CH5424802, a Selective ALK Inhibitor Capable of Blocking the Resistant Gatekeeper Mutant
Sakamoto, Hiroshi, Tsukaguchi, Toshiyuki, Hiroshima, Sayuri, Kodama, Tatsushi, Kobayashi, Takamitsu, Fukami, Takaaki A., Oikawa, Nobuhiro, Tsukuda, Takuo, Ishii, Nobuya, Aoki, Yuko
Published in Cancer cell (17.05.2011)
Published in Cancer cell (17.05.2011)
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Journal Article
Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802)
Kinoshita, Kazutomo, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Miyagi, Takuho, Kobayashi, Takamitsu, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Bioorganic & medicinal chemistry (01.02.2012)
Published in Bioorganic & medicinal chemistry (01.02.2012)
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Journal Article
Selective TRK Inhibitor CH7057288 against TRK Fusion-Driven Cancer
Tanaka, Hiroshi, Sase, Hitoshi, Tsukaguchi, Toshiyuki, Hasegawa, Masami, Tanimura, Hiromi, Yoshida, Miyuki, Sakata, Kiyoaki, Fujii, Toshihiko, Tachibana, Yukako, Takanashi, Kenji, Higashida, Atsuko, Hasegawa, Kiyoshi, Ono, Yoshiyuki, Oikawa, Nobuhiro, Mio, Toshiyuki
Published in Molecular cancer therapeutics (01.12.2018)
Published in Molecular cancer therapeutics (01.12.2018)
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Enhanced antitumor activity of erlotinib in combination with the Hsp90 inhibitor CH5164840 against non‐small‐cell lung cancer
Ono, Naomi, Yamazaki, Toshikazu, Tsukaguchi, Toshiyuki, Fujii, Toshihiko, Sakata, Kiyoaki, Suda, Atsushi, Tsukuda, Takuo, Mio, Toshiyuki, Ishii, Nobuya, Kondoh, Osamu, Aoki, Yuko
Published in Cancer science (01.10.2013)
Published in Cancer science (01.10.2013)
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Synthesis and structure–activity relationships of novel benzofuran farnesyltransferase inhibitors
Asoh, Kohsuke, Kohchi, Masami, Hyoudoh, Ikumi, Ohtsuka, Tatsuo, Masubuchi, Miyako, Kawasaki, Kenichi, Ebiike, Hirosato, Shiratori, Yasuhiko, Fukami, Takaaki A., Kondoh, Osamu, Tsukaguchi, Toshiyuki, Ishii, Nobuya, Aoki, Yuko, Shimma, Nobuo, Sakaitani, Masahiro
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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Selective ALK inhibitor alectinib with potent antitumor activity in models of crizotinib resistance
Kodama, Tatsushi, Tsukaguchi, Toshiyuki, Yoshida, Miyuki, Kondoh, Osamu, Sakamoto, Hiroshi
Published in Cancer letters (01.09.2014)
Published in Cancer letters (01.09.2014)
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Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer
Kodama, Tatsushi, Tsukaguchi, Toshiyuki, Satoh, Yasuko, Yoshida, Miyuki, Watanabe, Yoshiaki, Kondoh, Osamu, Sakamoto, Hiroshi
Published in Molecular cancer therapeutics (01.12.2014)
Published in Molecular cancer therapeutics (01.12.2014)
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Journal Article
The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor
Nakanishi, Yoshito, Akiyama, Nukinori, Tsukaguchi, Toshiyuki, Fujii, Toshihiko, Sakata, Kiyoaki, Sase, Hitoshi, Isobe, Takehito, Morikami, Kenji, Shindoh, Hidetoshi, Mio, Toshiyuki, Ebiike, Hirosato, Taka, Naoki, Aoki, Yuko, Ishii, Nobuya
Published in Molecular cancer therapeutics (01.11.2014)
Published in Molecular cancer therapeutics (01.11.2014)
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Abstract 4179: Potent and selective TRK inhibitor CH7057288
Tanaka, Hiroshi, Sase, Hitoshi, Tsukaguchi, Toshiyuki, Tanimura, Hiromi, Hasegawa, Masami, Hasegawa, Kiyoshi, Ono, Yoshiyuki, Oikawa, Nobuhiro, Sakamoto, Hiroshi, Mio, Toshiyuki
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Abstract 123: Mechanism of oncogenic signal activation by the novel fusion kinase FGFR3-BAIAP2L1
Nakanishi, Yoshito, Akiyama, Nukinori, Tsukaguchi, Toshiyuki, Fujii, Toshihiko, Satoh, Yasuko, Mizuno, Hideaki, Ishii, Nobuya, Aoki, Masahiro
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract 773: Alectinib shows potent antitumor activity against both ALK- and RET-rearranged non-small cell lung cancers
Kodama, Tatsushi, Tsukaguchi, Toshiyuki, Satoh, Yasuko, Yoshida, Miyuki, Watanabe, Yoshiaki, Kondoh, Osamu, Sakamoto, Hiroshi
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors
Kinoshita, Kazutomo, Kobayashi, Takamitsu, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Hattori, Kazuo, Miyagi, Takuho, Hong, Woo-Sang, Park, Min-Jeong, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Journal of medicinal chemistry (22.09.2011)
Published in Journal of medicinal chemistry (22.09.2011)
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Abstract 754: Selective ALK inhibitor alectinib (CH5424802/RO5424802) with potent antitumor activity in models of crizotinib resistance, including intracranial metastases
Kodama, Tatsushi, Tsukaguchi, Toshiyuki, Hasegawa, Masami, Yoshida, Miyuki, Takanashi, Kenji, Kondoh, Osamu, Sakamoto, Hiroshi
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Abstract 5252: Inhibition of FGFR3-BAIAP2L1 fusion kinase oncogenic potential by CH5183284/Debio 1347, a compound that inhibits FGFR3 kinase activity constitutively activated by BAIAP2L1 BAR domain dimerization
Akiyama, Nukinori, Nakanishi, Yoshito, Tsukaguchi, Toshiyuki, Satoh, Yasuko, Nagata, Yasue, Takahashi, Tsutomu, Nishito, Yukari, Ashihara, Motoki, Ishii, Nobuya, Aoki, Masahiro
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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A Novel Mechanism of EML4-ALK Rearrangement Mediated by Chromothripsis in a Patient-Derived Cell Line
Kodama, Tatsushi, Motoi, Noriko, Ninomiya, Hironori, Sakamoto, Hiroshi, Kitada, Kunio, Tsukaguchi, Toshiyuki, Satoh, Yasuko, Nomura, Kimie, Nagano, Hiroko, Ishii, Nobuya, Terui, Yasuhito, Hatake, Kiyohiko, Ishikawa, Yuichi
Published in Journal of thoracic oncology (01.11.2014)
Published in Journal of thoracic oncology (01.11.2014)
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Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors
Kinoshita, Kazutomo, Ono, Yoshiyuki, Emura, Takashi, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Tanaka, Shota, Morikami, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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