Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses
Saunders, Kevin O., Lee, Esther, Parks, Robert, Martinez, David R., Li, Dapeng, Chen, Haiyan, Edwards, Robert J., Gobeil, Sophie, Barr, Maggie, Mansouri, Katayoun, Alam, S. Munir, Sutherland, Laura L., Cai, Fangping, Sanzone, Aja M., Berry, Madison, Manne, Kartik, Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Kapingidza, Anyway B., Azoitei, Mihai, Tse, Longping V., Scobey, Trevor D., Spreng, Rachel L., Rountree, R. Wes, DeMarco, C. Todd, Denny, Thomas N., Woods, Christopher W., Petzold, Elizabeth W., Tang, Juanjie, Oguin, Thomas H., Sempowski, Gregory D., Gagne, Matthew, Douek, Daniel C., Tomai, Mark A., Fox, Christopher B., Seder, Robert, Wiehe, Kevin, Weissman, Drew, Pardi, Norbert, Golding, Hana, Khurana, Surender, Acharya, Priyamvada, Andersen, Hanne, Lewis, Mark G., Moore, Ian N., Montefiori, David C., Baric, Ralph S., Haynes, Barton F.
Published in Nature (London) (24.06.2021)
Published in Nature (London) (24.06.2021)
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Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies
Mullins, Stefanie R., Vasilakos, John P., Deschler, Katharina, Grigsby, Iwen, Gillis, Pete, John, Julius, Elder, Matthew J., Swales, John, Timosenko, Elina, Cooper, Zachary, Dovedi, Simon J., Leishman, Andrew J., Luheshi, Nadia, Elvecrog, James, Tilahun, Ashenafi, Goodwin, Richard, Herbst, Ronald, Tomai, Mark A., Wilkinson, Robert W.
Published in Journal for immunotherapy of cancer (11.09.2019)
Published in Journal for immunotherapy of cancer (11.09.2019)
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A molecular atlas of innate immunity to adjuvanted and live attenuated vaccines, in mice
Lee, Audrey, Scott, Madeleine K. D., Wimmers, Florian, Arunachalam, Prabhu S., Luo, Wei, Fox, Christopher B., Tomai, Mark, Khatri, Purvesh, Pulendran, Bali
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Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways
Philbin, Victoria J., DPhil, Dowling, David J., PhD, Gallington, Leighanne C., BSc, Cortés, Guadalupe, PhD, Tan, Zhen, MD, Suter, Eugénie E., MA, Chi, Kevin W., BA, Shuckett, Ariel, MPH, Stoler-Barak, Liat, MSc, Tomai, Mark, PhD, Miller, Richard L., PhD, Mansfield, Keith, DVM, Levy, Ofer, MD, PhD
Published in Journal of allergy and clinical immunology (01.07.2012)
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Synthetic TLR Agonists Reveal Functional Differences between Human TLR7 and TLR8
Gorden, Keith B, Gorski, Kevin S, Gibson, Sheila J, Kedl, Ross M, Kieper, William C, Qiu, Xiaohong, Tomai, Mark A, Alkan, Sefik S, Vasilakos, John P
Published in The Journal of immunology (1950) (01.02.2005)
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Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach
Fox, Christopher B., Orr, Mark T., Van Hoeven, Neal, Parker, Sarah C., Mikasa, Traci J.T., Phan, Tony, Beebe, Elyse A., Nana, Ghislain I., Joshi, Sharvari W, Tomai, Mark A., Elvecrog, James, Fouts, Timothy R., Reed, Steven G.
