Cystine–glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity
Arensman, Michael D., Yang, Xiaoran S., Leahy, Danielle M., Toral-Barza, Lourdes, Mileski, Mary, Rosfjord, Edward C., Wang, Fang, Deng, Shibing, Myers, Jeremy S., Abraham, Robert T., Eng, Christina H.
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2019)
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Journal Article
Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy
Eng, Christina H., Wang, Zuncai, Tkach, Diane, Toral-Barza, Lourdes, Ugwonali, Savuth, Liu, Shanming, Fitzgerald, Stephanie L., George, Elizabeth, Frias, Elizabeth, Cochran, Nadire, De Jesus, Rowena, McAllister, Gregory, Hoffman, Gregory R., Bray, Kevin, Lemon, LuAnna, Lucas, Judy, Fantin, Valeria R., Abraham, Robert T., Murphy, Leon O., Nyfeler, Beat
Published in Proceedings of the National Academy of Sciences - PNAS (05.01.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (05.01.2016)
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Journal Article
Requirement of the mTOR Kinase for the Regulation of Maf1 Phosphorylation and Control of RNA Polymerase III-dependent Transcription in Cancer Cells
Shor, Boris, Wu, Jiang, Shakey, Quazi, Toral-Barza, Lourdes, Shi, Celine, Follettie, Max, Yu, Ker
Published in The Journal of biological chemistry (14.05.2010)
Published in The Journal of biological chemistry (14.05.2010)
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Journal Article
Biochemical, Cellular, and In vivo Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin
KER YU, TORAL-BARZA, Lourdes, COLE, Derek C, ELLINGBOE, John, AYRAL-KALOUSTIAN, Semiramis, MANSOUR, Tarek S, GIBBONS, James J, ABRAHAM, Robert T, NOWAK, Pawel, ZASK, Arie, SHI, Celine, ZHANG, Wei-Guo, LUCAS, Judy, SHOR, Boris, KIM, Jamie, VERHEIJEN, Jeroen, CURRAN, Kevin, MALWITZ, David J
Published in Cancer research (Chicago, Ill.) (01.08.2009)
Published in Cancer research (Chicago, Ill.) (01.08.2009)
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Journal Article
Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2
KER YU, SHI, Celine, SUNG KYOO KIM, CONANT, Roger, CURRAN, Kevin, KAPLAN, Joshua, VERHEIJEN, Jeroen, AYRAL-KALOUSTIAN, Semiramis, MANSOUR, Tarek S, ABRAHAM, Robert T, ZASK, Arie, GIBBONS, James J, TORAL-BARZA, Lourdes, LUCAS, Judy, SHOR, Boris, JAE EUN KIM, ZHANG, Wei-Guo, MAHONEY, Robert, GAYDOS, Christine, TARDIO, Luanna
Published in Cancer research (Chicago, Ill.) (15.01.2010)
Published in Cancer research (Chicago, Ill.) (15.01.2010)
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Journal Article
A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis
Shor, Boris, Zhang, Wei-Guo, Toral-Barza, Lourdes, Lucas, Jessica, Abraham, Robert T, Gibbons, James J, Yu, Ker
Published in Cancer research (Chicago, Ill.) (15.04.2008)
Published in Cancer research (Chicago, Ill.) (15.04.2008)
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Journal Article
Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)
KAPLAN, Joshua, VERHEIJEN, Jeroen C, BROOIJMANS, Natasja, TORAL-BARZA, Lourdes, HOLLANDER, Irwin, YU, Ker, ZASK, Arie
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Pyranonaphthoquinone Lactones: A New Class of AKT Selective Kinase Inhibitors Alkylate a Regulatory Loop Cysteine
Salaski, Edward J, Krishnamurthy, Girija, Ding, Wei-Dong, Yu, Ker, Insaf, Shabana S, Eid, Clark, Shim, Jaechul, Levin, Jeremy I, Tabei, Keiko, Toral-Barza, Lourdes, Zhang, Wei-Guo, McDonald, Leonard A, Honores, Erick, Hanna, Cilien, Yamashita, Ayako, Johnson, Bernard, Li, Zhong, Laakso, Leif, Powell, Dennis, Mansour, Tarek S
Published in Journal of medicinal chemistry (23.04.2009)
Published in Journal of medicinal chemistry (23.04.2009)
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Journal Article
Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines
Toral-Barza, Lourdes, Zhang, Wei-Guo, Huang, Xinyi, McDonald, Leonard A, Salaski, Edward J, Barbieri, Laurel R, Ding, Wei-Dong, Krishnamurthy, Girija, Hu, Yong Bo, Lucas, Judy, Bernan, Valerie S, Cai, Ping, Levin, Jeremy I, Mansour, Tarek S, Gibbons, James J, Abraham, Robert T, Yu, Ker
