iminosugars
Cooper, Tracey S, Larigo, Alexander S, Laurent, Pierre, Moody, Christopher J, Takle, Andrew K
Published in Organic & biomolecular chemistry (07.04.2005)
Published in Organic & biomolecular chemistry (07.04.2005)
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Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation
Witherington, Jason, Abberley, Lee, Briggs, Michael A., Collis, Katharine, Dean, David K., Gaiba, Alessandra, King, N. Paul, Kraus, Helmut, Shuker, Nicola, Steadman, Jon G.A., Takle, Andrew K., Sanger, Gareth, Wadsworth, Graham, Butler, Sharon, McKay, Fiona, Muir, Alison, Winborn, Kim, Heightman, Tom D.
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
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(1 H-Imidazo[4,5- c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors
Bamford, Mark J., Alberti, Michael J., Bailey, Nicholas, Davies, Susannah, Dean, David K., Gaiba, Alessandra, Garland, Stephen, Harling, John D., Jung, David K., Panchal, Terence A., Parr, Christopher A., Steadman, Jon G., Takle, Andrew K., Townsend, James T., Wilson, David M., Witherington, Jason
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
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