Distinct Immune Responses Elicited From Cervicovaginal Epithelial Cells by Lactic Acid and Short Chain Fatty Acids Associated With Optimal and Non-optimal Vaginal Microbiota
Delgado-Diaz, David J, Tyssen, David, Hayward, Joshua A, Gugasyan, Raffi, Hearps, Anna C, Tachedjian, Gilda
Published in Frontiers in cellular and infection microbiology (10.01.2020)
Published in Frontiers in cellular and infection microbiology (10.01.2020)
Get full text
Journal Article
SPL7013 Gel (VivaGel®) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humans
Price, Clare F, Tyssen, David, Sonza, Secondo, Davie, Ashley, Evans, Sonya, Lewis, Gareth R, Xia, Shirley, Spelman, Tim, Hodsman, Peter, Moench, Thomas R, Humberstone, Andrew, Paull, Jeremy R A, Tachedjian, Gilda
Published in PloS one (15.09.2011)
Published in PloS one (15.09.2011)
Get full text
Journal Article
Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach
Mansouri, Mahta, Rumrill, Shawn, Dawson, Shane, Johnson, Adam, Pinson, Jo-Anne, Gunzburg, Menachem J, Latham, Catherine F, Barlow, Nicholas, Mbogo, George W, Ellenberg, Paula, Headey, Stephen J, Sluis-Cremer, Nicolas, Tyssen, David, Bauman, Joseph D, Ruiz, Francesc X, Arnold, Eddy, Chalmers, David K, Tachedjian, Gilda
Published in Molecules (Basel, Switzerland) (30.03.2023)
Published in Molecules (Basel, Switzerland) (30.03.2023)
Get full text
Journal Article
Structure activity relationship of dendrimer microbicides with dual action antiviral activity
Tyssen, David, Henderson, Scott A, Johnson, Adam, Sterjovski, Jasminka, Moore, Katie, La, Jennifer, Zanin, Mark, Sonza, Secondo, Karellas, Peter, Giannis, Michael P, Krippner, Guy, Wesselingh, Steve, McCarthy, Tom, Gorry, Paul R, Ramsland, Paul A, Cone, Richard, Paull, Jeremy R A, Lewis, Gareth R, Tachedjian, Gilda
Published in PloS one (23.08.2010)
Published in PloS one (23.08.2010)
Get full text
Journal Article
Combination anti-HIV therapy via tandem release of prodrugs from macromolecular carriers
Danial, Maarten, Telwatte, Sushama, Tyssen, David, Cosson, Steffen, Tachedjian, Gilda, Moad, Graeme, Postma, Almar
Published in Polymer chemistry (01.01.2016)
Published in Polymer chemistry (01.01.2016)
Get full text
Journal Article
Anti-HIV-1 Activity of Lactic Acid in Human Cervicovaginal Fluid
Tyssen, David, Wang, Ying-Ying, Hayward, Joshua A, Agius, Paul A, DeLong, Kevin, Aldunate, Muriel, Ravel, Jacques, Moench, Thomas R, Cone, Richard A, Tachedjian, Gilda
Published in mSphere (05.07.2018)
Published in mSphere (05.07.2018)
Get full text
Journal Article
N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance
Yap, Soo-Huey, Sheen, Chih-Wei, Fahey, Jonathan, Zanin, Mark, Tyssen, David, Lima, Viviane Dias, Wynhoven, Brian, Kuiper, Michael, Sluis-Cremer, Nicolas, Harrigan, P Richard, Tachedjian, Gilda
Published in PLoS medicine (01.12.2007)
Published in PLoS medicine (01.12.2007)
Get full text
Journal Article
Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening
La, Jennifer, Latham, Catherine F., Tinetti, Ricky N., Johnson, Adam, Tyssen, David, Huber, Kelly D., Sluis-Cremer, Nicolas, Simpson, Jamie S., Headey, Stephen J., Chalmers, David K., Tachedjian, Gilda
Published in Proceedings of the National Academy of Sciences - PNAS (02.06.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (02.06.2015)
Get full text
Journal Article
The Impact of Over-The-Counter Lactic Acid Containing Vaginal Gels on the Integrity and Inflammatory State of the Vaginal Epithelium in vitro
Tyssen, David, Hearps, Anna C., Guntur, Kalyani, Masson, Lindi, Cook, Simon, Moulton, Simon E., Ravel, Jacques, Bradshaw, Catriona S., Ayehunie, Seyoum, Tachedjian, Gilda
Published in Frontiers in reproductive health (23.06.2022)
Published in Frontiers in reproductive health (23.06.2022)
Get full text
Journal Article
Enhancement of Human Immunodeficiency Virus Type 1 Replication Is Not Intrinsic to All Polyanion-Based Microbicides
SONZA, Secondo, JOHNSON, Adam, TYSSEN, David, SPELMAN, Tim, LEWIS, Gareth R, PAULL, Jeremy R. A, TACHEDJIAN, Gilda
Published in Antimicrobial Agents and Chemotherapy (01.08.2009)
Published in Antimicrobial Agents and Chemotherapy (01.08.2009)
Get full text
Journal Article
