OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice
Matsumoto, Makoto, Hashizume, Hiroyuki, Tomishige, Tatsuo, Kawasaki, Masanori, Tsubouchi, Hidetsugu, Sasaki, Hirofumi, Shimokawa, Yoshihiko, Komatsu, Makoto
Published in PLoS medicine (01.11.2006)
Published in PLoS medicine (01.11.2006)
Get full text
Journal Article
Phase 2, randomized, double‐blind, placebo‐controlled, 4‐week study to evaluate the safety and efficacy of OPA‐ 15406 (difamilast), a new topical selective phosphodiesterase type‐4 inhibitor, in Japanese pediatric patients aged 2–14 years with atopic dermatitis
Saeki, Hidehisa, Baba, Naoko, Oshiden, Kazuhide, Abe, Yuji, Tsubouchi, Hidetsugu
Published in Journal of dermatology (01.01.2020)
Published in Journal of dermatology (01.01.2020)
Get full text
Journal Article
An Interim Report of a Phase 3, Long-Term, Open-Label Study to Evaluate Efficacy and Safety of Difamilast Ointment in Japanese Infants with Atopic Dermatitis
Saeki, Hidehisa, Ohya, Yukihiro, Baba, Naoko, Imamura, Tomomi, Yokota, Daisuke, Tsubouchi, Hidetsugu
Published in Dermatology and therapy (01.09.2024)
Published in Dermatology and therapy (01.09.2024)
Get full text
Journal Article
Predictive factors of the pharmacological action of tolvaptan in patients with liver cirrhosis: a post hoc analysis
Sakaida, Isao, Terai, Shuji, Nakajima, Koji, Shibasaki, Yoshiyuki, Tachikawa, Sayaka, Tsubouchi, Hidetsugu
Published in Journal of gastroenterology (01.02.2017)
Published in Journal of gastroenterology (01.02.2017)
Get full text
Journal Article
Synthesis and Antituberculosis Activity of a Novel Series of Optically Active 6-Nitro-2,3-dihydroimidazo[2,1-b]oxazoles
Sasaki, Hirofumi, Haraguchi, Yoshikazu, Itotani, Motohiro, Kuroda, Hideaki, Hashizume, Hiroyuki, Tomishige, Tatsuo, Kawasaki, Masanori, Matsumoto, Makoto, Komatsu, Makoto, Tsubouchi, Hidetsugu
Published in Journal of medicinal chemistry (28.12.2006)
Published in Journal of medicinal chemistry (28.12.2006)
Get full text
Journal Article
Efficacy and safety of topical OPA‐15406, a new phosphodiesterase 4 inhibitor, in Japanese patients with atopic dermatitis for 8 weeks: A phase 2, randomized, double‐blind, placebo‐controlled study
Saeki, Hidehisa, Kawashima, Makoto, Sugaya, Satoko, Oshiden, Kazuhide, Tsubouchi, Hidetsugu, Onozuka, Takashi, Takahashi, Yoshimasa, Takata, Hideyasu, Yoshihara, Nobuko, Toyofuku, Kazutomo, Kitahara, Hiroto, Izumi, Tatsuya, Nogita, Toshitatsu, Yamamoto, Aisaku, Nakasu, Ichiro, Kume, Akihiro, Sasase, Akihiro, Watanabe, Masako, Houki, Ken
Published in Journal of dermatology (01.08.2019)
Published in Journal of dermatology (01.08.2019)
Get full text
Journal Article
Can serum albumin level affect the pharmacological action of tolvaptan in patients with liver cirrhosis? A post hoc analysis of previous clinical trials in Japan
Sakaida, Isao, Nakajima, Koji, Okita, Kiwamu, Hori, Masatsugu, Izumi, Tohru, Sakurai, Masaya, Shibasaki, Yoshiyuki, Tachikawa, Sayaka, Tsubouchi, Hidetsugu, Oka, Hiromi, Kobayashi, Hiroyuki
