Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice
Lau, Janet, Cheung, Jeanne, Navarro, Armando, Lianoglou, Steve, Haley, Benjamin, Totpal, Klara, Sanders, Laura, Koeppen, Hartmut, Caplazi, Patrick, McBride, Jacqueline, Chiu, Henry, Hong, Rebecca, Grogan, Jane, Javinal, Vincent, Yauch, Robert, Irving, Bryan, Belvin, Marcia, Mellman, Ira, Kim, Jeong M., Schmidt, Maike
Published in Nature communications (21.02.2017)
Published in Nature communications (21.02.2017)
Get full text
Journal Article
Relative Target Affinities of T-Cell-Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model
Mandikian, Danielle, Takahashi, Nene, Lo, Amy A, Li, Ji, Eastham-Anderson, Jeffrey, Slaga, Dionysos, Ho, Jason, Hristopoulos, Maria, Clark, Robyn, Totpal, Klara, Lin, Kedan, Joseph, Sean B, Dennis, Mark S, Prabhu, Saileta, Junttila, Teemu T, Boswell, C Andrew
Published in Molecular cancer therapeutics (01.04.2018)
Published in Molecular cancer therapeutics (01.04.2018)
Get full text
Journal Article
The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors
Hagenbeek, Thijs J, Webster, Joshua D, Kljavin, Noelyn M, Chang, Matthew T, Pham, Trang, Lee, Ho-June, Klijn, Christiaan, Cai, Allen G, Totpal, Klara, Ravishankar, Buvana, Yang, Naiying, Lee, Da-Hye, Walsh, Kevin B, Hatzivassiliou, Georgia, de la Cruz, Cecile C, Gould, Stephen E, Wu, Xiumin, Lee, Wyne P, Yang, Shuqun, Zhang, Zhixiang, Gu, Qingyang, Ji, Qunsheng, Jackson, Erica L, Lim, Dae-Sik, Dey, Anwesha
Published in Science signaling (11.09.2018)
Published in Science signaling (11.09.2018)
Get more information
Journal Article
Avidity-based binding to HER2 results in selective killing of HER2-overexpressing cells by anti-HER2/CD3
Slaga, Dionysos, Ellerman, Diego, Lombana, T Noelle, Vij, Rajesh, Li, Ji, Hristopoulos, Maria, Clark, Robyn, Johnston, Jennifer, Shelton, Amy, Mai, Elaine, Gadkar, Kapil, Lo, Amy A, Koerber, James T, Totpal, Klara, Prell, Rodney, Lee, Genee, Spiess, Christoph, Junttila, Teemu T
Published in Science translational medicine (17.10.2018)
Published in Science translational medicine (17.10.2018)
Get more information
Journal Article
An anti-CD3/anti–CLL-1 bispecific antibody for the treatment of acute myeloid leukemia
Leong, Steven R., Sukumaran, Siddharth, Hristopoulos, Maria, Totpal, Klara, Stainton, Shannon, Lu, Elizabeth, Wong, Alfred, Tam, Lucinda, Newman, Robert, Vuillemenot, Brian R., Ellerman, Diego, Gu, Chen, Mathieu, Mary, Dennis, Mark S., Nguyen, Allen, Zheng, Bing, Zhang, Crystal, Lee, Genee, Chu, Yu-Waye, Prell, Rodney A., Lin, Kedan, Laing, Steven T., Polson, Andrew G.
