Directed evolution of proteins for increased stability and expression using yeast display
Traxlmayr, Michael W., Obinger, Christian
Published in Archives of biochemistry and biophysics (15.10.2012)
Published in Archives of biochemistry and biophysics (15.10.2012)
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Journal Article
Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function
Salzer, Benjamin, Schueller, Christina M, Zajc, Charlotte U, Peters, Timo, Schoeber, Michael A, Kovacic, Boris, Buri, Michelle C, Lobner, Elisabeth, Dushek, Omer, Huppa, Johannes B, Obinger, Christian, Putz, Eva M, Holter, Wolfgang, Traxlmayr, Michael W, Lehner, Manfred
Published in Nature communications (20.08.2020)
Published in Nature communications (20.08.2020)
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Journal Article
A conformation-specific ON-switch for controlling CAR T cells with an orally available drug
Zajc, Charlotte U., Dobersberger, Markus, Schaffner, Irene, Mlynek, Georg, Pühringer, Dominic, Salzer, Benjamin, Djinović-Carugo, Kristina, Steinberger, Peter, De Sousa Linhares, Annika, Yang, Nicole J., Obinger, Christian, Holter, Wolfgang, Traxlmayr, Michael W., Lehner, Manfred
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2020)
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Journal Article
PhosphoFlowSeq – A High-throughput Kinase Activity Assay for Screening Drug Resistance Mutations in EGFR
Wagner, Anja, Teufl, Magdalena, Gold, Lukas, Lehner, Manfred, Obinger, Christian, Sykacek, Peter, Traxlmayr, Michael W.
Published in Journal of molecular biology (05.11.2021)
Published in Journal of molecular biology (05.11.2021)
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Journal Article
Engineered IgG1-Fc - one fragment to bind them all
Lobner, Elisabeth, Traxlmayr, Michael W., Obinger, Christian, Hasenhindl, Christoph
Published in Immunological reviews (01.03.2016)
Published in Immunological reviews (01.03.2016)
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Journal Article
Identification of Activating Mutations in the Transmembrane and Extracellular Domains of EGFR
Wagner, Anja, Galicia-Andrés, Edgar, Teufl, Magdalena, Gold, Lukas, Obinger, Christian, Sykacek, Peter, Oostenbrink, Chris, Traxlmayr, Michael W.
Published in Biochemistry (Easton) (04.10.2022)
Published in Biochemistry (Easton) (04.10.2022)
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Journal Article
An engineered protein antagonist of K-Ras/B-Raf interaction
Kauke, Monique J, Traxlmayr, Michael W, Parker, Jillian A, Kiefer, Jonathan D, Knihtila, Ryan, McGee, John, Verdine, Greg, Mattos, Carla, Wittrup, K Dane
Published in Scientific reports (19.07.2017)
Published in Scientific reports (19.07.2017)
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Journal Article
Solving the mystery of the FMC63-CD19 affinity
Seigner, Jacqueline, Zajc, Charlotte U, Dötsch, Sarah, Eigner, Caroline, Laurent, Elisabeth, Busch, Dirk H, Lehner, Manfred, Traxlmayr, Michael W
Published in Scientific reports (27.12.2023)
Published in Scientific reports (27.12.2023)
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Journal Article
Engineering Strategies to Overcome the Stability–Function Trade-Off in Proteins
Teufl, Magdalena, Zajc, Charlotte U, Traxlmayr, Michael W
Published in ACS synthetic biology (18.03.2022)
Published in ACS synthetic biology (18.03.2022)
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Journal Article
Fcab-HER2 Interaction: a Ménage à Trois. Lessons from X-Ray and Solution Studies
Lobner, Elisabeth, Humm, Anne-Sophie, Göritzer, Kathrin, Mlynek, Georg, Puchinger, Martin G., Hasenhindl, Christoph, Rüker, Florian, Traxlmayr, Michael W., Djinović-Carugo, Kristina, Obinger, Christian
Published in Structure (London) (06.06.2017)
Published in Structure (London) (06.06.2017)
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Journal Article
Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library
Traxlmayr, Michael W., Kiefer, Jonathan D., Srinivas, Raja R., Lobner, Elisabeth, Tisdale, Alison W., Mehta, Naveen K., Yang, Nicole J., Tidor, Bruce, Wittrup, K. Dane
Published in The Journal of biological chemistry (21.10.2016)
Published in The Journal of biological chemistry (21.10.2016)
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Journal Article
Construction of a Stability Landscape of the CH3 Domain of Human IgG1 by Combining Directed Evolution with High Throughput Sequencing
Traxlmayr, Michael W., Hasenhindl, Christoph, Hackl, Matthias, Stadlmayr, Gerhard, Rybka, Jakub D., Borth, Nicole, Grillari, Johannes, Rüker, Florian, Obinger, Christian
Published in Journal of molecular biology (26.10.2012)
Published in Journal of molecular biology (26.10.2012)
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Journal Article
Directed evolution of stabilized IgG1-Fc scaffolds by application of strong heat shock to libraries displayed on yeast
Traxlmayr, Michael W., Faissner, Maximilian, Stadlmayr, Gerhard, Hasenhindl, Christoph, Antes, Bernhard, Rüker, Florian, Obinger, Christian
Published in Biochimica et biophysica acta (01.04.2012)
Published in Biochimica et biophysica acta (01.04.2012)
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Journal Article
Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential
Paumann-Page, Martina, Kienzl, Nikolaus F., Motwani, Jyoti, Bathish, Boushra, Paton, Louise N., Magon, Nicholas J., Sevcnikar, Benjamin, Furtmüller, Paul G., Traxlmayr, Michael W., Obinger, Christian, Eccles, Mike R., Winterbourn, Christine C.
Published in Redox biology (01.10.2021)
Published in Redox biology (01.10.2021)
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Journal Article
Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR-T Cell Patients
Laurent, Elisabeth, Sieber, Anna, Salzer, Benjamin, Wachernig, Anna, Seigner, Jacqueline, Lehner, Manfred, Geyeregger, René, Kratzer, Bernhard, Jäger, Ulrich, Kunert, Renate, Pickl, Winfried F, Traxlmayr, Michael W
Published in ACS synthetic biology (21.05.2021)
Published in ACS synthetic biology (21.05.2021)
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Journal Article
Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins
Yang, Nicole J, Kauke, Monique J, Sun, Fangdi, Yang, Lucy F, Maass, Katie F, Traxlmayr, Michael W, Yu, Yao, Xu, Yingda, Langer, Robert S, Anderson, Daniel G, Wittrup, K Dane
Published in Nucleic acids research (27.07.2017)
Published in Nucleic acids research (27.07.2017)
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Journal Article
An engineering strategy to target activated EGFR with CAR T cells
Dobersberger, Markus, Sumesgutner, Delia, Zajc, Charlotte U., Salzer, Benjamin, Laurent, Elisabeth, Emminger, Dominik, Sylvander, Elise, Lehner, Elisabeth, Teufl, Magdalena, Seigner, Jacqueline, Bobbili, Madhusudhan Reddy, Kunert, Renate, Lehner, Manfred, Traxlmayr, Michael W.
Published in Cell reports methods (22.04.2024)
Published in Cell reports methods (22.04.2024)
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Journal Article