Published in Journal of gastroenterology (01.10.2015)
Published in Journal of gastroenterology (01.10.2015)
Get full text
Journal Article
Long-term safety profile of tolvaptan in autosomal dominant polycystic kidney disease patients: TEMPO Extension Japan Trial
Muto, Satoru, Okada, Tadashi, Yasuda, Moriyoshi, Tsubouchi, Hidetsugu, Nakajima, Koji, Horie, Shigeo
Published in Drug, healthcare and patient safety (01.01.2017)
Published in Drug, healthcare and patient safety (01.01.2017)
Get full text
Journal Article
Screening for novel antituberculosis agents that are effective against multidrug resistant tuberculosis
Matsumoto, Makoto, Hashizume, Hiroyuki, Tsubouchi, Hidetsugu, Sasaki, Hirofumi, Itotani, Motohiro, Kuroda, Hideaki, Tomishige, Tatsuo, Kawasaki, Masanori, Komatsu, Makoto
Published in Current topics in medicinal chemistry (01.03.2007)
Published in Current topics in medicinal chemistry (01.03.2007)
Get more information
Journal Article
Long-term safety profile of tolvaptan in autosomal dominant polycystic kidney disease patients: TEMPO Extension Japan Trial [Corrigendum]
Muto, Satoru, Okada, Tadashi, Yasuda, Moriyoshi, Tsubouchi, Hidetsugu, Nakajima, Koji, Horie, Shigeo
Published in Drug, healthcare and patient safety (01.01.2018)
Published in Drug, healthcare and patient safety (01.01.2018)
Get full text
Journal Article
Synthesis and Antibacterial Activities of 2-Oxaisocephems
TSUBOUCHI, Hidetsugu, TSUJI, Koichi, YASUMURA, Koichi, ISHIKAWA, Hiroshi
Published in Chemical & pharmaceutical bulletin (1994)
Published in Chemical & pharmaceutical bulletin (1994)
Get full text
Journal Article
Synthesis and Some Properties of 2-Azathiabenzene 1-Oxides
IKEDA, MASAZUMI, TSUBOUCHI, HIDETSUGU, TSUNEKAWA, MASAYOSHI, KONDO, HIROSHI, TAMURA, YASUMITSU
Published in Chemical & pharmaceutical bulletin (01.01.1984)
Published in Chemical & pharmaceutical bulletin (01.01.1984)
Get full text
Journal Article
1-SUBSTITUTED 4-NITROIMIDAZOLE COMPOUND AND PROCESS FOR PRODUCING THE SAME
SHITSUTA, TAKUYA, SASAKI, HIROFUMI, OTANI, TADAAKI, TSUBOUCHI, HIDETSUGU, KURODA, HIDEAKI, FUJITA, SHIGEKAZU, TAKEMURA, NORIAKI, HASEGAWA, TAKESHI, GOTO, FUMITAKA, UTSUMI, NAOTO
Year of Publication 29.04.2004
Get full text
Year of Publication 29.04.2004
Patent
AQUEOUS OLANEXIDINE SOLUTION, METHOD OF PREPARING THE SAME, AND DISINFECTANT
OHNO, HITOSHI, TSUBOUCHI, HIDETSUGU, IWATA, KOUSHI, ISHIKAWA, HIROSHI, HASHIMOTO, KINJI, OKAMURA, TAKASHI, MIYATA, KAZUYOSHI, INOUE, YASUHIDE, KIKUCHI, MOTOYA, OHGURO, KINUE, HAGI, AKIFUMI, SATO, TETSUYA
Year of Publication 09.12.2004
Get full text
Year of Publication 09.12.2004
Patent
DIHYDROPHENAZINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND DRUGS FOR TUBERCLE BACILLI AND ATYPICAL ACID-FAST BACTERIA
SHITSUTA, TAKUYA, SASAKI, HIROFUMI, ITOTANI, MOTOHIRO, TSUBOUCHI, HIDETSUGU, ISHIKAWA, HIROSHI, HORIMOTO, HIDEAKI, KIKUCHI, MIKIO
Year of Publication 12.09.1997
Get full text
Year of Publication 12.09.1997
Patent