Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors
Kumar, R, Crouthamel, M-C, Rominger, D H, Gontarek, R R, Tummino, P J, Levin, R A, King, A G
Published in British journal of cancer (17.11.2009)
Published in British journal of cancer (17.11.2009)
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Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
Alm, Richard A, Ling, Lo-See L, Moir, Donald T, King, Benjamin L, Brown, Eric D, Doig, Peter C, Smith, Douglas R, Noonan, Brian, Guild, Braydon C, deJonge, Boudewijn L, Carmel, Gilles, Tummino, Peter J, Caruso, Anthony, Uria-Nickelsen, Maria, Mills, Debra M, Ives, Cameron, Gibson, Rene, Merberg, David, Mills, Scott D, Jiang, Qin, Taylor, Diane E, Vovis, Gerald F, Trust, Trevor J
Published in Nature (London) (14.01.1999)
Published in Nature (London) (14.01.1999)
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The human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein zinc ejection activity of disulfide benzamides and benzisothiazolones: correlation with anti-HIV and virucidal activities
TUMMINO, P. J, HARVEY, P. J, MCQUADE, T, DOMAGALA, J, GOGLIOTTI, R, SANCHEZ, J, SONG, Y, HUPE, D
Published in Antimicrobial Agents and Chemotherapy (01.02.1997)
Published in Antimicrobial Agents and Chemotherapy (01.02.1997)
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The in vitro Ejection of Zinc from Human Immunodeficiency Virus (HIV) Type 1 Nucleocapsid Protein by Disulfide Benzamides with Cellular Anti-HIV Activity
Tummino, Peter J., Scholten, Jeffrey D., Harvey, Patricia J., Holler, Tod P., Maloney, Lisa, Gogliotti, Rocco, Domagala, John, Hupe, Donald
Published in Proceedings of the National Academy of Sciences - PNAS (06.02.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (06.02.1996)
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5,6-Dihydropyran-2-ones Possessing Various Sulfonyl Functionalities: Potent Nonpeptidic Inhibitors of HIV Protease
Boyer, Frederick E, Vara Prasad, J. V. N, Domagala, John M, Ellsworth, Edmund L, Gajda, Christopher, Hagen, Susan E, Markoski, Larry J, Tait, Bradley D, Lunney, Elizabeth A, Palovsky, Alexander, Ferguson, Donna, Graham, Neil, Holler, Tod, Hupe, Donald, Nouhan, Carolyn, Tummino, Peter J, Urumov, A, Zeikus, Eric, Zeikus, Greg, Gracheck, Stephen J, Sanders, James M, VanderRoest, Steven, Brodfuehrer, Joanne, Iyer, Krishna, Sinz, Michael, Gulnik, Sergei V, Erickson, John W
Published in Journal of medicinal chemistry (09.03.2000)
Published in Journal of medicinal chemistry (09.03.2000)
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Synthesis of 5,6-Dihydro-4-hydroxy-2- pyrones as HIV-1 Protease Inhibitors: The Profound Effect of Polarity on Antiviral Activity
Hagen, Susan E, Vara Prasad, J. V. N, Boyer, Frederick E, Domagala, John M, Ellsworth, Edmund L, Gajda, Christopher, Hamilton, Harriet W, Markoski, Larry J, Steinbaugh, Bruce A, Tait, Bradley D, Lunney, Elizabeth A, Tummino, Peter J, Ferguson, Donna, Hupe, Donald, Nouhan, Carolyn, Gracheck, Stephen J, Saunders, James M, VanderRoest, Steven
Published in Journal of medicinal chemistry (07.11.1997)
Published in Journal of medicinal chemistry (07.11.1997)
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Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390 : A lead HIV protease inhibitor
VARA PRASAD, J. V. N, BOYER, F. E, HUMBLET, C, LUNNEY, E. A, PAVLOVSKY, A, RUBIN, J. R, FERGUSON, D, GRAHAM, N, HOLLER, T, HUPE, D, NOUHAN, C, TUMMINO, P. J, DOMAGALA, J. M, URUMOV, A, ZEIKUS, E, ZEIKUS, G, GRACHECK, S. J, SAUNDERS, J. M, VANDERROEST, S, BRODFUEHRER, J, IYER, K, SINZ, M, GULNIK, S. V, ELLSWORTH, E. L, ERICKSON, J. W, GAJDA, C, HAMILTON, H. W, HAGEN, S. E, MARKOSKI, L. J, STEINBAUGH, B. A, TAIT, B. D
Published in Bioorganic & medicinal chemistry (01.12.1999)
Published in Bioorganic & medicinal chemistry (01.12.1999)
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4-Hydroxy-5,6-dihydropyrones. 2. Potent Non-Peptide Inhibitors of HIV Protease
