Complex Pharmacology of Free Fatty Acid Receptors
Milligan, Graeme, Shimpukade, Bharat, Ulven, Trond, Hudson, Brian D
Published in Chemical reviews (11.01.2017)
Published in Chemical reviews (11.01.2017)
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Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival
Theiler, Anna, Bärnthaler, Thomas, Platzer, Wolfgang, Richtig, Georg, Peinhaupt, Miriam, Rittchen, Sonja, Kargl, Julia, Ulven, Trond, Marsh, Leigh M., Marsche, Gunther, Schuligoi, Rufina, Sturm, Eva M., Heinemann, Akos
Published in Journal of allergy and clinical immunology (01.09.2019)
Published in Journal of allergy and clinical immunology (01.09.2019)
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Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production
Sencio, Valentin, Barthelemy, Adeline, Tavares, Luciana P., Machado, Marina G., Soulard, Daphnée, Cuinat, Céline, Queiroz-Junior, Celso Martins, Noordine, Marie-Louise, Salomé-Desnoulez, Sophie, Deryuter, Lucie, Foligné, Benoit, Wahl, Céline, Frisch, Benoit, Vieira, Angelica T., Paget, Christophe, Milligan, Graeme, Ulven, Trond, Wolowczuk, Isabelle, Faveeuw, Christelle, Le Goffic, Ronan, Thomas, Muriel, Ferreira, Stéphanie, Teixeira, Mauro M., Trottein, François
Published in Cell reports (Cambridge) (03.03.2020)
Published in Cell reports (Cambridge) (03.03.2020)
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Journal Article
Discovery of a Potent and Selective GPR120 Agonist
Shimpukade, Bharat, Hudson, Brian D, Hovgaard, Christine Kiel, Milligan, Graeme, Ulven, Trond
Published in Journal of medicinal chemistry (10.05.2012)
Published in Journal of medicinal chemistry (10.05.2012)
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Journal Article
Chemogenetics defines a short-chain fatty acid receptor gut-brain axis
Barki, Natasja, Bolognini, Daniele, Börjesson, Ulf, Jenkins, Laura, Riddell, John, Hughes, David I, Ulven, Trond, Hudson, Brian D, Ulven, Elisabeth Rexen, Dekker, Niek, Tobin, Andrew B, Milligan, Graeme
Published in eLife (01.03.2022)
Published in eLife (01.03.2022)
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The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism
Hudson, Brian D, Shimpukade, Bharat, Mackenzie, Amanda E, Butcher, Adrian J, Pediani, John D, Christiansen, Elisabeth, Heathcote, Helen, Tobin, Andrew B, Ulven, Trond, Milligan, Graeme
Published in Molecular pharmacology (01.11.2013)
Published in Molecular pharmacology (01.11.2013)
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Journal Article
The Molecular Basis of Ligand Interaction at Free Fatty Acid Receptor 4 (FFA4/GPR120)
Hudson, Brian D., Shimpukade, Bharat, Milligan, Graeme, Ulven, Trond
Published in The Journal of biological chemistry (18.07.2014)
Published in The Journal of biological chemistry (18.07.2014)
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Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation
Dragano, Nathalia R V, Solon, Carina, Ramalho, Albina F, de Moura, Rodrigo F, Razolli, Daniela S, Christiansen, Elisabeth, Azevedo, Carlos, Ulven, Trond, Velloso, Licio A
Published in Journal of neuroinflammation (26.04.2017)
Published in Journal of neuroinflammation (26.04.2017)
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Journal Article
Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice
Murtaza, Babar, Hichami, Aziz, Khan, Amira S., Shimpukade, Bharat, Ulven, Trond, Ozdener, Mehmet Hakan, Khan, Naim A.
Published in Journal of lipid research (01.02.2020)
Published in Journal of lipid research (01.02.2020)
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Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3
Hudson, Brian D., Tikhonova, Irina G., Pandey, Sunil K., Ulven, Trond, Milligan, Graeme
Published in The Journal of biological chemistry (30.11.2012)
Published in The Journal of biological chemistry (30.11.2012)
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Journal Article
Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120
Prihandoko, Rudi, Alvarez-Curto, Elisa, Hudson, Brian D, Butcher, Adrian J, Ulven, Trond, Miller, Ashley M, Tobin, Andrew B, Milligan, Graeme
Published in Molecular pharmacology (01.05.2016)
Published in Molecular pharmacology (01.05.2016)
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FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells
Lorza-Gil, Estela, Kaiser, Gabriele, Rexen Ulven, Elisabeth, König, Gabriele M., Gerst, Felicia, Oquendo, Morgana Barroso, Birkenfeld, Andreas L., Häring, Hans-Ulrich, Kostenis, Evi, Ulven, Trond, Ullrich, Susanne
Published in Scientific reports (05.10.2020)
Published in Scientific reports (05.10.2020)
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Journal Article
Defining the Molecular Basis for the First Potent and Selective Orthosteric Agonists of the FFA2 Free Fatty Acid Receptor
Hudson, Brian D., Due-Hansen, Maria E., Christiansen, Elisabeth, Hansen, Anna Mette, Mackenzie, Amanda E., Murdoch, Hannah, Pandey, Sunil K., Ward, Richard J., Marquez, Rudi, Tikhonova, Irina G., Ulven, Trond, Milligan, Graeme
Published in The Journal of biological chemistry (14.06.2013)
Published in The Journal of biological chemistry (14.06.2013)
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Journal Article
Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43)
Hansen, Anders Højgaard, Sergeev, Eugenia, Pandey, Sunil K, Hudson, Brian D, Christiansen, Elisabeth, Milligan, Graeme, Ulven, Trond
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
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Journal Article
The GPR120 agonist TUG‐891 promotes metabolic health by stimulating mitochondrial respiration in brown fat
Schilperoort, Maaike, van Dam, Andrea D, Hoeke, Geerte, Shabalina, Irina G, Okolo, Anthony, Hanyaloglu, Aylin C, Dib, Lea H, Mol, Isabel M, Caengprasath, Natarin, Chan, Yi‐Wah, Damak, Sami, Miller, Anne Reifel, Coskun, Tamer, Shimpukade, Bharat, Ulven, Trond, Kooijman, Sander, Rensen, Patrick CN, Christian, Mark
Published in EMBO molecular medicine (01.03.2018)
Published in EMBO molecular medicine (01.03.2018)
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