Pharmacological Characterization of [trans-5′-(4-Amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2′,3′-dihydrospiro(cyclohexane-1,1′-inden)-4-yl]acetic Acid Monobenzenesulfonate (JTT-553), a Novel Acyl CoA:Diacylglycerol Transferase (DGAT) 1 Inhibitor
Tomimoto, Daisuke, Okuma, Chihiro, Ishii, Yukihito, Akiyama, Yoshiyuki, Ohta, Takeshi, Kakutani, Makoto, Ohkuma, Yoshiaki, Ogawa, Nobuya
Published in Biological & pharmaceutical bulletin (2015)
Published in Biological & pharmaceutical bulletin (2015)
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Journal Article
JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice
Tomimoto, Daisuke, Okuma, Chihiro, Ishii, Yukihito, Kobayashi, Akio, Ohta, Takeshi, Kakutani, Makoto, Imanaka, Tsuneo, Ogawa, Nobuya
Published in Journal of pharmacological sciences (01.09.2015)
Published in Journal of pharmacological sciences (01.09.2015)
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A Novel TNF-α Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-Ay Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice
Maekawa, Mariko, Tadaki, Hironobu, Tomimoto, Daisuke, Okuma, Chihiro, Sano, Ryuhei, Ishii, Yukihito, Katsuda, Yoshiaki, Yoshiuchi, Hiromi, Kakefuda, Reina, Ohta, Takeshi, Sasase, Tomohiko
Published in Biological & pharmaceutical bulletin (01.11.2019)
Published in Biological & pharmaceutical bulletin (01.11.2019)
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Diabetic Peripheral Neuropathy in Spontaneously Diabetic Torii-Leprfa (SDT Fatty) Rats
YAMAGUCHI, Takayuki, SASASE, Tomohiko, MERA, Yasuko, TOMIMOTO, Daisuke, TADAKI, Hironobu, KEMMOCHI, Yusuke, OHTA, Takeshi, SATO, Eimei, MATSUSHITA, Mutsuyoshi
Published in Journal of Veterinary Medical Science (2012)
Published in Journal of Veterinary Medical Science (2012)
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Diabetic peripheral neuropathy in Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rats
Yamaguchi, Takayuki, Sasase, Tomohiko, Mera, Yasuko, Tomimoto, Daisuke, Tadaki, Hironobu, Kemmochi, Yusuke, Ohta, Takeshi, Sato, Eimei, Matsushita, Mutsuyoshi
Published in Journal of veterinary medical science (01.12.2012)
Published in Journal of veterinary medical science (01.12.2012)
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Journal Article
A Novel TNF-α Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-Ay Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice
Mariko Maekawaa, Hironobu Tadakia, Daisuke Tomimotoa, Chihiro Okumaa, Ryuhei Sanoa, Yukihito Ishiia, Yoshiaki Katsudaa, Hiromi Yoshiuchia, Reina Kakefudaa, Takeshi Ohtab, Tomohiko Sasasea
Published in Biological and Pharmaceutical Bulletin (01.11.2019)
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Published in Biological and Pharmaceutical Bulletin (01.11.2019)
Journal Article
JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Reduces Food Preference for Fat
Kakutani, Makoto, Kawai, Takashi, Tomimoto, Daisuke, Ishii, Yukihito, Hata, Takahiro, Mera, Yasuko, Ohta, Takeshi
Published in Journal of Diabetes Research (01.01.2014)
Published in Journal of Diabetes Research (01.01.2014)
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Journal Article
TNF-α converting enzyme (TACE) inhibitor prevents insulin resistance and diabetic peripheral neuropathy
Maekawa, Mariko, Tomimoto, Daisuke, Okuma, Chihiro, Tadaki, Hironobu, Katsuda, Yoshiaki, Ohta, Takeshi, Sasase, Tomohiko
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2019)
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2019)
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Journal Article
JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses food intake and gastric emptying with the elevation of plasma peptide YY and glucagon-like peptide-1 in a dietary fat-dependent manner
Hata, Takahiro, Mera, Yasuko, Ishii, Yukihito, Tadaki, Hironobu, Tomimoto, Daisuke, Kuroki, Yukiharu, Kawai, Takashi, Ohta, Takeshi, Kakutani, Makoto
Published in The Journal of pharmacology and experimental therapeutics (01.03.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2011)
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Journal Article
A pyruvate dehydrogenase kinase inhibitor prevents retinal cell death and improves energy metabolism in rat retinas after ischemia/reperfusion injury
Sato, Kota, Mochida, Seiya, Tomimoto, Daisuke, Konuma, Takahiro, Kiyota, Naoki, Tsuda, Satoru, Shiga, Yukihiro, Omodaka, Kazuko, Nakazawa, Toru
Published in Experimental eye research (01.04.2020)
Published in Experimental eye research (01.04.2020)
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Journal Article
Pharmacological Characterization of [trans-5'-(4-Amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl]acetic Acid Monobenzenesulfonate (JTT-553), a Novel Acyl CoA
Tomimoto, Daisuke, Okuma, Chihiro, Ishii, Yukihito, Akiyama, Yoshiyuki, Ohta, Takeshi, Kakutani, Makoto, Ohkuma, Yoshiaki, Ogawa, Nobuya
Published in Biological & pharmaceutical bulletin (01.02.2015)
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Published in Biological & pharmaceutical bulletin (01.02.2015)
Journal Article
Discovery of 6‑Phenylpyrimido[4,5‑b][1,4]oxazines as Potent and Selective Acyl CoA:Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors with in Vivo Efficacy in Rodents
Fox, Brian M, Sugimoto, Kazuyuki, Iio, Kiyosei, Yoshida, Atsuhito, Zhang, Jian (Ken), Li, Kexue, Hao, Xiaolin, Labelle, Marc, Smith, Marie-Louise, Rubenstein, Steven M, Ye, Guosen, McMinn, Dustin, Jackson, Simon, Choi, Rebekah, Shan, Bei, Ma, Ji, Miao, Shichang, Matsui, Takuya, Ogawa, Nobuya, Suzuki, Masahiro, Kobayashi, Akio, Ozeki, Hidekazu, Okuma, Chihiro, Ishii, Yukihito, Tomimoto, Daisuke, Furakawa, Noboru, Tanaka, Masahiro, Matsushita, Mutsuyoshi, Takahashi, Mitsuru, Inaba, Takashi, Sagawa, Shoichi, Kayser, Frank
Published in Journal of medicinal chemistry (24.04.2014)
Published in Journal of medicinal chemistry (24.04.2014)
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Journal Article
A Novel TNF-α Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-A y Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice
Maekawa, Mariko, Tadaki, Hironobu, Tomimoto, Daisuke, Okuma, Chihiro, Sano, Ryuhei, Ishii, Yukihito, Katsuda, Yoshiaki, Yoshiuchi, Hiromi, Kakefuda, Reina, Ohta, Takeshi, Sasase, Tomohiko
Published in Biological & pharmaceutical bulletin (2019)
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Published in Biological & pharmaceutical bulletin (2019)
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