Utility of a Multiplex PCR Assay for Detecting Herpesvirus DNA in Clinical Samples
DRUCE, Julian, CATTON, Mike, CHIBO, Doris, MINERDS, Kirsty, TYSSEN, David, KOSTECKI, Renata, MASKILL, Bill, LEONG-SHAW, Wendy, GERRARD, Marie, BIRCH, Chris
Published in Journal of Clinical Microbiology (01.05.2002)
Published in Journal of Clinical Microbiology (01.05.2002)
Get full text
Journal Article
β-Strand Mimicking Macrocyclic Amino Acids: Templates for Protease Inhibitors with Antiviral Activity
Glenn, Matthew P, Pattenden, Leonard K, Reid, Robert C, Tyssen, David P, Tyndall, Joel D. A, Birch, Christopher J, Fairlie, David P
Published in Journal of medicinal chemistry (17.01.2002)
Published in Journal of medicinal chemistry (17.01.2002)
Get full text
Journal Article
Ubisol-Aqua: coenzyme Q10 prevents antiretroviral toxic neuropathy in an in vitro model
Cherry, Catherine L, Mobarok, Masqura, Wesselingh, Steven L, Fain, Randi, Weinstock, Shelley, Tachedjian, Gilda, Srivastava, Seema, Tyssen, David P, Glass, Jonathan D, Hooker, David J
Published in Current HIV research (01.04.2010)
Published in Current HIV research (01.04.2010)
Get more information
Journal Article
Vaginal concentrations of lactic acid potently inactivate HIV
Aldunate, Muriel, Tyssen, David, Johnson, Adam, Zakir, Tasnim, Sonza, Secondo, Moench, Thomas, Cone, Richard, Tachedjian, Gilda
Published in Journal of antimicrobial chemotherapy (01.09.2013)
Published in Journal of antimicrobial chemotherapy (01.09.2013)
Get full text
Journal Article
Synthesis, Stability, Antiviral Activity, and Protease-Bound Structures of Substrate-Mimicking Constrained Macrocyclic Inhibitors of HIV-1 Protease
Tyndall, Joel D. A, Reid, Robert C, Tyssen, David P, Jardine, Darren K, Todd, Belinda, Passmore, Margaret, March, Darren R, Pattenden, Leonard K, Bergman, Douglas A, Alewood, Dianne, Hu, Shu-Hong, Alewood, Paul F, Birch, Christopher J, Martin, Jennifer L, Fairlie, David P
Published in Journal of medicinal chemistry (21.09.2000)
Published in Journal of medicinal chemistry (21.09.2000)
Get full text
Journal Article
Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import
Wagstaff, Kylie M., Headey, Stephen, Telwatte, Sushama, Tyssen, David, Hearps, Anna C., Thomas, David R., Tachedjian, Gilda, Jans, David A.
Published in Cellular microbiology (01.01.2019)
Published in Cellular microbiology (01.01.2019)
Get full text
Journal Article
Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression
Delgado-Diaz, David Jose, Jesaveluk, Brianna, Hayward, Joshua A., Tyssen, David, Alisoltani, Arghavan, Potgieter, Matthys, Bell, Liam, Ross, Elizabeth, Iranzadeh, Arash, Allali, Imane, Dabee, Smritee, Barnabas, Shaun, Gamieldien, Hoyam, Blackburn, Jonathan M., Mulder, Nicola, Smith, Steven B., Edwards, Vonetta L., Burgener, Adam D., Bekker, Linda-Gail, Ravel, Jacques, Passmore, Jo-Ann S., Masson, Lindi, Hearps, Anna C., Tachedjian, Gilda
Published in Microbiome (31.08.2022)
Published in Microbiome (31.08.2022)
Get full text
Journal Article
Combination anti-HIV therapy via tandem release of prodrugs from macromolecular carriersElectronic supplementary information (ESI) available: Additional synthesis protocols, monomer and polymer characterisation and biological assays. See DOI: 10.1039/c6py01882c
Danial, Maarten, Telwatte, Sushama, Tyssen, David, Cosson, Steffen, Tachedjian, Gilda, Moad, Graeme, Postma, Almar
Year of Publication 06.12.2016
Year of Publication 06.12.2016
Get full text
Journal Article
Virucidal activity of the dendrimer microbicide SPL7013 against HIV-1
Telwatte, Sushama, Moore, Katie, Johnson, Adam, Tyssen, David, Sterjovski, Jasminka, Aldunate, Muriel, Gorry, Paul R., Ramsland, Paul A., Lewis, Gareth R., Paull, Jeremy R.A., Sonza, Secondo, Tachedjian, Gilda
Published in Antiviral research (01.06.2011)
Published in Antiviral research (01.06.2011)
Get full text
Journal Article
SPL7013 Gel
Price, Clare F, Tyssen, David, Sonza, Secondo, Davie, Ashley, Evans, Sonya, Lewis, Gareth R, Xia, Shirley, Spelman, Tim, Hodsman, Peter, Moench, Thomas R, Humberstone, Andrew, Paull, Jeremy R.A, Tachedjian, Gilda
Published in PloS one (15.09.2011)
Published in PloS one (15.09.2011)
Get full text
Journal Article