Published in Journal of controlled release (28.12.2016)
Published in Journal of controlled release (28.12.2016)
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Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection
Saunders, Kevin O, Edwards, Robert J, Tilahun, Kedamawit, Manne, Kartik, Lu, Xiaozhi, Cain, Derek W, Wiehe, Kevin, Williams, Wilton B, Mansouri, Katayoun, Hernandez, Giovanna E, Sutherland, Laura, Scearce, Richard, Parks, Robert, Barr, Maggie, DeMarco, Todd, Eater, Chloe M, Eaton, Amanda, Morton, Georgeanna, Mildenberg, Benjamin, Wang, Yunfei, Rountree, R Wes, Tomai, Mark A, Fox, Christopher B, Moody, M Anthony, Alam, S Munir, Santra, Sampa, Lewis, Mark G, Denny, Thomas N, Shaw, George M, Montefiori, David C, Acharya, Priyamvada, Haynes, Barton F
Published in Science translational medicine (07.09.2022)
Published in Science translational medicine (07.09.2022)
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Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction
Wiehe, Kevin, Saunders, Kevin O., Stalls, Victoria, Cain, Derek W., Venkatayogi, Sravani, Martin Beem, Joshua S., Berry, Madison, Evangelous, Tyler, Henderson, Rory, Hora, Bhavna, Xia, Shi-Mao, Jiang, Chuancang, Newman, Amanda, Bowman, Cindy, Lu, Xiaozhi, Bryan, Mary E., Bal, Joena, Sanzone, Aja, Chen, Haiyan, Eaton, Amanda, Tomai, Mark A., Fox, Christopher B., Tam, Ying K., Barbosa, Christopher, Bonsignori, Mattia, Muramatsu, Hiromi, Alam, S. Munir, Montefiori, David C., Williams, Wilton B., Pardi, Norbert, Tian, Ming, Weissman, Drew, Alt, Frederick W., Acharya, Priyamvada, Haynes, Barton F.
Published in Cell host & microbe (08.05.2024)
Published in Cell host & microbe (08.05.2024)
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A Formulated TLR7/8 Agonist is a Flexible, Highly Potent and Effective Adjuvant for Pandemic Influenza Vaccines
Van Hoeven, Neal, Fox, Christopher B., Granger, Brian, Evers, Tara, Joshi, Sharvari W., Nana, Ghislain I., Evans, Sarah C., Lin, Susan, Liang, Hong, Liang, Li, Nakajima, Rie, Felgner, Philip L., Bowen, Richard A., Marlenee, Nicole, Hartwig, Airn, Baldwin, Susan L., Coler, Rhea N., Tomai, Mark, Elvecrog, James, Reed, Steven G., Carter, Darrick
Published in Scientific reports (21.04.2017)
Published in Scientific reports (21.04.2017)
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Nanoformulation of synergistic TLR ligands to enhance vaccination against Entamoeba histolytica
Abhyankar, Mayuresh M, Noor, Zannatun, Tomai, Mark A, Elvecrog, James, Fox, Christopher B, Petri, William A
Published in Vaccine (07.02.2017)
Published in Vaccine (07.02.2017)
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Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques
Berendam, Stella J, Morgan-Asiedu, Papa K, Mangan, Riley J, Li, Shuk Hang, Heimsath, Holly, Luo, Kan, Curtis, 2nd, Alan D, Eudailey, Joshua A, Fox, Christopher B, Tomai, Mark A, Phillips, Bonnie, Itell, Hannah L, Kunz, Erika, Hudgens, Michael, Cronin, Kenneth, Wiehe, Kevin, Alam, S Munir, Van Rompay, Koen K A, De Paris, Kristina, Permar, Sallie R, Moody, M Anthony, Fouda, Genevieve G
Published in PloS one (31.12.2021)
Published in PloS one (31.12.2021)
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Immunogenicity and safety of an Entamoeba histolytica adjuvanted protein vaccine candidate (LecA+GLA-3M-052 liposomes) in rhesus macaques
Abhyankar, Mayuresh M, Xu, Feifan, Chavez, Deborah, Goodroe, Anna, Mendoza, Elda, Chen, Christopher, Singh, Dhiraj K, Varnador, Jr, Fernando, Sivananthan, Sandra J, Kinsey, Robert, Lykins, William R, Murphy, Brynn M, Martin, Andrew R, Tomai, Mark A, Ghosal, Soutik, Casper, Corey, Pedersen, Karl, Petri, Jr, William A, Fox, Christopher B
Published in Human vaccines & immunotherapeutics (31.12.2024)
Published in Human vaccines & immunotherapeutics (31.12.2024)
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Optimizing a Multi-Component Intranasal Entamoeba Histolytica Vaccine Formulation Using a Design of Experiments Strategy
Abhyankar, Mayuresh M, Orr, Mark T, Kinsey, Robert, Sivananthan, Sandra, Nafziger, Andrew J, Oakland, David N, Young, Mary K, Farr, Laura, Uddin, Md Jashim, Leslie, Jhansi L, Burgess, Stacey L, Liang, Hong, De Lima, Ines, Larson, Elise, Guderian, Jeffrey A, Lin, Susan, Kahn, Aaron, Ghosh, Prakash, Reed, Sierra, Tomai, Mark A, Pedersen, Karl, Petri, Jr, William A, Fox, Christopher B
Published in Frontiers in immunology (25.06.2021)
Published in Frontiers in immunology (25.06.2021)
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Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists
Gorski, Kevin S., Waller, Emily L., Bjornton-Severson, Jacqueline, Hanten, John A., Riter, Christie L., Kieper, William C., Gorden, Keith B., Miller, Jeffrey S., Vasilakos, John P., Tomai, Mark A., Alkan, Sefik S.
