The discovery of potent, selective, and orally bioavailable hNK1 antagonists derived from pyrrolidine
LIN, Peter, LEHUA CHANG, KURTZ, Marc M, TSAO, Kwei-Lan C, WHEELDON, Alan, CARLSON, Emma J, ENG, Waisi, BURNS, H. Donald, HARGREAVES, Richard J, MILLS, Sander G, DEVITA, Robert J, YOUNG, Jonathan R, EID, Ronsar, XINCHUN TONG, SONG ZHENG, BALL, Richard G, TSOU, Nancy N, CHICCHI, Gary G
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
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Journal Article
Synthesis and structure-activity relationships of 8-azabicyclo[3.2.1]octane benzylamine NK1 antagonists
THOMSON, Christopher G, CARLSON, Emma, CHICCHI, Gary G, KULAGOWSKI, Janusz J, KURTZ, Marc M, SWAIN, Christopher J, TSAO, Kwei-Lan C, WHEELDON, Alan
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
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Journal Article
Potent, Brain-Penetrant, Hydroisoindoline-Based Human Neurokinin-1 Receptor Antagonists
Jiang, Jinlong, Bunda, Jaime L, Doss, Geoge A, Chicchi, Gary G, Kurtz, Marc M, Tsao, Kwei-Lan C, Tong, Xinchun, Zheng, Song, Upthagrove, Alana, Samuel, Koppara, Tschirret-Guth, Richard, Kumar, Sanjeev, Wheeldon, Alan, Carlson, Emma J, Hargreaves, Richard, Burns, Donald, Hamill, Terence, Ryan, Christine, Krause, Stephen M, Eng, WaiSi, DeVita, Robert J, Mills, Sander G
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
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Journal Article
Fused bicyclic pyrrolizinones as new scaffolds for human NK1 antagonists
Morriello, Gregori J, Devita, Robert J, Mills, Sander G, Young, Jonathan R, Lin, Peter, Doss, George, Chicchi, Gary G, Demartino, Julie, Kurtz, Marc M, Tsao, Kwei-Lan C, Carlson, Emma, Townson, Karen, Wheeldon, Alan, Boyce, Susan, Collinson, Neil, Rupniak, Nadia, Moore, Stephen
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
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Journal Article
Tetrahydroindolizinone NK1 antagonists
JIANMING BAO, HUAGANG LU, MILLS, Sander G, DEVITA, Robert J, MORRIELLO, Gregori J, CARLSON, Emma J, WHEELDON, Alan, CHICCHI, Gary G, KURTZ, Marc M, TSAO, Kwei-Lan C, SONG ZHENG, XINCHUN TONG
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Journal Article
Pyrrolidine-carboxamides and oxadiazoles as potent hNK1 antagonists
YOUNG, Jonathan R, EID, Ronsar, TURNER, Cherilyn, DEVITA, Robert J, KURTZ, Marc M, TSAO, Kwei-Lan C, CHICCHI, Gary G, WHEELDON, Alan, CARLSON, Emma, MILLS, Sander G
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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Journal Article
2‑[(3aR,4R,5S,7aS)‑5-{(1S)‑1-[3,5-Bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro‑2H‑isoindol-2-yl]-1,3-oxazol-4(5H)‑one: A Potent Human NK1 Receptor Antagonist with Multiple Clearance Pathways
Kassick, Andrew J, Jiang, Jinlong, Bunda, Jaime, Wilson, David, Bao, Jianming, Lu, Huagang, Lin, Peter, Ball, Richard G, Doss, George A, Tong, Xinchun, Tsao, Kwei-Lan C, Wang, Hong, Chicchi, Gary, Karanam, Bindhu, Tschirret-Guth, Richard, Samuel, Koppara, Hora, Donald F, Kumar, Sanjeev, Madeira, Maria, Eng, Waisi, Hargreaves, Richard, Purcell, Mona, Gantert, Liza, Cook, Jacquelyn, DeVita, Robert J, Mills, Sander G
Published in Journal of medicinal chemistry (25.07.2013)
Published in Journal of medicinal chemistry (25.07.2013)
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Journal Article
2-[(3a R ,4 R ,5 S ,7a S )-5-{(1 S )-1-[3,5-Bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2 H -isoindol-2-yl]-1,3-oxazol-4(5 H )-one: A Potent Human NK 1 Receptor Antagonist with Multiple Clearance Pathways
Kassick, Andrew J., Jiang, Jinlong, Bunda, Jaime, Wilson, David, Bao, Jianming, Lu, Huagang, Lin, Peter, Ball, Richard G., Doss, George A., Tong, Xinchun, Tsao, Kwei-Lan C., Wang, Hong, Chicchi, Gary, Karanam, Bindhu, Tschirret-Guth, Richard, Samuel, Koppara, Hora, Donald F., Kumar, Sanjeev, Madeira, Maria, Eng, Waisi, Hargreaves, Richard, Purcell, Mona, Gantert, Liza, Cook, Jacquelyn, DeVita, Robert J., Mills, Sander G.
