Comparison of Topological, Shape, and Docking Methods in Virtual Screening
McGaughey, Georgia B, Sheridan, Robert P, Bayly, Christopher I, Culberson, J. Chris, Kreatsoulas, Constantine, Lindsley, Stacey, Maiorov, Vladimir, Truchon, Jean-Francois, Cornell, Wendy D
Published in Journal of chemical information and modeling (01.07.2007)
Published in Journal of chemical information and modeling (01.07.2007)
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A Cavity Corrected 3D-RISM Functional for Accurate Solvation Free Energies
Truchon, Jean-François, Pettitt, B. Montgomery, Labute, Paul
Published in Journal of chemical theory and computation (11.03.2014)
Published in Journal of chemical theory and computation (11.03.2014)
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Journal Article
Natural Products in Medicine: Transformational Outcome of Synthetic Chemistry
Szychowski, Janek, Truchon, Jean-François, Bennani, Youssef L
Published in Journal of medicinal chemistry (26.11.2014)
Published in Journal of medicinal chemistry (26.11.2014)
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Journal Article
Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ
Bubenik, Monica, Mader, Pavel, Mochirian, Philippe, Vallée, Fréderic, Clark, Jillian, Truchon, Jean-François, Perryman, Alexander L., Pau, Victor, Kurinov, Igor, Zahn, Karl E., Leclaire, Marie-Eve, Papp, Robert, Mathieu, Marie-Claude, Hamel, Martine, Duffy, Nicole M., Godbout, Claude, Casas-Selves, Matias, Falgueyret, Jean-Pierre, Baruah, Prasamit S., Nicolas, Olivier, Stocco, Rino, Poirier, Hugo, Martino, Giovanni, Fortin, Alexanne Bonneau, Roulston, Anne, Chefson, Amandine, Dorich, Stéphane, St-Onge, Miguel, Patel, Purvish, Pellerin, Charles, Ciblat, Stéphane, Pinter, Thomas, Barabé, Francis, El Bakkouri, Majida, Parikh, Paranjay, Gervais, Christian, Sfeir, Agnel, Mamane, Yael, Morris, Stephen J., Black, W. Cameron, Sicheri, Frank, Gallant, Michel
Published in Journal of medicinal chemistry (13.10.2022)
Published in Journal of medicinal chemistry (13.10.2022)
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Journal Article
Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500)
Black, W. Cameron, Abdoli, Abbas, An, Xiuli, Auger, Anick, Beaulieu, Patrick, Bernatchez, Michel, Caron, Cathy, Chefson, Amandine, Crane, Sheldon, Diallo, Mohamed, Dorich, Stéphane, Fader, Lee D., Ferraro, Gino B., Fournier, Sara, Gao, Qi, Ginzburg, Yelena, Hamel, Martine, Han, Yongshuai, Jones, Paul, Lanoix, Stéphanie, Lacbay, Cyrus M., Leclaire, Marie-Eve, Levy, Maayan, Mamane, Yael, Mulani, Amina, Papp, Robert, Pellerin, Charles, Picard, Audrey, Skeldon, Alexander, Skorey, Kathryn, Stocco, Rino, St.-Onge, Miguel, Truchon, Jean-François, Truong, Vouy Linh, Zimmermann, Michal, Zinda, Michael, Roulston, Anne
Published in Journal of medicinal chemistry (22.02.2024)
Published in Journal of medicinal chemistry (22.02.2024)
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Journal Article
Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306
Szychowski, Janek, Papp, Robert, Dietrich, Evelyne, Liu, Bingcan, Vallée, Frédéric, Leclaire, Marie-Eve, Fourtounis, Jimmy, Martino, Giovanni, Perryman, Alexander L., Pau, Victor, Yin, Shou Yun, Mader, Pavel, Roulston, Anne, Truchon, Jean-Francois, Marshall, C. Gary, Diallo, Mohamed, Duffy, Nicole M., Stocco, Rino, Godbout, Claude, Bonneau-Fortin, Alexanne, Kryczka, Rosie, Bhaskaran, Vivek, Mao, Daniel, Orlicky, Stephen, Beaulieu, Patrick, Turcotte, Pascal, Kurinov, Igor, Sicheri, Frank, Mamane, Yael, Gallant, Michel, Black, W. Cameron
Published in Journal of medicinal chemistry (11.08.2022)
Published in Journal of medicinal chemistry (11.08.2022)
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Journal Article
Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses
