Engineering the protein dynamics of an ancestral luciferase
Schenkmayerova, Andrea, Pinto, Gaspar P., Toul, Martin, Marek, Martin, Hernychova, Lenka, Planas-Iglesias, Joan, Daniel Liskova, Veronika, Pluskal, Daniel, Vasina, Michal, Emond, Stephane, Dörr, Mark, Chaloupkova, Radka, Bednar, David, Prokop, Zbynek, Hollfelder, Florian, Bornscheuer, Uwe T., Damborsky, Jiri
Published in Nature communications (14.06.2021)
Published in Nature communications (14.06.2021)
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Journal Article
Structural Biology and Protein Engineering of Thrombolytics
Mican, Jan, Toul, Martin, Bednar, David, Damborsky, Jiri
Published in Computational and structural biotechnology journal (01.01.2019)
Published in Computational and structural biotechnology journal (01.01.2019)
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Journal Article
Illuminating the mechanism and allosteric behavior of NanoLuc luciferase
Nemergut, Michal, Pluskal, Daniel, Horackova, Jana, Sustrova, Tereza, Tulis, Jan, Barta, Tomas, Baatallah, Racha, Gagnot, Glwadys, Novakova, Veronika, Majerova, Marika, Sedlackova, Karolina, Marques, Sérgio M., Toul, Martin, Damborsky, Jiri, Prokop, Zbynek, Bednar, David, Janin, Yves L., Marek, Martin
Published in Nature communications (29.11.2023)
Published in Nature communications (29.11.2023)
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Journal Article
Development and Testing of Thrombolytics in Stroke
Nikitin, Dmitri, Choi, Seungbum, Mican, Jan, Toul, Martin, Ryu, Wi-Sun, Damborsky, Jiri, Mikulik, Robert, Kim, Dong-Eog
Published in Journal of stroke (01.01.2021)
Published in Journal of stroke (01.01.2021)
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Journal Article
Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin
Nikitin, Dmitri, Mican, Jan, Toul, Martin, Bednar, David, Peskova, Michaela, Kittova, Patricia, Thalerova, Sandra, Vitecek, Jan, Damborsky, Jiri, Mikulik, Robert, Fleishman, Sarel J., Prokop, Zbynek, Marek, Martin
Published in Computational and structural biotechnology journal (01.01.2022)
Published in Computational and structural biotechnology journal (01.01.2022)
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Journal Article
Extended Mechanism of the Plasminogen Activator Staphylokinase Revealed by Global Kinetic Analysis: 1000-fold Higher Catalytic Activity than That of Clinically Used Alteplase
Toul, Martin, Nikitin, Dmitri, Marek, Martin, Damborsky, Jiri, Prokop, Zbynek
Published in ACS catalysis (01.04.2022)
Published in ACS catalysis (01.04.2022)
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Journal Article
Hidden Potential of Highly Efficient and Widely Accessible Thrombolytic Staphylokinase
Toul, Martin, Mican, Jan, Slonkova, Veronika, Nikitin, Dmitri, Marek, Martin, Bednar, David, Damborsky, Jiri, Prokop, Zbynek
Published in Stroke (1970) (01.10.2022)
Published in Stroke (1970) (01.10.2022)
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Journal Article
Identification, characterization, and engineering of glycosylation in thrombolytics
Toul, Martin, Slonkova, Veronika, Mican, Jan, Urminsky, Adam, Tomkova, Maria, Sedlak, Erik, Bednar, David, Damborsky, Jiri, Hernychova, Lenka, Prokop, Zbynek
Published in Biotechnology advances (01.09.2023)
Published in Biotechnology advances (01.09.2023)
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Journal Article
A catalytic mechanism for Renilla-type bioluminescence
Schenkmayerova, Andrea, Toul, Martin, Pluskal, Daniel, Baatallah, Racha, Gagnot, Glwadys, Pinto, Gaspar P, Santana, Vinicius T, Stuchla, Marketa, Neugebauer, Petr, Chaiyen, Pimchai, Damborsky, Jiri, Bednar, David, Janin, Yves L, Prokop, Zbynek, Martin, Marek
Published in bioRxiv (09.02.2022)
Published in bioRxiv (09.02.2022)
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Paper
Light-Emitting Dehalogenases: Reconstruction of Multifunctional Biocatalysts
Chaloupkova, Radka, Liskova, Veronika, Toul, Martin, Markova, Klara, Sebestova, Eva, Hernychova, Lenka, Marek, Martin, Pinto, Gaspar P, Pluskal, Daniel, Waterman, Jitka, Prokop, Zbynek, Damborsky, Jiri
Published in ACS catalysis (07.06.2019)
Published in ACS catalysis (07.06.2019)
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Journal Article
Azobenzene-Based Photoswitchable Substrates for Advanced Mechanistic Studies of Model Haloalkane Dehalogenase Enzyme Family
Slanska, Michaela, Stackova, Lenka, Marques, Sergio M., Stacko, Peter, Martínek, Marek, Jílek, Luboš, Toul, Martin, Damborsky, Jiri, Bednar, David, Klán, Petr, Prokop, Zbynek
Published in ACS catalysis (02.08.2024)
Published in ACS catalysis (02.08.2024)
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Journal Article
COELENTERAZINE-UTILIZING LUCIFERASES WITH STABLE GLOW-TYPE LIGHT EMISSION AND METHODS OF PRODUCING AND USING THEREOF
Toul, Martin, Smith, Andrea, Planas-Inglesias, Joan, Vasina, Michal, Rangel Pamplona Pizarro Pinto, Jose Gaspar, Pluskal, Daniel, Prokop, Zbynek, Marek, Martin, Bednar, David, Damborsky, Jiri
Year of Publication 22.08.2024
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Year of Publication 22.08.2024
Patent
COELENTERAZINE-UTILIZING LUCIFERASES WITH STABLE GLOW-TYPE LIGHT EMISSION AND METHODS OF PRODUCING AND USING THEREOF
TOUL, Martin, PLUSKAL, Daniel, MAREK, Martin, SMITH, Andrea, DAMBORSKY, Jiri, PLANASLESIAS, Joan, VASINA, Michal, BEDNAR, David, RANGEL PAMPLONA PIZARRO PINTO, Jose Gaspar, PROKOP, Zbynek
Year of Publication 26.06.2024
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Year of Publication 26.06.2024
Patent
COELENTERAZINE-UTILIZING LUCIFERASES WITH STABLE GLOW-TYPE LIGHT EMISSION AND METHODS OF PRODUCING AND USING THEREOF
TOUL, Martin, PLUSKAL, Daniel, MAREK, Martin, SMITH, Andrea, DAMBORSKY, Jiri, PLANASLESIAS, Joan, VASINA, Michal, BEDNAR, David, RANGEL PAMPLONA PIZARRO PINTO, Jose Gaspar, PROKOP, Zbynek
Year of Publication 23.02.2023
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Year of Publication 23.02.2023
Patent
COELENTERAZINE-UTILIZING LUCIFERASES WITH STABLE GLOW-TYPE LIGHT EMISSION, INCREASED SUBSTRATE AFFINITY, SUPPRESED PRODUCT INHIBITION, AND MODULATED EMISSION WAVELENGTHS, AND METHODS OF PRODUCING AND USING THEREOF
Toul, Martin, Vasina, Michal, Schenkmayerová, Andrea, Rangel Pamplona Pizarro Pinto, Jose Gaspar, Pluskal, Daniel, Planas Iglesias, Joan, Prokop, Zbynek, Marek, Martin, Bednar, David, Damborský, Jirí
Year of Publication 22.02.2023
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Year of Publication 22.02.2023
Patent