Design, synthesis and structure-activity relationship studies of pyrido[2,3-d]pyrimidin-7-ones as potent Janus Kinase 3 (JAK3) covalent inhibitors
Su, Wenhong, Chen, Zhiwen, Liu, Meiying, He, Rui, Liu, Chaoyi, Li, Rui, Gao, Mingshan, Zheng, Mingyue, Tu, Zhengchao, Zhang, Zhang, Xu, Tianfeng
Published in Bioorganic & medicinal chemistry letters (15.05.2022)
Published in Bioorganic & medicinal chemistry letters (15.05.2022)
Get full text
Journal Article
Identification of GZD824 as an Orally Bioavailable Inhibitor That Targets Phosphorylated and Nonphosphorylated Breakpoint Cluster Region–Abelson (Bcr-Abl) Kinase and Overcomes Clinically Acquired Mutation-Induced Resistance against Imatinib
Ren, Xiaomei, Pan, Xiaofen, Zhang, Zhang, Wang, Deping, Lu, Xiaoyun, Li, Yupeng, Wen, Donghai, Long, Huoyou, Luo, Jinfeng, Feng, Yubing, Zhuang, Xiaoxi, Zhang, Fengxiang, Liu, Jianqi, Leng, Fang, Lang, Xingfen, Bai, Yang, She, Miaoqin, Tu, Zhengchao, Pan, Jingxuan, Ding, Ke
Published in Journal of medicinal chemistry (14.02.2013)
Published in Journal of medicinal chemistry (14.02.2013)
Get full text
Journal Article
Dual nicotinamide phosphoribosyltransferase and epidermal growth factor receptor inhibitors for the treatment of cancer
Zhang, Wanheng, Zhang, Kuojun, Yao, Yiwu, Liu, Yunyao, Ni, Yong, Liao, Chenzhong, Tu, Zhengchao, Qiu, Yatao, Wang, Dexiang, Chen, Dong, Qiang, Lei, Li, Zheng, Jiang, Sheng
Published in European journal of medicinal chemistry (05.02.2021)
Published in European journal of medicinal chemistry (05.02.2021)
Get full text
Journal Article
Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations
Wang, Zuqin, Wang, Jie, Wang, Yongjin, Xiang, Shuang, Zhou, Hengliang, Song, Shukai, Song, Xiaojuan, Tu, Zhengchao, Zhou, Yang, Ding, Ke, Zhang, Zhi-Min, Zhang, Zhang, Lu, Xiaoyun
Published in Journal of medicinal chemistry (28.09.2023)
Published in Journal of medicinal chemistry (28.09.2023)
Get full text
Journal Article
Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors
Sun, Jian, Lin, Cai, Qin, Xiaochu, Dong, Xiaoping, Tu, Zhengchao, Tang, Fei, Chen, Chaonan, Zhang, Jiancun
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
Get full text
Journal Article
Design, Synthesis, and Biological Evaluation of 5‑Formyl-pyrrolo[3,2‑b]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors
Yang, Fang, Chen, Xiaojuan, Song, Xiaojuan, Ortega, Raquel, Lin, Xiaojing, Deng, Wuqing, Guo, Jing, Tu, Zhengchao, Patterson, Adam V., Smaill, Jeff B., Chen, Yongheng, Lu, Xiaoyun
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
Get full text
Journal Article
Screening and identification of 3‐aryl‐quinolin‐2‐one derivatives as antiviral agents against influenza A
Cheng, Huimin, Fu, Liangbing, Yang, Xia, Yang, Yujian, Zhang, Zhening, Tao, Yuan, Wan, Junting, Tu, Zhengchao, Chen, Jianxin, Li, Yingjun
Published in Journal of medical virology (01.01.2023)
Published in Journal of medical virology (01.01.2023)
Get full text
Journal Article
Rational Design of Covalent Kinase Inhibitors by an Integrated Computational Workflow (Kin-Cov)
Zhou, Yang, Yu, Hang, Vind, Anna Constance, Kong, Lulu, Liu, Yiling, Song, Xiaojuan, Tu, Zhengchao, Yun, Caihong, Smaill, Jeff B., Zhang, Qing-Wen, Ding, Ke, Bekker-Jensen, Simon, Lu, Xiaoyun
Published in Journal of medicinal chemistry (08.06.2023)
Published in Journal of medicinal chemistry (08.06.2023)
Get full text
Journal Article
Switch type I to type II TRK inhibitors for combating clinical resistance induced by xDFG mutation for cancer therapy
Xiang, Shuang, Wang, Jie, Huang, Huisi, Wang, Zuqin, Song, Xiaojuan, Zhou, Yang, Jin, Feng, He, Xun, Zhang, Zhi-Min, Tu, Zhengchao, Ding, Ke, Zhang, Zhang, Lu, Xiaoyun
Published in European journal of medicinal chemistry (05.01.2023)
Published in European journal of medicinal chemistry (05.01.2023)
Get full text
Journal Article
Discovery of Hexahydrofuro[3,2‑b]furans as New Kinase-Selective and Orally Bioavailable JAK3 Inhibitors for the Treatment of Leukemia Harboring a JAK3 Activating Mutant
Li, Shan, Si, Hongfei, Song, Xiaojuan, Lei, Chong, He, Xiaoqiang, Wang, Jie, Liu, Yiling, Zhou, Yang, Song, Jian-Guo, Peng, Lijie, Tang, Xia, Chan, Shingpan, Ren, Xiaomei, Tu, Zhengchao, Li, Zhengqiu, Wang, Zhen, Zhang, Zhang, Ding, Ke
Published in Journal of medicinal chemistry (11.08.2022)
Published in Journal of medicinal chemistry (11.08.2022)
Get full text
Journal Article
Structure-based design and SAR development of novel selective polo-like kinase 1 inhibitors having the tetrahydropteridin scaffold
Lv, Xiao, Yang, Xiaoxiao, Zhan, Mei-Miao, Cao, Peichang, Zheng, Shihong, Peng, Ruijun, Han, Jihong, Xie, Zhouling, Tu, Zhengchao, Liao, Chenzhong
Published in European journal of medicinal chemistry (15.12.2019)
Published in European journal of medicinal chemistry (15.12.2019)
Get full text
Journal Article
3-Methoxy-2-phenylimidazo[1,2-b]pyridazines highly active against Mycobacterium tuberculosis and Mycobacterium marinum
Farrell, Kyle D., Gao, Yamin, Hughes, Deborah A., Henches, Robin, Tu, Zhengchao, Perkins, Michael V., Zhang, Tianyu, Francis, Craig L.
