Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations
Tyhonas, John S., Arnold, Lee D., Cox, Jason M., Franovic, Aleksandra, Gardiner, Elisabeth, Grandinetti, Kathryn, Kania, Robert, Kanouni, Toufike, Lardy, Matthew, Li, Chun, Martin, Eric S., Miller, Nichol, Mohan, Adithi, Murphy, Eric A., Perez, Michelle, Soroceanu, Liliana, Timple, Noel, Uryu, Sean, Womble, Scott, Kaldor, Stephen W.
Published in Journal of medicinal chemistry (08.02.2024)
Published in Journal of medicinal chemistry (08.02.2024)
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Journal Article
The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition
Chen, Young K., Kanouni, Toufike, Arnold, Lee D., Cox, Jason M., Gardiner, Elisabeth, Grandinetti, Kathryn, Jiang, Ping, Kaldor, Stephen W., Lee, Catherine, Li, Chun, Martin, Eric S., Miller, Nichol, Murphy, Eric A., Timple, Noel, Tyhonas, John S., Vassar, Angie, Wang, Tim S., Williams, Richard, Yuan, Ding, Kania, Robert S.
Published in Journal of medicinal chemistry (08.02.2024)
Published in Journal of medicinal chemistry (08.02.2024)
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Journal Article
A tailored therapy for the metabolic syndrome: The dual peroxisome proliferator-activated receptor-α/γ agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in preclinical models
ETGEN, Garret J, OLDHAM, Brian A, SHUKER, Anthony J, RITO, Christopher J, MCCARTHY, James R, ARDECKY, Robert J, TYHONAS, John S, DANA, Sharon L, BILAKOVICS, James M, PATERNITI, James R, OGILVIE, Kathleen M, SHA LIU, JOHNSON, William T, KAUFFMAN, Raymond F, BRODERICK, Carol L, MONTROSE, Chahrzad R, BROZINICK, Joseph T, MISENER, Elizabeth A, BEAN, James S, BENSCH, William R, BROOKS, Dawn A
Published in Diabetes (New York, N.Y.) (01.04.2002)
Published in Diabetes (New York, N.Y.) (01.04.2002)
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Design, Synthesis, and Structure−Activity Relationship Studies of Novel 6,7-Locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids
Michellys, Pierre-Yves, Ardecky, Robert J, Chen, Jyun-Hung, D'Arrigo, Jennifer, Grese, Timothy A, Karanewsky, Donald S, Leibowitz, Mark D, Liu, Sha, Mais, Dale A, Mapes, Christopher M, Montrose-Rafizadeh, Chahrzad, Ogilvie, Katheen M, Reifel-Miller, Anne, Rungta, Deepa, Thompson, Anthony W, Tyhonas, John S, Boehm, Marcus F
Published in Journal of medicinal chemistry (11.09.2003)
Published in Journal of medicinal chemistry (11.09.2003)
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Journal Article
5 (Z) -Benzylidene -1,2 -dihydro -9 -hydroxy -10 -methoxy -2,2, 4 -trimethyl -5H-1 -aza -6 -oxa -chrysenes as non-steroidal glucocorticoid receptor modulators
ARDECKY, Robert J, HUDSON, Andrew R, LOPEZ, Francisco J, MARSCHKE, Keith B, MINER, Jeffrey N, KARANEWSKY, Donald S, NEGRO-VILAR, Andrés, LIN ZHI, PHILLIPS, Dean P, TYHONAS, John S, DECKHUT, Charlotte, LAU, Thomas L, YONGKAI LI, MARTINBOROUGH, Esther A, ROACH, Steven L, HIGUCHI, Robert I
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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Journal Article
Investigation of a Synthesis of meso-Porphyrins Employing High Concentration Conditions and an Electron Transport Chain for Aerobic Oxidation
Lindsey, Jonathan S, MacCrum, Kristy A, Tyhonas, John S, Chuang, Yao Yuan
Published in Journal of organic chemistry (01.02.1994)
Published in Journal of organic chemistry (01.02.1994)
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Journal Article
Design and synthesis of novel RXR-selective modulators with improved pharmacological profile
Michellys, Pierre-Yves, Boehm, Marcus F, Chen, Jyun-Hung, Grese, Timothy A, Karanewsky, Donald S, Leibowitz, Mark D, Liu, Sha, Mais, Dale A, Mapes, Christopher M, Reifel-Miller, Anne, Ogilvie, Katheen M, Rungta, Deepa, Thompson, Anthony W, Tyhonas, John S, Yumibe, Nathan, Ardecky, Robert J
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
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Journal Article
Activity of KIN-3248, a next-generation pan-FGFR inhibitor, against acquired FGFR-gatekeeper and molecular-brake drug resistance mutations
Franovic, Aleksandra, Mohan, Adithi, Uryu, Sean, Wu, Qibiao, Jiang, Ping, Miller, Nichol, Tyhonas, John, Timple, Noelito, Severson, Paul, Kania, Robert, Murphy, Eric, Bardeesy, Nabeel, Martin, Eric
Published in Journal of clinical oncology (01.02.2022)
Published in Journal of clinical oncology (01.02.2022)
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Journal Article
Beneficial effects of salts on an acid-catalyzed condensation leading to porphyrin formation
Li, Feirong, Kexin Yang, Tyhonas, John S., MacCrum, Kristy A., Lindsey, Jonathan S.