Côté, Bernard, Burch, Jason D., Asante-Appiah, Ernest, Bayly, Chris, Bédard, Leanne, Blouin, Marc, Campeau, Louis-Charles, Cauchon, Elizabeth, Chan, Manuel, Chefson, Amandine, Coulombe, Nathalie, Cromlish, Wanda, Debnath, Smita, Deschênes, Denis, Dupont-Gaudet, Kristina, Falgueyret, Jean-Pierre, Forget, Robert, Gagné, Sébastien, Gauvreau, Danny, Girardin, Melina, Guiral, Sébastien, Langlois, Eric, Li, Chun Sing, Nguyen, Natalie, Papp, Rob, Plamondon, Serge, Roy, Amélie, Roy, Stéphanie, Seliniotakis, Ria, St-Onge, Miguel, Ouellet, Stéphane, Tawa, Paul, Truchon, Jean-François, Vacca, Joe, Wrona, Marc, Yan, Youwei, Ducharme, Yves
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
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Journal Article
Discovery of 2‑Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV‑1 Integrase Strand Transfer Inhibitors
Raheem, Izzat T, Walji, Abbas M, Klein, Daniel, Sanders, John M, Powell, David A, Abeywickrema, Pravien, Barbe, Guillaume, Bennet, Amrith, Clas, Sophie−Dorothee, Dubost, David, Embrey, Mark, Grobler, Jay, Hafey, Michael J, Hartingh, Timothy J, Hazuda, Daria J, Miller, Michael D, Moore, Keith P, Pajkovic, Natasa, Patel, Sangita, Rada, Vanessa, Rearden, Paul, Schreier, John D, Sisko, John, Steele, Thomas G, Truchon, Jean-François, Wai, John, Xu, Min, Coleman, Paul J
Published in Journal of medicinal chemistry (22.10.2015)
Published in Journal of medicinal chemistry (22.10.2015)
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Journal Article
A generally applicable method for assessing the electrophilicity and reactivity of diverse nitrile-containing compounds
Oballa, Renata M., Truchon, Jean-François, Bayly, Christopher I., Chauret, Nathalie, Day, Stephen, Crane, Sheldon, Berthelette, Carl
Published in Bioorganic & medicinal chemistry letters (15.02.2007)
Published in Bioorganic & medicinal chemistry letters (15.02.2007)
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Journal Article
Using electronic polarization from the internal continuum (EPIC) for intermolecular interactions
Truchon, Jean-François, Nicholl's, Anthony, Grant, J. Andrew, Iftimie, Radu I, Roux, Benoît, Bayly, Christopher I
Published in Journal of computational chemistry (01.03.2010)
Published in Journal of computational chemistry (01.03.2010)
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Journal Article
Integrated Continuum Dielectric Approaches To Treat Molecular Polarizability and the Condensed Phase: Refractive Index and Implicit Solvation
Truchon, Jean-François, Nicholls, Anthony, Roux, Benoît, Iftimie, Radu I, Bayly, Christopher I
Published in Journal of chemical theory and computation (14.07.2009)
Published in Journal of chemical theory and computation (14.07.2009)
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Journal Article
The identification of potent, selective, and bioavailable cathepsin S inhibitors
Gauthier, Jacques Yves, Black, W. Cameron, Courchesne, Isabelle, Cromlish, Wanda, Desmarais, Sylvie, Houle, Robert, Lamontagne, Sonia, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Ouellet, Marc, Robichaud, Joël, Truchon, Jean-François, Truong, Vouy-Linh, Wang, Qingping, Percival, M. David
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
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Journal Article
Corrigendum to “Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C” [Bioorg. Med. Chem. Lett. 19 (2009) 5392]
Guay, Daniel, Beaulieu, Christian, Truchon, Jean-Francois, Reddy, T. Jagadeeswar, Bayly, Christopher I., Zamboni, Robert, Methot, Nathalie, Rubin, Joel, Ethier, Diane, Percival, M. David
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
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Journal Article
화합물, 약제학적 조성물, 및 화합물의 제조 방법 및 그의 사용 방법
PERRYMAN ALEXANDER, DIETRICH EVELYNE, VALLEE FREDERIC, BEAULIEU PATRICK, PAPP ROBERT, SZYCHOWSKI JANEK, TRUCHON JEAN FRANCOIS, LIU BINGCAN
Year of Publication 20.01.2023
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Year of Publication 20.01.2023
Patent
Primary amides as selective inhibitors of cathepsin K
Léger, Serge, Bayly, Christopher I., Black, W. Cameron, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Massé, Frédéric, Percival, M. David, Truchon, Jean-François
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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