An orally available non-nucleotide STING agonist with antitumor activity
Pan, Bo-Sheng, Perera, Samanthi A, Piesvaux, Jennifer A, Presland, Jeremy P, Schroeder, Gottfried K, Cumming, Jared N, Trotter, B Wesley, Altman, Michael D, Buevich, Alexei V, Cash, Brandon, Cemerski, Saso, Chang, Wonsuk, Chen, Yiping, Dandliker, Peter J, Feng, Guo, Haidle, Andrew, Henderson, Timothy, Jewell, James, Kariv, Ilona, Knemeyer, Ian, Kopinja, Johnny, Lacey, Brian M, Laskey, Jason, Lesburg, Charles A, Liang, Rui, Long, Brian J, Lu, Min, Ma, Yanhong, Minnihan, Ellen C, O'Donnell, Greg, Otte, Ryan, Price, Laura, Rakhilina, Larissa, Sauvagnat, Berengere, Sharma, Sharad, Tyagarajan, Sriram, Woo, Hyun, Wyss, Daniel F, Xu, Serena, Bennett, David Jonathan, Addona, George H
Published in Science (American Association for the Advancement of Science) (21.08.2020)
Published in Science (American Association for the Advancement of Science) (21.08.2020)
Get full text
Journal Article
Imidazopyridine CB2 agonists: Optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy
Trotter, B. Wesley, Nanda, Kausik K., Burgey, Christopher S., Potteiger, Craig M., Deng, James Z., Green, Ahren I., Hartnett, John C., Kett, Nathan R., Wu, Zhicai, Henze, Darrell A., Penna, Kimberly Della, Desai, Reshma, Leitl, Michael D., Lemaire, Wei, White, Rebecca B., Yeh, Suzie, Urban, Mark O., Kane, Stefanie A., Hartman, George D., Bilodeau, Mark T.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Get full text
Journal Article
Design and Synthesis of Novel Isoquinoline-3-nitriles as Orally Bioavailable Kv1.5 Antagonists for the Treatment of Atrial Fibrillation
Trotter, B. Wesley, Nanda, Kausik K, Kett, Nathan R, Regan, Christopher P, Lynch, Joseph J, Stump, Gary L, Kiss, Laszlo, Wang, Jixin, Spencer, Robert H, Kane, Stefanie A, White, Rebecca B, Zhang, Rena, Anderson, Kenneth D, Liverton, Nigel J, McIntyre, Charles J, Beshore, Douglas C, Hartman, George D, Dinsmore, Christopher J
Published in Journal of medicinal chemistry (30.11.2006)
Published in Journal of medicinal chemistry (30.11.2006)
Get full text
Journal Article
Total Syntheses of Vancomycin and Eremomycin Aglycons
Evans, David A., Wood, Michael R., Trotter, B. Wesley, Richardson, Timothy I., Barrow, James C., Katz, Jeffrey L.
