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Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models
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A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti-Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors
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Dual IGF-I/II-Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth
JIN GAO, CHESEBROUGH, Jon W, COATS, Steven, BOSSLET, Klaus, CHANG, Yong S, CARTLIDGE, Susan A, RICKETTS, Sally-Ann, INCOGNITO, Leonard, VELDMAN-JONES, Margaret, BLAKEY, David C, TABRIZI, Mohammad, JALLAL, Bahija, TRAIL, Pamela A
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A Multispecific Anti-CD40 DARPin Construct Induces Tumor-Selective CD40 Activation and Tumor Regression
Rigamonti, Nicolò, Veitonmäki, Niina, Domke, Clara, Barsin, Sophie, Jetzer, Sarah, Abdelmotaleb, Omar, Bessey, Ralph, Lekishvili, Tamara, Malvezzi, Francesca, Gachechiladze, Mariam, Behe, Martin, Levitsky, Victor, Trail, Pamela A
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Published in Cancer immunology research (03.05.2022)
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Preclinical Activity of the Novel Anti-Prolactin Receptor (PRLR) Antibody-Drug Conjugate REGN2878-DM1 in PRLR-Positive Breast Cancers
Kelly, Marcus P, Hickey, Carlos, Makonnen, Sosina, Coetzee, Sandra, Jalal, Sumreen, Wang, Yu, Delfino, Frank, Shan, Jing, Potocky, Terra B, Chatterjee, Ishita, Andreev, Julian, Kunz, Arthur, D'Souza, Christopher, Giurleo, Jason T, Nittoli, Thomas, Trail, Pamela A, Thurston, Gavin, Kirshner, Jessica R
Published in Molecular cancer therapeutics (01.07.2017)
Published in Molecular cancer therapeutics (01.07.2017)
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Cathepsin B-Labile Dipeptide Linkers for Lysosomal Release of Doxorubicin from Internalizing Immunoconjugates: Model Studies of Enzymatic Drug Release and Antigen-Specific In Vitro Anticancer Activity
Dubowchik, Gene M, Firestone, Raymond A, Padilla, Linda, Willner, David, Hofstead, Sandra J, Mosure, Kathleen, Knipe, Jay O, Lasch, Shirley J, Trail, Pamela A
Published in Bioconjugate chemistry (01.07.2002)
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Monoclonal antibody drug immunoconjugates for targeted treatment of cancer
Trail, Pamela A, King, H Dalton, Dubowchik, Gene M
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Monoclonal Antibody Conjugates of Doxorubicin Prepared with Branched Peptide Linkers: Inhibition of Aggregation by Methoxytriethyleneglycol Chains
King, H. Dalton, Dubowchik, Gene M, Mastalerz, Harold, Willner, David, Hofstead, Sandra J, Firestone, Raymond A, Lasch, Shirley J, Trail, Pamela A
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Inhibition of angiogenesis and metastasis in two murine models by the matrix metalloproteinase inhibitor, BMS-275291
NAGLICH, Joseph G, JURE-KUNKEL, Maria, WILLS, Ruth, KRAMER, Robert A, TRAIL, Pamela A, GUPTA, Elora, FARGNOLI, Joseph, HENDERSON, Arris J, LEWIN, Anne C, TALBOTT, Randy, BAXTER, Andy, BIRD, John, SAVOPOULOS, Ranjev
Published in Cancer research (Chicago, Ill.) (01.12.2001)
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Published in Cancer research (Chicago, Ill.) (01.12.2001)
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Monoclonal antibody drug conjugates in the treatment of cancer
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Characterization of kringle domains of angiostatin as antagonists of endothelial cell migration, an important process in angiogenesis
Ji, W R, Castellino, F J, Chang, Y, Deford, M E, Gray, H, Villarreal, X, Kondri, M E, Marti, D N, Llinás, M, Schaller, J, Kramer, R A, Trail, P A
Published in The FASEB journal (01.12.1998)
Published in The FASEB journal (01.12.1998)
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Constitutive Expression of Functional 4-1BB (CD137) Ligand on Carcinoma Cells
Salih, Helmut R, Kosowski, Steven G, Haluska, Vanessa F, Starling, Gary C, Loo, Deryk T, Lee, Francis, Aruffo, Alejandro A, Trail, Pamela A, Kiener, Peter A
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Synthesis of an immunoconjugate of camptothecin
Walker, Michael A, Dubowchik, Gene M, Hofstead, Sandra J, Trail, Pamela A, Firestone, Raymond A
Published in Bioorganic & medicinal chemistry letters (21.01.2002)
Published in Bioorganic & medicinal chemistry letters (21.01.2002)
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(6-Maleimidocaproyl)hydrazone of doxorubicin. A new derivative for the preparation of immunoconjugates of doxorubicin
Willner, David, Trail, Pamela A, Hofstead, Sandra J, King, H. Dalton, Lasch, Shirley J, Braslawsky, Gary R, Greenfield, Robert S, Kaneko, Takushi, Firestone, Raymond A
Published in Bioconjugate chemistry (01.11.1993)
Published in Bioconjugate chemistry (01.11.1993)
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Doxorubicin immunoconjugates containing bivalent, lysosomally-Cleavable dipeptide linkages
Dubowchik, Gene M, Radia, Shilpa, Mastalerz, Harold, Walker, Michael A, Firestone, Raymond A, Dalton King, H, Hofstead, Sandra J, Willner, David, Lasch, Shirley J, Trail, Pamela A
Published in Bioorganic & medicinal chemistry letters (03.06.2002)
Published in Bioorganic & medicinal chemistry letters (03.06.2002)
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Monoclonal Antibody Conjugates of Doxorubicin Prepared with Branched Linkers: A Novel Method for Increasing the Potency of Doxorubicin Immunoconjugates
King, H. Dalton, Yurgaitis, Derek, Willner, David, Firestone, Raymond A, Yang, Michael B, Lasch, Shirley J, Hellström, Karl Erik, Trail, Pamela A
Published in Bioconjugate chemistry (01.03.1999)
Published in Bioconjugate chemistry (01.03.1999)
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