Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells
Wang, Peng, Karakose, Esra, Liu, Hongtao, Swartz, Ethan, Ackeifi, Courtney, Zlatanic, Viktor, Wilson, Jessica, González, Bryan J., Bender, Aaron, Takane, Karen K., Ye, Lillian, Harb, George, Pagliuca, Felicia, Homann, Dirk, Egli, Dieter, Argmann, Carmen, Scott, Donald K., Garcia-Ocaña, Adolfo, Stewart, Andrew F.
Published in Cell metabolism (05.03.2019)
Published in Cell metabolism (05.03.2019)
Get full text
Journal Article
Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas
Wang, Huan, Bender, Aaron, Wang, Peng, Karakose, Esra, Inabnet, William B, Libutti, Steven K, Arnold, Andrew, Lambertini, Luca, Stang, Micheal, Chen, Herbert, Kasai, Yumi, Mahajan, Milind, Kinoshita, Yayoi, Fernandez-Ranvier, Gustavo, Becker, Thomas C, Takane, Karen K, Walker, Laura A, Saul, Shira, Chen, Rong, Scott, Donald K, Ferrer, Jorge, Antipin, Yevgeniy, Donovan, Michael, Uzilov, Andrew V, Reva, Boris, Schadt, Eric E, Losic, Bojan, Argmann, Carmen, Stewart, Andrew F
Published in Nature communications (03.10.2017)
Published in Nature communications (03.10.2017)
Get full text
Journal Article
Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome
Hasegawa, N, Oshima, M, Sashida, G, Matsui, H, Koide, S, Saraya, A, Wang, C, Muto, T, Takane, K, Kaneda, A, Shimoda, K, Nakaseko, C, Yokote, K, Iwama, A
Published in Leukemia (01.04.2017)
Published in Leukemia (01.04.2017)
Get full text
Journal Article
Plasma Membrane Subdomain Compartmentalization Contributes to Distinct Mechanisms of Ceramide Action on Insulin Signaling
BLOUIN, Cédric M, PRADO, Cécilia, TAKANE, Karen K, LASNIER, Françoise, GARCIA-OCANA, Adolfo, FERRE, Pascal, DUGAIL, Isabelle, HAJDUCH, Eric
Published in Diabetes (New York, N.Y.) (01.03.2010)
Published in Diabetes (New York, N.Y.) (01.03.2010)
Get full text
Journal Article
c-myc and skp2 Coordinate p27 Degradation, Vascular Smooth Muscle Proliferation, and Neointima Formation Induced by the Parathyroid Hormone-Related Protein
Sicari, Brian M, Troxell, Ronnie, Salim, Fatimah, Tanwir, Mansoor, Takane, Karen K, Fiaschi-Taesch, Nathalie
Published in Endocrinology (Philadelphia) (01.02.2012)
Published in Endocrinology (Philadelphia) (01.02.2012)
Get full text
Journal Article
Transgenic Overexpression of Hepatocyte Growth Factor in the β-Cell Markedly Improves Islet Function and Islet Transplant Outcomes in Mice
García-Ocaña, Adolfo, Vasavada, Rupangi C., Cebrian, Ana, Reddy, Vasumathi, Takane, Karen K., López-Talavera, Juan-Carlos, Stewart, Andrew F.
Published in Diabetes (New York, N.Y.) (01.12.2001)
Published in Diabetes (New York, N.Y.) (01.12.2001)
Get full text
Journal Article
Hepatocyte growth factor enhances engraftment and function of nonhuman primate islets
Fiaschi-Taesch, Nathalie M, Berman, Dora M, Sicari, Brian M, Takane, Karen K, Garcia-Ocaña, Adolfo, Ricordi, Camillo, Kenyon, Norma S, Stewart, Andrew F
Published in Diabetes (New York, N.Y.) (01.10.2008)
Published in Diabetes (New York, N.Y.) (01.10.2008)
Get full text
Journal Article
Induction of β-Cell Proliferation and Retinoblastoma Protein Phosphorylation in Rat and Human Islets Using Adenovirus-Mediated Transfer of Cyclin-Dependent Kinase-4 and Cyclin D1
COZAR-CASTELLANO, Irene, TAKANE, Karen K, BOTTINO, Rita, BALAMURUGAN, A. N, STEWART, Andrew F
Published in Diabetes (New York, N.Y.) (01.01.2004)
Published in Diabetes (New York, N.Y.) (01.01.2004)
Get full text
Journal Article
Hepatocyte Growth Factor Gene Therapy for Pancreatic Islets in Diabetes: Reducing the Minimal Islet Transplant Mass Required in a Glucocorticoid-Free Rat Model of Allogeneic Portal Vein Islet Transplantation
Lopez-Talavera, Juan Carlos, Garcia-Ocaña, Adolfo, Sipula, Ian, Takane, Karen K, Cozar-Castellano, Irene, Stewart, Andrew F
Published in Endocrinology (Philadelphia) (01.02.2004)
Published in Endocrinology (Philadelphia) (01.02.2004)
Get full text
Journal Article
Adenovirus-mediated Hepatocyte Growth Factor Expression in Mouse Islets Improves Pancreatic Islet Transplant Performance and Reduces Beta Cell Death
Garcı́a-Ocaña, Adolfo, Takane, Karen K., Reddy, Vasumathi T., Lopez-Talavera, Juan-Carlos, Vasavada, Rupangi C., Stewart, Andrew F.