Published in Tetrahedron (01.09.1997)
Published in Tetrahedron (01.09.1997)
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Journal Article
The Irreversible FGFR Inhibitor KIN-3248 Overcomes FGFR2 Kinase Domain Mutations
Balasooriya, Eranga R, Wu, Qibiao, Ellis, Haley, Zhen, Yuanli, Norden, Bryanna L, Corcoran, Ryan B, Mohan, Adithi, Martin, Eric, Franovic, Aleksandra, Tyhonas, John, Lardy, Matthew, Grandinetti, Kathryn B, Pelham, Robert, Soroceanu, Liliana, Silveira, Vanessa S, Bardeesy, Nabeel
Published in Clinical cancer research (15.05.2024)
Published in Clinical cancer research (15.05.2024)
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Journal Article
MET 키나제의 억제제
OUYANG XIAOHU S, COX JASON M, KANIA ROBERT, KANOUNI TOUFIKE, TYHONAS JOHN S
Year of Publication 09.08.2024
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Year of Publication 09.08.2024
Patent
FGFR 저해제의 고체 상태 형태
PHIMISTER ANDREW, KALDOR STEPHEN W, TYHONAS JOHN, COX JASON M, CHOPADE SHUBHAM, KANIA ROBERT, KANOUNI TOUFIKE, REDDY JAYACHANDRA P, PANDEY PREETANSHU
Year of Publication 06.08.2024
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Year of Publication 06.08.2024
Patent
FGFR 키나제 억제제를 이용하는 암의 치료
KOBAYASHI KEN, MARTIN ERIC S, MURPHY ERIC A, VASSAR ANGIE, FRANOVIC ALEKSANDRA, TYHONAS JOHN, COX JASON M, TIMPLE NOELITO, WILLIAMS RICHARD THOMAS, KANIA ROBERT, MILLER NICHOL
Year of Publication 26.07.2024
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Year of Publication 26.07.2024
Patent
CDK12/13 억제제에 의한 암 치료
ARNOLD LEE D, MARTIN ERIC, MURPHY ERIC A, GARDINER ELISABETH, TYHONAS JOHN, TIMPLE NOELITO, KANOUNI TOUFIKE
Year of Publication 05.09.2022
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Year of Publication 05.09.2022
Patent
섬유아세포 성장 인자 수용체 키나아제의 억제제
ARNOLD LEE D, MURPHY ERIC A, KALDOR STEPHEN W, TYHONAS JOHN, COX JASON M, KANIA ROBERT, KANOUNI TOUFIKE
Year of Publication 10.03.2023
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Year of Publication 10.03.2023
Patent
Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure
Lanier, Marion, Pickens, Jason, Bigi, Simone V, Bradshaw-Pierce, Erica L, Chambers, Alison, Cheruvallath, Zacharia S, Cole, Derek, Dougan, Douglas R, Ermolieff, Jacques, Gibson, Tony, Halkowycz, Petro, Hirokawa, Aki, Ivetac, Anthony, Miura, Joanne, Nunez, Evan, Sabat, Mark, Tyhonas, John, Wang, Haixia, Wang, Xiaolun, Swann, Steve
Published in ACS medicinal chemistry letters (09.03.2017)
Published in ACS medicinal chemistry letters (09.03.2017)
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Journal Article
사이클린 의존성 키나제의 억제제
ARNOLD LEE D, MURPHY ERIC A, KALDOR STEPHEN W, TYHONAS JOHN, KANOUNI TOUFIKE
Year of Publication 13.04.2021
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Year of Publication 13.04.2021
Patent
Correction to “Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure”
Lanier, Marion, Pickens, Jason, Bigi, Simone V, Bradshaw-Pierce, Erica L, Chambers, Alison, Cheruvallath, Zacharia S, Cole, Derek, Dougan, Douglas R, Ermolieff, Jacques, Gibson, Tony, Halkowycz, Petro, Hirokawa, Aki, Ivetac, Anthony, McBride, Christopher, Miura, Joanne, Nunez, Evan, Sabat, Mark, Tyhonas, John, Wang, Haixia, Wang, Xiaolun, Swann, Steve
Published in ACS medicinal chemistry letters (14.12.2017)
Published in ACS medicinal chemistry letters (14.12.2017)
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Journal Article