Rational design of a new antibiotic class for drug-resistant infections
Durand-Reville, Thomas F., Miller, Alita A., O’Donnell, John P., Wu, Xiaoyun, Sylvester, Mark A., Guler, Satenig, Iyer, Ramkumar, Shapiro, Adam B., Carter, Nicole M., Velez-Vega, Camilo, Moussa, Samir H., McLeod, Sarah M., Chen, April, Tanudra, Angela M., Zhang, Jing, Comita-Prevoir, Janelle, Romero, Jan A., Huynh, Hoan, Ferguson, Andrew D., Horanyi, Peter S., Mayclin, Stephen J., Heine, Henry S., Drusano, George L., Cummings, Jason E., Slayden, Richard A., Tommasi, Ruben A.
Published in Nature (London) (30.09.2021)
Published in Nature (London) (30.09.2021)
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Journal Article
Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β‑Lactamases
Durand-Réville, Thomas F, Comita-Prevoir, Janelle, Zhang, Jing, Wu, Xiaoyun, May-Dracka, Tricia L, Romero, Jan Antoinette C, Wu, Frank, Chen, April, Shapiro, Adam B, Carter, Nicole M, McLeod, Sarah M, Giacobbe, Robert A, Verheijen, Jeroen C, Lahiri, Sushmita D, Sacco, Michael D, Chen, Yu, O’Donnell, John P, Miller, Alita A, Mueller, John P, Tommasi, Rubén A
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
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Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class
Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Aristoff, Paul A, Johnson, Paul D, Skulnick, Harvey I, Dolak, Lester A, Seest, Eric P, Tomich, Paul K, Bohanon, Michael J, Horng, Miao-Miao, Lynn, Janet C, Chong, Kong-Teck, Hinshaw, Roger R, Watenpaugh, Keith D, Janakiraman, Musiri N, Thaisrivongs, Suvit
Published in Journal of medicinal chemistry (27.08.1998)
Published in Journal of medicinal chemistry (27.08.1998)
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Journal Article
Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B through Structure-Based Drug Design
Greenspan, Paul D, Clark, Kirk L, Tommasi, Ruben A, Cowen, Scott D, McQuire, Leslie W, Farley, David L, van Duzer, John H, Goldberg, Ronald L, Zhou, Huanghai, Du, Zhengming, Fitt, John J, Coppa, David E, Fang, Zheng, Macchia, William, Zhu, Lijuan, Capparelli, Michael P, Goldstein, Robert, Wigg, Andrew M, Doughty, John R, Bohacek, Regine S, Knap, Ania K
Published in Journal of medicinal chemistry (20.12.2001)
Published in Journal of medicinal chemistry (20.12.2001)
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Journal Article
Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors
Whitehead, Lewis, Dobler, Markus R., Radetich, Branko, Zhu, Yanyi, Atadja, Peter W., Claiborne, Tavina, Grob, Jonathan E., McRiner, Andrew, Pancost, Margaret R., Patnaik, Anup, Shao, Wenlin, Shultz, Michael, Tichkule, Ritesh, Tommasi, Ruben A., Vash, Brian, Wang, Ping, Stams, Travis
Published in Bioorganic & medicinal chemistry (01.08.2011)
Published in Bioorganic & medicinal chemistry (01.08.2011)
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Journal Article
ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii
Durand-Réville, Thomas F., Guler, Satenig, Comita-Prevoir, Janelle, Chen, Brendan, Bifulco, Neil, Huynh, Hoan, Lahiri, Sushmita, Shapiro, Adam B., McLeod, Sarah M., Carter, Nicole M., Moussa, Samir H., Velez-Vega, Camilo, Olivier, Nelson B., McLaughlin, Robert, Gao, Ning, Thresher, Jason, Palmer, Tiffany, Andrews, Beth, Giacobbe, Robert A., Newman, Joseph V., Ehmann, David E., de Jonge, Boudewijn, O'Donnell, John, Mueller, John P., Tommasi, Rubén A., Miller, Alita A.
Published in Nature microbiology (30.06.2017)
Published in Nature microbiology (30.06.2017)
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Journal Article
N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay
Furuya, Takeru, Shapiro, Adam B., Comita-Prevoir, Janelle, Kuenstner, Eric J., Zhang, Jing, Ribe, Seth D., Chen, April, Hines, Daniel, Moussa, Samir H., Carter, Nicole M., Sylvester, Mark A., Romero, Jan A.C., Vega, Camilo V., Sacco, Michael D., Chen, Yu, O'Donnell, John P., Durand-Reville, Thomas F., Miller, Alita A., Tommasi, Ruben A.