Published in The Journal of biological chemistry (03.01.2003)
Published in The Journal of biological chemistry (03.01.2003)
Get full text
Journal Article
Hepatocyte Growth Factor Overexpression in the Islet of Transgenic Mice Increases Beta Cell Proliferation, Enhances Islet Mass, and Induces Mild Hypoglycemia
Garcia-Ocaña, Adolfo, Takane, Karen K., Syed, Mushtaq A., Philbrick, William M., Vasavada, Rupangi C., Stewart, Andrew F.
Published in The Journal of biological chemistry (14.01.2000)
Published in The Journal of biological chemistry (14.01.2000)
Get full text
Journal Article
Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets
FIASCHI-TAESCH, Nathalie M, BERMAN, Dora M, SICARI, Brian M, TAKANE, Karen K, GARCIA-OCANA, Adolfo, RICORDI, Camillo, KENYON, Norma S, STEWART, Andrew F
Published in Diabetes (New York, N.Y.) (01.10.2008)
Published in Diabetes (New York, N.Y.) (01.10.2008)
Get full text
Journal Article
Gene Transfer of Constitutively Active Akt Markedly Improves Human Islet Transplant Outcomes in Diabetic Severe Combined Immunodeficient Mice
RAO, Poornima, ROCCISANA, Jennifer, TAKANE, Karen K, BOTTINO, Rita, ZHAO, Allan, TRUCCO, Massimo, GARCIA-OCANA, Adolfo
Published in Diabetes (New York, N.Y.) (01.06.2005)
Published in Diabetes (New York, N.Y.) (01.06.2005)
Get full text
Journal Article
The C-Terminal Region of PTHrP, in Addition to the Nuclear Localization Signal, Is Essential for the Intracrine Stimulation of Proliferation in Vascular Smooth Muscle Cells
de Miguel, F, Fiaschi-Taesch, N, López-Talavera, J. C, Takane, K. K, Massfelder, T, Helwig, J.-J, Stewart, A. F
Published in Endocrinology (Philadelphia) (01.09.2001)
Published in Endocrinology (Philadelphia) (01.09.2001)
Get full text
Journal Article
Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6
FIASCHI-TAESCH, Nathalie M, SALIM, Fatimah, KLEINBERGER, Jeffrey, TROXELL, Ronnie, COZAR-CASTELLANO, Irene, SELK, Karen, CHEROK, Edward, TAKANE, Karen K, SCOTT, Donald K, STEWART, Andrew F
Published in Diabetes (New York, N.Y.) (01.08.2010)
Published in Diabetes (New York, N.Y.) (01.08.2010)
Get full text
Journal Article
Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells
Chen, Hainan, Kleinberger, Jeffrey W, Takane, Karen K, Salim, Fatimah, Fiaschi-Taesch, Nathalie, Pappas, Kyrie, Parsons, Ramon, Jiang, Jing, Zhang, Yue, Liu, Hongtao, Wang, Peng, Bender, Aaron S, Frank, Stuart J, Stewart, Andrew F
Published in Diabetes (New York, N.Y.) (01.11.2015)
Published in Diabetes (New York, N.Y.) (01.11.2015)
Get full text
Journal Article
Survey of the Human Pancreatic β-Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D1 in Enhancing Human β-Cell Replication and Function In Vivo
Fiaschi-Taesch, Nathalie, Bigatel, Todd A, Sicari, Brian, Takane, Karen K, Salim, Fatima, Velazquez-Garcia, Silvia, Harb, George, Selk, Karen, Cozar-Castellano, Irene, Stewart, Andrew F
Published in Diabetes (New York, N.Y.) (01.04.2009)
Published in Diabetes (New York, N.Y.) (01.04.2009)
Get full text
Journal Article