Discovery of N -[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2- b ]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1 H -pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor
Miyamoto, Naoki, Sakai, Nozomu, Hirayama, Takaharu, Miwa, Kazuhiro, Oguro, Yuya, Oki, Hideyuki, Okada, Kengo, Takagi, Terufumi, Iwata, Hidehisa, Awazu, Yoshiko, Yamasaki, Seiji, Takeuchi, Toshiyuki, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (01.04.2013)
Published in Bioorganic & medicinal chemistry (01.04.2013)
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Journal Article
Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells
Ohashi, Akihiro, Ohori, Momoko, Iwai, Kenichi, Nakayama, Yusuke, Nambu, Tadahiro, Morishita, Daisuke, Kawamoto, Tomohiro, Miyamoto, Maki, Hirayama, Takaharu, Okaniwa, Masanori, Banno, Hiroshi, Ishikawa, Tomoyasu, Kandori, Hitoshi, Iwata, Kentaro
Published in Nature communications (06.07.2015)
Published in Nature communications (06.07.2015)
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Synthetic Studies on Centromere-Associated Protein‑E (CENP-E) Inhibitors: 2. Application of Electrostatic Potential Map (EPM) and Structure-Based Modeling to Imidazo[1,2‑a]pyridine Derivatives as Anti-Tumor Agents
Hirayama, Takaharu, Okaniwa, Masanori, Banno, Hiroshi, Kakei, Hiroyuki, Ohashi, Akihiro, Iwai, Kenichi, Ohori, Momoko, Mori, Kouji, Gotou, Mika, Kawamoto, Tomohiro, Yokota, Akihiro, Ishikawa, Tomoyasu
Published in Journal of medicinal chemistry (22.10.2015)
Published in Journal of medicinal chemistry (22.10.2015)
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Journal Article
Prolyl-tRNA synthetase inhibition promotes cell death in SK-MEL-2 cells through GCN2-ATF4 pathway activation
Arita, Takeo, Morimoto, Megumi, Yamamoto, Yukiko, Miyashita, Hitoshi, Kitazawa, Satoshi, Hirayama, Takaharu, Sakamoto, Sou, Miyamoto, Kazumasa, Adachi, Ryutaro, Iwatani, Misa, Hara, Takahito
Published in Biochemical and biophysical research communications (08.07.2017)
Published in Biochemical and biophysical research communications (08.07.2017)
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Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors
Matsumoto, Shigemitsu, Miyamoto, Naoki, Hirayama, Takaharu, Oki, Hideyuki, Okada, Kengo, Tawada, Michiko, Iwata, Hidehisa, Nakamura, Kazuhide, Yamasaki, Seiji, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (15.12.2013)
Published in Bioorganic & medicinal chemistry (15.12.2013)
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Journal Article
Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3′,4′:3,4]benzo[1,2-d]isothiazole derivatives
Ono, Koji, Banno, Hiroshi, Okaniwa, Masanori, Hirayama, Takaharu, Iwamura, Naoki, Hikichi, Yukiko, Murai, Saomi, Hasegawa, Maki, Hasegawa, Yuka, Yonemori, Kazuko, Hata, Akito, Aoyama, Kazunobu, Cary, Douglas R.
Published in Bioorganic & medicinal chemistry (15.04.2017)
Published in Bioorganic & medicinal chemistry (15.04.2017)
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Journal Article
Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential
Fujimoto, Jun, Hirayama, Takaharu, Hirata, Yasuhiro, Hikichi, Yukiko, Murai, Saomi, Hasegawa, Maki, Hasegawa, Yuka, Yonemori, Kazuko, Hata, Akito, Aoyama, Kazunobu, Cary, Douglas R.
