Exploitation of Castration-Resistant Prostate Cancer Transcription Factor Dependencies by the Novel BET Inhibitor ABBV-075
Faivre, Emily J, Wilcox, Denise, Lin, Xiaoyu, Hessler, Paul, Torrent, Maricel, He, Wei, Uziel, Tamar, Albert, Daniel H, McDaniel, Keith, Kati, Warren, Shen, Yu
Published in Molecular cancer research (01.01.2017)
Published in Molecular cancer research (01.01.2017)
Get full text
Journal Article
Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315
Jakob, Clarissa G, Upadhyay, Anup K, Donner, Pamela L, Nicholl, Emily, Addo, Sadiya N, Qiu, Wei, Ling, Christopher, Gopalakrishnan, Sujatha M, Torrent, Maricel, Cepa, Steven P, Shanley, Jason, Shoemaker, Alexander R, Sun, Chaohong C, Vasudevan, Anil, Woller, Kevin R, Shotwell, J. Brad, Shaw, Bailin, Bian, Zhiguo, Hutti, Jessica E
Published in Journal of medicinal chemistry (09.08.2018)
Published in Journal of medicinal chemistry (09.08.2018)
Get full text
Journal Article
SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding
Curtin, Michael L., Pliushchev, Marina A., Li, Huan-Qiu, Torrent, Maricel, Dietrich, Justin D., Jakob, Clarissa G., Zhu, Haizhong, Zhao, Hongyu, Wang, Ying, Ji, Zhiqin, Clark, Richard F., Sarris, Kathy A., Selvaraju, Sujatha, Shaw, Bailin, Algire, Mikkel A., He, Yupeng, Richardson, Paul L., Sweis, Ramzi F., Sun, Chaohong, Chiang, Gary G., Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry letters (01.04.2017)
Published in Bioorganic & medicinal chemistry letters (01.04.2017)
Get full text
Journal Article
Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP
Cox, Christopher D., Breslin, Michael J., Mariano, Brenda J., Coleman, Paul J., Buser, Carolyn A., Walsh, Eileen S., Hamilton, Kelly, Huber, Hans E., Kohl, Nancy E., Torrent, Maricel, Yan, Youwei, Kuo, Laurence C., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
Get full text
Journal Article
Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP
Rickert, Keith W., Schaber, Michael, Torrent, Maricel, Neilson, Lou Anne, Tasber, Edward S., Garbaccio, Robert, Coleman, Paul J., Harvey, Diane, Zhang, Yun, Yang, Yi, Marshall, Gary, Lee, Ling, Walsh, Eileen S., Hamilton, Kelly, Buser, Carolyn A.
Published in Archives of biochemistry and biophysics (15.01.2008)
Published in Archives of biochemistry and biophysics (15.01.2008)
Get full text
Journal Article
Effects of the Protein Environment on the Structure and Energetics of Active Sites of Metalloenzymes. ONIOM Study of Methane Monooxygenase and Ribonucleotide Reductase
Torrent, Maricel, Vreven, Thom, Musaev, Djamaladdin G, Morokuma, Keiji, Farkas, Ödön, Schlegel, H. Bernhard
Published in Journal of the American Chemical Society (16.01.2002)
Published in Journal of the American Chemical Society (16.01.2002)
Get full text
Journal Article
WD40 repeat domain proteins: a novel target class?
