Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit
Hu, Essa, Tasker, Andrew, White, Ryan D, Kunz, Roxanne K, Human, Jason, Chen, Ning, Bürli, Roland, Hungate, Randall, Novak, Perry, Itano, Andrea, Zhang, Xuxia, Yu, Violeta, Nguyen, Yen, Tudor, Yanyan, Plant, Matthew, Flynn, Shaun, Xu, Yang, Meagher, Kristin L, Whittington, Douglas A, Ng, Gordon Y
Published in Journal of medicinal chemistry (12.06.2008)
Published in Journal of medicinal chemistry (12.06.2008)
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Putative Predictive Biomarkers of Survival in Patients with Metastatic Pancreatic Adenocarcinoma Treated with Gemcitabine and Ganitumab, an IGF1R Inhibitor
MCCAFFERY, Ian, TUDOR, Yanyan, LI CHEN, GANSERT, Jennifer L, HONGJIE DENG, RUI TANG, SUZUKI, Samuel, BADOLA, Sunita, KINDLER, Hedy L, FUCHS, Charles S, LOH, Elwyn, PATTERSON, Scott D
Published in Clinical cancer research (01.08.2013)
Published in Clinical cancer research (01.08.2013)
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High-Throughput Implementation of the NanoBRET Target Engagement Intracellular Kinase Assay to Reveal Differential Compound Engagement by SIK2/3 Isoforms
Jin, Hyun Yong, Tudor, Yanyan, Choi, Kaylee, Shao, Zhifei, Sparling, Brian A., McGivern, Joseph G., Symons, Antony
Published in SLAS discovery (01.02.2020)
Published in SLAS discovery (01.02.2020)
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Structure-Based Design of Novel 2-Amino-6-phenyl-pyrimido[5′,4′:5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as Potent and Orally Active Inhibitors of Lymphocyte Specific Kinase (Lck): Synthesis, SAR, and In Vivo Anti-Inflammatory Activity
Martin, Matthew W, Newcomb, John, Nunes, Joseph J, Boucher, Christina, Chai, Lilly, Epstein, Linda F, Faust, Theodore, Flores, Sylvia, Gallant, Paul, Gore, Anu, Gu, Yan, Hsieh, Faye, Huang, Xin, Kim, Joseph L, Middleton, Scot, Morgenstern, Kurt, Oliveira-dos-Santos, Antonio, Patel, Vinod F, Powers, David, Rose, Paul, Tudor, Yanyan, Turci, Susan M, Welcher, Andrew A, Zack, Debra, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian, Ghiron, Chiara, Ermann, Monika, Johnston, David, Saluste, Carl-Gustaf Pierre
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
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Megakaryocytes Do Not Express Erythropoietin Receptor (EpoR) and Do Not Respond to Recombinant Human Erythropoietin (rHuEpo) Stimulation
Loberg, Robert D, Rossi, John M, Manoukian, Raffi, Wang, Shen-Wu, Paweletz, Katherine L, Sable, Beate, Tudor, Yanyan, Patterson, Scott D, McCaffery, Ian
Published in Blood (18.11.2011)
Published in Blood (18.11.2011)
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Epor Is Not Expressed or Functional in Primary Tumor Cells Isolated Directly From Human Primary and Metastatic Epithelial Tumors Including Breast, Non-Small Cell Lung, Colorectal, and Ovarian Tissues
McCaffery, Ian, Rossi, John M, Paweletz, Katherine L, Tudor, Yanyan, Elliott, Steve, Fitzpatrick, V Dan, Begley, C. Glenn, Patterson, Scott D
Published in Blood (18.11.2011)
Published in Blood (18.11.2011)
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3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38α Mitogen-Activated Protein Kinase
Pettus, Liping H, Xu, Shimin, Cao, Guo-Qiang, Chakrabarti, Partha P, Rzasa, Robert M, Sham, Kelvin, Wurz, Ryan P, Zhang, Dawei, Middleton, Scott, Henkle, Bradley, Plant, Matthew H, Saris, Christiaan J. M, Sherman, Lisa, Wong, Lu Min, Powers, David A, Tudor, Yanyan, Yu, Violeta, Lee, Matthew R, Syed, Rashid, Hsieh, Faye, Tasker, Andrew S
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
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Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck: Synthesis, SAR, and in Vivo Antiinflammatory Activity
Martin, Matthew W, Newcomb, John, Nunes, Joseph J, McGowan, David C, Armistead, David M, Boucher, Christina, Buchanan, John L, Buckner, William, Chai, Lilly, Elbaum, Daniel, Epstein, Linda F, Faust, Theodore, Flynn, Shaun, Gallant, Paul, Gore, Anu, Gu, Yan, Hsieh, Faye, Huang, Xin, Lee, Josie H, Metz, Daniela, Middleton, Scot, Mohn, Deanna, Morgenstern, Kurt, Morrison, Michael J, Novak, Perry M, Oliveira-dos-Santos, Antonio, Powers, David, Rose, Paul, Schneider, Stephen, Sell, Stephanie, Tudor, Yanyan, Turci, Susan M, Welcher, Andrew A, White, Ryan D, Zack, Debra, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian, Ghiron, Chiara, Amouzegh, Patricia, Ermann, Monika, Jenkins, James, Johnston, David, Napier, Spencer, Power, Eoin
Published in Journal of medicinal chemistry (10.08.2006)
Published in Journal of medicinal chemistry (10.08.2006)
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Analysis of Cell Surface Erythropoietin Receptor (EpoR) Expression and Function in Epithelial Human Tumor Tissues Reveals No Detectable Cell Surface Expression or Function
McCaffery, Ian, Rossi, John, Paweletz, Katherine, Tudor, Yanyan, Elliott, Steve, Busse, Leigh, Fitzpatrick, V. Dan, Patterson, Scott D.
