A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism
Turner, Nigel, Lim, Xin Ying, Toop, Hamish D., Osborne, Brenna, Brandon, Amanda E., Taylor, Elysha N., Fiveash, Corrine E., Govindaraju, Hemna, Teo, Jonathan D., McEwen, Holly P., Couttas, Timothy A., Butler, Stephen M., Das, Abhirup, Kowalski, Greg M., Bruce, Clinton R., Hoehn, Kyle L., Fath, Thomas, Schmitz-Peiffer, Carsten, Cooney, Gregory J., Montgomery, Magdalene K., Morris, Jonathan C., Don, Anthony S.
Published in Nature communications (21.08.2018)
Published in Nature communications (21.08.2018)
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Journal Article
MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity
Li, Jing Jing, MS, Tay, Hock L., PhD, Maltby, Steven, PhD, Xiang, Yang, PhD, Eyers, Fiona, BSci, Hatchwell, Luke, B Biomed Sci, Zhou, Hong, BMed, Toop, Hamish D., BSci(Hons), Morris, Jonathan C., PhD, Nair, Parameswaran, MD, PhD, Mattes, Joerg, MD, PhD, Foster, Paul S., PhD, DSc, Yang, Ming, PhD
Published in Journal of allergy and clinical immunology (01.08.2015)
Published in Journal of allergy and clinical immunology (01.08.2015)
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Journal Article
Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease
Batson, Jennifer, Toop, Hamish D, Redondo, Clara, Babaei-Jadidi, Roya, Chaikuad, Apirat, Wearmouth, Stephen F, Gibbons, Brian, Allen, Claire, Tallant, Cynthia, Zhang, Jingxue, Du, Chunyun, Hancox, Jules C, Hawtrey, Tom, Da Rocha, Joana, Griffith, Renate, Knapp, Stefan, Bates, David O, Morris, Jonathan C
Published in ACS chemical biology (17.03.2017)
Published in ACS chemical biology (17.03.2017)
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Journal Article
Salmeterol attenuates chemotactic responses in rhinovirus-induced exacerbation of allergic airways disease by modulating protein phosphatase 2A
Hatchwell, Luke, BBiomedSci (Hons), Girkin, Jason, BBiomedSci (Hons), Dun, Matthew D., PhD, Morten, Matthew, BBiomedSci (Hons), Verrills, Nicole, PhD, Toop, Hamish D., BSci (Hons), Morris, Jonathan C., PhD, Johnston, Sebastian L., PhD, Foster, Paul S., PhD, DSc, Collison, Adam, PhD, Mattes, Joerg, MD, PhD
Published in Journal of allergy and clinical immunology (01.06.2014)
Published in Journal of allergy and clinical immunology (01.06.2014)
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Journal Article
Concise Total Synthesis of Dioncophylline E through an ortho‐Arylation Strategy
Toop, Hamish D., Brusnahan, Jason S., Morris, Jonathan C.
Published in Angewandte Chemie International Edition (10.07.2017)
Published in Angewandte Chemie International Edition (10.07.2017)
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Journal Article
Insights into the Interaction between Immobilized Biocatalysts and Metal–Organic Frameworks: A Case Study of PCN-333
Yang, Wenjie, Liang, Weibin, O’Dell, Luke A, Toop, Hamish D, Maddigan, Natasha, Zhang, Xingmo, Kochubei, Alena, Doonan, Christian J, Jiang, Yijiao, Huang, Jun
Published in JACS Au (27.12.2021)
Published in JACS Au (27.12.2021)
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Journal Article
TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis
Collison, Adam M, Li, Junyao, de Siqueira, Ana Pereira, Lv, Xuejiao, Toop, Hamish D, Morris, Jonathan C, Starkey, Malcolm R, Hansbro, Philip M, Zhang, Jie, Mattes, Joerg
Published in BMC pulmonary medicine (07.02.2019)
Published in BMC pulmonary medicine (07.02.2019)
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Journal Article
Shwachman–Bodian–Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia
Dun, Matthew D., Mannan, Abdul, Rigby, Callum J., Butler, Stephen, Toop, Hamish D., Beck, Dominik, Connerty, Patrick, Sillar, Jonathan, Kahl, Richard G. S., Duchatel, Ryan J., Germon, Zacary, Faulkner, Sam, Chi, Mengna, Skerrett-Byrne, David, Murray, Heather C., Flanagan, Hayley, Almazi, Juhura G., Hondermarck, Hubert, Nixon, Brett, De Iuliis, Geoff, Chamberlain, Janis, Alvaro, Frank, de Bock, Charles E., Morris, Jonathan C., Enjeti, Anoop K., Verrills, Nicole M.
