YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology
Tanaka, Hikari, Homma, Hidenori, Fujita, Kyota, Kondo, Kanoh, Yamada, Shingo, Jin, Xiaocen, Waragai, Masaaki, Ohtomo, Gaku, Iwata, Atsushi, Tagawa, Kazuhiko, Atsuta, Naoki, Katsuno, Masahisa, Tomita, Naoki, Furukawa, Katsutoshi, Saito, Yuko, Saito, Takashi, Ichise, Ayaka, Shibata, Shinsuke, Arai, Hiroyuki, Saido, Takaomi, Sudol, Marius, Muramatsu, Shin-ichi, Okano, Hideyuki, Mufson, Elliott J., Sobue, Gen, Murayama, Shigeo, Okazawa, Hitoshi
Published in Nature communications (24.01.2020)
Published in Nature communications (24.01.2020)
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The intellectual disability gene PQBP1 rescues Alzheimer’s disease pathology
Tanaka, Hikari, Kondo, Kanoh, Chen, Xigui, Homma, Hidenori, Tagawa, Kazuhiko, Kerever, Aurelian, Aoki, Shigeki, Saito, Takashi, Saido, Takaomi, Muramatsu, Shin-ichi, Fujita, Kyota, Okazawa, Hitoshi
Published in Molecular psychiatry (01.10.2018)
Published in Molecular psychiatry (01.10.2018)
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Drebrin-like (Dbnl) Controls Neuronal Migration via Regulating N-Cadherin Expression in the Developing Cerebral Cortex
Inoue, Seika, Hayashi, Kanehiro, Fujita, Kyota, Tagawa, Kazuhiko, Okazawa, Hitoshi, Kubo, Ken-Ichiro, Nakajima, Kazunori
Published in The Journal of neuroscience (23.01.2019)
Published in The Journal of neuroscience (23.01.2019)
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Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology
Mao, Ying, Chen, Xigui, Xu, Min, Fujita, Kyota, Motoki, Kazumi, Sasabe, Toshikazu, Homma, Hidenori, Murata, Miho, Tagawa, Kazuhiko, Tamura, Takuya, Kaye, Julia, Finkbeiner, Steven, Blandino, Giovanni, Sudol, Marius, Okazawa, Hitoshi
Published in Human molecular genetics (01.11.2016)
Published in Human molecular genetics (01.11.2016)
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Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology
Fujita, Kyota, Chen, Xigui, Homma, Hidenori, Tagawa, Kazuhiko, Amano, Mutsuki, Saito, Ayumu, Imoto, Seiya, Akatsu, Hiroyasu, Hashizume, Yoshio, Kaibuchi, Kozo, Miyano, Satoru, Okazawa, Hitoshi
Published in Nature communications (30.01.2018)
Published in Nature communications (30.01.2018)
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Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1
Fujita, Kyota, Mao, Ying, Uchida, Shigenori, Chen, Xigui, Shiwaku, Hiroki, Tamura, Takuya, Ito, Hikaru, Watase, Kei, Homma, Hidenori, Tagawa, Kazuhiko, Sudol, Marius, Okazawa, Hitoshi
Published in Nature communications (30.11.2017)
Published in Nature communications (30.11.2017)
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Mutant huntingtin impairs Ku70-mediated DNA repair
Enokido, Yasushi, Tamura, Takuya, Ito, Hikaru, Arumughan, Anup, Komuro, Akihiko, Shiwaku, Hiroki, Sone, Masaki, Foulle, Raphaele, Sawada, Hirohide, Ishiguro, Hiroshi, Ono, Tetsuya, Murata, Miho, Kanazawa, Ichiro, Tomilin, Nikolai, Tagawa, Kazuhiko, Wanker, Erich E, Okazawa, Hitoshi
Published in The Journal of cell biology (03.05.2010)
Published in The Journal of cell biology (03.05.2010)
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Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity
Shiwaku, Hiroki, Yoshimura, Natsue, Tamura, Takuya, Sone, Masaki, Ogishima, Soichi, Watase, Kei, Tagawa, Kazuhiko, Okazawa, Hitoshi
Published in The EMBO journal (21.07.2010)
Published in The EMBO journal (21.07.2010)
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Journal Article
HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology
Tanaka, Hikari, Kondo, Kanoh, Fujita, Kyota, Homma, Hidenori, Tagawa, Kazuhiko, Jin, Xiaocen, Jin, Meihua, Yoshioka, Yuki, Takayama, Sumire, Masuda, Hitomi, Tokuyama, Rie, Nakazaki, Yukoh, Saito, Takashi, Saido, Takaomi, Murayama, Shigeo, Ikura, Teikichi, Ito, Nobutoshi, Yamamori, Yu, Tomii, Kentaro, Bianchi, Marco E., Okazawa, Hitoshi
Published in Communications biology (11.10.2021)
Published in Communications biology (11.10.2021)
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Mild Maternal Hypothyroxinemia During Pregnancy Induces Persistent DNA Hypermethylation in the Hippocampal Brain-Derived Neurotrophic Factor Gene in Mouse Offspring