Published in Molecular cancer therapeutics (01.11.2007)
Published in Molecular cancer therapeutics (01.11.2007)
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Journal Article
PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors
Yu, Ker, Lucas, Judy, Zhu, Tianmin, Zask, Arie, Gaydos, Christine, Toral-Barza, Lourdes, Gu, Jianxin, Li, Fangbiao, Chaudhary, Inder, Cai, Ping, Lotvin, Jason, Petersen, Roseann, Ruppen, Mark, Fawzi, Mahdi, Ayral-Kaloustian, Semiramis, Skotnicki, Jerauld, Mansour, Tarek, Frost, Philip, Gibbons, James
Published in Cancer biology & therapy (01.05.2005)
Published in Cancer biology & therapy (01.05.2005)
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Journal Article
mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer
Chen, Yaqing, Qian, Jianchang, He, Qun, Zhao, Hui, Toral-Barza, Lourdes, Shi, Celine, Zhang, Xuesai, Wu, Jiang, Yu, Ker
Published in Oncotarget (03.05.2016)
Published in Oncotarget (03.05.2016)
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Journal Article
Morpholine Derivatives Greatly Enhance the Selectivity of Mammalian Target of Rapamycin (mTOR) Inhibitors
Zask, Arie, Kaplan, Joshua, Verheijen, Jeroen C, Richard, David J, Curran, Kevin, Brooijmans, Natasja, Bennett, Eric M, Toral-Barza, Lourdes, Hollander, Irwin, Ayral-Kaloustian, Semiramis, Yu, Ker
Published in Journal of medicinal chemistry (24.12.2009)
Published in Journal of medicinal chemistry (24.12.2009)
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Journal Article
Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabicyclo[3.2.1 ]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K
VERHEIJEN, Jeroen C, YU, Ker, TORAL-BARZA, Lourdes, HOLLANDER, Irwin, ZASK, Arie
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines
Zask, Arie, Verheijen, Jeroen C, Curran, Kevin, Kaplan, Joshua, Richard, David J, Nowak, Pawel, Malwitz, David J, Brooijmans, Natasja, Bard, Joel, Svenson, Kristine, Lucas, Judy, Toral-Barza, Lourdes, Zhang, Wei-Guo, Hollander, Irwin, Gibbons, James J, Abraham, Robert T, Ayral-Kaloustian, Semiramis, Mansour, Tarek S, Yu, Ker
Published in Journal of medicinal chemistry (27.08.2009)
Published in Journal of medicinal chemistry (27.08.2009)
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Journal Article
Discovery of 2-arylthieno[3,2- d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K
Verheijen, Jeroen C., Yu, Ker, Toral-Barza, Lourdes, Hollander, Irwin, Zask, Arie
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): Optimization of the 1-substituent
Curran, Kevin J., Verheijen, Jeroen C., Kaplan, Joshua, Richard, David J., Toral-Barza, Lourdes, Hollander, Irwin, Lucas, Judy, Ayral-Kaloustian, Semiramis, Yu, Ker, Zask, Arie
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
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Journal Article
Discovery of 4-Morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as Highly Potent and Selective ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin (mTOR): Optimization of the 6-Aryl Substituent
Verheijen, Jeroen C, Richard, David J, Curran, Kevin, Kaplan, Joshua, Lefever, Mark, Nowak, Pawel, Malwitz, David J, Brooijmans, Natasja, Toral-Barza, Lourdes, Zhang, Wei-Guo, Lucas, Judy, Hollander, Irwin, Ayral-Kaloustian, Semiramis, Mansour, Tarek S, Yu, Ker, Zask, Arie
Published in Journal of medicinal chemistry (24.12.2009)
Published in Journal of medicinal chemistry (24.12.2009)
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Journal Article
Discovery of 2-ureidophenyltriazines bearing bridged morpholines as potent and selective ATP-competitive mTOR inhibitors
Zask, Arie, Verheijen, Jeroen C., Richard, David J., Kaplan, Joshua, Curran, Kevin, Toral-Barza, Lourdes, Lucas, Judy, Hollander, Irwin, Yu, Ker
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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Journal Article