Natural Occurring and Engineered Enzymes for Peptide Ligation and Cyclization
Nuijens, Timo, Toplak, Ana, Schmidt, Marcel, Ricci, Antonio, Cabri, Walter
Published in Frontiers in chemistry (29.11.2019)
Published in Frontiers in chemistry (29.11.2019)
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Journal Article
Omniligase‐1: A Powerful Tool for Peptide Head‐to‐Tail Cyclization
Schmidt, Marcel, Toplak, Ana, Quaedflieg, Peter J. L. M., Ippel, Hans, Richelle, Gaston J. J., Hackeng, Tilman M., van Maarseveen, Jan H., Nuijens, Timo
Published in Advanced synthesis & catalysis (19.06.2017)
Published in Advanced synthesis & catalysis (19.06.2017)
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Journal Article
Engineering a Diverse Ligase Toolbox for Peptide Segment Condensation
Nuijens, Timo, Toplak, Ana, Quaedflieg, Peter J. L. M, Drenth, Jeroen, Wu, Bian, Janssen, Dick B.
Published in Advanced synthesis & catalysis (22.12.2016)
Published in Advanced synthesis & catalysis (22.12.2016)
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Journal Article
Efficient Enzymatic Cyclization of Disulfide‐Rich Peptides by Using Peptide Ligases
Schmidt, Marcel, Huang, Yen‐Hua, Texeira de Oliveira, Eduardo F., Toplak, Ana, Wijma, Hein J., Janssen, Dick B., van Maarseveen, Jan H., Craik, David J., Nuijens, Timo
Published in Chembiochem : a European journal of chemical biology (14.06.2019)
Published in Chembiochem : a European journal of chemical biology (14.06.2019)
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Journal Article
Improved solid phase synthesis of peptide carboxyamidomethyl (Cam) esters for enzymatic segment condensation
Nuijens, Timo, Toplak, Ana, van de Meulenreek, Mathijs B.A.C., Schmidt, Marcel, Goldbach, Michel, Quaedflieg, Peter J.L.M.
Published in Tetrahedron letters (10.08.2016)
Published in Tetrahedron letters (10.08.2016)
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Journal Article
Proteolysin, a Novel Highly Thermostable and Cosolvent-Compatible Protease from the Thermophilic Bacterium Coprothermobacter proteolyticus
TOPLAK, Ana, BIAN WU, FUSETTI, Fabrizia, QUAEDFLIEG, Peter J. L. M, JANSSEN, Dick B
Published in Applied and Environmental Microbiology (01.09.2013)
Published in Applied and Environmental Microbiology (01.09.2013)
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Journal Article
From thiol-subtilisin to omniligase: Design and structure of a broadly applicable peptide ligase
Toplak, Ana, Teixeira de Oliveira, Eduardo F., Schmidt, Marcel, Rozeboom, Henriëtte J., Wijma, Hein J., Meekels, Linda K.M., de Visser, Rowin, Janssen, Dick B., Nuijens, Timo
Published in Computational and structural biotechnology journal (01.01.2021)
Published in Computational and structural biotechnology journal (01.01.2021)
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Journal Article
Enzyme-mediated ligation technologies for peptides and proteins
Schmidt, Marcel, Toplak, Ana, Quaedflieg, Peter JLM, Nuijens, Timo
Published in Current opinion in chemical biology (01.06.2017)
Published in Current opinion in chemical biology (01.06.2017)
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Journal Article
Sustainable, cost-efficient manufacturing of therapeutic peptides using chemo-enzymatic peptide synthesis (CEPS)
Pawlas, Jan, Nuijens, Timo, Persson, Jonas, Svensson, Thomas, Schmidt, Marcel, Toplak, Ana, Nilsson, Mikael, Rasmussen, Jon H
Published in Green chemistry : an international journal and green chemistry resource : GC (2019)
Published in Green chemistry : an international journal and green chemistry resource : GC (2019)
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Journal Article
A Sustainable Chemo-Enzymatic Approach to the Synthesis of Liraglutide
Rizzo, Silvia, Toplak, Ana, Macis, Marco, Ferrazzano, Lucia, Ricci, Antonio, Tolomelli, Alessandra, Cabri, Walter
Published in ACS sustainable chemistry & engineering (11.11.2024)
Published in ACS sustainable chemistry & engineering (11.11.2024)
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Journal Article
Design of a substrate-tailored peptiligase variant for the efficient synthesis of thymosin-alpha(1)
Schmidt, Marcel, Toplak, Ana, Rozeboom, Henriette J., Wijma, Hein J., Quaedflieg, Peter J. L. M., van Maarseveen, Jan H., Janssen, Dick B., Nuijens, Timo
Published in Organic & biomolecular chemistry (28.01.2018)
Published in Organic & biomolecular chemistry (28.01.2018)
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Journal Article
Design of a substrate-tailored peptiligase variant for the efficient synthesis of thymosin-α1
Schmidt, Marcel, Toplak, Ana, Rozeboom, Henriëtte J, Wijma, Hein J, Peter J L M Quaedflieg, van Maarseveen, Jan H, Janssen, Dick B, Nuijens, Timo
Published in Organic & biomolecular chemistry (2018)
Published in Organic & biomolecular chemistry (2018)
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Journal Article
서브틸리신 변이체 및 그의 용도
CABRI WALTER, WALLRAVEN KERSTIN, RICCI ANTONIO, MATEMAN JURGEN, DE VISSER ROWIN, NUIJENS TIMO, WIJKER ELVIRA, TOPLAK ANA
Year of Publication 13.10.2023
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Year of Publication 13.10.2023
Patent
Peptide synthesis in neat organic solvents with novel thermostable proteases
Toplak, Ana, Nuijens, Timo, Quaedflieg, Peter J.L.M., Wu, Bian, Janssen, Dick B.
Published in Enzyme and microbial technology (01.06.2015)
Published in Enzyme and microbial technology (01.06.2015)
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Journal Article
Design of a substrate-tailored peptiligase variant for the efficient synthesis of thymosin-α1Electronic supplementary information (ESI) available: Experimental details and supplementary results. See DOI: 10.1039/c7ob02812a
Schmidt, Marcel, Toplak, Ana, Rozeboom, Henriëtte J, Wijma, Hein J, Quaedflieg, Peter J. L. M, van Maarseveen, Jan H, Janssen, Dick B, Nuijens, Timo
Year of Publication 24.01.2018
Year of Publication 24.01.2018
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Journal Article
Novel hybrid molecules based on 15-membered azalide as potential antimalarial agents
Starčević, Kristina, Pešić, Dijana, Toplak, Ana, Landek, Goran, Alihodžić, Sulejman, Herreros, Esperanza, Ferrer, Santiago, Spaventi, Radan, Perić, Mihaela
Published in European journal of medicinal chemistry (01.03.2012)
Published in European journal of medicinal chemistry (01.03.2012)
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Journal Article