Published in International immunology (01.07.2006)
Published in International immunology (01.07.2006)
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Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors
Schölch, Sebastian, Rauber, Conrad, Tietz, Alexandra, Rahbari, Nuh N, Bork, Ulrich, Schmidt, Thomas, Kahlert, Christoph, Haberkorn, Uwe, Tomai, Mark A, Lipson, Kenneth E, Carretero, Rafael, Weitz, Jürgen, Koch, Moritz, Huber, Peter E
Published in Oncotarget (10.03.2015)
Published in Oncotarget (10.03.2015)
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A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates
Pino, Maria, Abid, Talha, Pereira Ribeiro, Susan, Edara, Venkata Viswanadh, Floyd, Katharine, Smith, Justin C, Latif, Muhammad Bilal, Pacheco-Sanchez, Gabriela, Dutta, Debashis, Wang, Shelly, Gumber, Sanjeev, Kirejczyk, Shannon, Cohen, Joyce, Stammen, Rachelle L, Jean, Sherrie M, Wood, Jennifer S, Connor-Stroud, Fawn, Pollet, Jeroen, Chen, Wen-Hsiang, Wei, Junfei, Zhan, Bin, Lee, Jungsoon, Liu, Zhuyun, Strych, Ulrich, Shenvi, Neeta, Easley, Kirk, Weiskopf, Daniela, Sette, Alessandro, Pollara, Justin, Mielke, Dieter, Gao, Hongmei, Eisel, Nathan, LaBranche, Celia C, Shen, Xiaoying, Ferrari, Guido, Tomaras, Georgia D, Montefiori, David C, Sekaly, Rafick P, Vanderford, Thomas H, Tomai, Mark A, Fox, Christopher B, Suthar, Mehul S, Kozlowski, Pamela A, Hotez, Peter J, Paiardini, Mirko, Bottazzi, Maria Elena, Kasturi, Sudhir Pai
Published in Science Immunology (15.07.2021)
Published in Science Immunology (15.07.2021)
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TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth
Dowling, David J, van Haren, Simon D, Scheid, Annette, Bergelson, Ilana, Kim, Dhohyung, Mancuso, Christy J, Foppen, Willemina, Ozonoff, Al, Fresh, Lynn, Theriot, Terese B, Lackner, Andrew A, Fichorova, Raina N, Smirnov, Dmitri, Vasilakos, John P, Beaurline, Joe M, Tomai, Mark A, Midkiff, Cecily C, Alvarez, Xavier, Blanchard, James L, Gilbert, Margaret H, Aye, Pyone Pyone, Levy, Ofer
Published in JCI insight (23.03.2017)
Published in JCI insight (23.03.2017)
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Development of COVID-19 vaccine using a dual Toll-like receptor ligand liposome adjuvant
Abhyankar, Mayuresh M., Mann, Barbara J., Sturek, Jeffrey M., Brovero, Savannah, Moreau, G. Brett, Sengar, Anjali, Richardson, Crystal M., Agah, Sayeh, Pomés, Anna, Kasson, Peter M., Tomai, Mark A., Fox, Christopher B., Petri, William A.
Published in npj vaccines (18.11.2021)
Published in npj vaccines (18.11.2021)
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Early Post-Vaccination Gene Signatures Correlate With the Magnitude and Function of Vaccine-Induced HIV Envelope-Specific Plasma Antibodies in Infant Rhesus Macaques
Vijayan, K K Vidya, Cross, Kaitlyn A, Curtis, 2nd, Alan D, Van Rompay, Koen K A, Pollara, Justin, Fox, Christopher B, Tomai, Mark, Hanke, Tomáš, Fouda, Genevieve, Hudgens, Michael G, Permar, Sallie R, De Paris, Kristina
Published in Frontiers in immunology (27.04.2022)
Published in Frontiers in immunology (27.04.2022)
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