Published in Blood (02.02.2017)
Published in Blood (02.02.2017)
Get full text
Journal Article
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
Ashkenazi, Avi, Lancaster, Kate, Punnoose, Elizabeth A, Lee, Dori, Pitti, Robert M, Lawrence, David A, Totpal, Klara, Hymowitz, Sarah G, Cavet, Guy, Huw, Ling, Wagner, Klaus W, von Goetz, Melissa, Yee, Sharon Fong, Katta, Viswanatham, Amler, Lukas, Januario, Thomas
Published in Nature medicine (01.09.2007)
Published in Nature medicine (01.09.2007)
Get full text
Journal Article
The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma
Lee, Ho-June, Pham, Trang, Chang, Matthew T, Barnes, Dwight, Cai, Allen G, Noubade, Rajkumar, Totpal, Klara, Chen, Xu, Tran, Christopher, Hagenbeek, Thijs, Wu, Xiumin, Eastham-Anderson, Jeff, Tao, Janet, Lee, Wyne, Bastian, Boris C, Carbone, Michele, Webster, Joshua D, Dey, Anwesha
Published in Cancer research (Chicago, Ill.) (15.04.2020)
Published in Cancer research (Chicago, Ill.) (15.04.2020)
Get full text
Journal Article
Receptor-selective Mutants of Apoptosis-inducing Ligand 2/Tumor Necrosis Factor-related Apoptosis-inducing Ligand Reveal a Greater Contribution of Death Receptor (DR) 5 than DR4 to Apoptosis Signaling
Kelley, Robert F., Totpal, Klara, Lindstrom, Stephanie H., Mathieu, Mary, Billeci, Karen, DeForge, Laura, Pai, Roger, Hymowitz, Sarah G., Ashkenazi, Avi
Published in The Journal of biological chemistry (21.01.2005)
Published in The Journal of biological chemistry (21.01.2005)
Get full text
Journal Article
Tumor-cell resistance to death receptor-induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax
Ashkenazi, Avi, LeBlanc, Heidi, Lawrence, David, Varfolomeev, Eugene, Totpal, Klara, Morlan, John, Schow, Peter, Fong, Sharon, Schwall, Ralph, Sinicropi, Dominick
Published in Nature medicine (01.03.2002)
Published in Nature medicine (01.03.2002)
Get full text
Journal Article
Erlotinib directly inhibits HER2 kinase activation and downstream signaling events in intact cells lacking epidermal growth factor receptor expression
SCHAEFER, Gabriele, LIHUA SHAO, TOTPAL, Klara, AKITA, Robert W
Published in Cancer research (Chicago, Ill.) (01.02.2007)
Published in Cancer research (Chicago, Ill.) (01.02.2007)
Get full text
Journal Article
Preclinical Studies to Predict the Disposition of Apo2L/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Humans: Characterization of in Vivo Efficacy, Pharmacokinetics, and Safety
Kelley, S K, Harris, L A, Xie, D, Deforge, L, Totpal, K, Bussiere, J, Fox, J A
Published in The Journal of pharmacology and experimental therapeutics (01.10.2001)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.10.2001)
Journal Article
Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions
Lawrence, David, Shahrokh, Zahra, Marsters, Scot, Achilles, Kirsten, Shih, Danny, Mounho, Barbara, Hillan, Kenneth, Totpal, Klara, DeForge, Laura, Schow, Peter, Hooley, Jeffrey, Sherwood, Steve, Pai, Roger, Leung, Susan, Khan, Lolo, Gliniak, Brian, Bussiere, Jeanine, Smith, Craig A, Strom, Stephen S, Kelley, Sean, Fox, Judith A, Thomas, Deborah, Ashkenazi, Avi
Published in Nature medicine (01.04.2001)
Published in Nature medicine (01.04.2001)
Get full text
Journal Article
Death-Receptor Activation Halts Clathrin-Dependent Endocytosis
Austin, Cary D., Lawrence, David A., Peden, Andrew A., Varfolomeev, Eugene E., Totpal, Klara, De Mazière, Ann M., Klumperman, Judith, Arnott, David, Pham, Victoria, Scheller, Richard H., Ashkenazi, Avi