Published in Bioorganic & medicinal chemistry (15.06.2017)
Published in Bioorganic & medicinal chemistry (15.06.2017)
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Journal Article
Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor
Miyamoto, Naoki, Sakai, Nozomu, Hirayama, Takaharu, Miwa, Kazuhiro, Oguro, Yuya, Oki, Hideyuki, Okada, Kengo, Takagi, Terufumi, Iwata, Hidehisa, Awazu, Yoshiko, Yamasaki, Seiji, Takeuchi, Toshiyuki, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (15.04.2013)
Published in Bioorganic & medicinal chemistry (15.04.2013)
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Journal Article
Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1. Exploration of fused bicyclic core scaffolds using electrostatic potential map
Hirayama, Takaharu, Okaniwa, Masanori, Imada, Takashi, Ohashi, Akihiro, Ohori, Momoko, Iwai, Kenichi, Mori, Kouji, Kawamoto, Tomohiro, Yokota, Akihiro, Tanaka, Toshimasa, Ishikawa, Tomoyasu
Published in Bioorganic & medicinal chemistry (01.09.2013)
Published in Bioorganic & medicinal chemistry (01.09.2013)
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Journal Article
Design and synthesis of fused bicyclic inhibitors targeting the L5 loop site of centromere-associated protein E
Hirayama, Takaharu, Okaniwa, Masanori, Banno, Hiroshi, Kakei, Hiroyuki, Ohashi, Akihiro, Ohori, Momoko, Nambu, Tadahiro, Iwai, Kenichi, Kawamoto, Tomohiro, Yokota, Akihiro, Miyamoto, Maki, Ishikawa, Tomoyasu
Published in Bioorganic & medicinal chemistry letters (01.09.2016)
Published in Bioorganic & medicinal chemistry letters (01.09.2016)
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Journal Article
Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map
Hirayama, Takaharu, Okaniwa, Masanori, Imada, Takashi, Ohashi, Akihiro, Ohori, Momoko, Iwai, Kenichi, Mori, Kouji, Kawamoto, Tomohiro, Yokota, Akihiro, Tanaka, Toshimasa, Ishikawa, Tomoyasu
Published in Bioorganic & medicinal chemistry (01.09.2013)
Published in Bioorganic & medicinal chemistry (01.09.2013)
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Journal Article
Abstract 3407: A novel CENP-E-selective inhibitor exhibits potent anti-tumor efficacy by two distinct mechanisms of action dependent on spindle assembly checkpoint activity
Ohashi, Akihiro, Ohori, Momoko, Iwai, Kenichi, Nakayama, Yusuke, Nambu, Tadahiro, Morishita, Daisuke, Kawamoto, Tomohiro, Miyamoto, Maki, Hirayama, Takaharu, Okaniwa, Masanori, Banno, Hiroshi, Ishikawa, Tomoyasu, Kandori, Hitoshi, Iwata, Kentaro
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Journal Article
Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl} o xy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor
Miyamoto, Naoki, Sakai, Nozomu, Hirayama, Takaharu, Miwa, Kazuhiro, Oguro, Yuya, Oki, Hideyuki, Okada, Kengo, Takagi, Terufumi, Iwata, Hidehisa, Awazu, Yoshiko, Yamasaki, Seiji, Takeuchi, Toshiyuki, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (01.04.2013)
Published in Bioorganic & medicinal chemistry (01.04.2013)
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Journal Article
Preparation of Enolate-Homoenolate Species as (Z)-γ-Siloxyallylmetal Equivalents: Sequential 1,4-Addition of Bis(iodozincio)methane to 1,4-Dicarbonylbutenes and Cyclopropanation
Hirayama, Takaharu, Oshima, Koichiro, Matsubara, Seijiro
Published in Angewandte Chemie International Edition (20.05.2005)
Published in Angewandte Chemie International Edition (20.05.2005)
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Journal Article
Heterocyclic compound
Ito, Yoshiteru, Imamura, Shinichi, Hirayama, Takaharu, Kawakita, Youichi, Nii, Noriyuki
Year of Publication 13.02.2024
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Year of Publication 13.02.2024
Patent
HETEROCYCLIC COMPOUND
Ito, Yoshiteru, Imamura, Shinichi, Hirayama, Takaharu, Kawakita, Youichi, Nii, Noriyuki
Year of Publication 24.03.2022
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Year of Publication 24.03.2022
Patent
Heterocyclic compound
Imamura, Shinichi, Ito, Yoshiteru, Arikawa, Yasuyoshi, Banno, Hiroshi, Hirayama, Takaharu, Tanaka, Toshio, Kawakita, Youichi, Tokuhara, Hidekazu, Nii, Noriyuki
Year of Publication 31.05.2024
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Year of Publication 31.05.2024
Patent