Published in Angewandte Chemie (International ed.) (16.10.1998)
Published in Angewandte Chemie (International ed.) (16.10.1998)
Get full text
Journal Article
Decahydroquinoline amides as highly selective CB2 agonists: Role of selectivity on in vivo efficacy in a rodent model of analgesia
Manley, Peter J., Zartman, Amy, Paone, Daniel V., Burgey, Christopher S., Henze, Darrell A., Penna, Kimberly Della, Desai, Reshma, Leitl, Michael D., Lemaire, Wei, White, Rebecca B., Yeh, Suzie, Urban, Mark O., Kane, Stefanie A., Hartman, George D., Bilodeau, Mark T., Trotter, B. Wesley
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Get full text
Journal Article
Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists
Melamed, Jeffrey Y., Zartman, Amy E., Kett, Nathan R., Gotter, Anthony L., Uebele, Victor N., Reiss, Duane R., Condra, Cindra L., Fandozzi, Christine, Lubbers, Laura S., Rowe, Blake A., McGaughey, Georgia B., Henault, Martin, Stocco, Rino, Renger, John J., Hartman, George D., Bilodeau, Mark T., Trotter, B. Wesley
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Get full text
Journal Article
A kinase-cGAS cascade to synthesize a therapeutic STING activator
McIntosh, John A, Liu, Zhijian, Andresen, Brian M, Marzijarani, Nastaran Salehi, Moore, Jeffrey C, Marshall, Nicholas M, Borra-Garske, Margie, Obligacion, Jennifer V, Fier, Patrick S, Peng, Feng, Forstater, Jacob H, Winston, Matthew S, An, Chihui, Chang, Wonsuk, Lim, Jongwon, Huffman, Mark A, Miller, Steven P, Tsay, Fuh-Rong, Altman, Michael D, Lesburg, Charles A, Steinhuebel, Dietrich, Trotter, B Wesley, Cumming, Jared N, Northrup, Alan, Bu, Xiaodong, Mann, Benjamin F, Biba, Mirlinda, Hiraga, Kaori, Murphy, Grant S, Kolev, Joshua N, Makarewicz, Amanda, Pan, Weilan, Farasat, Iman, Bade, Rachel S, Stone, Kevin, Duan, Da, Alvizo, Oscar, Adpressa, Donovan, Guetschow, Erik, Hoyt, Erik, Regalado, Erik L, Castro, Steve, Rivera, Nelo, Smith, Joseph P, Wang, Fengqiang, Crespo, Alejandro, Verma, Deeptak, Axnanda, Stephanus, Dance, Zachary E X, Devine, Paul N, Tschaen, David, Canada, Keith A, Bulger, Paul G, Sherry, Benjamin D, Truppo, Matthew D, Ruck, Rebecca T, Campeau, Louis-Charles, Bennett, David Jonathan, Humphrey, Guy R, Campos, Kevin R, Maddess, Matthew L
Published in Nature (London) (17.03.2022)
Published in Nature (London) (17.03.2022)
Get full text
Journal Article
NMR Data‐Driven Docking of HDM2‐Inhibitor Complexes
Fradera, Xavier, Reutershan, Michael H., Machacek, Michelle R., Trotter, B. Wesley, McCoy, Mark A.
Published in Chembiochem : a European journal of chemical biology (18.03.2022)
Published in Chembiochem : a European journal of chemical biology (18.03.2022)
Get full text
Journal Article
Identification of an allosteric binding site for RORγt inhibition
Scheepstra, Marcel, Leysen, Seppe, van Almen, Geert C, Miller, J Richard, Piesvaux, Jennifer, Kutilek, Victoria, van Eenennaam, Hans, Zhang, Hongjun, Barr, Kenneth, Nagpal, Sunil, Soisson, Stephen M, Kornienko, Maria, Wiley, Kristen, Elsen, Nathaniel, Sharma, Sujata, Correll, Craig C, Trotter, B Wesley, van der Stelt, Mario, Oubrie, Arthur, Ottmann, Christian, Parthasarathy, Gopal, Brunsveld, Luc
Published in Nature communications (07.12.2015)
Published in Nature communications (07.12.2015)
Get full text
Journal Article