Published in European journal of medicinal chemistry (05.11.2023)
Published in European journal of medicinal chemistry (05.11.2023)
Get full text
Journal Article
Discovery of 5-methylpyrimidopyridone analogues as selective antimycobacterial agents
Wu, Yu, Cheung, Chen-Yi, Zhou, Yang, Wang, Zhen, Tu, Zhengchao, Cook, Gregory M., Lu, Xiaoyun
Published in Bioorganic & medicinal chemistry (01.11.2021)
Published in Bioorganic & medicinal chemistry (01.11.2021)
Get full text
Journal Article
Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus Cladosporium sp. SCSIO41007
Pang, Xiaoyan, Lin, Xiuping, Wang, Junfeng, Liang, Rui, Tian, Yongqi, Salendra, Limbadri, Luo, Xiaowei, Zhou, Xuefeng, Yang, Bin, Tu, Zhengchao, Liu, Yonghong
Published in Steroids (01.01.2018)
Published in Steroids (01.01.2018)
Get full text
Journal Article
Discovery of 6‑Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity
Yang, Fang, Lin, Qianmeng, Song, Xiaojuan, Huang, Huisi, Chen, Xiaojuan, Tan, Jianwen, Li, Yun, Zhou, Yang, Tu, Zhengchao, Du, Hongli, Zhang, Zhi-min, Ortega, Raquel, Lin, Xiaojing, Patterson, Adam V., Smaill, Jeff B., Chen, Yongheng, Lu, Xiaoyun
Published in Journal of medicinal chemistry (22.02.2024)
Published in Journal of medicinal chemistry (22.02.2024)
Get full text
Journal Article
Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5‑a]pyridine-3-carboxamides as Novel Antitubercular Agents
Tang, Jian, Wang, Bangxing, Wu, Tian, Wan, Junting, Tu, Zhengchao, Njire, Moses, Wan, Baojie, Franzblauc, Scott G, Zhang, Tianyu, Lu, Xiaoyun, Ding, Ke
Published in ACS medicinal chemistry letters (09.07.2015)
Published in ACS medicinal chemistry letters (09.07.2015)
Get full text
Journal Article
Design, Synthesis, and in Vitro Biological Evaluation of 1 H -1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein
Cheng, Huimin, Wan, Junting, Lin, Meng-I, Liu, Yingxue, Lu, Xiaoyun, Liu, Jinsong, Xu, Yong, Chen, Jianxin, Tu, Zhengchao, Cheng, Yih-Shyun E., Ding, Ke
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
Get full text
Journal Article
Eight new polyketide metabolites from the fungus Pestalotiopsis vaccinii endogenous with the mangrove plant Kandelia candel (L.) Druce
Wang, Junfeng, Wei, Xiaoyi, Lu, Xin, Xu, Fuquan, Wan, Junting, Lin, Xiuping, Zhou, Xuefeng, Liao, Shengrong, Yang, Bin, Tu, Zhengchao, Liu, Yonghong
Published in Tetrahedron (23.12.2014)
Published in Tetrahedron (23.12.2014)
Get full text
Journal Article
Guignardins A–F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp. KcF8 as a new class of PTP1B and SIRT1 inhibitors
Ai, Wen, Wei, Xiaoyi, Lin, Xiuping, Sheng, Li, Wang, Zhen, Tu, Zhengchao, Yang, Xianwen, Zhou, Xuefeng, Li, Jia, Liu, Yonghong
Published in Tetrahedron (02.09.2014)
Published in Tetrahedron (02.09.2014)
Get full text
Journal Article
Identification and Development of 1,4-Diaryl-1,2,3-triazolo-Based Ureas as Novel FLT3 Inhibitors
Liu, Jisheng, Wang, Yuting, Chen, Chen, Tu, Zhengchao, Zhu, Sihua, Zhou, Fengtao, Si, Hongfei, Zheng, Canhui, Zhang, Zhang, Cai, Qian
Published in ACS medicinal chemistry letters (13.08.2020)
Published in ACS medicinal chemistry letters (13.08.2020)
Get full text
Journal Article