Tait, Bradley D, Hagen, Susan, Domagala, John, Ellsworth, Edmund L, Gajda, Christopher, Hamilton, Harriet W, Vara Prasad, J. V. N, Ferguson, Donna, Graham, Neil, Hupe, Donald, Nouhan, Carolyn, Tummino, Peter J, Humblet, Christine, Lunney, Elizabeth A, Pavlovsky, Alexander, Rubin, John, Gracheck, Stephen J, Baldwin, Eric T, Bhat, T. N, Erickson, John W, Gulnik, Sergei V, Liu, Beishan
Published in Journal of medicinal chemistry (07.11.1997)
Published in Journal of medicinal chemistry (07.11.1997)
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Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing a novel and achiral 3-(2- t-butyl-5-methyl-4-sulfamate)phenylthio moiety
Vara Prasad, J.V.N, Markoski, Larry J, Boyer, Fred E, Domagala, John M, Ellsworth, Edmund L, Gajda, Christopher, Hagen, Susan E, Tait, Bradley D, Lunney, Elizabeth A, Tummino, Peter J, Ferguson, Donna, Holler, Tod, Hupe, Donald, Nouhan, Carolyn, Gracheck, Stephen J, VanderRoest, Steven, Saunders, James, Iyer, K, Sinz, M
Published in Bioorganic & medicinal chemistry letters (02.08.1999)
Published in Bioorganic & medicinal chemistry letters (02.08.1999)
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Inhibitors of HIV protease: Unique non-peptide active site templates
Tait, Bradley D., Domagala, John, Ellsworth, Edmund L., Ferguson, Donna, Gajda, Christopher, Hupe, Donald, Lunney, Elizabeth A., Tummino, Peter J.
Published in Journal of molecular recognition (01.03.1996)
Published in Journal of molecular recognition (01.03.1996)
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Novel Series of Achiral, Low Molecular Weight, and Potent HIV-1 Protease Inhibitors
Vara Prasad, J. V. N, Para, Kimberly S, Lunney, Elizabeth A, Ortwine, Daniel F, Dunbar, James B, Ferguson, Donna, Tummino, Peter J, Hupe, Donald, Tait, Bradley D
Published in Journal of the American Chemical Society (01.07.1994)
Published in Journal of the American Chemical Society (01.07.1994)
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Competitive Inhibition of HIV-1 Protease by Warfarin Derivatives
Tummino, P.J., Ferguson, D., Hupe, D.
Published in Biochemical and biophysical research communications (30.05.1994)
Published in Biochemical and biophysical research communications (30.05.1994)
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A Novel Nonpeptide HIV-1 Protease Inhibitor: Elucidation of the Binding Mode and Its Application in the Design of Related Analogs
Lunney, Elizabeth A, Hagen, Susan E, Domagala, John M, Humblet, Christine, Kosinski, Janet, Tait, Bradley D, Warmus, Joseph S, Wilson, Michael, Ferguson, Donna
Published in Journal of medicinal chemistry (01.08.1994)
Published in Journal of medicinal chemistry (01.08.1994)
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Nonpeptidic HIV protease inhibitors: 6-alkyl-5, 6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxamide-2- t-butyl, 5-methylphenyl thio) moiety: Antiviral activities and pharmacokinetic properties
Vara Prasad, J.V.N., Boyer, Fred E., Domagala, John M., Ellsworth, Edmund L., Gajda, Christopher, Hagen, Susan E., Markoski, Larry J., Tait, Bradley D., Lunney, Elizabeth A., Tummino, Peter J., Ferguson, Donna, Holler, Tod, Hupe, Donald, Nouhan, Carolyn, Gracheck, Stephen J., VanderRoest, Steven, Saunders, James, Iyer, Krishna, Sinz, Michael, Brodfuehrer, Joanne
Published in Bioorganic & medicinal chemistry letters (07.06.1999)
Published in Bioorganic & medicinal chemistry letters (07.06.1999)
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A new class of anti-HIV-1 agents targeted toward the nucleocapsid protein NCp7: The 2,2′-dithiobisbenzamides
Domagala, John M., Bader, John P., Gogliotti, Rocco D., Sanchez, Joseph P., Stier, Michael A., Song, Yuntao, Vara Prasad, J.V.N., Tummino, Peter J., Scholten, Jeffrey, Harvey, Patricia, Holler, Tod, Gracheck, Steve, Hupe, Donald, Rice, William G., Schultz, Robert
Published in Bioorganic & medicinal chemistry (01.03.1997)
Published in Bioorganic & medicinal chemistry (01.03.1997)
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