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Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation
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Potent and Long-Acting Dimeric Inhibitors of Influenza Virus Neuraminidase Are Effective at a Once-Weekly Dosing Regimen
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Brown, Renee N., Cameron, Rachel, Chalmers, David K., Hamilton, Stephanie, Luttick, Angela, Krippner, Guy Y., McConnell, Darryl B., Nearn, Roland, Stanislawski, Pauline C., Tucker, Simon P., Watson, Keith G.
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
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[1,2,5]Oxadiazolo[3,4‑b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis
Childress, Elizabeth S, Salamoun, Joseph M, Hargett, Stefan R, Alexopoulos, Stephanie J, Chen, Sing-Young, Shah, Divya P, Santiago-Rivera, José, Garcia, Christopher J, Dai, Yumin, Tucker, Simon P, Hoehn, Kyle L, Santos, Webster L
Published in Journal of medicinal chemistry (12.03.2020)
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Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice
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6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis
Salamoun, Joseph M., Garcia, Christopher J., Hargett, Stefan R., Murray, Jacob H., Chen, Sing-Young, Beretta, Martina, Alexopoulos, Stephanie J., Shah, Divya P., Olzomer, Ellen M., Tucker, Simon P., Hoehn, Kyle L., Santos, Webster L.
Published in Journal of medicinal chemistry (11.06.2020)
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Characterization of drug-resistant influenza virus A(H1N1) and A(H3N2) variants selected in vitro with laninamivir
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Published in Antimicrobial agents and chemotherapy (01.09.2014)
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Structural characterization of respiratory syncytial virus fusion inhibitor escape mutants: homology model of the F protein and a syncytium formation assay
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Published in Virology (New York, N.Y.) (05.07.2003)
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Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake
Chen, Sing-Young, Beretta, Martina, Alexopoulos, Stephanie J., Shah, Divya P., Olzomer, Ellen M., Hargett, Stefan R., Childress, Elizabeth S., Salamoun, Joseph M., Aleksovska, Isabella, Roseblade, Ariane, Cranfield, Charles, Rawling, Tristan, Quinlan, Kate G.R., Morris, Margaret J., Tucker, Simon P., Santos, Webster L., Hoehn, Kyle L.
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Prodrugs of imidazotriazine and pyrrolotriazine C-nucleosides can increase anti-HCV activity and enhance nucleotide triphosphate concentrations in vitro
Tyndall, Edward M., Draffan, Alistair G., Frey, Barbara, Pool, Brett, Halim, Rosliana, Jahangiri, Saba, Bond, Silas, Wirth, Veronika, Luttick, Angela, Tilmanis, Danielle, Thomas, Jesse, Porter, Kate, Tucker, Simon P.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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The discovery of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 1
Bond, Silas, Draffan, Alistair G., Fenner, Jennifer E., Lambert, John, Lim, Chin Yu, Lin, Bo, Luttick, Angela, Mitchell, Jeffrey P., Morton, Craig J., Nearn, Roland H., Sanford, Vanessa, Stanislawski, Pauline C., Tucker, Simon P.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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A zanamivir dimer with prophylactic and enhanced therapeutic activity against influenza viruses
Tarbet, E Bart, Hamilton, Stephanie, Vollmer, Almut H, Luttick, Angela, Ng, Wy Ching, Pryor, Melinda, Hurst, Brett L, Crawford, Simon, Smee, Donald F, Tucker, Simon P
Published in Journal of antimicrobial chemotherapy (01.08.2014)
Published in Journal of antimicrobial chemotherapy (01.08.2014)
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1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: Identification of BTA9881 as a preclinical candidate
Bond, Silas, Draffan, Alistair G., Fenner, Jennifer E., Lambert, John, Lim, Chin Yu, Lin, Bo, Luttick, Angela, Mitchell, Jeffrey P., Morton, Craig J., Nearn, Roland H., Sanford, Vanessa, Anderson, Kelly H., Mayes, Penelope A., Tucker, Simon P.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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Derivatives of imidazotriazine and pyrrolotriazine C-nucleosides as potential new anti-HCV agents
Draffan, Alistair G., Frey, Barbara, Fraser, Benjamin H., Pool, Brett, Gannon, Carlie, Tyndall, Edward M., Cianci, Julia, Harding, Michael, Lilly, Michael, Hufton, Richard, Halim, Rosliana, Jahangiri, Saba, Bond, Silas, Jeynes, Tyrone P., Nguyen, Van T.T., Wirth, Veronika, Luttick, Angela, Tilmanis, Danielle, Pryor, Melinda, Porter, Kate, Morton, Craig J., Lin, Bo, Duan, Jianmin, Bethell, Richard C., Kukolj, George, Simoneau, Bruno, Tucker, Simon P.
