GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees
Lanford, Robert E, Guerra, Bernadette, Chavez, Deborah, Giavedoni, Luis, Hodara, Vida L, Brasky, Kathleen M, Fosdick, Abigail, Frey, Christian R, Zheng, Jim, Wolfgang, Grushenka, Halcomb, Randall L, Tumas, Daniel B
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2013)
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2013)
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Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses
Fosdick, Abigail, Zheng, Jim, Pflanz, Stefan, Frey, Christian R, Hesselgesser, Joseph, Halcomb, Randall L, Wolfgang, Grushenka, Tumas, Daniel B
Published in The Journal of pharmacology and experimental therapeutics (01.01.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2014)
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Journal Article
Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis
Roethle, Paul A, McFadden, Ryan M, Yang, Hong, Hrvatin, Paul, Hui, Hon, Graupe, Michael, Gallagher, Brian, Chao, Jessica, Hesselgesser, Joseph, Duatschek, Paul, Zheng, Jim, Lu, Bing, Tumas, Daniel B, Perry, Jason, Halcomb, Randall L
Published in Journal of medicinal chemistry (26.09.2013)
Published in Journal of medicinal chemistry (26.09.2013)
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GS-9219—A Novel Acyclic Nucleotide Analogue with Potent Antineoplastic Activity in Dogs with Spontaneous Non–Hodgkin's Lymphoma
Reiser, Hans, Wang, Jianying, Chong, Lee, Watkins, William J, Ray, Adrian S, Shibata, Riri, Birkus, Gabriel, Cihlar, Tomas, Wu, Sylvia, Li, Bei, Liu, Xiaohong, Henne, Ilana N, Wolfgang, Grushenka H I, Desai, Manoj, Rhodes, Gerald R, Fridland, Arnold, Lee, William A, Plunkett, William, Vail, David, Thamm, Douglas H, Jeraj, Robert, Tumas, Daniel B
Published in Clinical cancer research (01.05.2008)
Published in Clinical cancer research (01.05.2008)
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Assessment of GS-9219 in a Pet Dog Model of Non-Hodgkin's Lymphoma
VAIL, David M, THAMM, Douglas H, JERAJ, Robert, VANDERHOEK, Matt, PLAZA, Susan, ANDERSON, Christie, WESSEL, Mackenzie A, REBATE, Cecilia, LAWRENCE, Jessica, TUMAS, Daniel B, REISER, Hans, RAY, Adrian S, WOLFGANG, Grushenka H. I, WATKINS, William J, BABUSIS, Darius, HENNE, Ilana N, HAWKINS, Michael J, KURZMAN, Ilene D
Published in Clinical cancer research (15.05.2009)
Published in Clinical cancer research (15.05.2009)
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Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B
Menne, Stephan, Tumas, Daniel B, Liu, Katherine H, Thampi, Linta, AlDeghaither, Dalal, Baldwin, Betty H, Bellezza, Christine A, Cote, Paul J, Zheng, Jim, Halcomb, Randall, Fosdick, Abigail, Fletcher, Simon P, Daffis, Stephane, Li, Li, Yue, Peng, Wolfgang, Grushenka H.I, Tennant, Bud C
Published in Journal of hepatology (01.06.2015)
Published in Journal of hepatology (01.06.2015)
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Characterization of huJAM: evidence for involvement in cell-cell contact and tight junction regulation
Liang, Tony W, DeMarco, Richard A, Mrsny, Randy J, Gurney, Austin, Gray, Alane, Hooley, Jeffery, Aaron, Holly L, Huang, Arthur, Klassen, Toni, Tumas, Daniel B, Fong, Sherman
Published in American Journal of Physiology: Cell Physiology (01.12.2000)
Published in American Journal of Physiology: Cell Physiology (01.12.2000)
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Modulation of allergic inflammation in mice deficient in TNF receptors
Rudmann, Daniel G, Moore, Mark W, Tepper, Jeffery S, Aldrich, Melinda C, Pfeiffer, Juergen W, Hogenesch, Harm, Tumas, Daniel B
Published in American journal of physiology. Lung cellular and molecular physiology (01.12.2000)
Published in American journal of physiology. Lung cellular and molecular physiology (01.12.2000)
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Anti-IgE efficacy in murine asthma models is dependent on the method of allergen sensitization
Tumas, Daniel B., Chan, Betty, Werther, Winifred, Wrin, Terri, Vennari, Joann, Desjardin, Noelyn, Shields, Robert L., Jardieu, Paula
Published in Journal of allergy and clinical immunology (01.06.2001)
Published in Journal of allergy and clinical immunology (01.06.2001)
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Journal Article
FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family
Holcomb, Ilona N., Kabakoff, Rhona C., Chan, Betty, Baker, Thad W., Gurney, Austin, Henzel, William, Nelson, Chris, Lowman, Henry B., Wright, Barbara D., Skelton, Nicholas J., Frantz, Gretchen D., Tumas, Daniel B., Peale, Jr, Franklin V., Shelton, David L., Hébert, Caroline C.
