Application of statistical ‘design of experiments’ methods in drug discovery
Get full text
Book Review
Journal Article
Minimisation of palladium content in Suzuki cross-coupling reactions
Tye, Heather, Whittaker, Mark, Ramdeehul, Shailesh
Published in Combinatorial chemistry & high throughput screening (01.11.2006)
Published in Combinatorial chemistry & high throughput screening (01.11.2006)
Get more information
Journal Article
A study of the functional group compatibility of sulfoximination methods
Cren, Sylvaine, Kinahan, Taryn C., Skinner, Catharine L., Tye, Heather
Published in Tetrahedron letters (08.04.2002)
Published in Tetrahedron letters (08.04.2002)
Get full text
Journal Article
Palladium-catalysed cross-coupling of 2-trimethylsilylpyridine with aryl halides
Napier, Spencer, Marcuccio, Sebastian M., Tye, Heather, Whittaker, Mark
Published in Tetrahedron letters (27.10.2008)
Published in Tetrahedron letters (27.10.2008)
Get full text
Journal Article
A robust method for the Hiyama-type coupling of arylsiloxanes and disiloxanes with aryl halides
Napier, Spencer, Marcuccio, Sebastian M., Tye, Heather, Whittaker, Mark
Published in Tetrahedron letters (09.06.2008)
Published in Tetrahedron letters (09.06.2008)
Get full text
Journal Article
BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis
Sanderson, Michael P, Apgar, Joshua, Garin-Chesa, Pilar, Hofmann, Marco H, Kessler, Dirk, Quant, Jens, Savchenko, Alexander, Schaaf, Otmar, Treu, Matthias, Tye, Heather, Zahn, Stephan K, Zoephel, Andreas, Haaksma, Eric, Adolf, Günther R, Kraut, Norbert
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
Get full text
Journal Article
Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5‑Lipoxygenase Activating Protein Inhibitors: Discovery of 2‑[4-(3-{(R)‑1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]‑N,N‑dimethyl-acetamide (BI 665915)
Takahashi, Hidenori, Riether, Doris, Bartolozzi, Alessandra, Bosanac, Todd, Berger, Valentina, Binetti, Ralph, Broadwater, John, Chen, Zhidong, Crux, Rebecca, De Lombaert, Stéphane, Dave, Rajvee, Dines, Jonathon A, Fadra-Khan, Tazmeen, Flegg, Adam, Garrigou, Michael, Hao, Ming-Hong, Huber, John, Hutzler, J. Matthew, Kerr, Steven, Kotey, Adrian, Liu, Weimin, Lo, Ho Yin, Loke, Pui Leng, Mahaney, Paige E, Morwick, Tina M, Napier, Spencer, Olague, Alan, Pack, Edward, Padyana, Anil K, Thomson, David S, Tye, Heather, Wu, Lifen, Zindell, Renee M, Abeywardane, Asitha, Simpson, Thomas
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
Get full text
Journal Article
TBAF-Catalysed silver oxide-mediated cross-coupling of functional trimethysilylpyridines: access to arylpyridines and bihetaryl compounds
Louerat, Frederic, Tye, Heather, Napier, Spencer, Garrigou, Michael, Whittaker, Mark, Gros, Philippe C.
Published in Organic & biomolecular chemistry (21.03.2011)
Published in Organic & biomolecular chemistry (21.03.2011)
Get full text
Journal Article
DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity
East, Stephen P., White, Clara Bantry, Barker, Oliver, Barker, Stephanie, Bennett, James, Brown, David, Boyd, E. Andrew, Brennan, Christopher, Chowdhury, Chandana, Collins, Ian, Convers-Reignier, Emmanuelle, Dymock, Brian W., Fletcher, Rowena, Haydon, David J., Gardiner, Mihaly, Hatcher, Stuart, Ingram, Peter, Lancett, Paul, Mortenson, Paul, Papadopoulos, Konstantinos, Smee, Carol, Thomaides-Brears, Helena B., Tye, Heather, Workman, James, Czaplewski, Lloyd G.
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Get full text
Journal Article
Novel 6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene analogues as potent and selective 5-HT2C agonists for the treatment of metabolic disorders
Tye, Heather, Mueller, Stephan G., Prestle, Juergen, Scheuerer, Stefan, Schindler, Marcus, Nosse, Bernd, Prevost, Natacha, Brown, Christopher J., Heifetz, Alexander, Moeller, Clemens, Pedret-Dunn, Anna, Whittaker, Mark
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Get full text
Journal Article
PAD4의 아자-벤즈이미다졸 억제제
KOTEY ADRIAN, GLEAVE LAURA, WIGGINTON IAN, KUMARAVEL GNANASAMBANDAM, LECCI CRISTINA, DEVRAJ RAJESH, TYE HEATHER, KRULLE THOMAS
Year of Publication 04.09.2018
Get full text
Year of Publication 04.09.2018
Patent