Concomitant Action of Structural Elements and Receptor Phosphorylation Determines Arrestin-3 Interaction with the Free Fatty Acid Receptor FFA4
Butcher, Adrian J., Hudson, Brian D., Shimpukade, Bharat, Alvarez-Curto, Elisa, Prihandoko, Rudi, Ulven, Trond, Milligan, Graeme, Tobin, Andrew B.
Published in The Journal of biological chemistry (27.06.2014)
Published in The Journal of biological chemistry (27.06.2014)
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Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3
Schmidt, Johannes, Smith, Nicola J, Christiansen, Elisabeth, Tikhonova, Irina G, Grundmann, Manuel, Hudson, Brian D, Ward, Richard J, Drewke, Christel, Milligan, Graeme, Kostenis, Evi, Ulven, Trond
Published in The Journal of biological chemistry (25.03.2011)
Published in The Journal of biological chemistry (25.03.2011)
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Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets
Lorza-Gil, Estela, Kaiser, Gabriele, Carlein, Christopher, Hoffmann, Markus D. A., König, Gabriele M., Haug, Sieglinde, Prates Roma, Leticia, Rexen Ulven, Elisabeth, Ulven, Trond, Kostenis, Evi, Birkenfeld, Andreas L., Häring, Hans-Ulrich, Ullrich, Susanne, Gerst, Felicia
Published in Diabetologia (01.08.2023)
Published in Diabetologia (01.08.2023)
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Structure–activity relationship of GPR15L peptide analogues and investigation of their interaction with the GPR15 receptor
Deng, Yufang, Perez Almeria, Claudia V., Gijzel, Lieke, Schaller, Kay, Vedel, Line, Gloriam, David E., Ulven, Trond, Bräuner‐Osborne, Hans
Published in Basic & clinical pharmacology & toxicology (01.06.2023)
Published in Basic & clinical pharmacology & toxicology (01.06.2023)
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Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization
Kjær, Viktoria M S, Daugvilaite, Viktorija, Stepniewski, Tomasz M, Madsen, Christian M, Jørgensen, Astrid S, Bhuskute, Kaustubh R, Inoue, Asuka, Ulven, Trond, Benned-Jensen, Tau, Hjorth, Siv A, Hjortø, Gertrud M, Moo, Ee Von, Selent, Jana, Rosenkilde, Mette M
Published in Science signaling (04.04.2023)
Published in Science signaling (04.04.2023)
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Identification of a Potent and Selective Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist with Favorable Physicochemical and in Vitro ADME Properties
Christiansen, Elisabeth, Urban, Christian, Grundmann, Manuel, Due-Hansen, Maria E, Hagesaether, Ellen, Schmidt, Johannes, Pardo, Leonardo, Ullrich, Susanne, Kostenis, Evi, Kassack, Matthias, Ulven, Trond
Published in Journal of medicinal chemistry (13.10.2011)
Published in Journal of medicinal chemistry (13.10.2011)
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Pathophysiological regulation of lung function by the free fatty acid receptor FFA4
Prihandoko, Rudi, Kaur, Davinder, Wiegman, Coen H, Alvarez-Curto, Elisa, Donovan, Chantal, Chachi, Latifa, Ulven, Trond, Tyas, Martha R, Euston, Eloise, Dong, Zhaoyang, Alharbi, Abdulrahman Ghali M, Kim, Richard Y, Lowe, Jack G, Hansbro, Philip M, Chung, Kian Fan, Brightling, Christopher E, Milligan, Graeme, Tobin, Andrew B
Published in Science translational medicine (19.08.2020)
Published in Science translational medicine (19.08.2020)
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A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor
Grundmann, Manuel, Tikhonova, Irina G., Hudson, Brian D., Smith, Nicola J., Mohr, Klaus, Ulven, Trond, Milligan, Graeme, Kenakin, Terry, Kostenis, Evi
Published in Cell chemical biology (17.03.2016)
Published in Cell chemical biology (17.03.2016)
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The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment
Björkman, Lena, Mårtensson, Jonas, Winther, Malene, Gabl, Michael, Holdfeldt, André, Uhrbom, Martin, Bylund, Johan, Højgaard Hansen, Anders, Pandey, Sunil K., Ulven, Trond, Forsman, Huamei, Dahlgren, Claes
Published in Molecular and cellular biology (15.10.2016)
Published in Molecular and cellular biology (15.10.2016)
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Mucus can change the permeation rank order of drug candidates
Hagesaether, Ellen, Christiansen, Elisabeth, Due-Hansen, Maria Elisabeth, Ulven, Trond
Published in International journal of pharmaceutics (16.08.2013)
Published in International journal of pharmaceutics (16.08.2013)
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Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5)
Karlshøj, Stefanie, Amarandi, Roxana Maria, Larsen, Olav, Daugvilaite, Viktorija, Steen, Anne, Brvar, Matjaž, Pui, Aurel, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette Marie
Published in The Journal of biological chemistry (23.12.2016)
Published in The Journal of biological chemistry (23.12.2016)
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Structure–Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators
Ulven, Elisabeth Rexen, Quon, Tezz, Sergeev, Eugenia, Barki, Natasja, Brvar, Matjaz, Hudson, Brian D, Dutta, Palash, Hansen, Anders Højgaard, Bielefeldt, Line Ø, Tobin, Andrew B, McKenzie, Christine J, Milligan, Graeme, Ulven, Trond
Published in Journal of medicinal chemistry (09.04.2020)
Published in Journal of medicinal chemistry (09.04.2020)
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Discovery of Potent and Selective Agonists for the Free Fatty Acid Receptor 1 (FFA(1)/GPR40), a Potential Target for the Treatment of Type II Diabetes
Christiansen, Elisabeth, Urban, Christian, Merten, Nicole, Liebscher, Kathrin, Karlsen, Kasper K., Hamacher, Alexandra, Spinrath, Andreas, Bond, Andrew D., Drewke, Christel, Ullrich, Susanne, Kassack, Matthias U., Kostenis, Evi, Ulven, Trond
Published in Journal of medicinal chemistry (27.11.2008)
Published in Journal of medicinal chemistry (27.11.2008)
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Discovery of GPR183 Agonists Based on an Antagonist Scaffold
Kjær, Viktoria M. S., Ieremias, Loukas, Daugvilaite, Viktorija, Lückmann, Michael, Frimurer, Thomas M., Ulven, Trond, Rosenkilde, Mette M., Våbenø, Jon
Published in ChemMedChem (06.09.2021)
Published in ChemMedChem (06.09.2021)
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A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer
Blättermann, Stefanie, Peters, Lucas, Ottersbach, Philipp Aaron, Bock, Andreas, Konya, Viktoria, Weaver, C David, Gonzalez, Angel, Schröder, Ralf, Tyagi, Rahul, Luschnig, Petra, Gäb, Jürgen, Hennen, Stephanie, Ulven, Trond, Pardo, Leonardo, Mohr, Klaus, Gütschow, Michael, Heinemann, Akos, Kostenis, Evi
Published in Nature chemical biology (01.07.2012)
Published in Nature chemical biology (01.07.2012)
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