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer
Chang, Wonsuk, Altman, Michael D, Lesburg, Charles A, Perera, Samanthi A, Piesvaux, Jennifer A, Schroeder, Gottfried K, Wyss, Daniel F, Cemerski, Saso, Chen, Yiping, DiNunzio, Edward, Haidle, Andrew M, Ho, Thu, Kariv, Ilona, Knemeyer, Ian, Kopinja, Johnny E, Lacey, Brian M, Laskey, Jason, Lim, Jongwon, Long, Brian J, Ma, Yanhong, Maddess, Matthew L, Pan, Bo-Sheng, Presland, Jeremy P, Spooner, Edward, Steinhuebel, Dietrich, Truong, Quang, Zhang, Zhibo, Fu, Jianmin, Addona, George H, Northrup, Alan B, Parmee, Emma, Tata, James R, Bennett, David Jonathan, Cumming, Jared N, Siu, Tony, Trotter, B. Wesley
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
Get full text
Journal Article
Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors
Richters, André, Doyle, Shelby K., Freeman, David B., Lee, Christina, Leifer, Becky S., Jagannathan, Sajjeev, Kabinger, Florian, Koren, Jošt Vrabič, Struntz, Nicholas B., Urgiles, Julie, Stagg, Ryan A., Curtin, Brice H., Chatterjee, Deep, Mathea, Sebastian, Mikochik, Peter J., Hopkins, Tamara D., Gao, Hua, Branch, Jonathan R., Xin, Hong, Westover, Lori, Bignan, Gilles C., Rupnow, Brent A., Karlin, Kristen L., Olson, Calla M., Westbrook, Thomas F., Vacca, Joseph, Wilfong, Chris M., Trotter, B. Wesley, Saffran, Douglas C., Bischofberger, Norbert, Knapp, Stefan, Russo, Joshua W., Hickson, Ian, Bischoff, James R., Gottardis, Marco M., Balk, Steven P., Lin, Charles Y., Pop, Marius S., Koehler, Angela N.
Published in Cell chemical biology (18.02.2021)
Published in Cell chemical biology (18.02.2021)
Get full text
Journal Article
Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers
Freeman, David B., Hopkins, Tamara D., Mikochik, Peter J., Vacca, Joseph P., Gao, Hua, Naylor-Olsen, Adel, Rudra, Sonali, Li, Huixu, Pop, Marius S., Villagomez, Rosa A., Lee, Christina, Li, Heng, Zhou, Minyun, Saffran, Douglas C., Rioux, Nathalie, Hood, Tressa R., Day, Melinda A. L., McKeown, Michael R., Lin, Charles Y., Bischofberger, Norbert, Trotter, B. Wesley
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
Get full text
Journal Article
Discovery of MK-4688: an Efficient Inhibitor of the HDM2–p53 Protein–Protein Interaction
Reutershan, Michael H, Machacek, Michelle R, Altman, Michael D, Bogen, Stephane, Cai, Mingmei, Cammarano, Carolyn, Chen, Dapeng, Christopher, Matthew, Cryan, John, Daublain, Pierre, Fradera, Xavier, Geda, Prasanthi, Goldenblatt, Peter, Hill, Armetta D, Kemper, Raymond A, Kutilek, Victoria, Li, Chaomin, Martinez, Michelle, McCoy, Mark, Nair, Latha, Pan, Weidong, Thompson, Christopher F, Scapin, Giovanna, Shizuka, Manami, Spatz, Marianne L, Steinhuebel, Dietrich, Sun, Binyuan, Voss, Matthew E, Wang, Xiao, Yang, Liping, Yeh, Tammie C, Dussault, Isabelle, Marshall, C. Gary, Trotter, B. Wesley
Published in Journal of medicinal chemistry (11.11.2021)
Published in Journal of medicinal chemistry (11.11.2021)
Get full text
Journal Article
STimulator of INterferon Genes Agonism Accelerates Antitumor Activity in Poorly Immunogenic Tumors
