Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets
Ohta, Atsushi, Tanada, Mikimasa, Shinohara, Shojiro, Morita, Yuya, Nakano, Kazuhiko, Yamagishi, Yusuke, Takano, Ryusuke, Kariyuki, Shiori, Iida, Takeo, Matsuo, Atsushi, Ozeki, Kazuhisa, Emura, Takashi, Sakurai, Yuuji, Takano, Koji, Higashida, Atsuko, Kojima, Miki, Muraoka, Terushige, Takeyama, Ryuuichi, Kato, Tatsuya, Kimura, Kaori, Ogawa, Kotaro, Ohara, Kazuhiro, Tanaka, Shota, Kikuchi, Yasufumi, Hisada, Nozomi, Hayashi, Ryuji, Nishimura, Yoshikazu, Nomura, Kenichi, Tachibana, Tatsuhiko, Irie, Machiko, Kawada, Hatsuo, Torizawa, Takuya, Murao, Naoaki, Kotake, Tomoya, Tanaka, Masahiko, Ishikawa, Shiho, Miyake, Taiji, Tamiya, Minoru, Arai, Masako, Chiyoda, Aya, Akai, Sho, Sase, Hitoshi, Kuramoto, Shino, Ito, Toshiya, Shiraishi, Takuya, Kojima, Tetsuo, Iikura, Hitoshi
Published in Journal of the American Chemical Society (08.11.2023)
Published in Journal of the American Chemical Society (08.11.2023)
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Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802)
Kinoshita, Kazutomo, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Miyagi, Takuho, Kobayashi, Takamitsu, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Bioorganic & medicinal chemistry (01.02.2012)
Published in Bioorganic & medicinal chemistry (01.02.2012)
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Structural and functional characterization of aspartate racemase from the acidothermophilic archaeon Picrophilus torridus
Aihara, Takayuki, Ito, Toshiya, Yamanaka, Yasuaki, Noguchi, Keiichi, Odaka, Masafumi, Sekine, Masae, Homma, Hiroshi, Yohda, Masafumi
Published in Extremophiles : life under extreme conditions (01.07.2016)
Published in Extremophiles : life under extreme conditions (01.07.2016)
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Enantioselective Total Synthesis of (−)-Erinacine B
Watanabe, Hideaki, Takano, Masashi, Umino, Akinori, Ito, Toshiya, Ishikawa, Hiroyuki, Nakada, Masahisa
Published in Organic letters (18.01.2007)
Published in Organic letters (18.01.2007)
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Journal Article
Discovery of CH7057288 as an Orally Bioavailable, Selective, and Potent pan-TRK Inhibitor
Ito, Toshiya, Kinoshita, Kazutomo, Tomizawa, Masaki, Shinohara, Shojiro, Nishii, Hiroki, Matsushita, Masayuki, Hattori, Kazuo, Kohchi, Yasunori, Kohchi, Masami, Hayase, Tadakatsu, Watanabe, Fumio, Hasegawa, Kiyoshi, Tanaka, Hiroshi, Kuramoto, Shino, Takanashi, Kenji, Oikawa, Nobuhiro
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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Structure-activity relationships of middle-size cyclic peptides, KRAS inhibitors derived from an mRNA display
Kage, Mirai, Hayashi, Ryuji, Matsuo, Atsushi, Tamiya, Minoru, Kuramoto, Shino, Ohara, Kazuhiro, Irie, Machiko, Chiyoda, Aya, Takano, Koji, Ito, Toshiya, Kotake, Tomoya, Takeyama, Ryuuichi, Ishikawa, Shiho, Nomura, Kenichi, Furuichi, Noriyuki, Morita, Yuya, Hashimoto, Satoshi, Kawada, Hatsuo, Nishimura, Yoshikazu, Nii, Keiji, Sase, Hitoshi, Ohta, Atsushi, Kojima, Tetsuo, Iikura, Hitoshi, Tanada, Mikimasa, Shiraishi, Takuya
Published in Bioorganic & medicinal chemistry (01.08.2024)
Published in Bioorganic & medicinal chemistry (01.08.2024)
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Development of a Scalable Manufacturing Process for Alectinib with a Concise Preparation of the Indole-Containing Tetracyclic Core