Kawahori, Kenichi, Hashimoto, Koshi, Yuan, Xunmei, Tsujimoto, Kazutaka, Hanzawa, Nozomi, Hamaguchi, Miho, Kase, Saori, Fujita, Kyota, Tagawa, Kazuhiko, Okazawa, Hitoshi, Nakajima, Yasuyo, Shibusawa, Nobuyuki, Yamada, Masanobu, Ogawa, Yoshihiro
Published in Thyroid (New York, N.Y.) (01.03.2018)
Published in Thyroid (New York, N.Y.) (01.03.2018)
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RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair
Taniguchi, Juliana Bosso, Kondo, Kanoh, Fujita, Kyota, Chen, Xigui, Homma, Hidenori, Sudo, Takeaki, Mao, Ying, Watase, Kei, Tanaka, Toshihiro, Tagawa, Kazuhiko, Tamura, Takuya, Muramatsu, Shin-Ichi, Okazawa, Hitoshi
Published in Human molecular genetics (15.10.2016)
Published in Human molecular genetics (15.10.2016)
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Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis
Jin, Meihua, Jin, Xiaocen, Homma, Hidenori, Fujita, Kyota, Tanaka, Hikari, Murayama, Shigeo, Akatsu, Hiroyasu, Tagawa, Kazuhiko, Okazawa, Hitoshi
Published in Communications biology (12.08.2021)
Published in Communications biology (12.08.2021)
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A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases
Fujita, Kyota, Nakamura, Yoko, Oka, Tsutomu, Ito, Hikaru, Tamura, Takuya, Tagawa, Kazuhiko, Sasabe, Toshikazu, Katsuta, Asuka, Motoki, Kazumi, Shiwaku, Hiroki, Sone, Masaki, Yoshida, Chisato, Katsuno, Masahisa, Eishi, Yoshinobu, Murata, Miho, Paul Taylor, J., Wanker, Erich E., Kono, Kazuteru, Tashiro, Satoshi, Sobue, Gen, La Spada, Albert R., Okazawa, Hitoshi
Published in Nature communications (07.05.2013)
Published in Nature communications (07.05.2013)
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AAV-mediated editing of PMP22 rescues Charcot-Marie-Tooth disease type 1A features in patient-derived iPS Schwann cells
Yoshioka, Yuki, Taniguchi, Juliana Bosso, Homma, Hidenori, Tamura, Takuya, Fujita, Kyota, Inotsume, Maiko, Tagawa, Kazuhiko, Misawa, Kazuharu, Matsumoto, Naomichi, Nakagawa, Masanori, Inoue, Haruhisa, Tanaka, Hikari, Okazawa, Hitoshi
Published in Communications medicine (28.11.2023)
Published in Communications medicine (28.11.2023)
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The Relationship between Neurite Density Measured with Confocal Microscopy in a Cleared Mouse Brain and Metrics Obtained from Diffusion Tensor and Diffusion Kurtosis Imaging
Irie, Ryusuke, Kamagata, Koji, Kerever, Aurelien, Ueda, Ryo, Yokosawa, Suguru, Otake, Yosuke, Ochi, Hisaaki, Yoshizawa, Hidekazu, Hayashi, Ayato, Tagawa, Kazuhiko, Okazawa, Hitoshi, Takahashi, Kohske, Sato, Kanako, Hori, Masaaki, Arikawa-Hirasawa, Eri, Aoki, Shigeki
Published in Magnetic Resonance in Medical Sciences (01.01.2018)
Published in Magnetic Resonance in Medical Sciences (01.01.2018)
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Journal Article
A novel form of necrosis, TRIAD, occurs in human Huntington's disease
Yamanishi, Emiko, Hasegawa, Kazuko, Fujita, Kyota, Ichinose, Shizuko, Yagishita, Saburo, Murata, Miho, Tagawa, Kazuhiko, Akashi, Takumi, Eishi, Yoshinobu, Okazawa, Hitoshi
Published in Acta neuropathologica communications (08.03.2017)
Published in Acta neuropathologica communications (08.03.2017)
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Understanding microstructure of the brain by comparison of neurite orientation dispersion and density imaging (NODDI) with transparent mouse brain
Sato, Kanako, Kerever, Aurelien, Kamagata, Koji, Tsuruta, Kohei, Irie, Ryusuke, Tagawa, Kazuhiko, Okazawa, Hitoshi, Arikawa-Hirasawa, Eri, Nitta, Nobuhiro, Aoki, Ichio, Aoki, Shigeki
Published in Acta radiologica open (01.04.2017)
Published in Acta radiologica open (01.04.2017)
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Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease
Tamura, Takuya, Sone, Masaki, Iwatsubo, Takeshi, Tagawa, Kazuhiko, Wanker, Erich E, Okazawa, Hitoshi
Published in PloS one (07.11.2011)
Published in PloS one (07.11.2011)
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Sox2 transcriptionally regulates PQBP1, an intellectual disability-microcephaly causative gene, in neural stem progenitor cells
Li, Chan, Ito, Hikaru, Fujita, Kyota, Shiwaku, Hiroki, Qi, Yunlong, Tagawa, Kazuhiko, Tamura, Takuya, Okazawa, Hitoshi
Published in PloS one (16.07.2013)
Published in PloS one (16.07.2013)
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