An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers
Villa, Genaro R., Hulce, Jonathan J., Zanca, Ciro, Bi, Junfeng, Ikegami, Shiro, Cahill, Gabrielle L., Gu, Yuchao, Lum, Kenneth M., Masui, Kenta, Yang, Huijun, Rong, Xin, Hong, Cynthia, Turner, Kristen M., Liu, Feng, Hon, Gary C., Jenkins, David, Martini, Michael, Armando, Aaron M., Quehenberger, Oswald, Cloughesy, Timothy F., Furnari, Frank B., Cavenee, Webster K., Tontonoz, Peter, Gahman, Timothy C., Shiau, Andrew K., Cravatt, Benjamin F., Mischel, Paul S.
Published in Cancer cell (14.11.2016)
Published in Cancer cell (14.11.2016)
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Journal Article
Exploring the landscape of focal amplifications in cancer using AmpliconArchitect
Deshpande, Viraj, Luebeck, Jens, Nguyen, Nam-Phuong D., Bakhtiari, Mehrdad, Turner, Kristen M., Schwab, Richard, Carter, Hannah, Mischel, Paul S., Bafna, Vineet
Published in Nature communications (23.01.2019)
Published in Nature communications (23.01.2019)
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Journal Article
Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity
Turner, Kristen M., Deshpande, Viraj, Beyter, Doruk, Koga, Tomoyuki, Rusert, Jessica, Lee, Catherine, Li, Bin, Arden, Karen, Ren, Bing, Nathanson, David A., Kornblum, Harley I., Taylor, Michael D., Kaushal, Sharmeela, Cavenee, Webster K., Wechsler-Reya, Robert, Furnari, Frank B., Vandenberg, Scott R., Rao, P. Nagesh, Wahl, Geoffrey M., Bafna, Vineet, Mischel, Paul S.
Published in Nature (London) (02.03.2017)
Published in Nature (London) (02.03.2017)
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Journal Article
Circular ecDNA promotes accessible chromatin and high oncogene expression
Wu, Sihan, Turner, Kristen M., Nguyen, Nam, Raviram, Ramya, Erb, Marcella, Santini, Jennifer, Luebeck, Jens, Rajkumar, Utkrisht, Diao, Yarui, Li, Bin, Zhang, Wenjing, Jameson, Nathan, Corces, M. Ryan, Granja, Jeffrey M., Chen, Xingqi, Coruh, Ceyda, Abnousi, Armen, Houston, Jack, Ye, Zhen, Hu, Rong, Yu, Miao, Kim, Hoon, Law, Julie A., Verhaak, Roel G. W., Hu, Ming, Furnari, Frank B., Chang, Howard Y., Ren, Bing, Bafna, Vineet, Mischel, Paul S.
Published in Nature (London) (01.11.2019)
Published in Nature (London) (01.11.2019)
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Journal Article
Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
Bi, Junfeng, Ichu, Taka-Aki, Zanca, Ciro, Yang, Huijun, Zhang, Wei, Gu, Yuchao, Chowdhry, Sudhir, Reed, Alex, Ikegami, Shiro, Turner, Kristen M., Zhang, Wenjing, Villa, Genaro R., Wu, Sihan, Quehenberger, Oswald, Yong, William H., Kornblum, Harley I., Rich, Jeremy N., Cloughesy, Timothy F., Cavenee, Webster K., Furnari, Frank B., Cravatt, Benjamin F., Mischel, Paul S.
Published in Cell metabolism (03.09.2019)
Published in Cell metabolism (03.09.2019)
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Journal Article
EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling
Liu, Feng, Hon, Gary C., Villa, Genaro R., Turner, Kristen M., Ikegami, Shiro, Yang, Huijun, Ye, Zhen, Li, Bin, Kuan, Samantha, Lee, Ah Young, Zanca, Ciro, Wei, Bowen, Lucey, Greg, Jenkins, David, Zhang, Wei, Barr, Cathy L., Furnari, Frank B., Cloughesy, Timothy F., Yong, William H., Gahman, Timothy C., Shiau, Andrew K., Cavenee, Webster K., Ren, Bing, Mischel, Paul S.
