Aspirin Inhibits Cancer Metastasis and Angiogenesis via Targeting Heparanase
Dai, Xiaoyang, Yan, Juan, Fu, Xuhong, Pan, Qiuming, Sun, Danni, Xu, Yuan, Wang, Jiang, Nie, Litong, Tong, Linjiang, Shen, Aijun, Zheng, Mingyue, Huang, Min, Tan, Minjia, Liu, Hong, Huang, Xun, Ding, Jian, Geng, Meiyu
Published in Clinical cancer research (15.10.2017)
Published in Clinical cancer research (15.10.2017)
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Journal Article
Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFR(L858R/T790M/C797S))
Shen, Jiayi, Zhang, Tao, Zhu, Su-Jie, Sun, Min, Tong, Linjiang, Lai, Mengzhen, Zhang, Rong, Xu, Wei, Wu, Ruibo, Ding, Jian, Yun, Cai-Hong, Xie, Hua, Lu, Xiaoyun, Ding, Ke
Published in Journal of medicinal chemistry (08.08.2019)
Published in Journal of medicinal chemistry (08.08.2019)
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SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors
Wang, Xiaomin, Chen, Ziqi, Xu, Jun, Tang, Shuai, An, Nan, Jiang, Lei, Zhang, Yixiang, Zhang, Shaoying, Zhang, Qingli, Shen, Yanyan, Chen, Shijie, Lan, Xiaojing, Wang, Ting, Zhai, Linhui, Cao, Siyuwei, Guo, Siqi, Liu, Yingluo, Bi, Aiwei, Chen, Yuehong, Gai, Xiameng, Duan, Yichen, Zheng, Ying, Fu, Yixian, Li, Yize, Yuan, Liang, Tong, Linjiang, Mo, Kun, Wang, Mingcheng, Lin, Shu-Hai, Tan, Minjia, Luo, Cheng, Chen, Yi, Liu, Jia, Zhang, Qiansen, Li, Leping, Huang, Min
Published in Cell research (01.07.2022)
Published in Cell research (01.07.2022)
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Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
Zhang, Tao, Qu, Rong, Chan, Shingpan, Lai, Mengzhen, Tong, Linjiang, Feng, Fang, Chen, Hongyu, Song, Tingting, Song, Peiran, Bai, Gang, Liu, Yingqiang, Wang, Yanan, Li, Yan, Su, Yi, Shen, Yanyan, Sun, Yiming, Chen, Yi, Geng, Meiyu, Ding, Ke, Ding, Jian, Xie, Hua
Published in Molecular cancer (13.05.2020)
Published in Molecular cancer (13.05.2020)
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LS‐106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
Liu, Yingqiang, Lai, Mengzhen, Li, Shan, Wang, Yanan, Feng, Fang, Zhang, Tao, Tong, Linjiang, Zhang, Mengge, Chen, Hao, Chen, Yi, Song, Peiran, Li, Yan, Bai, Gang, Ning, Yi, Tang, Haotian, Fang, Yan, Chen, Yi, Lu, Xiaoyun, Geng, Meiyu, Ding, Ke, Yu, Ker, Xie, Hua, Ding, Jian
Published in Cancer science (01.02.2022)
Published in Cancer science (01.02.2022)
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Design, Synthesis, and Biological Evaluation of Pyrimido[4,5‑d]pyrimidine-2,4(1H,3H)‑diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation
Hao, Yongjia, Lyu, Jiankun, Qu, Rong, Tong, Yi, Sun, Deheng, Feng, Fang, Tong, Linjiang, Yang, Tingyuan, Zhao, Zhenjiang, Zhu, Lili, Ding, Jian, Xu, Yufang, Xie, Hua, Li, Honglin
Published in Journal of medicinal chemistry (12.07.2018)
Published in Journal of medicinal chemistry (12.07.2018)
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Journal Article
Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation
Su, Zhicheng, Yang, Tingyuan, Wang, Jie, Lai, Mengzhen, Tong, Linjiang, Wumaier, Gulinuer, Chen, Zhuo, Li, Shengqing, Li, Honglin, Xie, Hua, Zhao, Zhenjiang
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
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Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFRL858R/T790M/C797S
Li, Qiannan, Zhang, Tao, Li, Shiliang, Tong, Linjiang, Li, Junyu, Su, Zhicheng, Feng, Fang, Sun, Deheng, Tong, Yi, Wang, Xia, Zhao, Zhenjiang, Zhu, Lili, Ding, Jian, Li, Honglin, Xie, Hua, Xu, Yufang
Published in ACS medicinal chemistry letters (13.06.2019)
Published in ACS medicinal chemistry letters (13.06.2019)
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Design, Synthesis, and Structure–Activity Relationship Study of 2‑Oxo-3,4-dihydropyrimido[4,5‑d]pyrimidines as New Colony Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitors
Xun, Qiuju, Zhang, Zhang, Luo, Jinfeng, Tong, Linjiang, Huang, Minhao, Wang, Zhen, Zou, Jian, Liu, Yingqiang, Xu, Yong, Xie, Hua, Tu, Zheng-Chao, Lu, Xiaoyun, Ding, Ke
Published in Journal of medicinal chemistry (22.03.2018)
Published in Journal of medicinal chemistry (22.03.2018)
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Correction: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
Zhang, Tao, Qu, Rong, Chan, Shingpan, Lai, Mengzhen, Tong, Linjiang, Feng, Fang, Chen, Hongyu, Song, Tingting, Song, Peiran, Bai, Gang, Liu, Yingqiang, Wang, Yanan, Li, Yan, Su, Yi, Shen, Yanyan, Sun, Yiming, Chen, Yi, Geng, Meiyu, Ding, Ke, Ding, Jian, Xie, Hua
