Synthesis of 2,4-disubstituted thiazoles and selenazoles as potential antifilarial and antitumor agents. 2. 2-Arylamido and 2-alkylamido derivatives of 2-amino-4-(isothiocyanatomethyl)thiazole and 2-amino-4-(isothiocyanatomethyl)selenazole
Kumar, Yatendra, Green, Rachel, Wise, Dean S, Wotring, Linda L, Townsend, Leroy B
Published in Journal of medicinal chemistry (01.11.1993)
Published in Journal of medicinal chemistry (01.11.1993)
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Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action
BIRON, Karen K, HARVEY, Robert J, STANAT, Sylvia C, DRACH, John C, TOWNSEND, Leroy B, KOSZALKA, George W, CHAMBERLAIN, Stanley C, GOOD, Steven S, SMITH, Albert A, DAVIS, Michelle G, TALARICO, Christine L, MILLER, Wayne H, FERRIS, Robert, DORNSIFE, Ronna E
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Published in Antimicrobial Agents and Chemotherapy (01.08.2002)
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Synthesis and Antiviral Activity of Novel Erythrofuranosyl Imidazo[1,2-a]pyridine C-Nucleosides Constructed via Palladium Coupling of Iodoimidazo[1,2-a]pyridines and Dihydrofuran
Gudmundsson, Kristjan S, Williams, John D, Drach, John C, Townsend, Leroy B
Published in Journal of medicinal chemistry (10.04.2003)
Published in Journal of medicinal chemistry (10.04.2003)
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Design, synthesis and antiviral activity of novel 4,5-disubstituted 7-(beta-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazines and the novel 3-amino-5-methyl-1-(beta-D-ribofuranosyl)- and 3-amino-5-methyl-1-(2-deoxy-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,7,8-hexa-azaacenaphthylene as analogues of triciribine
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Amino Acid Ester Prodrugs of the Antiviral Agent 2-Bromo-5,6-dichloro-1-(β-d-ribofuranosyl)benzimidazole as Potential Substrates of hPEPT1 Transporter
Song, Xueqin, Vig, Balvinder S, Lorenzi, Philip L, Drach, John C, Townsend, Leroy B, Amidon, Gordon L
Published in Journal of medicinal chemistry (24.02.2005)
Published in Journal of medicinal chemistry (24.02.2005)
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Interaction of the Putative Human Cytomegalovirus Portal Protein pUL104 with the Large Terminase Subunit pUL56 and Its Inhibition by Benzimidazole-d-Ribonucleosides
DITTMER, Alexandra, DRACH, John C, TOWNSEND, Leroy B, FISCHER, Anke, BOGNER, Elke
Published in Journal of Virology (01.12.2005)
Published in Journal of Virology (01.12.2005)
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Design, Synthesis, and Antiviral Evaluations of 1-(Substituted benzyl)-2-substituted-5,6-dichlorobenzimidazoles as Nonnucleoside Analogues of 2,5,6-Trichloro-1-(β-d-ribofuranosyl)benzimidazole
Porcari, Anthony R., Devivar, Rodrigo V., Kucera, Louis S., Drach, John C., Townsend, Leroy B.
Published in Journal of medicinal chemistry (09.04.1998)
Published in Journal of medicinal chemistry (09.04.1998)
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Resistance of Human Cytomegalovirus to the Benzimidazole l-Ribonucleoside Maribavir Maps to UL27
Komazin, Gloria, Ptak, Roger G, Emmer, Brian T, Townsend, Leroy B, Drach, John C
Published in Journal of Virology (01.11.2003)
Published in Journal of Virology (01.11.2003)
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Design, Synthesis, and Antiviral Activity of α-Nucleosides: d- and l-Isomers of Lyxofuranosyl- and (5-Deoxylyxofuranosyl)benzimidazoles
Migawa, Michael T., Girardet, Jean-Luc, Walker, John A., Koszalka, George W., Chamberlain, Stanley D., Drach, John C., Townsend, Leroy B.
Published in Journal of medicinal chemistry (09.04.1998)
Published in Journal of medicinal chemistry (09.04.1998)
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Identification of the ATP‐binding site in the terminase subunit pUL56 of human cytomegalovirus
Scholz, Brigitte, Rechter, Sabine, Drach, John C., Townsend, Leroy B., Bogner, Elke
Published in Nucleic acids research (01.03.2003)
Published in Nucleic acids research (01.03.2003)
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Synthesis and Antiviral Evaluation of Polyhalogenated Imidazole Nucleosides: Dimensional Analogues of 2,5,6-Trichloro-1-(β-d-ribofuranosyl)benzimidazole
Chien, Tun-Cheng, Saluja, Sunita S, Drach, John C, Townsend, Leroy B
Published in Journal of medicinal chemistry (04.11.2004)
Published in Journal of medicinal chemistry (04.11.2004)
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Inhibition of Human Cytomegalovirus Replication by Benzimidazole Nucleosides Involves Three Distinct Mechanisms
EVERS, David L, KOMAZIN, Gloria, PTAK, Roger G, DONGJIN SHIN, EMMER, Brian T, TOWNSEND, Leroy B, DRACH, John C
Published in Antimicrobial Agents and Chemotherapy (01.10.2004)
Published in Antimicrobial Agents and Chemotherapy (01.10.2004)
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Preclinical and Toxicology Studies of 1263W94, a Potent and Selective Inhibitor of Human Cytomegalovirus Replication
KOSZALKA, George W, JOHNSON, Nelson W, GOOD, Steven S, BOYD, Leslie, CHAMBERLAIN, Stanley C, TOWNSEND, Leroy B, DRACH, John C, BIRON, Karen K
Published in Antimicrobial Agents and Chemotherapy (01.08.2002)
Published in Antimicrobial Agents and Chemotherapy (01.08.2002)
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Design, Synthesis, and Biological Evaluation of Tricyclic Nucleosides (Dimensional Probes) as Analogues of Certain Antiviral Polyhalogenated Benzimidazole Ribonucleosides
Zhu, Zhijian, Lippa, Blaise, Drach, John C, Townsend, Leroy B
Published in Journal of medicinal chemistry (15.06.2000)
Published in Journal of medicinal chemistry (15.06.2000)
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Inhibition of Human Cytomegalovirus DNA Maturation by a Benzimidazole Ribonucleoside Is Mediated through the UL89 Gene Product
Underwood, M R, Harvey, R J, Stanat, S C, Hemphill, M L, Miller, T, Drach, J C, Townsend, L B, Biron, K K
Published in Journal of Virology (01.01.1998)
Published in Journal of Virology (01.01.1998)
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Resistance of Human Cytomegalovirus to Benzimidazole Ribonucleosides Maps to Two Open Reading Frames: UL89 and UL56
Krosky, P M, Underwood, M R, Turk, S R, Feng, K W, Jain, R K, Ptak, R G, Westerman, A C, Biron, K K, Townsend, L B, Drach, J C
Published in Journal of Virology (01.06.1998)
Published in Journal of Virology (01.06.1998)
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Mechanism of Action of the Ribopyranoside Benzimidazole GW275175X against Human Cytomegalovirus
UNDERWOOD, Mark R, FERRIS, Robert G, SELLESETH, Dean W, DAVIS, Michelle G, DRACH, John C, TOWNSEND, Leroy B, BIRON, Karen K, BOYD, F. Leslie
Published in Antimicrobial Agents and Chemotherapy (01.05.2004)
Published in Antimicrobial Agents and Chemotherapy (01.05.2004)
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