A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies
Phillips, Darren C., Jin, Sha, Gregory, Gareth P., Zhang, Qi, Xue, John, Zhao, Xiaoxian, Chen, Jun, Tong, Yunsong, Zhang, Haichao, Smith, Morey, Tahir, Stephen K., Clark, Rick F., Penning, Thomas D., Devlin, Jennifer R., Shortt, Jake, Hsi, Eric D., Albert, Daniel H., Konopleva, Marina, Johnstone, Ricky W., Leverson, Joel D., Souers, Andrew J.
Published in Leukemia (01.06.2020)
Published in Leukemia (01.06.2020)
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Synthesis and Evaluation of a New Generation of Orally Efficacious Benzimidazole-Based Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors as Anticancer Agents
Tong, Yunsong, Bouska, Jennifer J, Ellis, Paul A, Johnson, Eric F, Leverson, Joel, Liu, Xuesong, Marcotte, Patrick A, Olson, Amanda M, Osterling, Donald J, Przytulinska, Magdalena, Rodriguez, Luis E, Shi, Yan, Soni, Nirupama, Stavropoulos, Jason, Thomas, Sheela, Donawho, Cherrie K, Frost, David J, Luo, Yan, Giranda, Vincent L, Penning, Thomas D
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Published in Journal of medicinal chemistry (12.11.2009)
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Selective Chk1 inhibitors differentially sensitize p53‐deficient cancer cells to cancer therapeutics
Chen, Zehan, Xiao, Zhan, Gu, Wen‐zhen, Xue, John, Bui, Mai H., Kovar, Peter, Li, Gaoquan, Wang, Gary, Tao, Zhi‐Fu, Tong, Yunsong, Lin, Nan‐Horng, Sham, Hing L., Wang, Jean Y. J., Sowin, Thomas J., Rosenberg, Saul H., Zhang, Haiying
Published in International journal of cancer (15.12.2006)
Published in International journal of cancer (15.12.2006)
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Isoxazolo[3,4- b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling
Tong, Yunsong, Stewart, Kent D., Thomas, Sheela, Przytulinska, Magdalena, Johnson, Eric F., Klinghofer, Vered, Leverson, Joel, McCall, Owen, Soni, Niru B., Luo, Yan, Lin, Nan-horng, Sowin, Thomas J., Giranda, Vincent L., Penning, Thomas D.
Published in Bioorganic & medicinal chemistry (01.10.2008)
Published in Bioorganic & medicinal chemistry (01.10.2008)
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Aminopyrimidinone Cdc7 Kinase Inhibitors
Woods, Keith W., Lai, Chunqiu, Miyashiro, Julie M., Tong, Yunsong, Florjancic, Alan S., Han, Edward K., Soni, Niru, Shi, Yan, Lasko, Loren, Leverson, Joel D., Johnson, Eric F., Shoemaker, Alexander R., Penning, Thomas D.
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
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Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195
Tong, Yunsong, Stewart, Kent D, Florjancic, Alan S, Harlan, John E, Merta, Philip J, Przytulinska, Magdalena, Soni, Nirupama, Swinger, Kerren K, Zhu, Haizhong, Johnson, Eric F, Shoemaker, Alexander R, Penning, Thomas D
Published in ACS medicinal chemistry letters (14.02.2013)
Published in ACS medicinal chemistry letters (14.02.2013)
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Discovery of 1,4-dihydroindeno[1,2- c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors
Tong, Yunsong, Claiborne, Akiyo, Stewart, Kent D., Park, Chang, Kovar, Peter, Chen, Zehan, Credo, Robert B., Gu, Wen-Zhen, Gwaltney, Stephen L., Judge, Russell A., Zhang, Haiying, Rosenberg, Saul H., Sham, Hing L., Sowin, Thomas J., Lin, Nan-horng
Published in Bioorganic & medicinal chemistry (01.04.2007)
Published in Bioorganic & medicinal chemistry (01.04.2007)
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Discovery of 4′-(1,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors
Tao, Zhi-Fu, Li, Gaoquan, Tong, Yunsong, Stewart, Kent D., Chen, Zehan, Bui, Mai-Ha, Merta, Philip, Park, Chang, Kovar, Peter, Zhang, Haiying, Sham, Hing L., Rosenberg, Saul H., Sowin, Thomas J., Lin, Nan-Horng
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
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Synthesis and biological evaluation of 4′-(6,7-disubstituted-2,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors
Tao, Zhi-Fu, Li, Gaoquan, Tong, Yunsong, Chen, Zehan, Merta, Philip, Kovar, Peter, Zhang, Haiying, Rosenberg, Saul H., Sham, Hing L., Sowin, Thomas J., Lin, Nan-Horng
