Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype
Ivashchenko, Christine Y, Pipes, Gordon C, Lozinskaya, Irina M, Lin, Zuojun, Xiaoping, Xu, Needle, Saul, Grygielko, Eugene T, Hu, Erding, Toomey, John R, Lepore, John J, Willette, Robert N
Published in American journal of physiology. Heart and circulatory physiology (15.09.2013)
Published in American journal of physiology. Heart and circulatory physiology (15.09.2013)
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Factor Xa Inhibitors: S1 Binding Interactions of a Series of N-{(3S)-1-[(1S)-1-Methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides
Chan, Chuen, Borthwick, Alan D, Brown, David, Burns-Kurtis, Cynthia L, Campbell, Matthew, Chaudry, Laiq, Chung, Chun-wa, Convery, Máire A, Hamblin, J. Nicole, Johnstone, Lisa, Kelly, Henry A, Kleanthous, Savvas, Patikis, Angela, Patel, Champa, Pateman, Anthony J, Senger, Stefan, Shah, Gita P, Toomey, John R, Watson, Nigel S, Weston, Helen E, Whitworth, Caroline, Young, Robert J, Zhou, Ping
Published in Journal of medicinal chemistry (05.04.2007)
Published in Journal of medicinal chemistry (05.04.2007)
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Comparative analyses of the small molecule thrombopoietin receptor agonist eltrombopag and thrombopoietin on in vitro platelet function
Erhardt, Joseph A, Erickson-Miller, Connie L, Aivado, Manuel, Abboud, Melanie, Pillarisetti, Kodandaram, Toomey, John R
Published in Experimental hematology (01.09.2009)
Published in Experimental hematology (01.09.2009)
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Antithrombotic Efficacy of a Novel Murine Antihuman Factor IX Antibody in Rats
Feuerstein, Giora Z, Patel, Arun, Toomey, John R, Bugelski, Peter, Nichols, Andrew J, Church, William R, Valocik, Richard, Koster, Paul, Baker, Audrey, Blackburn, Michael N
Published in Arteriosclerosis, thrombosis, and vascular biology (01.10.1999)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.10.1999)
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Effect of Tissue Factor Deficiency on Mouse and Tumor Development
Toomey, John R., Kratzer, Kenneth E., Lasky, Nina M., Broze, George J.
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.1997)
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High FGF23 Levels Failed to Predict Cardiac Hypertrophy in Animal Models of Hyperphosphatemia and Chronic Renal Failure
Moench, Ian, Aravindhan, Karpagam, Kuziw, Joanne, Schnackenberg, Christine G, Willette, Robert N, Toomey, John R, Gatto, Gregory J
Published in Journal of the Endocrine Society (01.08.2021)
Published in Journal of the Endocrine Society (01.08.2021)
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The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs
Watson, Nigel S., Adams, Carl, Belton, David, Brown, David, Burns-Kurtis, Cynthia L., Chaudry, Laiq, Chan, Chuen, Convery, Máire A., Davies, David E., Exall, Anne M., Harling, John D., Irvine, Stephanie, Irving, Wendy R., Kleanthous, Savvas, McLay, Iain M., Pateman, Anthony J., Patikis, Angela N., Roethke, Theresa J., Senger, Stefan, Stelman, Gary J., Toomey, John R., West, Robert I., Whittaker, Caroline, Zhou, Ping, Young, Robert J.
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs
Young, Robert J., Adams, Carl, Blows, Mike, Brown, David, Burns-Kurtis, Cynthia L., Chan, Chuen, Chaudry, Laiq, Convery, Máire A., Davies, David E., Exall, Anne M., Foster, Graham, Harling, John D., Hortense, Eric, Irvine, Stephanie, Irving, Wendy R., Jackson, Steve, Kleanthous, Savvas, Pateman, Anthony J., Patikis, Angela N., Roethka, Theresa J., Senger, Stefan, Stelman, Gary J., Toomey, John R., West, Robert I., Whittaker, Caroline, Zhou, Ping, Watson, Nigel S.
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with biaryl P4 motifs
Young, Robert J., Borthwick, Alan D., Brown, David, Burns-Kurtis, Cynthia L., Campbell, Matthew, Chan, Chuen, Charbaut, Marie, Chung, Chun-wa, Convery, Máire A., Kelly, Henry A., Paul King, N., Kleanthous, Savvas, Mason, Andrew M., Pateman, Anthony J., Patikis, Angela N., Pinto, Ivan L., Pollard, Derek R., Senger, Stefan, Shah, Gita P., Toomey, John R., Watson, Nigel S., Weston, Helen E.