Published in The EMBO journal (01.08.2000)
Published in The EMBO journal (01.08.2000)
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GS-9219/VDC-1101--a prodrug of the acyclic nucleotide PMEG has antitumor activity in spontaneous canine multiple myeloma
Thamm, Douglas H, Vail, David M, Kurzman, Ilene D, Babusis, Darius, Ray, Adrian S, Sousa-Powers, Noel, Tumas, Daniel B
Published in BMC veterinary research (25.01.2014)
Published in BMC veterinary research (25.01.2014)
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GS-9219/VDC-1101 - a prodrug of the acyclic nucleotide PMEG has antitumor activity inspontaneous canine multiple myeloma
Thamm, Douglas H, Vail, David M, Kurzman, Ilene D, Babusis, Darius, Ray, Adrian S, Sousa-Powers, Noel, Tumas, Daniel B
Published in BMC veterinary research (25.01.2014)
Published in BMC veterinary research (25.01.2014)
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Vascular Endothelial-Junctional Adhesion Molecule (VE-JAM)/JAM 2 Interacts with T, NK, and Dendritic Cells Through JAM 3
Liang, Tony W, Chiu, Henry H, Gurney, Austin, Sidle, Aiko, Tumas, Daniel B, Schow, Peter, Foster, Jessica, Klassen, Toni, Dennis, Kathryn, DeMarco, Richard A, Pham, Thinh, Frantz, Gretchen, Fong, Sherman
Published in The Journal of immunology (1950) (15.02.2002)
Published in The Journal of immunology (1950) (15.02.2002)
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Anti-CD11a Ameliorates Disease in the Human Psoriatic Skin–SCID Mouse Transplant Model: Comparison of Antibody to CD11a with Cyclosporin A and Clobetasol Propionate
Zeigler, Mary, Chi, Yiqing, Tumas, Daniel B, Bodary, Sarah, Tang, Haicheng, Varani, James
Published in Laboratory investigation (01.09.2001)
Published in Laboratory investigation (01.09.2001)
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GS-9219 - A Novel Prodrug of the Acyclic Nucleotide PMEG Has Antitumor Activity Against Naive and Melphalan-Refractory Spontaneous Myeloma in Pet Dogs
Thamm, Douglas H., Tumas, Daniel B., Reiser, Hans, Wolfgang, Grushenka H.I., Kurzman, Ilene D., Plaza, Susan, Anderson, Christie, Robat, Cecilia, Vail, David M.
Published in Blood (16.11.2007)
Published in Blood (16.11.2007)
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GS-9219 - A Novel Prodrug of the Acyclic Nucleotide PMEG Demonstrates Significant Therapeutic Activity Against Spontaneous Non-Hodgkin's Lymphoma as Modeled in Pet Dogs
Vail, David M., Thamm, Douglas H., Tumas, Daniel B., Reiser, Hans, Ray, Adrian S., Wolfgang, Grushenka H.I., Babusis, Darius, Kurzman, Ilene D., Jeraj, Robert, Plaza, Susan, Anderson, Christie, Wessel, Mackenzie A., Robat, Cecilia, Lawrence, Jessica
Published in Blood (16.11.2007)
Published in Blood (16.11.2007)
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