Published in Molecular cancer (19.08.2023)
Published in Molecular cancer (19.08.2023)
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Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation
Hao, Yongjia, Wang, Xia, Zhang, Tao, Sun, Deheng, Tong, Yi, Xu, Yuqiong, Chen, Haiyang, Tong, Linjiang, Zhu, Lili, Zhao, Zhenjiang, Chen, Zhuo, Ding, Jian, Xie, Hua, Xu, Yufang, Li, Honglin
Published in Journal of medicinal chemistry (11.08.2016)
Published in Journal of medicinal chemistry (11.08.2016)
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ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK
Song, Peiran, Bai, Gang, Chan, Shingpan, Zhang, Tao, Tong, Linjiang, Su, Yi, Shen, Yanyan, Chen, Yi, Liu, Yingqiang, Lai, Mengzhen, Ning, Yi, Tang, Haotian, Fang, Yan, Ding, Ke, Ding, Jian, Xie, Hua
Published in Frontiers in pharmacology (15.12.2022)
Published in Frontiers in pharmacology (15.12.2022)
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The discovery and optimization of novel dual inhibitors of topoisomerase ii and histone deacetylase
Zhang, Xuan, Bao, Bin, Yu, Xiuhua, Tong, Linjiang, Luo, Yu, Huang, Qingqing, Su, Mingbo, Sheng, Li, Li, Jia, Zhu, Hong, Yang, Bo, Zhang, Xiongwen, Chen, Yi, Lu, Wei
Published in Bioorganic & medicinal chemistry (15.11.2013)
Published in Bioorganic & medicinal chemistry (15.11.2013)
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Journal Article
2-Oxo-3,4-dihydropyrimido[4,5-d] pyrimidines as new reversible inhibitors of EGFR C797S (Cys797 to Ser797) mutant
Hu, Xianglong, Xun, Qiuju, Zhang, Tao, Zhu, Su-Jie, Li, Qian, Tong, Linjiang, Lai, Mengzhen, Huang, Tao, Yun, Cai-Hong, Xie, Hua, Ding, Ke, Lu, Xiaoyun
Published in Chinese chemical letters (01.05.2020)
Published in Chinese chemical letters (01.05.2020)
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Correction to: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
Zhang, Tao, Qu, Rong, Chan, Shingpan, Lai, Mengzhen, Tong, Linjiang, Feng, Fang, Chen, Hongyu, Song, Tingting, Song, Peiran, Bai, Gang, Liu, Yingqiang, Wang, Yanan, Li, Yan, Su, Yi, Shen, Yanyan, Sun, Yiming, Chen, Yi, Geng, Meiyu, Ding, Ke, Ding, Jian, Xie, Hua
Published in Molecular cancer (17.08.2021)
Published in Molecular cancer (17.08.2021)
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A novel strategy for treating oncogene‐mutated tumors by targeting tumor microenvironment and synergistically enhancing anti‐PD‐1 immunotherapy
Liu, Yingqiang, Tong, Linjiang, Zhang, Mengge, Zhang, Qi, Liu, Qiupei, Feng, Fang, Li, Yan, Lai, Mengzhen, Tang, Haotian, Chen, Yi, Geng, Meiyu, Duan, Wenhu, Ding, Jian, Xie, Hua
Published in Cancer communications (London, England) (01.03.2024)
Published in Cancer communications (London, England) (01.03.2024)
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Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood–brain barrier and exhibits potent activity against glioblastoma
Liu, Yingqiang, Zhan, Zhengsheng, Kang, Zhuang, Li, Mengyuan, Lv, Yongcong, Li, Shenglan, Tong, Linjiang, Feng, Fang, Li, Yan, Zhang, Mengge, Xue, Yaping, Chen, Yi, Zhang, Tao, Song, Peiran, Su, Yi, Shen, Yanyan, Sun, Yiming, Yang, Xinying, Chen, Yi, Yao, Shanyan, Yang, Hanyu, Wang, Caixia, Geng, Meiyu, Li, Wenbin, Duan, Wenhu, Xie, Hua, Ding, Jian
Published in Acta pharmaceutica Sinica. B (01.12.2023)
Published in Acta pharmaceutica Sinica. B (01.12.2023)
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Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation
Zhang, Tao, Pan, Zilu, Gao, Jing, Wu, Qingqing, Bai, Gang, Li, Yan, Tong, Linjiang, Feng, Fang, Lai, Mengzhen, Liu, Yingqiang, Song, Peiran, Ning, Yi, Tang, Haotian, Luo, Wen, Chen, Yi, Fang, Yan, Zhang, Hui, Liu, Qiupei, Zhang, Yudi, Wang, Hua, Chen, Zhiwei, Chen, Yi, Geng, Meiyu, Ji, Hongbin, Zhao, Guilong, Zhou, Hu, Ding, Jian, Xie, Hua
Published in Signal transduction and targeted therapy (15.08.2024)
Published in Signal transduction and targeted therapy (15.08.2024)
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AST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo
Xie, Hua, Lin, Liping, Tong, Linjiang, Jiang, Yong, Zheng, Mingyue, Chen, Zhuo, Jiang, Xiaoyan, Zhang, Xiaowei, Ren, Xiaowei, Qu, Wenchao, Yang, Yang, Wan, Hua, Chen, Yi, Zuo, Jianping, Jiang, Hualiang, Geng, Meiyu, Ding, Jian
Published in PloS one (18.07.2011)
Published in PloS one (18.07.2011)
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