Experimentally Induced Blood-Stage Plasmodium vivax Infection in Healthy Volunteers
McCarthy, James S., Griffin, Paul M., Sekuloski, Silvana, Bright, A. Taylor, Rockett, Rebecca, Looke, David, Elliott, Suzanne, Whiley, David, Sloots, Theo, Winzeler, Elizabeth A., Trenholme, Katharine R.
Published in The Journal of infectious diseases (15.11.2013)
Published in The Journal of infectious diseases (15.11.2013)
Get full text
Journal Article
A pilot randomised trial of induced blood-stage Plasmodium falciparum infections in healthy volunteers for testing efficacy of new antimalarial drugs
McCarthy, James S, Sekuloski, Silvana, Griffin, Paul M, Elliott, Suzanne, Douglas, Nanette, Peatey, Chris, Rockett, Rebecca, O'Rourke, Peter, Marquart, Louise, Hermsen, Cornelius, Duparc, Stephan, Möhrle, Jörg, Trenholme, Katharine R, Humberstone, Andrew J
Published in PloS one (22.08.2011)
Published in PloS one (22.08.2011)
Get full text
Journal Article
Anti-malarial drugs: how effective are they against Plasmodium falciparum gametocytes?
Peatey, Christopher L, Leroy, Didier, Gardiner, Donald L, Trenholme, Katharine R
Published in Malaria journal (06.02.2012)
Published in Malaria journal (06.02.2012)
Get full text
Journal Article
Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum
Poreba, Marcin, McGowan, Sheena, Skinner-Adams, Tina S, Trenholme, Katharine R, Gardiner, Donald L, Whisstock, James C, To, Joyce, Salvesen, Guy S, Dalton, John P, Drag, Marcin
Published in PloS one (16.02.2012)
Published in PloS one (16.02.2012)
Get full text
Journal Article
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase
McGowan, Sheena, Porter, Corrine J, Lowther, Jonathan, Stack, Colin M, Golding, Sarah J, Skinner-Adams, Tina S, Trenholme, Katharine R, Teuscher, Franka, Donnelly, Sheila M, Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, DeGori, Ross, Buckle, Ashley M, Gardiner, Donald L, Whisstock, James C, Dalton, John P
Published in Proceedings of the National Academy of Sciences - PNAS (24.02.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (24.02.2009)
Get full text
Journal Article
Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases
McGowan, Sheena, Oellig, Christine A, Birru, Woldeamanuel A, Caradoc-Davies, Tom T, Stack, Colin M, Lowther, Jonathan, Skinner-Adams, Tina, Mucha, Artur, Kafarski, Pawel, Grembecka, Jolanta, Trenholme, Katharine R, Buckle, Ashley M, Gardiner, Donald L, Dalton, John P, Whisstock, James C
Published in Proceedings of the National Academy of Sciences - PNAS (09.02.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (09.02.2010)
Get full text
Journal Article
A repeat sequence domain of the ring‐exported protein‐1 of Plasmodium falciparum controls export machinery architecture and virulence protein trafficking
McHugh, Emma, Batinovic, Steven, Hanssen, Eric, McMillan, Paul J., Kenny, Shannon, Griffin, Michael D. W., Crawford, Simon, Trenholme, Katharine R., Gardiner, Donald L., Dixon, Matthew W. A., Tilley, Leann
Published in Molecular microbiology (01.12.2015)
Published in Molecular microbiology (01.12.2015)
Get full text
Journal Article
Infectivity of Plasmodium falciparum in Malaria-Naive Individuals Is Related to Knob Expression and Cytoadherence of the Parasite
Stanisic, Danielle I, Gerrard, John, Fink, James, Griffin, Paul M, Liu, Xue Q, Sundac, Lana, Sekuloski, Silvana, Rodriguez, Ingrid B, Pingnet, Jolien, Yang, Yuedong, Zhou, Yaoqi, Trenholme, Katharine R, Wang, Claire Y T, Hackett, Hazel, Chan, Jo-Anne A, Langer, Christine, Hanssen, Eric, Hoffman, Stephen L, Beeson, James G, McCarthy, James S, Good, Michael F
Published in Infection and immunity (01.09.2016)
Published in Infection and immunity (01.09.2016)
Get full text
Journal Article
The Aminopeptidase Inhibitor CHR-2863 Is an Orally Bioavailable Inhibitor of Murine Malaria
SKINNER-ADAMS, Tina S, PEATEY, Christopher L, DALTON, John P, GARDINER, Donald L, ANDERSON, Karen, TRENHOLME, Katharine R, KRIGE, David, BROWN, Christopher L, STACK, Colin, NSANGOU, Desire M. M, MATHEWS, Rency T, THIVIERGE, Karine
Published in Antimicrobial Agents and Chemotherapy (01.06.2012)