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs
Kleanthous, Savvas, Borthwick, Alan D., Brown, David, Burns-Kurtis, Cynthia L., Campbell, Matthew, Chaudry, Laiq, Chan, Chuen, Clarte, Marie-Olive, Convery, Máire A., Harling, John D., Hortense, Eric, Irving, Wendy R., Irvine, Stephanie, Pateman, Anthony J., Patikis, Angela N., Pinto, Ivan L., Pollard, Derek R., Roethka, Theresa J., Senger, Stefan, Shah, Gita P., Stelman, Gary J., Toomey, John R., Watson, Nigel S., West, Robert I., Whittaker, Caroline, Zhou, Ping, Young, Robert J.
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Structure and property based design of factor Xa inhibitors: Biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs
Young, Robert J., Borthwick, Alan D., Brown, David, Burns-Kurtis, Cynthia L., Campbell, Matthew, Chan, Chuen, Charbaut, Marie, Convery, Máire A., Diallo, Hawa, Hortense, Eric, Irving, Wendy R., Kelly, Henry A., King, N. Paul, Kleanthous, Savvas, Mason, Andrew M., Pateman, Anthony J., Patikis, Angela N., Pinto, Ivan L., Pollard, Derek R., Senger, Stefan, Shah, Gita P., Toomey, John R., Watson, Nigel S., Weston, Helen E., Zhou, Ping
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Selective and dual action orally active inhibitors of thrombin and factor Xa
Young, Robert J., Brown, David, Burns-Kurtis, Cynthia L., Chan, Chuen, Convery, Máire A., Hubbard, Julia A., Kelly, Henry A., Pateman, Anthony J., Patikis, Angela, Senger, Stefan, Shah, Gita P., Toomey, John R., Watson, Nigel S., Zhou, Ping
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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Antithrombotic potential of GW813893: a novel, orally active, active-site directed factor Xa inhibitor
Abboud, Melanie A, Needle, Saul J, Burns-Kurtis, Cynthia L, Valocik, Richard E, Koster, Paul F, Amour, Augustin J, Chan, Chuen, Brown, David, Chaudry, Laiq, Zhou, Ping, Patikis, Angela, Patel, Champa, Pateman, Anthony J, Young, Rob J, Watson, Nigel S, Toomey, John R
Published in Journal of cardiovascular pharmacology (01.07.2008)
Published in Journal of cardiovascular pharmacology (01.07.2008)
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Inhibition of factor IX(a) is protective in a rat model of thromboembolic stroke
TOOMEY, John R, VALOCIK, Richard E, KOSTER, Paul F, GABRIEL, Melanie A, MCVEY, Matt, HART, Timothy K, OHLSTEIN, Eliot H, PARSONS, Andrew A, BARONE, Frank C
Published in Stroke (1970) (01.02.2002)
Published in Stroke (1970) (01.02.2002)
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Comparing the Antithrombotic Efficacy of a Humanized Anti-factor IX(a) Monoclonal Antibody (SB 249417) to the Low Molecular Weight Heparin Enoxaparin In a Rat Model of Arterial Thrombosis
Toomey, John R, Blackburn, Michael N, Storer, Barbara L, Valocik, Richard E, Koster, Paul F, Feuerstein, Giora Z
Published in Thrombosis research (01.10.2000)
Published in Thrombosis research (01.10.2000)
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An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure
Thorneloe, Kevin S, Cheung, Mui, Bao, Weike, Alsaid, Hasan, Lenhard, Stephen, Jian, Ming-Yuan, Costell, Melissa, Maniscalco-Hauk, Kristeen, Krawiec, John A, Olzinski, Alan, Gordon, Earl, Lozinskaya, Irina, Elefante, Lou, Qin, Pu, Matasic, Daniel S, James, Chris, Tunstead, James, Donovan, Brian, Kallal, Lorena, Waszkiewicz, Anna, Vaidya, Kalindi, Davenport, Elizabeth A, Larkin, Jonathan, Burgert, Mark, Casillas, Linda N, Marquis, Robert W, Ye, Guosen, Eidam, Hilary S, Goodman, Krista B, Toomey, John R, Roethke, Theresa J, Jucker, Beat M, Schnackenberg, Christine G, Townsley, Mary I, Lepore, John J, Willette, Robert N
Published in Science translational medicine (07.11.2012)
Published in Science translational medicine (07.11.2012)
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Activation of Caspase-3/Caspase-3-Like Activity in Rat Cardiomyocytes by an RGD Peptide, but not the GPIIb/IIIa Antagonist Lotrafiban
Erhardt, Joseph A., Ohlstein, Eliot H., Toomey, John R., Gabriel, Melanie A., Willette, Robert N., Yue, Tian-Li, Barone, Frank C., Parsons, Andrew A.
Published in Thrombosis research (15.07.2001)
Published in Thrombosis research (15.07.2001)
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