Schapira, Matthieu, Tyers, Mike, Torrent, Maricel, Arrowsmith, Cheryl H
Published in Nature reviews. Drug discovery (01.11.2017)
Published in Nature reviews. Drug discovery (01.11.2017)
Get full text
Journal Article
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
Lasko, Loren M, Jakob, Clarissa G, Edalji, Rohinton P, Qiu, Wei, Montgomery, Debra, Digiammarino, Enrico L, Hansen, T Matt, Risi, Roberto M, Frey, Robin, Manaves, Vlasios, Shaw, Bailin, Algire, Mikkel, Hessler, Paul, Lam, Lloyd T, Uziel, Tamar, Faivre, Emily, Ferguson, Debra, Buchanan, Fritz G, Martin, Ruth L, Torrent, Maricel, Chiang, Gary G, Karukurichi, Kannan, Langston, J William, Weinert, Brian T, Choudhary, Chunaram, de Vries, Peter, Van Drie, John H, McElligott, David, Kesicki, Ed, Marmorstein, Ronen, Sun, Chaohong, Cole, Philip A, Rosenberg, Saul H, Michaelides, Michael R, Lai, Albert, Bromberg, Kenneth D
Published in Nature (London) (05.10.2017)
Published in Nature (London) (05.10.2017)
Get full text
Journal Article
Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer
Faivre, Emily J, McDaniel, Keith F, Albert, Daniel H, Mantena, Srinivasa R, Plotnik, Joshua P, Wilcox, Denise, Zhang, Lu, Bui, Mai H, Sheppard, George S, Wang, Le, Sehgal, Vasudha, Lin, Xiaoyu, Huang, Xiaoli, Lu, Xin, Uziel, Tamar, Hessler, Paul, Lam, Lloyd T, Bellin, Richard J, Mehta, Gaurav, Fidanze, Steve, Pratt, John K, Liu, Dachun, Hasvold, Lisa A, Sun, Chaohong, Panchal, Sanjay C, Nicolette, John J, Fossey, Stacey L, Park, Chang H, Longenecker, Kenton, Bigelow, Lance, Torrent, Maricel, Rosenberg, Saul H, Kati, Warren M, Shen, Yu
Published in Nature (London) (13.02.2020)
Published in Nature (London) (13.02.2020)
Get full text
Journal Article
Mechanisms for the formation of epoxide and chlorine-containing products in the oxidation of ethylene by chromyl chloride: a density functional study
Torrent, Maricel, Deng, Liqun, Duran, Miquel, Solà, Miquel, Ziegler, Tom
Published in Canadian journal of chemistry (01.09.1999)
Published in Canadian journal of chemistry (01.09.1999)
Get full text
Journal Article
Discovery of N‑Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo‑1H‑pyrrolo[2,3‑c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain
Sheppard, George S, Wang, Le, Fidanze, Steven D, Hasvold, Lisa A, Liu, Dachun, Pratt, John K, Park, Chang H, Longenecker, Kenton, Qiu, Wei, Torrent, Maricel, Kovar, Peter J, Bui, Mai, Faivre, Emily, Huang, Xiaoli, Lin, Xiaoyu, Wilcox, Denise, Zhang, Lu, Shen, Yu, Albert, Daniel H, Magoc, Terrance J, Rajaraman, Ganesh, Kati, Warren M, McDaniel, Keith F
Published in Journal of medicinal chemistry (28.05.2020)
Published in Journal of medicinal chemistry (28.05.2020)
Get full text
Journal Article
Discovery of N -Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1 H -pyrrolo[2,3- c ]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain
Sheppard, George S, Wang, Le, Fidanze, Steven D, Hasvold, Lisa A, Liu, Dachun, Pratt, John K, Park, Chang H, Longenecker, Kenton, Qiu, Wei, Torrent, Maricel, Kovar, Peter J, Bui, Mai, Faivre, Emily, Huang, Xiaoli, Lin, Xiaoyu, Wilcox, Denise, Zhang, Lu, Shen, Yu, Albert, Daniel H, Magoc, Terrance J, Rajaraman, Ganesh, Kati, Warren M, McDaniel, Keith F
Published in Journal of medicinal chemistry (28.05.2020)
Published in Journal of medicinal chemistry (28.05.2020)
Get full text
Journal Article
WD-repeat domain proteins: a novel target class?
Schapira, Matthieu, Tyers, Mike, Torrent, Maricel, Arrowsmith, Cheryl H.
Published in Nature reviews. Drug discovery (13.10.2017)
Published in Nature reviews. Drug discovery (13.10.2017)
Get full text
Journal Article
The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex
He, Yupeng, Selvaraju, Sujatha, Curtin, Michael L, Jakob, Clarissa G, Zhu, Haizhong, Comess, Kenneth M, Shaw, Bailin, The, Juliana, Lima-Fernandes, Evelyne, Szewczyk, Magdalena M, Cheng, Dong, Klinge, Kelly L, Li, Huan-Qiu, Pliushchev, Marina, Algire, Mikkel A, Maag, David, Guo, Jun, Dietrich, Justin, Panchal, Sanjay C, Petros, Andrew M, Sweis, Ramzi F, Torrent, Maricel, Bigelow, Lance J, Senisterra, Guillermo, Li, Fengling, Kennedy, Steven, Wu, Qin, Osterling, Donald J, Lindley, David J, Gao, Wenqing, Galasinski, Scott, Barsyte-Lovejoy, Dalia, Vedadi, Masoud, Buchanan, Fritz G, Arrowsmith, Cheryl H, Chiang, Gary G, Sun, Chaohong, Pappano, William N
Published in Nature chemical biology (01.04.2017)
Published in Nature chemical biology (01.04.2017)
Get full text
Journal Article