Published in Molecular cell (15.10.2015)
Published in Molecular cell (15.10.2015)
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Journal Article
AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications
Luebeck, Jens, Coruh, Ceyda, Dehkordi, Siavash R., Lange, Joshua T., Turner, Kristen M., Deshpande, Viraj, Pai, Dave A., Zhang, Chao, Rajkumar, Utkrisht, Law, Julie A., Mischel, Paul S., Bafna, Vineet
Published in Nature communications (01.09.2020)
Published in Nature communications (01.09.2020)
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Journal Article
Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression
Turner, Kristen M., Sun, Youting, Ji, Ping, Granberg, Kirsi J., Bernard, Brady, Hu, Limei, Cogdell, David E., Zhou, Xinhui, Yli-Harja, Olli, Nykter, Matti, Shmulevich, Ilya, Yung, W. K. Alfred, Fuller, Gregory N., Zhang, Wei
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2015)
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Journal Article
Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells
Koga, Tomoyuki, Chaim, Isaac A., Benitez, Jorge A., Markmiller, Sebastian, Parisian, Alison D., Hevner, Robert F., Turner, Kristen M., Hessenauer, Florian M., D’Antonio, Matteo, Nguyen, Nam-phuong D., Saberi, Shahram, Ma, Jianhui, Miki, Shunichiro, Boyer, Antonia D., Ravits, John, Frazer, Kelly A., Bafna, Vineet, Chen, Clark C., Mischel, Paul S., Yeo, Gene W., Furnari, Frank B.
Published in Nature communications (28.01.2020)
Published in Nature communications (28.01.2020)
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Journal Article
Incidence and impact of CMV infection in very low birth weight infants
Turner, Kristen M, Lee, Henry C, Boppana, Suresh B, Carlo, Waldemar A, Randolph, David A
Published in Pediatrics (Evanston) (01.03.2014)
Published in Pediatrics (Evanston) (01.03.2014)
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Journal Article
ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skeletal muscle
Fuqua, Jordan D., Mere, Caleb P., Kronemberger, Ana, Blomme, Jay, Bae, Dam, Turner, Kristen D., Harris, Matthew P., Scudese, Estevão, Edwards, Mitchell, Ebert, Scott M., Sousa, Luís G. O., Bodine, Sue C., Yang, Ling, Adams, Christopher M., Lira, Vitor A.
Published in The FASEB journal (01.11.2019)
Published in The FASEB journal (01.11.2019)
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Journal Article
Role of AKT signaling in DNA repair and clinical response to cancer therapy
Liu, Qun, Turner, Kristen M, Alfred Yung, W K, Chen, Kexin, Zhang, Wei
Published in Neuro-oncology (Charlottesville, Va.) (01.10.2014)
Published in Neuro-oncology (Charlottesville, Va.) (01.10.2014)
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Journal Article
Electrical pulse stimulation induces differential responses in insulin action in myotubes from severely obese individuals
Park, Sanghee, Turner, Kristen D., Zheng, Donghai, Brault, Jeffrey J., Zou, Kai, Chaves, Alec B., Nielsen, Thomas S., Tanner, Charles J., Treebak, Jonas T., Houmard, Joseph A.
Published in The Journal of physiology (01.01.2019)
Published in The Journal of physiology (01.01.2019)
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Journal Article
Amplification of the Mutation-Carrying BRCA2 Allele Promotes RAD51 Loading and PARP Inhibitor Resistance in the Absence of Reversion Mutations
Park, Pyoung Hwa, Yamamoto, Tomomi M, Li, Hua, Alcivar, Allen L, Xia, Bing, Wang, Yifan, Bernhardy, Andrea J, Turner, Kristen M, Kossenkov, Andrew V, Watson, Zachary L, Behbakht, Kian, Casadei, Silvia, Swisher, Elizabeth M, Mischel, Paul S, Johnson, Neil, Bitler, Benjamin G
Published in Molecular cancer therapeutics (01.02.2020)
Published in Molecular cancer therapeutics (01.02.2020)
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Journal Article
EcSeg: Semantic Segmentation of Metaphase Images Containing Extrachromosomal DNA
Rajkumar, Utkrisht, Turner, Kristen, Luebeck, Jens, Deshpande, Viraj, Chandraker, Manmohan, Mischel, Paul, Bafna, Vineet
Published in iScience (22.11.2019)
Published in iScience (22.11.2019)
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Journal Article
MET gene amplification is a mechanism of resistance to entrectinib in ROS1+ NSCLC
Tyler, Logan C., Le, Anh T., Chen, Nan, Nijmeh, Hala, Bao, Liming, Wilson, Timothy R., Chen, David, Simmons, Brian, Turner, Kristen M., Perusse, Dean, Kasibhatla, Shailaja, Christiansen, Jason, Dudek, Arkadiusz Z., Doebele, Robert C.
Published in Thoracic cancer (01.11.2022)
Published in Thoracic cancer (01.11.2022)
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Journal Article