A structurally engineered fatty acid, icosabutate, suppresses liver inflammation and fibrosis in NASH
Fraser, David A., Wang, Xiaoyu, Lund, Jenny, Nikolić, Nataša, Iruarrizaga-Lejarreta, Marta, Skjaeret, Tore, Alonso, Cristina, Kastelein, John J.P., Rustan, Arild C., Kim, Yong Ook, Schuppan, Detlef
Published in Journal of hepatology (01.04.2022)
Published in Journal of hepatology (01.04.2022)
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Dual targeting of hepatic fibrosis and atherogenesis by icosabutate, an engineered eicosapentaenoic acid derivative
Stokman, Geurt, Hoek, Anita M., Denker Thorbekk, Ditte, Pieterman, Elsbet J., Skovgård Veidal, Sanne, Basta, Brittany, Iruarrizaga‐Lejarreta, Marta, Hoorn, José W., Verschuren, Lars, Berbée, Jimmy F. P., Rensen, Patrick C. N., Skjæret, Tore, Alonso, Cristina, Feigh, Michael, Kastelein, John J. P., Friedman, Scott L., Princen, Hans M. G., Fraser, David A.
Published in Liver international (01.11.2020)
Published in Liver international (01.11.2020)
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Icosabutate Exerts Beneficial Effects Upon Insulin Sensitivity, Hepatic Inflammation, Lipotoxicity, and Fibrosis in Mice
Hoek, Anita M., Pieterman, Elsbet J., Hoorn, José W., Iruarrizaga‐Lejarreta, Marta, Alonso, Cristina, Verschuren, Lars, Skjæret, Tore, Princen, Hans M.G., Fraser, David A.
Published in Hepatology communications (01.02.2020)
Published in Hepatology communications (01.02.2020)
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Su101 STRUCTURALLY ENGINEERED FATTY ACID SEFA-1024 ALLEVIATES COLITIS IN MICE BY RESTORING INTESTINAL MUCOSAL BARRIER FUNCTION
Matzner, Johannes, Pickert, Geethanjali, Fittler, Nicola J., Skjaeret, Tore, Fraser, David A., Schuppan, Detlef
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2021)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2021)
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Su1087 A GUT-TARGETED EICOSAPENTAENOIC ACID DERIVATIVE, SEFA-1024, AMELIORATES DEXTRAN SODIUM SULFATE (DSS)-INDUCED INTESTINAL INFLAMMATION
Matzner, Johannes, Pickert, Geethanjali, Thies, Dorothe, Skjaeret, Tore, Fraser, David A., Schuppan, Detlef
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2020)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2020)
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Decline in NASH and atherosclerosis-associated oxidised phospholipids and 7-ketocholesterol in response to icosabutate therapy
Fraser, David A., Schuppan, Detlef, Kim, Yong Ook, Alonso, Cristina, Iruarrizaga-Lejarreta, Marta, Wang, Xiaoyu, Kastelein, John, Skjaeret, Tore
Published in Journal of hepatology (01.08.2020)
Published in Journal of hepatology (01.08.2020)
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FRI089 - Decline in NASH and atherosclerosis-associated oxidised phospholipids and 7-ketocholesterol in response to icosabutate therapy
Fraser, David A., Schuppan, Detlef, Kim, Yong Ook, Alonso, Cristina, Iruarrizaga-Lejarreta, Marta, Wang, Xiaoyu, Kastelein, John, Skjaeret, Tore
Published in Journal of hepatology (01.08.2020)
Published in Journal of hepatology (01.08.2020)
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SAT-346-Icosabutate induces a potent reduction in hepatic oxidative stress in rodent models of metabolic stress and fibrosing NASH
Fraser, David A., Schuppan, Detlef, Wang, Xiao-Yu, Feigh, Michael, Thorbek, Ditte Denker, Alonso, Cristina, Iruarrizaga-Lejarreta, Marta, Nikolić, Nataša, Rustan, Arild, Skjaeret, Tore
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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LBP-10-A structurally engineered fatty acid, icosabutate, rapidly normalises elevated plasma ALTand gamma-glutamyl transferase (GGT) concentrations in a study population at high risk of NAFLD/NASH
Fraser, David A., Wang, Xiao-Yu, Iruarrizaga-Lejarreta, Marta, Thorbek, Ditte Denker, Skjaeret, Tore, Feigh, Michael, Alonso, Cristina, Kastelein, John, Schuppan, Detlef
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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Preparation of oxo-substituted α-chloro ethers and their reaction with samarium diiodide
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Web Resource
Abstract 11889: Phase Ib Study of Icosabutate, a Novel Structurally Enhanced Fatty Acid, in Subjects With Hypercholesterolemia
Qin, Yan, Hallén, Jonas, Skjæret, Tore, Odden, Erling, Fraser, David, Nyheim, Hilde, Cornelissen, Karen, Chiesa, Joseph, Hustvedt, Svein Olaf
Published in Circulation (New York, N.Y.) (25.11.2014)
Published in Circulation (New York, N.Y.) (25.11.2014)
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