Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design
Woodhead, Andrew J, Angove, Hayley, Carr, Maria G, Chessari, Gianni, Congreve, Miles, Coyle, Joseph E, Cosme, Jose, Graham, Brent, Day, Philip J, Downham, Robert, Fazal, Lynsey, Feltell, Ruth, Figueroa, Eva, Frederickson, Martyn, Lewis, Jonathan, McMenamin, Rachel, Murray, Christopher W, O’Brien, M. Alistair, Parra, Lina, Patel, Sahil, Phillips, Theresa, Rees, David C, Rich, Sharna, Smith, Donna-Michelle, Trewartha, Gary, Vinkovic, Mladen, Williams, Brian, Woolford, Alison J.-A
Published in Journal of medicinal chemistry (26.08.2010)
Published in Journal of medicinal chemistry (26.08.2010)
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Journal Article
Identification of N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design
Wyatt, Paul G, Woodhead, Andrew J, Berdini, Valerio, Boulstridge, John A, Carr, Maria G, Cross, David M, Davis, Deborah J, Devine, Lindsay A, Early, Theresa R, Feltell, Ruth E, Lewis, E. Jonathan, McMenamin, Rachel L, Navarro, Eva F, O’Brien, Michael A, O’Reilly, Marc, Reule, Matthias, Saxty, Gordon, Seavers, Lisa C. A, Smith, Donna-Michelle, Squires, Matt S, Trewartha, Gary, Walker, Margaret T, Woolford, Alison J.-A
Published in Journal of medicinal chemistry (28.08.2008)
Published in Journal of medicinal chemistry (28.08.2008)
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Glycosidation via conjugate addition of anomeric alkoxides to nitroalkenes and nitrosoalkenes
Trewartha, Gary, Burrows, Jeremy N., Barrett, Anthony G.M.
Published in Tetrahedron letters (16.05.2005)
Published in Tetrahedron letters (16.05.2005)
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Journal Article
Identification of N -(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1 H -pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design
Wyatt, Paul G., Woodhead, Andrew J., Berdini, Valerio, Boulstridge, John A., Carr, Maria G., Cross, David M., Davis, Deborah J., Devine, Lindsay A., Early, Theresa R., Feltell, Ruth E., Lewis, E. Jonathan, McMenamin, Rachel L., Navarro, Eva F., O’Brien, Michael A., O’Reilly, Marc, Reule, Matthias, Saxty, Gordon, Seavers, Lisa C. A., Smith, Donna-Michelle, Squires, Matt S., Trewartha, Gary, Walker, Margaret T., Woolford, Alison J.-A.
Published in Journal of medicinal chemistry (01.08.2008)
Published in Journal of medicinal chemistry (01.08.2008)
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Journal Article
Farmasøytiske forbindelser
Wyatt, Paul Graham, Vinkovic, Mladen, Trewartha, Gary, Rees, David Charles
Year of Publication 06.06.2017
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Year of Publication 06.06.2017
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PHARMACEUTICAL COMPOUNDS
REES, DAVID CHARLES, TREWARTHA, GARY, WYATT, PAUL GRAHAM, VINKOVIC, MLADEN
Year of Publication 09.12.2014
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Year of Publication 09.12.2014
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PHARMACEUTICAL COMPOUNDS
GARY TREWARTHA, DAVID CHARLES REES, MLADEN VINKOVI?, PAUL GRAHAM WYATT
Year of Publication 14.06.2013
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Year of Publication 14.06.2013
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3,4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators
Carr, Maria Grazia, O'Brien, Michael Alistair, Wyatt, Paul Graham, Woolford, Alison Jo-Ann, Early, Theresa Rachel, Woodhead, Andrew James, Gill, Adrian Liam, Trewartha, Gary, Berdini, Valerio
Year of Publication 29.02.2016
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Year of Publication 29.02.2016
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3,4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators
TREWARTHA GARY, O'BRIEN MICHAEL ALISTAIR, EARLY THERESA RACHEL, WOODHEAD ANDREW JAMES, CARR MARIA GRAZIA, WYATT PAUL GRAHAM, BERDINI VALERIO, WOOLFORD ALISON JO-ANN, GILL ADRIAN LIAM
Year of Publication 30.10.2015
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Year of Publication 30.10.2015
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3,4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators
GILL, ADRIAN LIAM, WOOLFORD, ALISON JO-ANN, TREWARTHA, GARY, WYATT, PAUL GRAHAM, EARLY, THERESA RACHEL, BERDINI, VALERIO, O'BRIEN, MICHAEL ALISTAIR, WOODHEAD, ANDREW JAMES, CARR, MARIA GRAZIA
Year of Publication 31.08.2015
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Year of Publication 31.08.2015
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3,4-DISUBSTITUTED 1H-PYRAZOLE COMPOUNDS AND THEIR USE AS CYCLIN DEPENDENT KINASES (CDK) AND GLYCOGEN SYNTHASE KINASE-3 (GSK-3) MODULATORS
ANDREW JAMES WOODHEAD, GARY TREWARTHA, MICHAEL ALISTAIR O'BRIEN, ALISON JO-ANN WOOLFORD, VALERIO BERDINI, THERESA RACHEL EARLY, ADRIAN LIAM GILL, PAUL GRAHAM WYATT, MARIA GRAZIA CARR
Year of Publication 22.07.2015
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Year of Publication 22.07.2015
Patent