Published in Blood (16.11.2008)
Published in Blood (16.11.2008)
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Journal Article
Discovery of amido-benzisoxazoles as potent c-Kit inhibitors
Kunz, Roxanne K., Rumfelt, Shannon, Chen, Ning, Zhang, Dawei, Tasker, Andrew S., Bürli, Roland, Hungate, Randall, Yu, Violeta, Nguyen, Yen, Whittington, Douglas A., Meagher, Kristin L., Plant, Matthew, Tudor, Yanyan, Schrag, Michael, Xu, Yang, Ng, Gordon Y., Hu, Essa
Published in Bioorganic & medicinal chemistry (15.09.2008)
Published in Bioorganic & medicinal chemistry (15.09.2008)
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Journal Article
Discovery of a potent and selective c-Kit inhibitor for the treatment of inflammatory diseases
Chen, Ning, Bürli, Roland W., Neira, Susana, Hungate, Randall, Zhang, Dawei, Yu, Violeta, Nguyen, Yen, Tudor, Yanyan, Plant, Matthew, Flynn, Shaun, Meagher, Kristin L., Lee, Matthew R., Zhang, Xuxia, Itano, Andrea, Schrag, Michael, Xu, Yang, Ng, Gordon Y., Hu, Essa
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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Journal Article
3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38a Mitogen-Activated Protein Kinase
PETTUS, Liping H, SHIMIN XU, PLANT, Matthew H, SARIS, Christiaan J. M, SHERMAN, Lisa, LU MIN WONG, POWERS, David A, TUDOR, Yanyan, YU, Violeta, LEE, Matthew R, SYED, Rashid, HSIEH, Faye, CAO, Guo-Qiang, TASKER, Andrew S, CHAKRABARTI, Partha P, RZASA, Robert M, SHAM, Kelvin, WURZ, Ryan P, DAWEI ZHANG, MIDDLETON, Scott, HENKLE, Bradley
Published in Journal of medicinal chemistry (2008)
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Published in Journal of medicinal chemistry (2008)
Journal Article
High-content screening analysis of the p38 pathway: profiling of structurally related p38alpha kinase inhibitors using cell-based assays
Ross, Sandra, Chen, Teresa, Yu, Violeta, Tudor, Yanyan, Zhang, Dawei, Liu, Longbin, Tamayo, Nuria, Dominguez, Celia, Powers, David
Published in Assay and drug development technologies (01.08.2006)
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Published in Assay and drug development technologies (01.08.2006)
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High capacity homogeneous non-radioactive cortisol detection assays for human 11beta-hydroxysteroid dehydrogenase type 1
Yu, Violeta, Tudor, Yanyan, Hale, Clarence, Plant, Matthew, Kim, Ki Won, Wang, Minghan, Nguyen, Yen, Miguel, Tisha San, Chen, Michelle, Nybo, Rebecca, Baumgartner, Jamie, Kurzeja, Robert J M, Powers, David
Published in Assay and drug development technologies (01.02.2007)
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Published in Assay and drug development technologies (01.02.2007)
Journal Article
3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase
Pettus, Liping H, Xu, Shimin, Cao, Guo-Qiang, Chakrabarti, Partha P, Rzasa, Robert M, Sham, Kelvin, Wurz, Ryan P, Zhang, Dawei, Middleton, Scott, Henkle, Bradley, Plant, Matthew H, Saris, Christiaan J M, Sherman, Lisa, Wong, Lu Min, Powers, David A, Tudor, Yanyan, Yu, Violeta, Lee, Matthew R, Syed, Rashid, Hsieh, Faye, Tasker, Andrew S
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
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