Published in Bioorganic & medicinal chemistry (15.12.2020)
Published in Bioorganic & medicinal chemistry (15.12.2020)
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Journal Article
Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13
Monovich, Lauren G, Tommasi, Ruben A, Fujimoto, Roger A, Blancuzzi, Vincent, Clark, Kirk, Cornell, Wendy D, Doti, Robert, Doughty, John, Fang, James, Farley, David, Fitt, John, Ganu, Vishwas, Goldberg, Ronald, Goldstein, Robert, Lavoie, Stacey, Kulathila, Raviraj, Macchia, William, Parker, David T, Melton, Richard, O’Byrne, Elizabeth, Pastor, Gary, Pellas, Theodore, Quadros, Elizabeth, Reel, Noela, Roland, Dennis M, Sakane, Yumi, Singh, Hem, Skiles, Jerry, Somers, Joseph, Toscano, Karen, Wigg, Andrew, Zhou, Siyuan, Zhu, Lijuan, Shieh, Wen-Chung, Xue, Song, McQuire, Leslie W
Published in Journal of medicinal chemistry (11.06.2009)
Published in Journal of medicinal chemistry (11.06.2009)
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Journal Article
Potent and selective 2-naphthylsulfonamide substituted hydroxamic acid inhibitors of matrix metalloproteinase-13
Tommasi, Ruben A., Weiler, Sven, McQuire, Leslie W., Rogel, Olivier, Chambers, Mark, Clark, Kirk, Doughty, John, Fang, James, Ganu, Vishwas, Grob, Jonathan, Goldberg, Ronald, Goldstein, Robert, LaVoie, Stacey, Kulathila, Raviraj, Macchia, William, Melton, Richard, Springer, Clayton, Walker, Marc, Zhang, Jing, Zhu, Lijuan, Shultz, Michael
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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Journal Article
N-Arylaminonitriles as bioavailable peptidomimetic inhibitors of cathepsin B
Greenspan, Paul D., Clark, Kirk L., Cowen, Scott D., McQuire, Leslie W., Tommasi, Ruben A., Farley, David L., Quadros, Elizabeth, Coppa, David E., Du, Zengming, Fang, Zheng, Zhou, Huanghai, Doughty, John, Toscano, Karen T., Wigg, Andrew M., Zhou, Siyuan
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
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Journal Article
Structure-Based Design of HIV Protease Inhibitors: Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors
Thaisrivongs, Suvit, Skulnick, Harvey I, Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Johnson, Paul D, Aristoff, Paul A, Judge, Thomas M, Gammill, Ronald B, Morris, Jeanette K, Romines, Karen R, Chrusciel, Robert A, Hinshaw, Roger R, Chong, Kong-Teck, Tarpley, W. Gary, Poppe, Susan M, Slade, David E, Lynn, Janet C, Horng, Miao-Miao, Tomich, Paul K, Seest, Eric P, Dolak, Lester A, Howe, W. Jeffrey, Howard, Gina M, Schwende, Francis J, Toth, Lisa N, Padbury, Guy E, Wilson, Grace J, Shiou, Lihua, Zipp, Gail L, Wilkinson, Karen F, Rush, Bob D, Ruwart, Mary J, Koeplinger, Kenneth A, Zhao, Zhiyang, Cole, Serena, Zaya, Renee M, Kakuk, Thomas J, Janakiraman, Musiri N, Watenpaugh, Keith D
Published in Journal of medicinal chemistry (25.10.1996)
Published in Journal of medicinal chemistry (25.10.1996)
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Journal Article
Non-peptidic HIV protease inhibitors : C2-SYMMETRY-BASED design of bis-sulfonamide dihydropyrones
JANAKIRAMAN, M. N, WATENPAUGH, K. D, TOMICH, P. K, CHONG, K.-T, TURNER, S. R, TOMMASI, R. A, THAISRIVONGS, S, STROHBACH, J. W
Published in Bioorganic & medicinal chemistry letters (19.05.1998)
Published in Bioorganic & medicinal chemistry letters (19.05.1998)
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Journal Article
AutoChem: Automated Solution-Phase Parallel Synthesis and Purification via HPLC
Tommasi, Ruben A, Whaley, Louis W, Marepalli, Hanumantha R
Published in Journal of combinatorial chemistry (01.09.2000)
Published in Journal of combinatorial chemistry (01.09.2000)
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Journal Article
Structure-Based Design of HIV Protease Inhibitors: 5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors
Thaisrivongs, Suvit, Romero, Donna L, Tommasi, Ruben A, Janakiraman, Musiri N, Strohbach, Joseph W, Turner, Steve R, Biles, Carolyn, Morge, Raymond R, Johnson, Paul D, Aristoff, Paul A, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Howe, W. Jeffrey, Finzel, Barry C, Watenpaugh, Keith D
Published in Journal of medicinal chemistry (08.11.1996)
Published in Journal of medicinal chemistry (08.11.1996)
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Journal Article
Non-peptidic HIV protease inhibitors: C 2-symmetry-based design of bis-sulfonamide dihydropyrones
Janakiraman, Musiri N., Watenpaugh, Keith D., Tomich, Paul K., Chong, Kong-Teck, Turner, Steve R., Tommasi, Ruben A., Thaisrivongs, Suvit, Strohbach, Joseph W.
Published in Bioorganic & medicinal chemistry letters (19.05.1998)
Published in Bioorganic & medicinal chemistry letters (19.05.1998)
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Journal Article
Covalent or trapped? PFG diffusion MAS NMR for combinatorial chemistry
Shapiro, Michael J., Chin, Jefferson, Chen, Aidi, Wareing, James R., Tang, Qing, Tommasi, Ruben A., Marepalli, Hanumantha R.
Published in Tetrahedron letters (20.08.1999)
Published in Tetrahedron letters (20.08.1999)
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Journal Article
Novel method for the loading of nucleophiles on multipin crowns
Tommasi, Ruben A., Nantermet, Philippe G., Shapiro, Michael J., Chin, Jefferson, Brill, Wolfgang K.-D., Ang, Kiah
Published in Tetrahedron letters (30.07.1998)
Published in Tetrahedron letters (30.07.1998)
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