Published in Leukemia (01.12.2020)
Published in Leukemia (01.12.2020)
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Journal Article
A fluorescent assay for ceramide synthase activity
Kim, Hyun Joon, Qiao, Qiao, Toop, Hamish D., Morris, Jonathan C., Don, Anthony S.
Published in Journal of lipid research (01.08.2012)
Published in Journal of lipid research (01.08.2012)
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Journal Article
Tumor necrosis factor-related apoptosis-inducing ligand regulates hallmark features of airways remodeling in allergic airways disease
Collison, Adam, Li, Junyao, Pereira de Siqueira, Ana, Zhang, Jie, Toop, Hamish D, Morris, Jonathan C, Foster, Paul S, Mattes, Joerg
Published in American journal of respiratory cell and molecular biology (01.07.2014)
Published in American journal of respiratory cell and molecular biology (01.07.2014)
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Journal Article
Synthesis and biological evaluation of analogs of AAL(S) for use as ceramide synthase 1 inhibitors
Toop, Hamish D., Don, Anthony S., Morris, Jonathan C.
Published in Organic & biomolecular chemistry (28.12.2015)
Published in Organic & biomolecular chemistry (28.12.2015)
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Journal Article
Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors
Smith, Amanda M, Dun, Matthew D, Lee, Erwin M, Harrison, Celeste, Kahl, Richard, Flanagan, Hayley, Panicker, Nikita, Mashkani, Baratali, Don, Anthony S, Morris, Jonathan, Toop, Hamish, Lock, Richard B, Powell, Jason A, Thomas, Daniel, Guthridge, Mark A, Moore, Andrew, Ashman, Leonie K, Skelding, Kathryn A, Enjeti, Anoop, Verrills, Nicole M
Published in Oncotarget (26.07.2016)
Published in Oncotarget (26.07.2016)
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Journal Article
Concise Total Synthesis of DioncophyllineE through an ortho-Arylation Strategy
Toop, Hamish D, Brusnahan, Jason S, Morris, Jonathan C
Published in Angewandte Chemie International Edition (10.07.2017)
Published in Angewandte Chemie International Edition (10.07.2017)
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Journal Article
Shwachman-Bodian-Diamond syndrome activity and overexpressed in acute myeloid leukaemia
Dun, Matthew D, Mannan, Abdul, Rigby, Callum J, Butler, Stephen, Toop, Hamish D, Beck, Dominik, Connerty, Patrick
Published in Leukemia (01.12.2020)
Published in Leukemia (01.12.2020)
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Journal Article
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4
Tzelepis, Konstantinos, De Braekeleer, Etienne, Aspris, Demetrios, Barbieri, Isaia, Vijayabaskar, M. S., Liu, Wen-Hsin, Gozdecka, Malgorzata, Metzakopian, Emmanouil, Toop, Hamish D., Dudek, Monika, Robson, Samuel C., Hermida-Prado, Francisco, Yang, Yu Hsuen, Babaei-Jadidi, Roya, Garyfallos, Dimitrios A., Ponstingl, Hannes, Dias, Joao M. L., Gallipoli, Paolo, Seiler, Michael, Buonamici, Silvia, Vick, Binje, Bannister, Andrew J., Rad, Roland, Prinjha, Rab K., Marioni, John C., Huntly, Brian, Batson, Jennifer, Morris, Jonathan C., Pina, Cristina, Bradley, Allan, Jeremias, Irmela, Bates, David O., Yusa, Kosuke, Kouzarides, Tony, Vassiliou, George S.
Published in Nature communications (19.12.2018)
Published in Nature communications (19.12.2018)
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Journal Article
Development of novel PP2A activators for use in the treatment of acute myeloid leukaemiaElectronic supplementary information (ESI) available: Synthetic procedures and characterisation data for all new compounds. See DOI: 10.1039/c6ob00556j
Toop, Hamish D, Dun, Matthew D, Ross, Bryony K, Flanagan, Hayley M, Verrills, Nicole M, Morris, Jonathan C
Year of Publication 18.05.2016
Year of Publication 18.05.2016
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Journal Article