Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents
Juvvadi, Praveen R, Fox, 3rd, David, Bobay, Benjamin G, Hoy, Michael J, Gobeil, Sophie M C, Venters, Ronald A, Chang, Zanetta, Lin, Jackie J, Averette, Anna Floyd, Cole, D Christopher, Barrington, Blake C, Wheaton, Joshua D, Ciofani, Maria, Trzoss, Michael, Li, Xiaoming, Lee, Soo Chan, Chen, Ying-Lien, Mutz, Mitchell, Spicer, Leonard D, Schumacher, Maria A, Heitman, Joseph, Steinbach, William J
Published in Nature communications (19.09.2019)
Published in Nature communications (19.09.2019)
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Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents
Tari, Leslie W, Li, Xiaoming, Trzoss, Michael, Bensen, Daniel C, Chen, Zhiyong, Lam, Thanh, Zhang, Junhu, Lee, Suk Joong, Hough, Grayson, Phillipson, Doug, Akers-Rodriguez, Suzanne, Cunningham, Mark L, Kwan, Bryan P, Nelson, Kirk J, Castellano, Amanda, Locke, Jeff B, Brown-Driver, Vickie, Murphy, Timothy M, Ong, Voon S, Pillar, Chris M, Shinabarger, Dean L, Nix, Jay, Lightstone, Felice C, Wong, Sergio E, Nguyen, Toan B, Shaw, Karen J, Finn, John
Published in PloS one (26.12.2013)
Published in PloS one (26.12.2013)
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Synthesis of spirolactams via Diels-Alder addition of 1,3-butadienes to an α-methylene lactam
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APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental Coccidioides immitis Pneumonia
Viriyakosol, Suganya, Kapoor, Mili, Okamoto, Sharon, Covel, Jonathan, Soltow, Quinlyn A, Trzoss, Michael, Shaw, Karen Joy, Fierer, Joshua
Published in Antimicrobial agents and chemotherapy (01.02.2019)
Published in Antimicrobial agents and chemotherapy (01.02.2019)
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In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus
Shaw, Karen Joy, Schell, Wiley A, Covel, Jonathan, Duboc, Gisele, Giamberardino, C, Kapoor, Mili, Moloney, Molly, Soltow, Quinlyn A, Tenor, Jennifer L, Toffaletti, Dena L, Trzoss, Michael, Webb, Peter, Perfect, John R
Published in Antimicrobial agents and chemotherapy (01.08.2018)
Published in Antimicrobial agents and chemotherapy (01.08.2018)
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Sgr-1505 Is a Potent MALT1 Protease Inhibitor with a Potential Best-in-Class Profile
Yin, Wu, Ye, Min, Marshall, Netonia, Tan, Joanne BL, Paull, Evan, Nie, Zhe, Trzoss, MIchael, Krilov, Goran, Feng, Shulu, Pelletier, Robert, Bell, Jeff, Skrdla, Peter, Calkins, David, Grimes, MaryBeth, Wright, D. Hamish, Akinsanya, Karen
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7‑(Benzimidazol-1-yl)-2,4-diaminoquinazolines
Lam, Thanh, Hilgers, Mark T, Cunningham, Mark L, Kwan, Bryan P, Nelson, Kirk J, Brown-Driver, Vickie, Ong, Voon, Trzoss, Michael, Hough, Grayson, Shaw, Karen Joy, Finn, John
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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Synthesis of analogs of the Gwt1 inhibitor manogepix (APX001A) and in vitro evaluation against Cryptococcus spp
Trzoss, Michael, Covel, Jonathan A., Kapoor, Mili, Moloney, Molly K., Soltow, Quinlyn A., Webb, Peter J., Shaw, Karen Joy
Published in Bioorganic & medicinal chemistry letters (01.12.2019)
Published in Bioorganic & medicinal chemistry letters (01.12.2019)
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Identification of Potent Paracaspase MALT1 Inhibitors for Hematological Malignancies
Yin, Wu, Zhe, Nie, Placzek, Andrew, Trzoss, Michael, Krilov, Goran, Feng, Shulu, Lawrenz, Morgan, Pelletier, Robert, Lai, George, Bell, Jeff, Calkins, David, Grimes, Mary, Tang, Wayne, McRobb, Fiona, Gerasyuto, Aleksey, Feher, Victoria, Mondal, Sayan, Jensen, Kristian, Wright, Hamish, Akinsanya, Karen
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Characterization of Potent Paracaspase MALT1 Inhibitors for Hematological Malignancies
Yin, Wu, Nie, Zhe, Dingley, Karen, Trzoss, Michael, Krilov, Goran, Marshall, Netonia, Feng, Shulu, Pelletier, Robert, Bell, Jeff, Devine, Paul, Skrdla, Peter, Shimanovich, Roman, Ye, Min, Calkins, David, Grimes, Mary, Tang, Wayne, Placzek, Andrew, Lawrenz, Morgan, McRobb, Fiona, Gerasyuto, Aleksey, Feher, Victoria, Mondal, Sayan, Jensen, Kristian, Wright, Hamish, Weiss, Daniel, Akinsanya, Karen
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Abstract 1338: Discovery of novel, potent USP7 inhibitors that upregulate p53 leading to anti-proliferative effects in cancer cells
Futran, Alan, Lu, Tao, Amberg-Johnson, Katherine, Yang, Xiaoxiao, He, Saidi, Bell, Jeffrey, Boyce, Sarah, Dahlgren, Markus, Dingley, Karen, Fang, Liping, Koldsoe, Heidi, Konst, Zef, Lin, Fang-Yu, Pelleltier, Robert, Qian, Heng, Svensson, Mats, Trzoss, Michael, Xu, Jie, Xu, Shuping, Xu, Zhaowu, Yapici, Engin, Zhang, Yan, Xing, Li, Suzuki, Takao, Huang, Xianhai, Xu, Jiayi, Wright, Hamish, Jensen, Kristian, Tang, Wayne, Guo, Tao, Akinsanya, Karen, Madge, David
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity
Tari, Leslie W., Trzoss, Michael, Bensen, Daniel C., Li, Xiaoming, Chen, Zhiyong, Lam, Thanh, Zhang, Junhu, Creighton, Christopher J., Cunningham, Mark L., Kwan, Bryan, Stidham, Mark, Shaw, Karen J., Lightstone, Felice C., Wong, Sergio E., Nguyen, Toan B., Nix, Jay, Finn, John
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
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A calcineurin antifungal strategy with analogs of FK506
Nambu, Mitchell, Covel, Jonathan A., Kapoor, Mili, Li, Xiaoming, Moloney, Molly K., Numa, Mehdi M., Soltow, Quinlyn A., Trzoss, Michael, Webb, Peter, Webb, Robert R., Mutz, Mitchell
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
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시클릭 화합물 및 이의 사용 방법
TRZOSS MICHAEL, KRILOV GORAN, NIE ZHE, TRZOSS LYNNIE, LAWRENZ MORGAN, LAGIAKOS H. RACHEL, FENG SHULU, TANG HAIFENG, PLACZEK ANDREW
Year of Publication 05.09.2022
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Year of Publication 05.09.2022
Patent
Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines
Li, Xiaoming, Hilgers, Mark, Cunningham, Mark, Chen, Zhiyong, Trzoss, Michael, Zhang, Junhu, Kohnen, Lucy, Lam, Thanh, Creighton, Chris, GC, Kedar, Nelson, Kirk, Kwan, Bryan, Stidham, Mark, Brown-Driver, Vickie, Shaw, Karen J., Finn, John
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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