Published in Bioorganic & medicinal chemistry letters (01.11.2014)
Published in Bioorganic & medicinal chemistry letters (01.11.2014)
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Discovery and Synthesis of C‑Nucleosides as Potential New Anti-HCV Agents
Draffan, Alistair G, Frey, Barbara, Pool, Brett, Gannon, Carlie, Tyndall, Edward M, Lilly, Michael, Francom, Paula, Hufton, Richard, Halim, Rosliana, Jahangiri, Saba, Bond, Silas, Nguyen, Van T. T, Jeynes, Tyrone P, Wirth, Veronika, Luttick, Angela, Tilmanis, Danielle, Thomas, Jesse D, Pryor, Melinda, Porter, Kate, Morton, Craig J, Lin, Bo, Duan, Jianmin, Kukolj, George, Simoneau, Bruno, McKercher, Ginette, Lagacé, Lisette, Amad, Ma’an, Bethell, Richard C, Tucker, Simon P
Published in ACS medicinal chemistry letters (12.06.2014)
Published in ACS medicinal chemistry letters (12.06.2014)
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An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus
Feil, Susanne C, Hamilton, Stephanie, Krippner, Guy Y, Lin, Bo, Luttick, Angela, McConnell, Darryl B, Nearn, Roland, Parker, Michael W, Ryan, Jane, Stanislawski, Pauline C, Tucker, Simon P, Watson, Keith G, Morton, Craig J
Published in ACS medicinal chemistry letters (12.04.2012)
Published in ACS medicinal chemistry letters (12.04.2012)
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Dimeric Zanamivir Conjugates with Various Linking Groups Are Potent, Long-Lasting Inhibitors of Influenza Neuraminidase Including H5N1 Avian Influenza
Macdonald, Simon J. F, Cameron, Rachel, Demaine, Derek A, Fenton, Rob J, Foster, Graham, Gower, David, Hamblin, J. Nicole, Hamilton, Stephanie, Hart, Graham J, Hill, Alan P, Inglis, Graham G. A, Jin, Betty, Jones, Haydn T, McConnell, Darryl B, McKimm-Breschkin, Jennifer, Mills, Gail, Nguyen, Van, Owens, Ian J, Parry, Nigel, Shanahan, Stephen E, Smith, Donna, Watson, Keith G, Wu, Wen-Yang, Tucker, Simon P
Published in Journal of medicinal chemistry (21.04.2005)
Published in Journal of medicinal chemistry (21.04.2005)
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Synthesis and antiviral activity of dimeric capsid-binding inhibitors of human rhinovirus (HRV)
Krippner, GY, Chalmers, DK, Stanislawski, PC, Tucker, SP, Watson, KG
Published in Australian journal of chemistry (01.01.2004)
Published in Australian journal of chemistry (01.01.2004)
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Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B
Fraser, Benjamin H., Hamilton, Stephanie, Krause-Heuer, Anwen M., Wright, Philip J., Greguric, Ivan, Tucker, Simon P., Draffan, Alistair G., Fokin, Valery V., Sharpless, K. Barry
Published in MedChemComm (2013)
Published in MedChemComm (2013)
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