Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)
Tully, David C, Rucker, Paul V, Chianelli, Donatella, Williams, Jennifer, Vidal, Agnès, Alper, Phil B, Mutnick, Daniel, Bursulaya, Badry, Schmeits, James, Wu, Xiangdong, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Seidel, H. Martin, Molteni, Valentina, Liu, Bo, Phimister, Andrew, Joseph, Sean B, Laffitte, Bryan
Published in Journal of medicinal chemistry (28.12.2017)
Published in Journal of medicinal chemistry (28.12.2017)
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Journal Article
Chemical activation of the mechanotransduction channel Piezo1
Syeda, Ruhma, Xu, Jie, Dubin, Adrienne E, Coste, Bertrand, Mathur, Jayanti, Huynh, Truc, Matzen, Jason, Lao, Jianmin, Tully, David C, Engels, Ingo H, Petrassi, H Michael, Schumacher, Andrew M, Montal, Mauricio, Bandell, Michael, Patapoutian, Ardem
Published in eLife (22.05.2015)
Published in eLife (22.05.2015)
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Journal Article
Tropifexor‐Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents
Hernandez, Eloy D., Zheng, Lianxing, Kim, Young, Fang, Bin, Liu, Bo, Valdez, Reginald A., Dietrich, William F., Rucker, Paul V., Chianelli, Donatella, Schmeits, James, Bao, Dingjiu, Zoll, Jocelyn, Dubois, Claire, Federe, Glenn C., Chen, Lihao, Joseph, Sean B., Klickstein, Lloyd B., Walker, John, Molteni, Valentina, McNamara, Peter, Meeusen, Shelly, Tully, David C., Badman, Michael K., Xu, Jie, Laffitte, Bryan
Published in Hepatology communications (01.08.2019)
Published in Hepatology communications (01.08.2019)
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Journal Article
Discovery, Optimization, and Biological Evaluation of 5‑(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists
Rooney, Lisa, Vidal, Agnès, D’Souza, Anne-Marie, Devereux, Nick, Masick, Brian, Boissel, Valerie, West, Ryan, Head, Victoria, Stringer, Rowan, Lao, Jianmin, Petrus, Matt J, Patapoutian, Ardem, Nash, Mark, Stoakley, Natalie, Panesar, Moh, Verkuyl, J. Martin, Schumacher, Andrew M, Petrassi, H. Michael, Tully, David C
Published in Journal of medicinal chemistry (26.06.2014)
Published in Journal of medicinal chemistry (26.06.2014)
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Journal Article
Functional Profiling of Recombinant NS3 Proteases from All Four Serotypes of Dengue Virus Using Tetrapeptide and Octapeptide Substrate Libraries
Li, Jun, Lim, Siew Pheng, Beer, David, Patel, Viral, Wen, Daying, Tumanut, Christine, Tully, David C, Williams, Jennifer A, Jiricek, Jan, Priestle, John P, Harris, Jennifer L, Vasudevan, Subhash G
Published in The Journal of biological chemistry (05.08.2005)
Published in The Journal of biological chemistry (05.08.2005)
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Journal Article
Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations
Spraggon, Glen, Hornsby, Michael, Shipway, Aaron, Tully, David C., Bursulaya, Badry, Danahay, Henry, Harris, Jennifer L., Lesley, Scott A.
Published in Protein science (01.05.2009)
Published in Protein science (01.05.2009)
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Journal Article
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis
Chianelli, Donatella, Rucker, Paul V, Roland, Jason, Tully, David C, Nelson, John, Liu, Xiaodong, Bursulaya, Badry, Hernandez, Eloy D, Wu, Jane, Prashad, Mahavir, Schlama, Thierry, Liu, Yugang, Chu, Alan, Schmeits, James, Huang, David J, Hill, Robert, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Liu, Bo, Richmond, Wendy, Sancho-Martinez, Ignacio, Phimister, Andrew, Seidel, H. Martin, Badman, Michael K, Joseph, Sean B, Laffitte, Bryan, Molteni, Valentina
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
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Journal Article
Cell-based optimization of novel benzamides as potential antimalarial leads
Wu, Tao, Nagle, Advait, Sakata, Tomoyo, Henson, Kerstin, Borboa, Rachel, Chen, Zhong, Kuhen, Kelli, Plouffe, David, Winzeler, Elizabeth, Adrian, Francisco, Tuntland, Tove, Chang, Jonathan, Simerson, Susan, Howard, Steven, Ek, Jared, Isbell, John, Deng, Xianming, Gray, Nathanael S., Tully, David C., Chatterjee, Arnab K.