Perera, Samanthi A, Kopinja, Johnny E, Ma, Yanhong, Muise, Eric S, Laskey, Jason, Chakravarthy, Kalyan, Chen, Yiping, Cui, Long, Presland, Jeremy, Sathe, Manjiri, Javaid, Sarah, Minnihan, Ellen C, Ferguson, Heidi M, Piesvaux, Jennifer, Pan, Bo-Sheng, Zhao, Shuxia, Sharma, Sharad K, Woo, Hyun Chong, Pucci, Vincenzo, Knemeyer, Ian, Cemerski, Saso, Cumming, Jared, Trotter, B Wesley, Tse, Archie, Khilnani, Anuradha, Ranganath, Sheila, Long, Brian J, Bennett, David Jonathan, Addona, George H
Published in Molecular cancer therapeutics (01.02.2022)
Published in Molecular cancer therapeutics (01.02.2022)
Get full text
Journal Article
Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors
Methot, Joey L, Achab, Abdelghani, Christopher, Matthew, Zhou, Hua, McGowan, Meredeth A, Trotter, B. Wesley, Fradera, Xavier, Lesburg, Charles A, Goldenblatt, Peter, Hill, Armetta, Chen, Dapeng, Otte, Karin M, Augustin, Martin, Shah, Sanjiv, Katz, Jason D
Published in ACS medicinal chemistry letters (10.12.2020)
Published in ACS medicinal chemistry letters (10.12.2020)
Get full text
Journal Article
Potent antagonists of the Kv1.5 potassium channel: Synthesis and evaluation of analogous N, N-diisopropyl-2-(pyridine-3-yl)acetamides
Nanda, Kausik K., Brad Nolt, M., Cato, Matthew J., Kane, Stefanie A., Kiss, Laszlo, Spencer, Robert H., Wang, Jixin, Lynch, Joseph J., Regan, Christopher P., Stump, Gary L., Li, Bing, White, Rebecca, Yeh, Suzie, Bogusky, Michael J., Bilodeau, Mark T., Dinsmore, Christopher J., Lindsley, Craig W., Hartman, George D., Wolkenberg, Scott E., Wesley Trotter, B.
Published in Bioorganic & medicinal chemistry letters (15.11.2006)
Published in Bioorganic & medicinal chemistry letters (15.11.2006)
Get full text
Journal Article
Discovery of N‑(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases
Zhang, Hongjun, Lapointe, Blair T, Anthony, Neville, Azevedo, Rita, Cals, Jos, Correll, Craig C, Daniels, Matthew, Deshmukh, Sujal, van Eenenaam, Hans, Ferguson, Heidi, Hegde, Laxminarayan G, Karstens, Willem Jan, Maclean, John, Miller, J. Richard, Moy, Lily Y, Simov, Vladimir, Nagpal, Sunil, Oubrie, Arthur, Palte, Rachel L, Parthasarathy, Gopal, Sciammetta, Nunzio, van der Stelt, Mario, Woodhouse, Janice D, Trotter, B. Wesley, Barr, Kenneth
Published in ACS medicinal chemistry letters (13.02.2020)
Published in ACS medicinal chemistry letters (13.02.2020)
Get full text
Journal Article
Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen
Bukhtiyarova, Marina, Cook, Erica M., Hancock, Paula J., Hruza, Alan W., Shaw, Anthony W., Adam, Gregory C., Barnard, Richard J. O., McKenna, Philip M., Holloway, M. Katharine, Bell, Ian M., Carroll, Steve, Cornella-Taracido, Ivan, Cox, Christopher D., Kutchukian, Peter S., Powell, David A., Strickland, Corey, Trotter, B. Wesley, Tudor, Matthew, Wolkenberg, Scott, Li, Jing, Tellers, David M.
Published in ACS medicinal chemistry letters (14.01.2021)
Published in ACS medicinal chemistry letters (14.01.2021)
Get full text
Journal Article
Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics
Wolkenberg, Scott E., Nolt, M. Brad, Bilodeau, Mark T., Trotter, B. Wesley, Manley, Peter J., Kett, Nathan R., Nanda, Kausik K., Wu, Zhicai, Cato, Matthew J., Kane, Stefanie A., Kiss, Laszlo, Spencer, Robert H., Wang, Jixin, Lynch, Joseph J., Regan, Christopher P., Stump, Gary L., Li, Bing, White, Rebecca, Yeh, Suzie, Dinsmore, Christopher J., Lindsley, Craig W., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Get full text
Journal Article