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors
Li, Gaoquan, Tao, Zhi-Fu, Tong, Yunsong, Przytulinska, Magdalena K., Kovar, Peter, Merta, Philip, Chen, Zehan, Zhang, Haiying, Sowin, Thomas, Rosenberg, Saul H., Lin, Nan-Horng
Published in Bioorganic & medicinal chemistry (01.12.2007)
Published in Bioorganic & medicinal chemistry (01.12.2007)
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Cyanopyridyl containing 1,4-dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability
Tong, Yunsong, Przytulinska, Magdalena, Tao, Zhi-Fu, Bouska, Jennifer, Stewart, Kent D., Park, Chang, Li, Gaoquan, Claiborne, Akiyo, Kovar, Peter, Chen, Zehan, Merta, Philip J., Bui, Mai-Ha, Olson, Amanda, Osterling, Donald, Zhang, Haiying, Sham, Hing L., Rosenberg, Saul H., Sowin, Thomas J., Lin, Nan-horng
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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Design, Synthesis, and Biological Activity of 4-[(4-Cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as Potent and Selective Farnesyltransferase Inhibitors
Wang, Le, Wang, Gary T, Wang, Xilu, Tong, Yunsong, Sullivan, Gerry, Park, David, Leonard, Nicholas M, Li, Qun, Cohen, Jerry, Gu, Wen-Zhen, Zhang, Haiying, Bauch, Joy L, Jakob, Clarissa G, Hutchins, Charles W, Stoll, Vincent S, Marsh, Kennan, Rosenberg, Saul H, Sham, Hing L, Lin, Nan-Horng
Published in Journal of medicinal chemistry (29.01.2004)
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Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability
Tong, Yunsong, Lin, Nan-Horng, Wang, Le, Hasvold, Lisa, Wang, Weibo, Leonard, Nicholas, Li, Tongmei, Li, Qun, Cohen, Jerry, Gu, Wen-Zhen, Zhang, Haiying, Stoll, Vincent, Bauch, Joy, Marsh, Kennan, Rosenberg, Saul H., Sham, Hing L.
Published in Bioorganic & medicinal chemistry letters (05.05.2003)
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CHUNG SEUNGWON, CARMELA SIDRAUSKI, LAWRENCE A BLACK, TONG YUNSONG, JENNIFER M FROST, MARINA PLIUSCHEV, SHI LEI, CHARLES W HUTCHINS, MICHAEL J DART, XU XIANGDONG, RAMZI FARAH SWEIS, ZHANG QINWEI
Year of Publication 21.02.2024
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Year of Publication 04.08.2023
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Year of Publication 04.08.2023
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Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors
Tong, Yunsong, Florjancic, Alan S, Clark, Rick F, Lai, Chunqiu, Mastracchio, Anthony, Zhu, Gui-dong, Smith, Morey L, Kovar, Peter J, Shaw, Bailin, Albert, Daniel H, Qiu, Wei, Longenecker, Kenton L, Liu, Xiaoqin, Olson, Amanda M, Osterling, Donald J, Tahir, Stephen K, Phillips, Darren C, Leverson, Joel D, Souers, Andrew J, Penning, Thomas D
Published in ACS medicinal chemistry letters (08.07.2021)
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MODULATORS OF THE INTEGRATED STRESS PATHWAY
FROST JENNIFER M, HUTCHINS CHARLES W, BLACK LAWRENCE A, SIDRAUSKI CARMELA, SWEIS RAMZI FARATH, DART MICHAEL J, CHUNG SEUNGWON, TONG YUNSONG, SHI LEI, XU XIANGDONG, ZHANG QINGWEI, PLIUSHCHEV MARINA
Year of Publication 27.03.2023
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통합 스트레스 경로의 조절인자로서의 치환된 사이클로알킬
EDESON STEVEN, SIDRAUSKI CARMELA, DART MICHAEL J, BENELKEBIR HANAE, STARBUCK KATHRYN, TONG YUNSONG, MURAUSKI KATHLEEN J, MARTIN KATHLEEN ANN, SHI LEI, XU XIANGDONG, RANDOLPH JOHN T
Year of Publication 09.02.2022
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PRODRUG MODULATORS OF THE INTEGRATED STRESS PATHWAY
FROST JENNIFER M, SIDRAUSKI CARMELA, DART MICHAEL J, BROWN BRIAN S, MURAUSKI KATHLEEN, TONG YUNSONG, MARTIN KATHLEEN ANN, SHI LEI, VOIGHT ERIC, XU XIANGDONG, RANDOLPH JOHN T, PLIUSHCHEV MARINA
Year of Publication 14.11.2022
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CDK9 Inhibition Reverses Resistance to ABT-199 (GDC-0199) By Down-Regulating MCL-1
Chen, Jun, Jin, Sha, Tapang, Paul, Tahir, Stephen K, Smith, Morey, Xue, John, Zhang, Haichao, Gao, Wenqing, Tong, Yunsong, Clark, Richard, Ricker, Justin L., Penning, Thomas D, Albert, Daniel H, Phillips, Darren C, Souers, Andrew J, Leverson, Joel D.
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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