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
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Journal Article
Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents
Nagle, Advait, Wu, Tao, Kuhen, Kelli, Gagaring, Kerstin, Borboa, Rachel, Francek, Caroline, Chen, Zhong, Plouffe, David, Lin, Xuena, Caldwell, Christopher, Ek, Jared, Skolnik, Suzanne, Liu, Fenghua, Wang, Jianling, Chang, Jonathan, Li, Chun, Liu, Bo, Hollenbeck, Thomas, Tuntland, Tove, Isbell, John, Chuan, Tiffany, Alper, Philip B, Fischli, Christoph, Brun, Reto, Lakshminarayana, Suresh B, Rottmann, Matthias, Diagana, Thierry T, Winzeler, Elizabeth A, Glynne, Richard, Tully, David C, Chatterjee, Arnab K
Published in Journal of medicinal chemistry (10.05.2012)
Published in Journal of medicinal chemistry (10.05.2012)
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Journal Article
Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents
Wu, Tao, Nagle, Advait, Kuhen, Kelli, Gagaring, Kerstin, Borboa, Rachel, Francek, Caroline, Chen, Zhong, Plouffe, David, Goh, Anne, Lakshminarayana, Suresh B, Wu, Jeanette, Ang, Hui Qing, Zeng, Peiting, Kang, Min Low, Tan, William, Tan, Maria, Ye, Nicole, Lin, Xuena, Caldwell, Christopher, Ek, Jared, Skolnik, Suzanne, Liu, Fenghua, Wang, Jianling, Chang, Jonathan, Li, Chun, Hollenbeck, Thomas, Tuntland, Tove, Isbell, John, Fischli, Christoph, Brun, Reto, Rottmann, Matthias, Dartois, Veronique, Keller, Thomas, Diagana, Thierry, Winzeler, Elizabeth, Glynne, Richard, Tully, David C, Chatterjee, Arnab K
Published in Journal of medicinal chemistry (28.07.2011)
Published in Journal of medicinal chemistry (28.07.2011)
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Journal Article
Dendrimers at surfaces and interfaces: chemistry and applications
Tully, David C., Fréchet, Jean M. J.
Published in Chemical communications (Cambridge, England) (01.01.2001)
Published in Chemical communications (Cambridge, England) (01.01.2001)
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Journal Article
Lead Optimization of Imidazopyrazines: A New Class of Antimalarial with Activity on Plasmodium Liver Stages
Zou, Bin, Nagle, Advait, Chatterjee, Arnab K, Leong, Seh Yong, Tan, Liying Jocelyn, Sim, Wei Lin Sandra, Mishra, Pranab, Guntapalli, Prasuna, Tully, David C, Lakshminarayana, Suresh B, Lim, Chek Shik, Tan, Yong Cheng, Abas, Siti Nurdiana, Bodenreider, Christophe, Kuhen, Kelli L, Gagaring, Kerstin, Borboa, Rachel, Chang, Jonathan, Li, Chun, Hollenbeck, Thomas, Tuntland, Tove, Zeeman, Anne-Marie, Kocken, Clemens H. M, McNamara, Case, Kato, Nobutaka, Winzeler, Elizabeth A, Yeung, Bryan K. S, Diagana, Thierry T, Smith, Paul W, Roland, Jason
Published in ACS medicinal chemistry letters (14.08.2014)
Published in ACS medicinal chemistry letters (14.08.2014)
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Journal Article
Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials
Deng, Xianming, Nagle, Advait, Wu, Tao, Sakata, Tomoyo, Henson, Kerstin, Chen, Zhong, Kuhen, Kelli, Plouffe, David, Winzeler, Elizabeth, Adrian, Francisco, Tuntland, Tove, Chang, Jonathan, Simerson, Susan, Howard, Steven, Ek, Jared, Isbell, John, Tully, David C., Chatterjee, Arnab K., Gray, Nathanael S.
Published in Bioorganic & medicinal chemistry letters (15.07.2010)
Published in Bioorganic & medicinal chemistry letters (15.07.2010)
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Journal Article
Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design
Tully, David C., Vidal, Agnès, Chatterjee, Arnab K., Williams, Jennifer A., Roberts, Michael J., Petrassi, H. Michael, Spraggon, Glen, Bursulaya, Badry, Pacoma, Reynand, Shipway, Aaron, Schumacher, Andrew M., Danahay, Henry, Harris, Jennifer L.
Published in Bioorganic & medicinal chemistry (15.11.2008)
Published in Bioorganic & medicinal chemistry (15.11.2008)
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Journal Article
Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: Heterocyclic P3
Tully, David C., Liu, Hong, Alper, Phil B., Chatterjee, Arnab K., Epple, Robert, Roberts, Michael J., Williams, Jennifer A., Nguyen, KhanhLinh T., Woodmansee, David H., Tumanut, Christine, Li, Jun, Spraggon, Glen, Chang, Jonathan, Tuntland, Tove, Harris, Jennifer L., Karanewsky, Donald S.
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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Journal Article
Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers
Tully, David C., Liu, Hong, Chatterjee, Arnab K., Alper, Phil B., Epple, Robert, Williams, Jennifer A., Roberts, Michael J., Woodmansee, David H., Masick, Brian T., Tumanut, Christine, Li, Jun, Spraggon, Glen, Hornsby, Michael, Chang, Jonathan, Tuntland, Tove, Hollenbeck, Thomas, Gordon, Perry, Harris, Jennifer L., Karanewsky, Donald S.
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
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Journal Article
Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors
Tully, David C., Liu, Hong, Chatterjee, Arnab K., Alper, Phil B., Williams, Jennifer A., Roberts, Michael J., Mutnick, Daniel, Woodmansee, David H., Hollenbeck, Thomas, Gordon, Perry, Chang, Jonathan, Tuntland, Tove, Tumanut, Christine, Li, Jun, Harris, Jennifer L., Karanewsky, Donald S.
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
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Journal Article