Published in Journal of medicinal chemistry (25.07.2013)
Published in Journal of medicinal chemistry (25.07.2013)
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Journal Article
Synthesis and Structure-Activity Relationships of 8-Azabicyclo[3.2.1]octane Benzylamine NK1 Antagonists
Thomson, Christopher G., Carlson, Emma, Chicchi, Gary G., Kulagowski, Janusz J., Kurtz, Marc M., Swain, Christopher J., Tsao, Kwei-Lan C., Wheeldon, Alan
Published in ChemInform (25.04.2006)
Published in ChemInform (25.04.2006)
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Journal Article
Tetrahydroindolizinone NK sub(1) antagonists
Bao, Jianming, Lu, Huagang, Morriello, Gregori J, Carlson, Emma J, Wheeldon, Alan, Chicchi, Gary G, Kurtz, Marc M, Tsao, Kwei-Lan C, Zheng, Song, Tong, Xinchun, Mills, Sander G, DeVita, Robert J
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Journal Article
Tetrahydroindolizinone NK 1 antagonists
Bao, Jianming, Lu, Huagang, Morriello, Gregori J., Carlson, Emma J., Wheeldon, Alan, Chicchi, Gary G., Kurtz, Marc M., Tsao, Kwei-Lan C., Zheng, Song, Tong, Xinchun, Mills, Sander G., DeVita, Robert J.
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
Pyrrolidine-carboxamides and oxadiazoles as potent hNK 1 antagonists
Young, Jonathan R., Eid, Ronsar, Turner, Cherilyn, DeVita, Robert J., Kurtz, Marc M., Tsao, Kwei-Lan C., Chicchi, Gary G., Wheeldon, Alan, Carlson, Emma, Mills, Sander G.
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Journal Article
Fused bicyclic pyrrolizinones as new scaffolds for human NK1antagonists
MORRIELLO, Gregori J, DEVITA, Robert J, CARLSON, Emma, TOWNSON, Karen, WHEELDON, Alan, BOYCE, Susan, COLLINSON, Neil, RUPNIAK, Nadia, MOORE, Stephen, MILLS, Sander G, YOUNG, Jonathan R, LIN, Peter, DOSS, George, CHICCHI, Gary G, DEMARTINO, Julie, KURTZ, Marc M, TSAO, Kwei-Lan C
Published in Bioorganic & medicinal chemistry (2008)
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Published in Bioorganic & medicinal chemistry (2008)
Journal Article
Fused bicyclic pyrrolizinones as new scaffolds for human NK 1 antagonists
Morriello, Gregori J., DeVita, Robert J., Mills, Sander G., Young, Jonathan R., Lin, Peter, Doss, George, Chicchi, Gary G., DeMartino, Julie, Kurtz, Marc M., Tsao, Kwei-Lan C., Carlson, Emma, Townson, Karen, Wheeldon, Alan, Boyce, Susan, Collinson, Neil, Rupniak, Nadia, Moore, Stephen
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Journal Article
Synthesis and structure-activity relationships of 8-azabicyclo[3.2.1]octane benzylamine NK sub(1) antagonists
Thomson, Christopher G, Carlson, Emma, Chicchi, Gary G, Kulagowski, Janusz J, Kurtz, Marc M, Swain, Christopher J, Tsao, Kwei-Lan C, Wheeldon, Alan
Published in Bioorganic & medicinal chemistry letters (01.02.2006)
Published in Bioorganic & medicinal chemistry letters (01.02.2006)
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Journal Article
Synthesis and structure–activity relationships of 8-azabicyclo[3.2.1]octane benzylamine NK 1 antagonists
Thomson, Christopher G., Carlson, Emma, Chicchi, Gary G., Kulagowski, Janusz J., Kurtz, Marc M., Swain, Christopher J., Tsao, Kwei-Lan C., Wheeldon, Alan
Published in Bioorganic & medicinal chemistry letters (2006)
Published in Bioorganic & medicinal chemistry letters (2006)
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Journal Article
The discovery of potent, selective, and orally bioavailable hNK 1 antagonists derived from pyrrolidine
Lin, Peter, Chang, Lehua, DeVita, Robert J., Young, Jonathan R., Eid, Ronsar, Tong, Xinchun, Zheng, Song, Ball, Richard G., Tsou, Nancy N., Chicchi, Gary G., Kurtz, Marc M., Tsao, Kwei-Lan C., Wheeldon, Alan, Carlson, Emma J., Eng, WaiSi, Burns, H. Donald, Hargreaves, Richard J., Mills, Sander G.
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Journal Article
Synthesis and Structure—Activity Relationships of 8‐Azabicyclo[3.2.1]octane Benzylamine NK 1 Antagonists
Thomson, Christopher G., Carlson, Emma, Chicchi, Gary G., Kulagowski, Janusz J., Kurtz, Marc M., Swain, Christopher J., Tsao, Kwei‐Lan C., Wheeldon, Alan
Published in ChemInform (25.04.2006)
Published in ChemInform (25.04.2006)
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Journal Article