Oki, Tomohiro, Tsukazaki, Masao, Shiina, Junichi, Fukuda, Hiroshi, Yamawaki, Minoru, Kito, Yasushi, Ishizawa, Takenori, Kinoshita, Kazutomo, Hara, Sosuke, Furuichi, Noriyuki, Kawada, Hatsuo, Ito, Toshiya, Tanaka, Kota, Maruyama, Noriaki, Tamaru, Daisuke, Ichige, Takahiro, Koizumi, Masatoshi, Hosoya, Yosuke, Kimura, Masahiro, Yamaguchi, Mami, Sato, Shigeki, Miyazaki, Yuta, Toya, Azusa, Iwamura, Hiroshi, Maeda, Kenji
Published in Organic process research & development (22.10.2024)
Published in Organic process research & development (22.10.2024)
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Penetration of Oral Fluconazole into Gynecological Tissues
MIKAMO, H, KAWAZOE, K, SATO, Y, IZUMI, K, ITO, T, ITO, K, TAMAYA, T
Published in Antimicrobial Agents and Chemotherapy (01.01.1999)
Published in Antimicrobial Agents and Chemotherapy (01.01.1999)
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Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor
Tanada, Mikimasa, Tamiya, Minoru, Matsuo, Atsushi, Chiyoda, Aya, Takano, Koji, Ito, Toshiya, Irie, Machiko, Kotake, Tomoya, Takeyama, Ryuuichi, Kawada, Hatsuo, Hayashi, Ryuji, Ishikawa, Shiho, Nomura, Kenichi, Furuichi, Noriyuki, Morita, Yuya, Kage, Mirai, Hashimoto, Satoshi, Nii, Keiji, Sase, Hitoshi, Ohara, Kazuhiro, Ohta, Atsushi, Kuramoto, Shino, Nishimura, Yoshikazu, Iikura, Hitoshi, Shiraishi, Takuya
Published in Journal of the American Chemical Society (02.08.2023)
Published in Journal of the American Chemical Society (02.08.2023)
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Journal Article
9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors
Kinoshita, Kazutomo, Kobayashi, Takamitsu, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Hattori, Kazuo, Miyagi, Takuho, Hong, Woo-Sang, Park, Min-Jeong, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Journal of medicinal chemistry (22.09.2011)
Published in Journal of medicinal chemistry (22.09.2011)
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Journal Article
Correction to Enantioselective Total Synthesis of (−)-Erinacine B
Watanabe, Hideaki, Takano, Masashi, Umino, Akinori, Ito, Toshiya, Ishikawa, Hiroyuki, Nakada, Masahisa
Published in Organic letters (07.03.2014)
Published in Organic letters (07.03.2014)
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Journal Article
Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors
Kinoshita, Kazutomo, Ono, Yoshiyuki, Emura, Takashi, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Tanaka, Shota, Morikami, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Journal Article
9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5 H -benzo[ b ]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors
Kinoshita, Kazutomo, Kobayashi, Takamitsu, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Hattori, Kazuo, Miyagi, Takuho, Hong, Woo-Sang, Park, Min-Jeong, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Journal of medicinal chemistry (22.09.2011)
Published in Journal of medicinal chemistry (22.09.2011)
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Journal Article
Histopathological Case of Uterine Carcinoid Tumor Metastasized to the Lung
TOSHIMA, Satoshi, YASUDA, Yo, ARAI, Tadashi, ITO, Yuji, HAYAKAWA, Kazuyoshi, TAKAYA, Tadatake, DOI, Momoe, SHIBUYA, Chiken, ITO, Toshiya, KASHIKI, Yoshitomo, YOSHIMI, Naoki
Published in JOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE (1999)
Published in JOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE (1999)
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