Published in Antimicrobial Agents and Chemotherapy (01.06.2012)
Get full text
Journal Article
Identification of Phosphinate Dipeptide Analog Inhibitors Directed against the Plasmodium falciparum M17 Leucine Aminopeptidase as Lead Antimalarial Compounds
Skinner-Adams, Tina S, Lowther, Jonathan, Teuscher, Franka, Stack, Colin M, Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, Trenholme, Katharine R, Dalton, John P, Gardiner, Donald L
Published in Journal of medicinal chemistry (29.11.2007)
Published in Journal of medicinal chemistry (29.11.2007)
Get full text
Journal Article
X-ray Crystal Structure and Specificity of the Plasmodium falciparum Malaria Aminopeptidase PfM18AAP
Sivaraman, Komagal Kannan, Oellig, Christine A., Huynh, Kitmun, Atkinson, Sarah C., Poreba, Marcin, Perugini, Matthew A., Trenholme, Katharine R., Gardiner, Donald L., Salvesen, Guy, Drag, Marcin, Dalton, John P., Whisstock, James C., McGowan, Sheena
Published in Journal of molecular biology (28.09.2012)
Published in Journal of molecular biology (28.09.2012)
Get full text
Journal Article
Targeted mutagenesis of the ring-exported protein-1 of Plasmodium falciparum disrupts the architecture of Maurer's cleft organelles
Hanssen, Eric, Hawthorne, Paula, Dixon, Matthew W.A, Trenholme, Katharine R, McMillan, Paul J, Spielmann, Tobias, Gardiner, Donald L, Tilley, Leann
Published in Molecular microbiology (01.08.2008)
Published in Molecular microbiology (01.08.2008)
Get full text
Journal Article
The development of sexual stage malaria gametocytes in a Wave Bioreactor
Demanga, Corine G, Eng, Jenny W L, Gardiner, Donald L, Roth, Alison, Butterworth, Alice, Adams, John H, Trenholme, Katharine R, Dalton, John P
Published in Parasites & vectors (02.05.2017)
Published in Parasites & vectors (02.05.2017)
Get full text
Journal Article
Selective permeabilization of the host cell membrane of Plasmodium falciparum-infected red blood cells with streptolysin O and equinatoxin II
Jackson, Katherine E, Spielmann, Tobias, Hanssen, Eric, Adisa, Akinola, Separovic, Frances, Dixon, Matthew W A, Trenholme, Katharine R, Hawthorne, Paula L, Gardiner, Don L, Gilberger, Tim, Tilley, Leann
Published in Biochemical journal (01.04.2007)
Published in Biochemical journal (01.04.2007)
Get full text
Journal Article
Targeting of the Ring Exported Protein 1 to the Maurer's Clefts is Mediated by a Two-Phase Process
Dixon, Matthew W.A, Hawthorne, Paula L, Spielmann, Tobias, Anderson, Karen L, Trenholme, Katharine R, Gardiner, Donald L
Published in Traffic (Copenhagen, Denmark) (01.08.2008)
Published in Traffic (Copenhagen, Denmark) (01.08.2008)
Get full text
Journal Article
Dual stage synthesis and crucial role of cytoadherence-linked asexual gene 9 in the surface expression of malaria parasite var proteins
Goel, Suchi, Valiyaveettil, Manojkumar, Achur, Rajeshwara N., Goyal, Atul, Mattei, Denise, Salanti, Ali, Trenholme, Katharine R., Gardiner, Donald L., Gowda, D. Channe
Published in Proceedings of the National Academy of Sciences - PNAS (21.09.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (21.09.2010)
Get full text
Journal Article
Antimalarial Asexual Stage-Specific and Gametocytocidal Activities of HIV Protease Inhibitors
PEATEY, Christopher L, ANDREWS, Katherine T, EICKEL, Nina, MACDONALD, Timothy, BUTTERWORTH, Alice S, TRENHOLME, Katharine R, GARDINER, Donald L, MCCARTHY, James S, SKINNER-ADAMS, Tina S
Published in Antimicrobial Agents and Chemotherapy (01.03.2010)
Published in Antimicrobial Agents and Chemotherapy (01.03.2010)
Get full text
Journal Article
The M18 Aspartyl Aminopeptidase of the Human Malaria Parasite Plasmodium falciparum
Teuscher, Franka, Lowther, Jonathan, Skinner-Adams, Tina S., Spielmann, Tobias, Dixon, Matthew W.A., Stack, Colin M., Donnelly, Sheila, Mucha, Artur, Kafarski, Paweł, Vassiliou, Stamatia, Gardiner, Donald L., Dalton, John P., Trenholme, Katharine R.
Published in The Journal of biological chemistry (19.10.2007)
Published in The Journal of biological chemistry (19.10.2007)
Get full text
Journal Article