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2006)
Get full text
Journal Article
Cooperation of the Agonistic DR5 Antibody Apomab with Chemotherapy to Inhibit Orthotopic Lung Tumor Growth and Improve Survival
Jin, Hongkui, Yang, Renhui, Ross, Jed, Fong, Sharon, Carano, Richard, Totpal, Klara, Lawrence, David, Zheng, Zhong, Koeppen, Hartmut, Stern, Howard, Schwall, Ralph, Ashkenazi, Avi
Published in Clinical cancer research (01.12.2008)
Published in Clinical cancer research (01.12.2008)
Get full text
Journal Article
A Unique Zinc-Binding Site Revealed by a High-Resolution X-ray Structure of Homotrimeric Apo2L/TRAIL
Hymowitz, Sarah G, O'Connell, Mark P, Ultsch, Mark H, Hurst, Amy, Totpal, Klara, Ashkenazi, Avi, de Vos, Abraham M, Kelley, Robert F
Published in Biochemistry (Easton) (01.02.2000)
Published in Biochemistry (Easton) (01.02.2000)
Get full text
Journal Article
Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake
Shang, Yonglei, Mao, Yifan, Batson, Jennifer, Scales, Suzie J, Phillips, Gail, Lackner, Mark R, Totpal, Klara, Williams, Simon, Yang, Jihong, Tang, Zhijun, Modrusan, Zora, Tan, Christine, Liang, Wei-Ching, Tsai, Siao Ping, Vanderbilt, Alexander, Kozuka, Kenji, Hoeflich, Klaus, Tien, Janet, Ross, Sarajane, Li, Congfen, Lee, Sang Hoon, Song, An, Wu, Yan, Stephan, Jean-Philippe, Ashkenazi, Avi, Zha, Jiping
Published in Molecular cancer therapeutics (01.09.2008)
Published in Molecular cancer therapeutics (01.09.2008)
Get full text
Journal Article
Enhanced tumor killing by Apo2L/TRAIL and CPT-11 co-treatment is associated with p21 cleavage and differential regulation of Apo2L/TRAIL ligand and its receptors
HONG XIANG, FOX, Judith A, TOTPAL, Klara, AIKAWA, Mina, DUPREE, Kelly, SINICROPI, Dominick, LOWE, John, ESCANDON, Enrique
Published in Oncogene (16.05.2002)
Published in Oncogene (16.05.2002)
Get full text
Journal Article
CD3 bispecific antibody-induced cytokine release is dispensable for cytotoxic T cell activity
Li, Ji, Piskol, Robert, Ybarra, Ryan, Chen, Ying-Jiun J, Li, Jason, Slaga, Dionysos, Hristopoulos, Maria, Clark, Robyn, Modrusan, Zora, Totpal, Klara, Junttila, Melissa R, Junttila, Teemu T
Published in Science translational medicine (04.09.2019)
Published in Science translational medicine (04.09.2019)
Get more information
Journal Article
Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing
Li, Ji, Stagg, Nicola J., Johnston, Jennifer, Harris, Michael J., Menzies, Sam A., DiCara, Danielle, Clark, Vanessa, Hristopoulos, Maria, Cook, Ryan, Slaga, Dionysos, Nakamura, Rin, McCarty, Luke, Sukumaran, Siddharth, Luis, Elizabeth, Ye, Zhengmao, Wu, Thomas D., Sumiyoshi, Teiko, Danilenko, Dimitry, Lee, Genee Y., Totpal, Klara, Ellerman, Diego, Hötzel, Isidro, James, John R., Junttila, Teemu T.
Published in Cancer cell (13.03.2017)
Published in Cancer cell (13.03.2017)
Get full text
Journal Article
PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer
Oh, Soyoung A, Wu, Dai-Chen, Cheung, Jeanne, Navarro, Armando, Xiong, Huizhong, Cubas, Rafael, Totpal, Klara, Chiu, Henry, Wu, Yan, Comps-Agrar, Laetitia, Leader, Andrew M, Merad, Miriam, Roose-Germa, Merone, Warming, Soren, Yan, Minhong, Kim, Jeong M, Rutz, Sascha, Mellman, Ira
Published in Nature cancer (01.07.2020)
Published in Nature cancer (01.07.2020)
Get more information
Journal Article